Author: tianli

De Castro Dantas, T. N.’s team published research in Phosphorus and Sulfur and the Related Elements in 13 | CAS: 101-98-4

Phosphorus and Sulfur and the Related Elements published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Category: alcohols-buliding-blocks.

De Castro Dantas, T. N. published the artcilePreparation of aminoalkylphosphonium salts, Category: alcohols-buliding-blocks, the publication is Phosphorus and Sulfur and the Related Elements (1982), 13(1), 97-105, database is CAplus.

Three synthetic methods gave aminophosphonium salts Ph3P+(CH2)nNRR1 X– (n = 2-4; R, R1 = Me, Et, Me2CH, Ph, PhCH2). Yields are better with n = 3, but no intramol. stabilization was detected.

Phosphorus and Sulfur and the Related Elements published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elam, Christopher’s team published research in European Journal of Medicinal Chemistry in 46 | CAS: 903-19-5

European Journal of Medicinal Chemistry published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Elam, Christopher published the artcileDiscovery of novel SERCA inhibitors by virtual screening of a large compound library, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is European Journal of Medicinal Chemistry (2011), 46(5), 1512-1523, database is CAplus and MEDLINE.

Two screening protocols based on recursive partitioning and computational ligand docking methodologies, resp., were employed for virtual screens of a compound library with 345,000 entries for novel inhibitors of the enzyme sarco/endoplasmic reticulum calcium ATPase (SERCA), a potential target for cancer chemotherapy. A total of 72 compounds that were predicted to be potential inhibitors of SERCA were tested in bioassays and 17 displayed inhibitory potencies at concentrations below 100 μM. The majority of these inhibitors were composed of two Ph rings tethered to each other by a short link of one to three atoms. Putative interactions between SERCA and the inhibitors were identified by inspection of docking-predicted poses and some of the structural features required for effective SERCA inhibition were determined by anal. of the classification pattern employed by the recursive partitioning models.

European Journal of Medicinal Chemistry published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Name: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gilbert, Audrey’s team published research in Tetrahedron in 98 | CAS: 2240-88-2

Tetrahedron published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Gilbert, Audrey published the artcileSynthesis of N-(2-SF5-ethyl)amines and impact of the SF5 substituent on their basicity and lipophilicity, SDS of cas: 2240-88-2, the publication is Tetrahedron (2021), 132424, database is CAplus.

The synthesis of N-(2-SF5-ethyl)amines e.g., I is reported via the SN2 reaction between various amines, e.g., Me (2S)-pyrrolidine-2-carboxylate and 2-(pentafluoro-λ6-sulfanyl)ethyl trifluoromethanesulfonate as the SF5-containing electrophile. A total of 14 examples of SF5-containing aliphatic amines were synthesized, with yields going from 19 to 92%. Moreover, the effect of the SF5 substituent on the basicity and the lipophilicity of the amine was evaluated, and the SF5 group showed to decrease both the pKaH and the log D (pH = 7.0) values.

Tetrahedron published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Trzmiel, Simon P. O.’s team published research in Dalton Transactions in 51 | CAS: 597-52-4

Dalton Transactions published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C19H36BNO2Si, COA of Formula: C6H16OSi.

Trzmiel, Simon P. O. published the artcileChromous siloxides of variable nuclearity and magnetism, COA of Formula: C6H16OSi, the publication is Dalton Transactions (2022), 51(13), 5072-5081, database is CAplus and MEDLINE.

Treatment of Cr[N(SiMe3)2]2(THF)2 with HOSiR3 (R = Et, iPr) in THF afforded the bridged CrII siloxide complexes Cr3(OSiEt3)2(μ-OSiEt3)4(THF)2 and Cr2(OSiiPr3)2(μ-OSiiPr3)2(THF)2 in high yield. Exposure of these compounds to vacuum in aliphatic solvents led to the loss of coordinated THF and to the formation of the homoleptic chromous siloxides Cr4(μ-OSiEt3)8 and Cr3(OSiiPr3)2(μ-OSiiPr3)4, resp., in moderate to high yield. Use of TMEDA as a potentially bidentate donor mol. gave the monomeric cis-coordinated siloxide Cr(OSiiPr3)2(tmeda) (tmeda = N,N,N’,N’-tetramethylethane-1,2-diamine). Oxidation of Cr2(OSiiPr3)2(μ-OSiiPr3)2(THF)2 with CHI3 and C2Cl6 produced the trigonal bipyramidal chromic compound CrIII(OSiiPr)3(THF)2 and asym. coordinated Cr2Cl3(OSiiPr3)3(THF)3, resp. Magnetic measurements (Evans and SQUID) hinted at (a) antiferromagnetic interactions between the CrII centers, (b) revealed higher effective magnetic moments (μeff) for cis-coordinated monomeric heteroleptic complexes compared to trans-coordinated ones, and (c) pointed out the highest (μeff) for the tetranuclear complex Cr4(μ-OSiEt3)8 (6.26μB, SQUID, 300 K; Cr···Cradjacent average 2.535 Å).

Dalton Transactions published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C19H36BNO2Si, COA of Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Trzmiel, Simon P. O.’s team published research in Dalton Transactions in 51 | CAS: 17877-23-5

Dalton Transactions published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C12H17BO4S, SDS of cas: 17877-23-5.

Trzmiel, Simon P. O. published the artcileChromous siloxides of variable nuclearity and magnetism, SDS of cas: 17877-23-5, the publication is Dalton Transactions (2022), 51(13), 5072-5081, database is CAplus and MEDLINE.

Treatment of Cr[N(SiMe3)2]2(THF)2 with HOSiR3 (R = Et, iPr) in THF afforded the bridged CrII siloxide complexes Cr3(OSiEt3)2(μ-OSiEt3)4(THF)2 and Cr2(OSiiPr3)2(μ-OSiiPr3)2(THF)2 in high yield. Exposure of these compounds to vacuum in aliphatic solvents led to the loss of coordinated THF and to the formation of the homoleptic chromous siloxides Cr4(μ-OSiEt3)8 and Cr3(OSiiPr3)2(μ-OSiiPr3)4, resp., in moderate to high yield. Use of TMEDA as a potentially bidentate donor mol. gave the monomeric cis-coordinated siloxide Cr(OSiiPr3)2(tmeda) (tmeda = N,N,N’,N’-tetramethylethane-1,2-diamine). Oxidation of Cr2(OSiiPr3)2(μ-OSiiPr3)2(THF)2 with CHI3 and C2Cl6 produced the trigonal bipyramidal chromic compound CrIII(OSiiPr)3(THF)2 and asym. coordinated Cr2Cl3(OSiiPr3)3(THF)3, resp. Magnetic measurements (Evans and SQUID) hinted at (a) antiferromagnetic interactions between the CrII centers, (b) revealed higher effective magnetic moments (μeff) for cis-coordinated monomeric heteroleptic complexes compared to trans-coordinated ones, and (c) pointed out the highest (μeff) for the tetranuclear complex Cr4(μ-OSiEt3)8 (6.26μB, SQUID, 300 K; Cr···Cradjacent average 2.535 Å).

Dalton Transactions published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C12H17BO4S, SDS of cas: 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barth, Marie-Christin’s team published research in Dalton Transactions in 51 | CAS: 4410-99-5

Dalton Transactions published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Related Products of alcohols-buliding-blocks.

Barth, Marie-Christin published the artcileSynthesis and characterization of thiocarbonato-linked platinum(IV) complexes, Related Products of alcohols-buliding-blocks, the publication is Dalton Transactions (2022), 51(14), 5567-5576, database is CAplus and MEDLINE.

Herein we show the formation of new oxaliplatin-based platinum(IV) complexes by reaction with DSC-activated thiols via thiocarbonate linkage. Three model complexes based on aliphatic and aromatic thiols, as well as one complex with N-acetylcysteine as biol. active thiol were synthesized. This synthetic strategy affords the expansion of biol. active compounds other than those containing carboxylic, amine or hydroxy groups for coupling to the platinum(IV) center. The complexes were characterized by high-resolution mass spectrometry, NMR spectroscopy (1H, 13C, 195Pt) and elemental anal. Their biol. behavior was evaluated against two ovarian carcinoma cell lines and their cisplatin-resistant analogs. Remarkably, the platinum(IV) samples show modest in vitro cytotoxicity against A2780 cells and comparable effects against A2780cis cells. Two complexes in particular demonstrate improved activity against SKOV3cis cells. The reduction experiment of complex 8, investigated by UHPLC-HRMS, provides evidence of interesting platinum-species formed during reaction with ascorbic acid.

Dalton Transactions published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bai, Ping’s team published research in Journal of Medicinal Chemistry in 64 | CAS: 111-29-5

Journal of Medicinal Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Recommanded Product: Pentane-1,5-diol.

Bai, Ping published the artcileDesign, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins, Recommanded Product: Pentane-1,5-diol, the publication is Journal of Medicinal Chemistry (2021), 64(19), 14745-14756, database is CAplus and MEDLINE.

To better understand the role of bromodomain and extra-terminal domain (BET) proteins in epigenetic mechanisms, we developed a series of thienodiazepine-based derivatives and identified two compounds, 3a and 6a, as potent BET inhibitors. Further in vivo pharmacokinetic studies and anal. of in vitro metabolic stability of 6a revealed excellent brain penetration and reasonable metabolic stability. Compounds 3a and 6a were radiolabeled with fluorine-18 in two steps and utilized in positron emission tomog. (PET) imaging studies in mice. Preliminary PET imaging results demonstrated that [18F]3a and [18F]6a have good brain uptake (with maximum SUV = 1.7 and 2, resp.) and binding specificity in mice brains. These results show that [18F]6a is a potential PET radiotracer that could be applied to imaging BET proteins in the brain. Further optimization and improvement of the metabolic stability of [18F]6a are still needed in order to create optimal PET imaging probes of BET family members.

Journal of Medicinal Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Recommanded Product: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xueyan’s team published research in Journal of Polymer Research in 28 | CAS: 90-64-2

Journal of Polymer Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C6H11NO2, SDS of cas: 90-64-2.

Zhang, Xueyan published the artcileChiral discrimination of enantiomers based on different interactions with alterable chiral oligomer, SDS of cas: 90-64-2, the publication is Journal of Polymer Research (2021), 28(12), 486, database is CAplus.

Series of chiral oligomer ((S)-1-(S)-7)) based on the different proportions of achiral fluorophore unit (9, 9-dipropyl alkynyl fluorene (1a)) and chiral unit ((S)-2-(4-isopropyl-4, 5-dihydrooxazol-2-yl)-2-(prop-2-yn-1-yl) pent-4-ynenitrile (1b)) via Glaser coupling method were synthesized. The results showed that the fluorescent probe can be applied to the recognition of different enantiomers by changing the ratio of fluorophore to chiral group in the oligomer. The hydrogen bonding between chiral units and enantiomers in oligomers and large steric hindrance of rigid achiral units on conformation of the polymers may be the reasons for the different recognition abilities of oligomer with different ratios.

Journal of Polymer Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C6H11NO2, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bhatnagar, Madhu’s team published research in Indian Journal of Parasitology in 11 | CAS: 3818-50-6

Indian Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Bhatnagar, Madhu published the artcileThe in vitro effects of anthelmintics on phosphatases of sheep nodular worm, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Journal of Parasitology (1987), 11(2), 201-3, database is CAplus.

When tested in vitro, piperazine at 10 and 50 μg/mL inhibited acid phosphatase by 3.6 and 14.96%, resp., and activated alk. phosphatase by 2.35 and 5.9%, resp. Treatment with bephenium hydroxynaphoate at 10 and 50 μg/mL, inhibited acid phosphatase by 11.56 and 58.5%, resp., and increased alk. phosphatase by 11.8 and 55.3%, resp. Mebendazole at 10 and 50 μg/mL inhibited acid phosphatase by 64.6 and 93.87%, resp., and activated alk. phosphatase by 31.5 and 85.5%, resp. Thus, mebendazole showed the max inhibition of acid phosphatase and piperazine the least.

Indian Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tudorascu, Marius’s team published research in Progress in Catalysis in | CAS: 55376-31-3

Progress in Catalysis published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C16H14O6, SDS of cas: 55376-31-3.

Tudorascu, Marius published the artcileEnzymes in organic syntheses. I. Olefin transformation to addition products catalyzed by chloroperoxidase, SDS of cas: 55376-31-3, the publication is Progress in Catalysis (1993), 63-70, database is CAplus.

Chloroperoxidase in free or immobilized form catalyzed the addition reactions of olefins with hypohalous acids generated from metal halides and H2O2. Thus, the reaction of propylene with LiBr-H2O2 afforded 1-bromo-2-propanol (92-3%) and 2-bromo-1-propanol.

Progress in Catalysis published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C16H14O6, SDS of cas: 55376-31-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts