Author: tianli

Gazizov, M. B. published the artcile4-(Dibromomethyl)benzaldehyde and its reactions with primary amines, Synthetic Route of 6346-09-4, the publication is Russian Journal of General Chemistry (2015), 85(9), 2209-2211, database is CAplus.

The title compound, 4-Br₂CHC₆H₄CHO (1) was prepared by reaction of 1,4-(Br₂CH)₂C₆H₄ with tri-Me phosphate with 42% yield, the side product being di-Me phosphorobromidate (MeO)₂P(O)Br. The process shows advantages over usual acid hydrolysis, being selective and leaving less aggressive hydrogen bromide waste. The aldehyde 1 reacts with primary amines RNH₂, giving aldimines 4-Br₂CHC₆H₄CH:NR [13a–d; R = ⁱPr, 4-MeOC₆H₄, CH₂CH(OEt)₂, (CH₂)₃CH(OEt)₂].

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, M. B. published the artcileSynthesis of 4-(dibromomethyl)benzenecarbaldehyde and its reactions with N- and O-nucleophiles, Product Details of C8H19NO2, the publication is Russian Chemical Bulletin (2016), 65(1), 191-194, database is CAplus.

4-(Dibromomethyl)benzenecarbaldehyde (4-Br₂CHC₆H₄CHO, I) was prepared chemoselectively by debromination of 1,4-bis(dibromomethylbenzene) with tri-Me phosphate; reaction with primary amines RNH₂ [R = i-Pr, 4-MeOC₆H₄, (EtO)₂CHCH₂, (EtO)₂CH₂CH₂CH₂] yielded benzaldimines 4-Br₂CHC₆H₄CH:NR [R = i-Pr, 4-MeOC₆H₄, (EtO)₂CHCH₂, (EtO)₂CH₂CH₂CH₂], while reaction with tri-Me and tri-Et orthoformates in the presence of H₂SO₄ yielded the acetals 4-Br₂CHC₆H₄CH(OR¹)₂ (R¹ = Me, Et).

Russian Chemical Bulletin published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shimizu, Kuniaki published the artcileReductive cleavage reaction of N,N’-, N,O- and N,S-linked alkylidene compounds by sodium borohydride, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical & Pharmaceutical Bulletin (1974), 22(6), 1256-60, database is CAplus.

NaBH4 reduction was undertaken with a variety of N,n’-, N,O-, and N,S-linked alkylidene compounds (e.g. I-III) in aqueous ethanolic medium at room temperature Reductive cleavage of one of these two alkylidene carbon-heteroatom bonds is generally effected in this reduction The alkylidene bond initially cleaved when the two bonds were different was also determined

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C14H12O2, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ito, Masaki published the artcileSelective Boryl Silyl Ether Formation in the Photoreaction of Bisboryloxide/Boroxine with Hydrosilane Catalyzed by a Transition-Metal Carbonyl Complex, Safety of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Journal of the American Chemical Society (2014), 136(17), 6183-6186, database is CAplus and MEDLINE.

Selective B-O-Si bond formation was achieved in the reaction of bisboryloxide O(Bpin)₂ (pin = (OCMe₂)₂)/boroxine (MeBO)₃ system with tertiary silane R₃SiH in the presence of stoichiometric water and a catalytic amount of [M](CO)₅ ([M] = Mo(CO), W(CO), Fe) to give boryl silyl ethers. Moreover, this reaction can be applied to various hydrosilanes (disilyl compounds and secondary silanes) and hydrogermane. Some of the boryl silyl ethers thus formed were confirmed by X-ray anal.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Safety of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ito, Motoki published the artcileSynthesis of Boron-Substituted Diaryliodonium Salts and Selective Transformation into Functionalized Aryl Boronates, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Angewandte Chemie, International Edition (2012), 51(50), 12555-12558, database is CAplus and MEDLINE.

Diaryliodonium salts were synthesized from aryl boronate derivatives according to two alternative general methods with hypervalent iodine(III) reagents and fluoroalc. solvents: transformation of an aryl C-H bond and boron-iodine(III) exchange. The salts could be functionalized by both catalyst-free and metal-catalyzed reactions without loss of the boron functionality.

Angewandte Chemie, International Edition published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barfoot, Katie Louise published the artcileEffects of daily consumption of wild blueberry on cognition and urinary metabolites in school-aged children: a pilot study, Formula: C8H8O3, the publication is European Journal of Nutrition (2021), 60(8), 4263-4278, database is CAplus and MEDLINE.

Acute intervention with wild blueberry (WBB) has previously revealed pos. cognitive and mood effects in typically developing children; however, it is unclear whether effects persist after daily supplementation. In addition, no data have been published exploring the metabolite profiles of children following berry consumption, to our knowledge. A study of this kind could provide insight into a mechanism of action for the cognitive and mood improvements observed previously in children. The aim of this pilot study was to assess cognitive performance and urinary metabolite concentrations in healthy 7-10-yr-old children across a 4 wk daily WBB drink intervention. This pilot study examined the effects of daily WBB consumption for 4 wk (766 mg total polyphenols; 253 mg anthocyanins; equivalent to 240 g fresh blueberries per day) on cognition and mood in 15 healthy 7-10-yr-old children. Polyphenol metabolites were measured in 24 h urine before and after the 4 wk intervention. Chronic WBB-related benefits were seen on cognitively demanding trials on the modified attention network task, a task measuring executive functioning. Specifically, the WBB group maintained significantly higher accuracy on incongruent trials (96%; SE 0.03) compared with placebo participants (85%; SE 0.03; p = 0.038) after the 4 wk intervention, suggesting WBB was of most benefit on the more difficult aspects of the task. No significant WBB-related effects were observed on the auditory verbal learning task or the childs version of the pos. and neg. affect schedule. Urinary metabolite analyses indicated significant increases in different metabolites in WBB and placebo groups after 4 wk consumption. The research demonstrates 24 h WBB bioavailability in a child cohort for the first time with increases in urinary hippuric acid excretion during 2 wk daily WBB consumption. This study highlights the importance of conducting a larger study in children investigating the mechanism of action behind cognitive effects using bioavailability data.

European Journal of Nutrition published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ison, A. published the artcileOxorhenium Complexes for Catalytic Hydrosilylation and Hydrolytic Hydrogen Production: A Multiweek Advanced Laboratory Experiment for Undergraduate Students, Category: alcohols-buliding-blocks, the publication is Journal of Chemical Education (2017), 94(6), 790-794, database is CAplus.

An effective way of teaching undergraduates a full complement of research skills is through a multiweek advanced laboratory experiment Here we outline a comprehensive set of experiments adapted from current primary literature focusing on organic and inorganic synthesis, catalysis, reactivity, and reaction kinetics. The catalyst, bis(2-(2′-hydroxyphenyl)-2-oxazoline)oxorhenium(V) tetrapentafluorophenylborate (1) is isolated through a multistep reaction starting with the formation of the ligand, 2-(2′-hydroxyphenyl)-2-oxazoline (2), followed by complexation of a Re-oxo precursor to form chlorobis(2-(2′-hydroxyphenyl)-2-oxazoline)oxorhenium(V) (3). Both Re(V)-oxo complexes are diamagnetic and allow for NMR anal. Complex 1 is an air-stable and highly active catalyst for two reactions: (1) hydrosilylation of carbonyls and (2) hydrolysis of Et₃SiH to form Et₃SiOH and H₂ gas. Students monitor the evolution of hydrogen gas in the second reaction and use the data to investigate the reaction kinetics in order to obtain the complete rate law and the second-order rate constant for the catalytic reaction. The complete project provides a wealth of opportunities to focus on exptl. skills, fundamental concepts in inorganic and organic chem., catalysis, reactivity, and exptl. kinetics.

Journal of Chemical Education published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wilde, Nathan C. published the artcileTwo-Phase Synthesis of (-)-Taxuyunnanine D, SDS of cas: 597-52-4, the publication is Journal of the American Chemical Society (2014), 136(13), 4909-4912, database is CAplus and MEDLINE.

The first successful effort to replicate the beginning of the Taxol oxidase phase in the laboratory is reported, culminating in the total synthesis of taxuyunnanine D, itself a natural product. Through a combination of computational modeling, reagent screening, and oxidation sequence anal., the first three of eight C-H oxidations (at the allylic sites corresponding to C-5, C-10, and C-13) required to reach Taxol from taxadiene were accomplished. This work lays a foundation for an eventual total synthesis of Taxol capable of delivering not only the natural product but also analogs inaccessible via bioengineering.

Journal of the American Chemical Society published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C5H5F3O2, SDS of cas: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bautista-Aguilera, Oscar M. published the artcileAcetylcholinesterase inhibition of diversely functionalized quinolinones for alzheimer’s disease therapy, Synthetic Route of 622-40-2, the publication is International Journal of Molecular Sciences (2020), 21(11), 3913, database is CAplus and MEDLINE.

The synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of quinolinones I [R = 2-diethylaminoethyl, 1-methyl-4-piperidyl, 3-morpholinopropyl, etc.] and dihydroquinolinones II [R¹ = 1-methyl-4-piperidyl, 2-morpholinoethyl, 2-(4-isopropylpiperazin-1-yl)ethyl, etc.] designed as potential multitarget small mols. (MSM) for alzheimer’s disease therapy was reported.. None of them showed significant human recombinant MAO inhibition, but compounds I [R = 4-(4-isopropylpiperazin-1-yl)butyl, 5-(4-isopropylpiperazin-1-yl)pentyl] and compound II [R¹ = 4-(4-isopropylpiperazin-1-yl)butyl] displayed promising human recombinant acetylcholinesterase (hrAChE) and butyrylcholinesterase (hrBuChE) inhibition. In particular, compound I [R = 4-(4-isopropylpiperazin-1-yl)butyl] was found to be a potent and quite selective non-competitive inhibitor of hrAChE (IC₅₀ = 0.29μM), with Ki value in nanomolar range (79 nM). Pertinent docking anal. confirmed this result, suggesting that this ligand was an interesting hit for further investigation.

International Journal of Molecular Sciences published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Synthetic Route of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Asao, Naoki published the artcileNanostructured Materials as Catalysts: Nanoporous-Gold-Catalyzed Oxidation of Organosilanes with Water, Quality Control of 17877-23-5, the publication is Angewandte Chemie, International Edition (2010), 49(52), 10093-10095, S10093/1-S10093/4, database is CAplus and MEDLINE.

Oxidation of organosilanes R_4-nSiH_n (n = 1, R = Et, Bu, Me₂CH, Ph; n = 2, 3, R = Ph; n = 1, R₃ = PhMe₂, CH₂:CHMePh, PhCCMe₂) with n H₂O (same n) in acetone over nanoporous gold catalyst at room temperature for 1-9 h gave 80-100% of the corresponding silanols R_4-nSi(OH)_n (same R, n).

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts