Author: tianli

Lee, Hiu-Fung published the artcileSynthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase, Category: alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2022), 65(3), 2471-2496, database is CAplus and MEDLINE.

Novel analogs of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and exhibit antimyeloma activity in vivo. A key structural element of these inhibitors is a linker moiety that connects their (((2-phenylthieno[2,3-d]pyrimidin-4-yl)amino)methylene)bisphosphonic acid core to various side chains. The structural diversity of this linker moiety, as well as the side chains attached to it, was investigated and found to significantly impact the toxicity of these compounds in MM cells. The most potent inhibitor CML-07-119(13c)(I) was evaluated in mouse and rat for liver toxicity and systemic exposure, resp., providing further optimism for the potential value of such compounds as human therapeutics.

Journal of Medicinal Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shirbhate, Mukesh Eknath published the artcileOptical and Fluorescent Dual Sensing of Aminoalcohols by in Situ Generation of BODIPY-like Chromophore, Related Products of alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2020), 142(11), 4975-4979, database is CAplus and MEDLINE.

A novel multifunctional aminophenylboronic acid connected to a diphenylketone gives both CD and fluorescence signals by in situ generation of a BODIPY-like chromophore in the presence of aminoalcs. DFT calculations were used to understand the role of each functional group in the mechanism. This new sensor can distinguish different aminoalcs. and quant. indicate the concentration of the substrate, allowing for the convenient determination of the ee of racemic mixtures with a single probe.

Journal of the American Chemical Society published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C7H7IN2O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileThe tautomerism of hydroxy derivatives of five-membered oxygen, nitrogen, and sulfur heterocycles, Formula: C4H4OS, the publication is Tetrahedron Letters (1986), 27(28), 3275-8, database is CAplus.

The unstable enolic tautomers 3-hydroxyfuran, 2- and 3-hydroxythiophene, 3-hydroxypyrrole, 3-hydroxy-1-methylpyrrole and their benzo derivatives have been generated in solution and the rate and equilibrium constants for their ketonization determined

Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Formula: C4H4OS.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileThe tautomerism of hydroxy derivatives of five-membered oxygen, nitrogen, and sulfur heterocycles [Erratum to document cited in CA106(19):155813y], SDS of cas: 17236-59-8, the publication is Tetrahedron Letters (1988), 29(3), 250, database is CAplus.

An error in a k_H⁺ value for ketonization of 2-hydroxyindene was corrected (3.48 M^-1s^-1, not 83 M^-1s^-1. The error was not reflected in the abstract or the index entries.

Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, SDS of cas: 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileTautomerism of the monohydroxy derivatives of five-membered oxygen, nitrogen and sulfur heterocycles, Application of Thiophen-3-ol, the publication is Journal of the American Chemical Society (1989), 111(14), 5346-56, database is CAplus.

The O-deuterated enolic tautomers 3-deuteroxybenzofuran, 3-deuteroxybenzothiophene, 3-deuteroxyindole, 3-deuteroxy-1-methylindole, 3-deuteroxyfuran, 3-deuteroxythiophene, 2-deuteroxybenzothiophene, and 2-deuteroxythiophene were generated in solution in mixtures of CD₃COCD₃, CD₃CN, or CD₃SOCD₃ with D₂O by hydrolysis of their trimethylsilyl derivatives in the presence of DCl (10^-3-10^-1 M) and characterized by ¹H NMR spectroscopy. Solutions of 3-hydroxypyrrole and of 3-hydroxy-1-methylpyrrole were obtained by methanolysis of their trimethylsilyl derivatives, evaporation of the methanol, and immediate dissolution in DMSO-d₆. The carbocyclic analogs of the bicyclic heterocyclic enols 3-deuteroxyindene and 2-deuteroxyindene were also generated in solution Attempts to prepare solutions of 2-deuteroxyfuran, 2-deuteroxypyrrole, and 2-deuteroxy-1-methylpyrrole were unsuccessful. The kinetics of ketonization of the OH forms of these enols were investigated in water or aqueous acetonitrile solution The equilibrium constants for the keto-enol tautomerism were also determined either by direct measurement when sufficient enol was present at equilibrium or as the ratio of the rate constant for enolization of the keto form to that for ketonization of the enol form, the former being determined by the iodine-trapping technique. The effect of solvent on the equilibrium constants was also studied. Sufficient data were available for the equilibrium between 3-hydroxyindole and 3-ketoindole for them to be analyzed by the four-parameter equation of Mills and Beak to yield an a-value of 2.4 and a b-value of -3.0. The pK_as of the bicyclic enols were measured. 3-Hydroxybenzofuran and 3-hydroxybenzothiophene are stronger acids than 3-hydroxyindole and 3-hydroxy-1-methylindole. The ketonization reactions are general-acid and general-base catalyzed and their mechanisms are discussed.

Journal of the American Chemical Society published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Krotov, A. I. published the artcileActivity of some quaternary salts of β-aryloxyethylaralkylammonium during the infection of mice by Nippostrongylus brasiliensis, Application In Synthesis of 3818-50-6, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1968), 37(3), 361-4, database is CAplus.

Some quaternary salts of β-aryloxyethylaralkylammonium were synthesized and tested in Nippostrongylus braziliensis exptl. infection in mice. The anthelmintic drug naphthamone (N-(β-phenoxyethyl)-N,N-dimethyl-N-benzylammonium β-hydroxynaphthoate) served as a standard. Changes in the cation portion of the napthamone mol. by introduction of various substitutes (e.g. CHO, OH) in the phenoxygroup, or substitution of the latter by the naphthoxy group, gave inactive compounds Introduction of naphthyl, imidazolyl, and other groups instead of the benzyl group results in reduction of the activity, whereas the presence of the thenyl group preserved the activity. The most active compound was bephenium salicylate; bephenium α-bromo-β-hydroxynaphthoate was inactive.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application In Synthesis of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Masada, Koichiro published the artcileReductive Coupling of Carbon Dioxide and an Aldehyde Mediated by a Copper(I) Complex toward the Synthesis of α-Hydroxycarboxylic Acids, Related Products of alcohols-buliding-blocks, the publication is Organic Letters (2020), 22(13), 4922-4926, database is CAplus and MEDLINE.

Copper-mediated reductive coupling between CO₂ and an aldehyde to form α-hydroxycarboxylic acid was achieved using silylborane as a reductant. CO₂ cleanly inserted into a copper-carbon bond that was formed by the reaction between a silylcopper-NHC complex and an aldehyde. A series of reactions that regenerate the silylcopper complex were developed for the synthesis of an α-hydroxycarboxylic acid. After repeating each step iteratively for two cycles, 0.62 equiv of α-hydroxycarboxylic acid based on the copper complex was obtained.

Organic Letters published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nagasawa, Yoshiyuki published the artcile4-Propylphenol Hydrogenation over Pt-Pd Bimetallic Catalyst in Aqueous Ethanol Solution without External Hydrogen, Application In Synthesis of 645-56-7, the publication is Chemistry Letters (2021), 50(12), 1968-1971, database is CAplus.

Ring-hydrogenation of 4-propylphenol (4-PP) to 4-propylcyclohexanone, cis- and trans-4-propylcyclohexanols proceeded over graphite-supported palladium catalysts (Pd/G) in aqueous ethanol solution at 573 K without using external hydrogen gas. Compared to Pd/G, graphite-supported platinum (Pt/G) catalysts were active only for hydrogen production and not for the ring-hydrogenation under the same reaction conditions. We have found that the addition of platinum to palladium enhanced the cis- and trans-4-propylcyclohexanols yields. The optimum molar ratio of platinum to palladium in the Pt-Pd/G catalysts was found to be 1:2. The formation of Pt-Pd alloy sites was studied by TEM and EXAFS analyses.

Chemistry Letters published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Application In Synthesis of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Singh, A. K. published the artcileNear ab initio quality molecular electrostatic potential maps using hybridization displacement charges at PM3 level and effects of geometrical changes in amino groups, Quality Control of 17236-59-8, the publication is International Journal of Quantum Chemistry (2001), 82(6), 299-312, database is CAplus.

Charge distributions, dipole moments, and mol. electrostatic potentials (MEP) around several mols. consisting of carbon, nitrogen, oxygen, fluorine, sulfur, and chlorine atoms were studied using the PM3 semiempirical method and the results compared with those obtained using ab initio calculations at the RHF/6-31G^** level. Relative MEP values near different atoms can be obtained using hybridization displacement charges (HDC) obtained by employing PM3 d. matrixes that usually agree quite satisfactorily with the ab initio ones. Positions of ab initio MEP min. are correctly located and the corresponding relative MEP values usually correctly predicted using the PM3(HDC) charges distributed continuously in three dimensions according to the forms of squares of valence s AOs. The necessary parameters for HDC calculations using the PM3 method were optimized. Within the frameworks of both PM3 and AM1 methods the π electrons or lone pairs associated with amino group nitrogen atoms and ring atoms can be satisfactorily treated in different situations.

International Journal of Quantum Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C13H26N2, Quality Control of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shuto, Ayumi published the artcileπ-Extended Planarized Triphenylboranes with Thiophene Spacers, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Organic Letters (2013), 15(24), 6234-6237, database is CAplus and MEDLINE.

Planarized triphenylboranes extended with thiophene or bithiophene spacers were synthesized, which showed intense fluorescences in solution and reversible redox waves for reduction in cyclic voltammetry. Organic light-emitting diodes (OLEDs) using these compounds as an electron-transporting material were fabricated.

Organic Letters published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C17H19N3O6, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts