Author: tianli

Zhang, Chao published the artcileSynthesis, chiroptical properties, and self-assembled nanoparticles of chiral conjugated polymers based on optically stable helical aromatic esters, Product Details of C20H28B2O4S2, the publication is RSC Advances (2018), 8(2), 1014-1021, database is CAplus and MEDLINE.

By Suzuki coupling reaction, three pairs of chiral conjugated polymers with optically stable helical aromatic ester subunits as the main-chain were designed and synthesized. Polymers (+)-P-P1 and (-)-M-P1, (+)-P-P2 and (-)-M-P2 showed strong fluorescence emission, strong mirror image CD and circularly polarized luminescence (CPL) signals in THF. For polymers (+)-P-P3 and (-)-M-P3, containing the tetraphenylethene (TPE) moiety, they not only showed obvious aggregation induced enhancement emission (AIEE), but also exhibited mirror image CD signals and aggregation-induced enhancement CPL signals in THF-water mixtures Moreover, (+)-P-P3 and (-)-M-P3 could also form chiral nanoparticles by solvent evaporation induced self-assembly. Interestingly, it was further found that the size of the nanoparticles could be controlled by the changing of THF/water ratio, and their CPL properties were also shown.

RSC Advances published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C10H9NO, Product Details of C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yue, Rong published the artcileInsight into enzyme-catalyzed aziridine formation mechanism in ficellomycin biosynthesis, Safety of 2-Aminobutan-1-ol, the publication is European Journal of Medicinal Chemistry (2020), 112639, database is CAplus and MEDLINE.

Ficellomycin is an aziridine-containing antibiotic, produced by Streptomyces ficellus. Based on the newly identified ficellomycin gene cluster and the assigned functions of its genes, a possible pathway for aziridine ring formation in ficellomycin was proposed, which is a complex process involving at least 3 enzymic steps. To obtain support for the proposed mechanism, the targeted genes encoding sulfate adenylyltransferase, adenylsulfate kinase, and a putative sulfotransferase were resp. disrupted and the subsequent anal. of their fermentation products revealed that all the three genes were involved in aziridine formation. To further confirm the mechanism, the key gene encoding a putative sulfotransferase was over expressed in Escherichia coli Rosseta (DE3). Enzyme assays indicated that the expressed sulfotransferase could specifically transfer a sulfo group from 3′-phosphoadenosine-5′-phosphosulfate (PAPS) onto the hydroxyl group of (R)-(-)-2-pyrrolidinemethanol. This introduces a good leaving group in the form of the sulfated hydroxyl moiety, which is then converted into an aziridine ring through an intramol. nucleophilic attack by the adjacent secondary amine. The sulfation/intramol. cyclization reaction sequence maybe a general strategy for aziridine biosynthesis in microorganisms. Discovery of this mechanism revealed an enzyme-catalyzed route for the synthesis of aziridine-containing reagents and provided an important insight into the functional diversity of sulfotransferases.

European Journal of Medicinal Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C5H6N2O2, Safety of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jiguang published the artcileComparative investigation on aroma profiles of five different mint (Mentha) species using a combined sensory, spectroscopic and chemometric study, Formula: C10H18O, the publication is Food Chemistry (2022), 131104, database is CAplus and MEDLINE.

Mint is a widely used aromatic plant, and the aroma varies among different species. The aroma of five mint species, Mentha citrata L. (MC), Mentha piperita L. (MPI), Mentha spicata L. (MSP), Mentha persicaria L. (MPE), and Mentha suaveolens L. (MSU), were comparatively studied on the sensorial and mol. level. Quant. descriptive anal. revealed that MC presented a pronounced lemon-like note, MSU is dominated by citrus and floral aromas, MPI has a prominent minty flavor, MSP and MPE have a similar scent, both of which are flavored with a spearmint-like note. Forty-one odorants with odor activity values (OAVs) ≥1 were characterized. Principal component anal. and orthogonal partial least squares discrimination anal. based on OAVs indicated that α-citral, menthofuran, isomenthone, menthol, carvone, and linalool were potential odor-active markers for five mint species discrimination. This study herein will provide guidance for mint resources utilization and also aid mint breeding with better flavor.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C23H20BN, Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dong, Xiaorong published the artcileEffects of dexamethasone combined with ambroxol hydrochloride on T-Cell subsets and hearing in patients with secretory otitis media, Computed Properties of 23828-92-4, the publication is Pakistan Journal of Pharmaceutical Sciences (2019), 32(3), 1437-1440, database is CAplus.

The aim of the study was to investigate the effect of dexamethasone combined with ambroxol hydrochloride on T cell subsets and hearing in patients with secretory otitis media. Eighty-six cases of patients with secretory otitis media admitted to “Gansu Provincal Hospital, Lanzhou, China” from Sept. 2016 to Sept. 2018 were regarded as subjects of the study. The patients were divided in two groups according to the digital table method. Among them, the control group was treated with ambroxol hydrochloride, while the study group was treated with dexamethasone combined with ambroxol hydrochloride. The clin. efficacy, T cytokines before and after treatment, auditory threshold and middle ear resonance frequency were observed and compared between the two groups of the patients. SPSS 18.0 software was used to statistically analyze the data. The therapeutic efficacy of the study group was better than that of the control group and the levels of CD4+, CD417CD8+ after treatment of the study group were higher than that of the control group (P<0.05), while the content of CD8+ in the study group was lower than that in the control group (P<0.05). In addition, the auditory threshold of the study group was lower than that of the control group (P<0.05), whereas the middle ear resonance frequency was higher than that of the control group (P<0.05). The application of dexamethasone combined with ambroxol hydrochloride improved the clin. symptoms and restored hearing in the clin. treatment of patients with secretory otitis media and the therapeutic efficacy was ideal.

Pakistan Journal of Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Computed Properties of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Yu-Tao published the artcileSynthesis of Various Bridged Ring Systems via Rhodium-Catalyzed Bridged (3+2) Cycloadditions, Name: (R)-Oxiran-2-ylmethanol, the publication is Organic Letters (2022), 24(1), 186-190, database is CAplus and MEDLINE.

Here, the authors describe the rhodium-catalyzed bridged [3+2]-cycloaddition cascade reactions of N-sulfonyl-1,2,3-triazoles, which allowed the efficient diastereoselective construction of various functionalized and synthetically challenging bridged ring systems. This simple, direct transformation had a broad substrate scope and excellent functional group tolerance. The highly strained polycyclic bicyclo[2.2.2]octa[b]indole core of fruticosine was synthesized efficiently using this methodol.

Organic Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Name: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Ting published the artcileSpatiotemporal distribution of Streptococcus agalactiae attenuated vaccine strain YM001 in the intestinal tract of tilapia and its effect on mucosal associated immune cells, COA of Formula: C13H19Br2ClN2O, the publication is Fish & Shellfish Immunology (2019), 714-720, database is CAplus and MEDLINE.

In the current study, the tilapia was orally vaccinated by the attenuated Streptococcus agalactiae(S. agalactiae) strain YM001, and the distribution and the pathol. effect of strain YM001 in different intestinal segments of tilapia were evaluated by real-time PCR(qPCR), immunohistochem.(IHC) and histomorphol. The qPCR results showed that the number of bacteria was the highest in the intestinal tracts at 12 h post oral gavage in the YM001 group, then began to decrease sharply and eliminated at 7 d. And the number of bacteria was highest in the foregut, hindgut, and rectum at 12 h, 24 h, and 3 d, resp. IHC indicated that bacteria mainly distributed in the margin epithelium and the goblet cells at 12 h – 24 h, and in the submucosa and muscle layer in the YM001 group in 3 d post gavage, then almost disappeared at 7 d. Histol. examination of intestines post gavage displayed that an inflammation was observed at 7 d in the YM001 group and the intestinal structure was fully recovered at 15 d. and the intestinal structure was fully recovered at 15 d. The attenuated S. agalactiae vaccine strain YM001 could enter the intestinal tissue after oral gavage and had a strong spatial and temporal selectivity in the intestinal tract, which could cause obvious mucosal immune response and mild pathol. reaction, but the pathol. change could be gradually repaired with the extinction of bacteria in the body.

Fish & Shellfish Immunology published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Zhiruo published the artcileSize effect of Ru particles on the self-reforming-driven hydrogenolysis of a lignin model compound, Recommanded Product: 4-Propylphenol, the publication is Catalysis Science & Technology (2022), 12(16), 5143-5151, database is CAplus.

Particle size always has a great influence on catalytic performance. In this study, we investigated the size effect of Ru colloids on the self-reforming-driven hydrogenolysis of a lignin model compound by taking 4-(3-hydroxypropyl)-2-methoxyphenol (PG-OH) as the substrate and NiAl₂O₄ spinel as the support. This reaction provides a strategy to produce alkylphenols from lignin without the consumption of exogenous hydrogen. Three catalysts with different Ru particle sizes (Ru^1.5, Ru^2.6, and Ru^3.3) were prepared, and the catalytic results showed that the reaction activity presented a volcanic curve with the increase in the Ru particle sizes, in which Ru^2.6/NiAl₂O₄ possessed the best performance. Reaction pathway studies showed two different reaction routes over small (Ru^1.5 and Ru^2.6) and large (Ru^3.3) Ru particles. The reforming-driven hydrogenolysis of the methoxy group dominated over small Ru particles, with 4-ethylphenol (4-EP) as the main product; while the hydrogenation of hydroxypropyl and hydrolysis of the methoxy group dominated over the larger particles, with 4-propylcatechin (4-PC) as the main product. Comprehensive investigations indicates the difference in catalytic performance came from the interaction between Ru colloids and the NiAl₂O₄ spinel support, which led to different Ru^δ+/Ru⁰ ratios and finally changed the reaction routes or reaction rate in these three catalysts. This study proves that the particle size really affects catalytic reactions, and indeed, the self-reforming-driven hydrogenolysis of lignin (the model compound) to alkylphenols is structure-sensitive.

Catalysis Science & Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ho, Steven Sai Hang published the artcileSeasonal behavior of water-soluble organic nitrogen in fine particulate matter (PM_2.5) at urban coastal environments in Hong Kong, Quality Control of 96-20-8, the publication is Air Quality, Atmosphere & Health (2019), 12(4), 389-399, database is CAplus.

Water-soluble organic nitrogen (WSON) in fine particulate matter (PM_2.5) was determined at urban coastal environments in China based on 1-yr measurement. The WSON concentrations were in a range of 14.3-257.6 nmol N m^-3 and accounted for 22.0-61.2% of the water-soluble nitrogen (WSN) in composition The average total concentration of free amino acid (FAA) was 1264.5 ± 393.0 pmol m^-3, which was lower than those in continental urban cities but nevertheless comparable to the rural area of Pearl River Delta (PRD) in China. The total quantified amines and amino compounds ranged from 223.8 to 806.0 pmol m^-3 in which methylamine, ethylamine, and ethanolamine were the most abundant compounds The average concentration of urea was 7.8 ± 3.0 nmol m^-3 and at least one order of magnitude higher than those in marine and rural areas but comparable to other continental cities in China during non-dust period. Summer showed the highest average concentration of WSON (95.0 ± 66.6 nmol N m^-3) and composition in WSN (49.3%) compared to other seasons (27.9-37.0%). The results were consistent with previous findings that the inorganics can contribute more than the organics in secondary aerosol formation. There were no distinctive seasonal variations of organic compositions of FAA, amine and amino compounds, and urea. This observation was possibly attributed to a mix of original sources in urban and different prevailing wind directions. Fair correlations (r < 0.4) between WSON compounds and atm. oxidants [ozone (O₃) and nitrogen oxides (NO_x)] suggest that biogenic oxidation is possibly not a major contributing factor in atm. coastal urban location.

Air Quality, Atmosphere & Health published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Xiaozhong published the artcilePassive sampling hydrophilic and hydrophobic bisphenol analogues using hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane in surface waters, SDS of cas: 80-09-1, the publication is Science of the Total Environment (2022), 156239, database is CAplus and MEDLINE.

Bisphenol analogs (BPs) are ubiquitous emerging contaminants in water environments and have wide polarity ranges (1.65 < log K_OW< 7.2). Integrated passive sampling strategy rarely contains hydrophilic and hydrophobic organics simultaneously, while the method has good application perspective in monitoring organic contaminants. This work evaluated passive sampling performance for fifteen BPs in a newly developed passive sampler, i.e., hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane (HECAM). In the dynamic accumulation experiments, both hydrophilic and hydrophobic BPs (including moderately hydrophilic BPs) well followed first-order kinetic uptake in the HECAMs. The estimated uptake rate constants, elimination rate constants, and equilibrium partition coefficients for BPs ranged from 4.4 L g^-1 d^-1 to 14.7 L g^-1 d^-1, 0.22 d^-1 to 0.72 d^-1, and 3.99 to 4.64, resp. The kinetic parameters for BPs in HECAM show limited correlations to log K_OW values, which the rule differs from traditional passive sampler. In the study of elimination kinetics, three deuterium labeled compounds showed incomplete elimination in HECAM and did not follow first-order isotropic exchange kinetics. Dual sorption mechanisms including both adsorption and partition were found for chems. in HECAM, which the partitioned part could release to water and the adsorbed part could not easily release to water from HECAM. As a result, performance reference compounds (PRCs) calibration may be inapplicable to HLB sorbent-based passive sampler. The field deployment of HECAM in coastal waters of Guangdong, China resulted in the detection of eleven BPs, which indicated that the waters have been polluted by various BPs. Finally, monitoring strategy of simultaneous passive sampling hydrophobic and hydrophilic organic contaminants in surface waters was recommended.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tian, Wei published the artcileNovel Anthraquinone Compounds Induce Cancer Cell Death through Paraptosis, Synthetic Route of 622-40-2, the publication is ACS Medicinal Chemistry Letters (2019), 10(5), 732-736, database is CAplus and MEDLINE.

Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed and synthesized. Compound I is the first organic micromol. to kill tumor cells by only paraptosis, and its mechanism of action has been further explored. Paraptosis does not appear to involve either phosphatidylserine translocation associated with apoptosis or cell cycle arrest. The bisbenzyloxy and N-(2-hydroxyethyl)formamide structures may be two critical pharmacophores for paraptosis. Bisbenzyloxy can induce ER stress, and the N-(2-hydroxyethyl)formamide structure can increase the ratio of LC3II/I and cytoplasmic vacuolization and facilitates paraptosis. Some antitumor drugs fail to eradicate malignant cell lines with impaired apoptotic pathways; paraptosis may be a route to kill such cells and provides a new potential strategy for cancer chemotherapy.

ACS Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C14H14, Synthetic Route of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts