Author: tianli

Ma, Lina published the artcileGold nanoparticles supported on the periodic mesoporous organosilica SBA-15 as an efficient and reusable catalyst for selective oxidation of silanes to silanols, Formula: C6H16OSi, the publication is RSC Advances (2014), 4(13), 6807-6810, database is CAplus.

Gold nanoparticles are confined and stabilized within the channels of SBA-15 through the poly(ionic liquid) brushes that are anchored onto the pore walls of SBA-15. The supported gold catalyst exhibited remarkably high catalytic activities for selective oxidation of silanes into silanols using water as an oxidant without the use of organic solvents.

RSC Advances published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Lina published the artcileGold nanoparticles supported on the periodic mesoporous organosilica SBA-15 as an efficient and reusable catalyst for selective oxidation of silanes to silanols, Recommanded Product: Triisopropylsilanol, the publication is RSC Advances (2014), 4(13), 6807-6810, database is CAplus.

Gold nanoparticles are confined and stabilized within the channels of SBA-15 through the poly(ionic liquid) brushes that are anchored onto the pore walls of SBA-15. The supported gold catalyst exhibited remarkably high catalytic activities for selective oxidation of silanes into silanols using water as an oxidant without the use of organic solvents.

RSC Advances published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smith, Mark G. published the artcileNovel crystal forms of 4-aminoantipyrine and its derivatives: Co-crystallizing a reluctant molecule, Quality Control of 86-48-6, the publication is Journal of Molecular Structure (2019), 307-313, database is CAplus.

To the best of our knowledge, the first co-crystallization of the pharmaceutical ingredient 4-aminoantipyrine is reported with 2-aminobenzoic acid as the co-former, and the method used for its supramol. synthesis is discussed. Two mol. salts of 4-aminoantipyrine, as well as two co-crystals of a derivative of 4-aminoantipyrine were also synthesized. The complexes discussed show that careful application of synthon theory, choice of solvent and consideration of the pK_a difference between 4-aminoantipyrine and the co-former are required to successfully co-crystallize this reactive mol. In summary, the co-former must be chosen so that its functional group forms a robust heterosynthon with the reactive mol. The presence of polar solvents or large pK_a differences between 4-aminoantipyrine and its potential co-crystallizer favors salt formation, whereas a non-polar solvent and a small pK_a difference is required for the co-crystallization of 4-aminoantipyrine.

Journal of Molecular Structure published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C18H28N2O7, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Iwuoha, Emmanuel I. published the artcileReactivities of Organic-Phase Biosensors. 1. Enhancement of the Sensitivity and Stability of Amperometric Peroxidase Biosensors Using Chemically Modified Enzymes, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Analytical Chemistry (1997), 69(8), 1674-1681, database is CAplus.

Amperometric organic- and aqueous-phase peroxide biosensors were prepared with native and N-hydroxysuccinimide ester (NHS)-modified horseradish peroxidase (HRP). The ε-amino functions of the six free lysine residues of HRP were selectively modified with homobifunctional suberic acid bis(N-hydroxysuccinimide ester) (SA-NHS) or ethylene glycol bis(succinic acid N-hydroxysuccinimide ester) (EG-NHS). The biosensors were based on electrostatic complexation of the HRP variants with an osmium bis(bipyridyl)poly(4-vinylpyridine) polymer. The enzyme electrodes were operated in both aqueous (0.1 M phosphate buffer, pH 7.0) and organic (90% CH₃CN) phases, for the detection of hydrogen peroxide and Me isothiocyanate. Kinetic anal. of the steady-state amperometry data showed that chem. modification of HRP about up to a ∼5-fold enhancement of the biosensor sensitivity for H₂O₂ and an improvement in both sensor stability and organotolerance. Also, NHS modification of HRP results in a 3-fold extension of the range of linear response of the peroxide sensor in both aqueous and nonaqueous media. When used as a Me isothiocyanate sensor in the organic phase, the amperometric responses of the biosensors were doubled on changing from native HRP to NHS-HRP electrodes.

Analytical Chemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Denton, Elliott H. published the artcileCatalytic Carbochlorocarbonylation of Unsaturated Hydrocarbons via C-COCl Bond Cleavage, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Angewandte Chemie, International Edition (2021), 60(43), 23435-23443, database is CAplus and MEDLINE.

A palladium-catalyzed difunctionalisation of unsaturated C-C bonds with acid chlorides was reported. Formally, C-COCl bond of an acid chloride was cleaved and added, with complete atom economy, across either strained alkenes or a tethered alkyne to generate new acid chlorides I [Ar = Ph, 2-naphthyl, benzo[b]thiophen-2-yl, etc.]. The transformation does not require exogenous carbon monoxide, operated under mild conditions, showed a good functional group tolerance, and gave isolated products with excellent stereoselectivity. The intermol. reaction tolerated both aryl- and alkenyl-substituted acid chlorides and was successful when carboxylic acids were transformed to acid chloride in situ. The reaction also showed an example of temperature-dependent stereodivergence which, together with plausible mechanistic pathways, was investigated by DFT calculations Moreover, it was shown that benzofurans could be formed in an intramol. variant of reaction. Finally, derivatisation of products from intermol. reaction provided a highly stereoselective approach for synthesis of tetrasubstituted cyclopentanes.

Angewandte Chemie, International Edition published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Baek, Myung-Jin published the artcileLow band gap conjugated polymers consisting of alternating dodecyl thieno[3,4-b]thiophene-2-carboxylate and one or two thiophene rings: Synthesis and photovoltaic property, SDS of cas: 239075-02-6, the publication is Synthetic Metals (2010), 160(11-12), 1197-1203, database is CAplus.

In order to develop conjugated polymers with low band gaps and deep HOMO levels, copolymers consisting of alternating dodecyl thieno[3,4-b]thiophene-2-carboxylate and one (DTT-T₁) or two thiophene rings (DTT-T₂) were synthesized. The estimated optical band gap and HOMO level of DTT-T₁ and DTT-T₂ were ∼1.58/1.61 and ∼-5.15/-5.20 eV, resp., indicating that the polymers have relatively low band gaps and deep HOMO levels, as compared to many other reported polymers. Photovoltaic devices were fabricated using DTT-T₂ and a fullerene derivative (PCBM), and whose power conversion efficiency was 0.21% under the illumination of AM 1.5 (100 mW/cm²). The low conversion efficiency of the devices was attributed to the inefficiency of exciton formation due to the low absorption coefficient and self-quenching of the polymer and the un-optimized device conditions.

Synthetic Metals published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, SDS of cas: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shim, Young Key published the artcileNew synthetic route to 1,4-dihydropyridine monoacid derivatives, Quality Control of 101-98-4, the publication is Taehan Hwahakhoe Chi (1988), 32(2), 144-8, database is CAplus.

A novel synthetic route to 1,4-dihydropyridine mono carboxylic acid derivatives is described. Allyl Me 2,6-dimethyl-4-(3′-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate I (R = allyl) was treated with Pd(OAc)₂ in dioxane for 30 min at 100° C with reflux to give the mono acid I (R = H; II) in 94% yield. II was converted to Nicardipine (I, R = CH₂CH₂NMeCH₂Ph) and its derivatives in 70∼85% yield.

Taehan Hwahakhoe Chi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H10CoF6P, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tessensohn, Malcolm E. published the artcileMeasuring the Relative Hydrogen-Bonding Strengths of Alcohols in Aprotic Organic Solvents, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is ChemPhysChem (2015), 16(1), 160-168, database is CAplus and MEDLINE.

Voltammetric experiments with 9,10-anthraquinone and 1,4-benzoquinone performed under controlled moisture conditions indicate that the hydrogen-bond strengths of alcs. in aprotic organic solvents can be differentiated by the electrochem. parameter ΔE_p^red = |E_p^red(1)-E_p^red(2)|, which is the potential separation between the two 1-electron reduction processes. This electrochem. parameter is inversely related to the strength of the interactions and can be used to differentiate between primary, secondary, tertiary alcs., and even diols, as it is sensitive to both their steric and electronic properties. The results are highly reproducible across two solvents with substantially different hydrogen-bonding properties (CH₃CN and CH₂Cl₂) and are supported by d. functional theory calculations The numerous solvent-alc. interactions are less significant than the quinone-alc. hydrogen-bonding interactions. The utility of ΔE_p^red was illustrated by comparisons between (1) 3,3,3-trifluoro-n-propanol and 1,3-difluoroisopropanol and (2) ethylene glycol and 2,2,2-trifluoroethanol.

ChemPhysChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C6H12Br2, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Duraiswamy, Athisayamani Jeyaraj published the artcileDiscovery and Optimization of a Porcupine Inhibitor, Application In Synthesis of 23351-09-9, the publication is Journal of Medicinal Chemistry (2015), 58(15), 5889-5899, database is CAplus and MEDLINE.

Wnt proteins regulate various cellular functions and serve distinct roles in normal development throughout life. Wnt signaling is dysregulated in various diseases including cancers. Porcupine (PORCN) is a membrane-bound O-acyltransferase that palmitoleates the Wnts and hence is essential for their secretion and function. The inhibition of PORCN could serve as a therapeutic approach for the treatment of a number of Wnt-dependent cancers. Herein, the authors describe the identification of a Wnt secretion inhibitor from cellular high throughput screening. Classical SAR based cellular optimization provided us with a PORCN inhibitor I with nanomolar activity and excellent bioavailability that demonstrated efficacy in a Wnt-driven murine tumor model. Finally, the authors also discovered that enantiomeric PORCN inhibitors show very different activity in the reporter assay, suggesting that such compounds may be useful for mode of action studies on the PORCN O-acyltransferase.

Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gerard, Baudouin published the artcileSynthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C-Glycosides, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2013), 78(11), 5160-5171, database is CAplus and MEDLINE.

A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochem. diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and Me ester for further diversification via amine capping and amide coupling. Scaffold diversity was evaluated in comparison to previously prepared scaffolds by a shape-based principal moments of inertia (PMI) anal.

Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts