Author: tianli

Barth, Marie-Christin published the artcileSynthesis and characterization of thiocarbonato-linked platinum(IV) complexes, Related Products of alcohols-buliding-blocks, the publication is Dalton Transactions (2022), 51(14), 5567-5576, database is CAplus and MEDLINE.

Herein we show the formation of new oxaliplatin-based platinum(IV) complexes by reaction with DSC-activated thiols via thiocarbonate linkage. Three model complexes based on aliphatic and aromatic thiols, as well as one complex with N-acetylcysteine as biol. active thiol were synthesized. This synthetic strategy affords the expansion of biol. active compounds other than those containing carboxylic, amine or hydroxy groups for coupling to the platinum(IV) center. The complexes were characterized by high-resolution mass spectrometry, NMR spectroscopy (¹H, ¹³C, ¹⁹⁵Pt) and elemental anal. Their biol. behavior was evaluated against two ovarian carcinoma cell lines and their cisplatin-resistant analogs. Remarkably, the platinum(IV) samples show modest in vitro cytotoxicity against A2780 cells and comparable effects against A2780cis cells. Two complexes in particular demonstrate improved activity against SKOV3cis cells. The reduction experiment of complex 8, investigated by UHPLC-HRMS, provides evidence of interesting platinum-species formed during reaction with ascorbic acid.

Dalton Transactions published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bai, Ping published the artcileDesign, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins, Recommanded Product: Pentane-1,5-diol, the publication is Journal of Medicinal Chemistry (2021), 64(19), 14745-14756, database is CAplus and MEDLINE.

To better understand the role of bromodomain and extra-terminal domain (BET) proteins in epigenetic mechanisms, we developed a series of thienodiazepine-based derivatives and identified two compounds, 3a and 6a, as potent BET inhibitors. Further in vivo pharmacokinetic studies and anal. of in vitro metabolic stability of 6a revealed excellent brain penetration and reasonable metabolic stability. Compounds 3a and 6a were radiolabeled with fluorine-18 in two steps and utilized in positron emission tomog. (PET) imaging studies in mice. Preliminary PET imaging results demonstrated that [¹⁸F]3a and [¹⁸F]6a have good brain uptake (with maximum SUV = 1.7 and 2, resp.) and binding specificity in mice brains. These results show that [¹⁸F]6a is a potential PET radiotracer that could be applied to imaging BET proteins in the brain. Further optimization and improvement of the metabolic stability of [¹⁸F]6a are still needed in order to create optimal PET imaging probes of BET family members.

Journal of Medicinal Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Recommanded Product: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xueyan published the artcileChiral discrimination of enantiomers based on different interactions with alterable chiral oligomer, SDS of cas: 90-64-2, the publication is Journal of Polymer Research (2021), 28(12), 486, database is CAplus.

Series of chiral oligomer ((S)-1-(S)-7)) based on the different proportions of achiral fluorophore unit (9, 9-dipropyl alkynyl fluorene (1a)) and chiral unit ((S)-2-(4-isopropyl-4, 5-dihydrooxazol-2-yl)-2-(prop-2-yn-1-yl) pent-4-ynenitrile (1b)) via Glaser coupling method were synthesized. The results showed that the fluorescent probe can be applied to the recognition of different enantiomers by changing the ratio of fluorophore to chiral group in the oligomer. The hydrogen bonding between chiral units and enantiomers in oligomers and large steric hindrance of rigid achiral units on conformation of the polymers may be the reasons for the different recognition abilities of oligomer with different ratios.

Journal of Polymer Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C6H11NO2, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bhatnagar, Madhu published the artcileThe in vitro effects of anthelmintics on phosphatases of sheep nodular worm, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Journal of Parasitology (1987), 11(2), 201-3, database is CAplus.

When tested in vitro, piperazine at 10 and 50 μg/mL inhibited acid phosphatase by 3.6 and 14.96%, resp., and activated alk. phosphatase by 2.35 and 5.9%, resp. Treatment with bephenium hydroxynaphoate at 10 and 50 μg/mL, inhibited acid phosphatase by 11.56 and 58.5%, resp., and increased alk. phosphatase by 11.8 and 55.3%, resp. Mebendazole at 10 and 50 μg/mL inhibited acid phosphatase by 64.6 and 93.87%, resp., and activated alk. phosphatase by 31.5 and 85.5%, resp. Thus, mebendazole showed the max inhibition of acid phosphatase and piperazine the least.

Indian Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tudorascu, Marius published the artcileEnzymes in organic syntheses. I. Olefin transformation to addition products catalyzed by chloroperoxidase, SDS of cas: 55376-31-3, the publication is Progress in Catalysis (1993), 63-70, database is CAplus.

Chloroperoxidase in free or immobilized form catalyzed the addition reactions of olefins with hypohalous acids generated from metal halides and H₂O₂. Thus, the reaction of propylene with LiBr-H₂O₂ afforded 1-bromo-2-propanol (92-3%) and 2-bromo-1-propanol.

Progress in Catalysis published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C16H14O6, SDS of cas: 55376-31-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdallah el hadj, A. published the artcileAI-PCSAFT approach: New high predictive method for estimating PC-SAFT pure component properties and phase equilibria parameters, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Fluid Phase Equilibria (2022), 113297, database is CAplus.

In this work, a new approach based on the association of Artificial intelligence method (AI) and PC-SAFT equation of state is applied to conceive a model for estimating the solubility of solid drugs in supercritical carbon dioxide. Neuro-equation of state approach (NES) is the new technique that takes benefit from the advantages of both ANN and PC-SAFT equation of state. The new method decomposes into three main stages, first the optimization of direct ANN for predicting solids-scCO₂ phase equilibrium (where 15 binary systems are used), then the ANN inverse is performed to be an alternative to group contribution methods (GCMs) for estimating the pure components and phys. properties (reduce the uncertainty committed in estimating these properties) and enhance the PCSAFT equation of state to estimate phase equilibrium parameters and finally, ANN-PCSAFT approach is used to estimate the solubility of 213 solid solutes in supercritical carbon dioxide. The performance strategy has been carried out using a linear regression anal. of the predicted vs. exptl. outputs, as an indication of the predictive ability of the developed method. The new approach is successfully applied to the phase equilibrium modeling for 213 binary systems with high accuracy (the comparison in terms of average absolute relative deviation (AARD %) showed a variation from 2 to 6%) and allowed to enhance the phase equilibrium modeling by reducing the number of optimized parameters and surpass the main drawbacks faced in this area mainly the non-availability of phys. properties and EOS pure component properties and the limitation of the equation of state.

Fluid Phase Equilibria published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Mingyu published the artcileNovel amorphous solid dispersion based on natural deep eutectic solvent for enhancing delivery of anti-tumor RA-XII by oral administration in rats, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is European Journal of Pharmaceutical Sciences (2021), 105931, database is CAplus and MEDLINE.

At present, oral chemotherapy showing the advantages of non-invasiveness, convenience, and high patient compliance, is gradually replacing traditional i.v. chemotherapy to treat patients with cancer. RA-XII, a unique natural cyclopeptide, exhibits various biol. activities, such as anti-tumor, anti-angiogenic, and anti-metastatic activities. Designing an orally available formulation of RA-XII is of great importance in the development of clin. useful anticancer agents. However, RA-XII shows low oral bioavailability in rats due to its poor solubility and low permeability. To overcome these limitations, in this work, a natural deep eutectic solvent (NADES) was designed to efficiently deliver RA-XII by oral administration. A novel NADES composed of betaine and mandelic acid in the molar ratio of 1:1 (Bet-Man NADES) was successfully prepared based on a binary phase diagram of Bet and Man. Acute toxicity studies indicated that Bet-Man NADES was well tolerated with acceptable toxicity. In Bet-Man NADES solutions, the solubility of RA-XII was increased by up to 17.54-fold, and the diffusion and permeability of RA-XII carried out in a Franz cell was also significantly improved 10.35 times. In terms of biopharmaceutical classification this is translated into a change for RA-XII from class IV to class II systems. More importantly, Bet-Man NADES was transferred into the solid formulation by the inclusion of a polymer, and amorphous solid dispersions based on Bet-Man NADES (PVP K30/NADES/RA-XII, ASDs) were successfully prepared to improve uniformity, apparent solubility, dissolution, and cytotoxicity in vitro. Consequently, the oral bioavailability of RA-XII in NADES solutions and ASDs was enhanced by approx. 11.58 and 7.56 times compared with that of pure RA-XII in 0.5% CMC-Na. Thus, it can be seen that a natural deep eutectic solvent and its modified amorphous solid dispersions are appropriate novel strategies for improving dissolution rate and bioavailability of poor soluble natural products such as RA-XII.

European Journal of Pharmaceutical Sciences published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boyd, Mary K. published the artcileWater quenching behavior of excited 9-xanthylium cations in aqueous sulfuric acid solutions, SDS of cas: 596-38-3, the publication is Journal of the American Chemical Society (1991), 113(19), 7294-300, database is CAplus.

A series of 9-alkyl- and 9-aryl-substituted xanthylium cations (I; R = H, Me, Me₂CHr, cyclo-Pr, tert-Bu; II; R¹ = H, p-CF₃, p– and m-Me, p– and m-OMe) were generated from the corresponding 9-xanthenols in strongly acidic aqueous MeCH (2:1) solutions (39-78% H₂SO₄). Steady-state irradiation at 370 nm produced the excited cations, all of which were fluorescent in the 520-nm region. Fluorescence lifetimes varied considerably with acid concentration, from subnanosecond values at low acidity to 20-35 ns at high acidity. Stern-Volmer plots of Φ_F°/Φ_F vs. the free water concentration in these acid solutions gave linear plots in all cases, yielding k_q values in the 10⁶-10⁹ M^-1 s^-1 range, depending on substituents. For the 9-aryl systems, a plot of log k_q vs. a recently determined σ^hν scale was reasonably linear (r = 0.974) with a ρ value of -1.5, which is opposite in sign to that recently determined for H₂O quenching of the same cations in their ground states. Possible explanations for this surprising result are considered.

Journal of the American Chemical Society published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, SDS of cas: 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Qiao published the artcileSynthesis and photoluminescence of organotin-dithiothreitol clusters, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of Solid State Chemistry (2021), 122056, database is CAplus.

Three novel organotin oxysulfide hybrid clusters (BuSn)₄(DTT)₄M (M = Sn⁴⁺ (1), Ti⁴⁺ (2), Hf⁴⁺ (3); DTT = 1,4-dithiothreitol) were prepared by hydrothermal methods and their crystal structures were determined by single-crystal X-ray diffraction. These clusters are isostructural, pentanuclear complexes containing four peripheral butyltin fragments, and a central metal site of either tin, titanium or hafnium. Solid state variable temperature fluorescence spectra showed that the position and the intensity of key emission peaks of the three isomorphic compounds are significantly different. Compound 1 gave bimodal emission at 420 and 445 nm upon excitation at 360 nm, and its peak positions remained unchanged. Compounds 2 and 3 were excited by 365 and 460 nm radiation, resp., and their maximum emission peaks were red-shifted in different degrees with decreasing temperature All their peak intensity increased with decreasing temperature Solid-state UV/visible diffuse reflectance spectra displayed that these three isostructural compounds have wide optical band gaps of 3.72, 2.68, and 3.19 eV, resp.

Journal of Solid State Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C26H41N5O7S, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xiaojia published the artcileReductive Catalytic Depolymerization of Semi-industrial Wood-Based Lignin, SDS of cas: 111-29-5, the publication is Industrial & Engineering Chemistry Research (2021), 60(47), 16827-16838, database is CAplus and MEDLINE.

The current work studies the reductive catalytic depolymerization (RCD) of lignin from a novel semi-industrial process. The aim was to obtain aromatic mono-, di-, tri-, and tetramers for further valorization. The substrate and products were characterized by multiple anal. methods, including high pressure size-exclusion chromatog. (HPSEC), gas chromatog.-mass spectrometry, GC-flame ionization detector (FID), GC-FID/thermal conductivity detector (TCD), and NMR. The RCD was studied by exploring the influence of different parameters, such as lignin solubility, reaction time, hydrogen pressure, reaction temperature, pH, type and loading of the catalyst, as well as type and composition of the organic/aqueous solvent. The results show that an elevated temperature, a redox catalyst, and a hydrogen atm. are essential for the depolymerization and stability of the products, while the reaction medium also plays an important role. The highest obtained mono- to tetramers yield was 98% and mono- to dimers yield over 85% in the liquid phase products. The reaction mechanisms influenced the structure of the aliphatic chain in the monomers, but left the phenolic structure along with the methoxy groups largely unaltered. The current work contributes to the development and debottlenecking of the novel and sustainable overall process, which utilizes efficiently all the fractions of wood, in line with the principles of green engineering and chem.

Industrial & Engineering Chemistry Research published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts