Author: tianli

Layek, Buddhadev published the artcileAPC targeted micelle for enhanced intradermal delivery of hepatitis B DNA vaccine, HPLC of Formula: 96345-79-8, the publication is Journal of Controlled Release (2015), 143-153, database is CAplus and MEDLINE.

Chronic hepatitis B is a serious liver disease and puts people at high risk of death from cirrhosis and liver cancer. Although DNA vaccination has been emerged as a potential immunotherapeutic strategy for the treatment of chronic hepatitis B, the efficiencies were not adequate in clin. trials. Here we describe the design, synthesis, and evaluation of mannosylated phenylalanine grafted chitosan (Man-CS-Phe) as a DNA delivery vector for direct transfection of antigen presenting cells to improve cellular and humoral immunity to plasmid-coded antigen. The cationic Man-CS-Phe micelles condense plasmid DNA into nanoscale polyplexes and provide efficient protection of complexed DNA from nuclease degradation The mannose receptor-mediated enhanced cell uptake and high in vitro transfection efficiency of the polyplexes were demonstrated in RAW 264.7 and DC 2.4 cells using GFP-expressing plasmid DNA. Furthermore, intradermal immunization of BALB/c mice indicated that hepatitis B DNA vaccine/Man-CS-Phe polyplexes not only induced multi-fold higher serum antibody titer in comparison to all other formulations including FuGENE HD, but also significantly stimulated T-cell proliferation and skewed T helper toward Th1 polarization. These results illustrate that the Man-CS-Phe can serve as a promising DNA delivery vector to harness both cellular and humoral arms of immune system.

Journal of Controlled Release published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, HPLC of Formula: 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bouchet, Samuel published the artcileExtending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling, Related Products of alcohols-buliding-blocks, the publication is ACS Medicinal Chemistry Letters (2019), 10(6), 863-868, database is CAplus and MEDLINE.

Dissym. cross metathesis of alkenes as a convergent and general synthetic strategy allowed for the preparation of a new small series of human histone deacetylases (HDAC) inhibitors. Alkenes bearing Boc-protected hydroxamic acid and benzamide and trityl-protected thiols were used to provide the zinc binding groups and were reacted with alkenes bearing aromatic cap groups. One compound was identified as a selective HDAC6 inhibitor lead. Addnl. biol. evaluation in cancer cell lines demonstrated its ability to stimulate the expression of the epithelial marker E-cadherin and tumor suppressor genes like SEMA3F and p21, suggesting a potential use of this compound for lung cancer treatment. Mol. docking on all 11 HDAC isoforms was used to rationalize the observed biol. results.

ACS Medicinal Chemistry Letters published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Pengfei published the artcileA mild acetolysis procedure for the regioselective removal of isopropylidene in di-O-isopropylidene-protected pyranoside systems, Computed Properties of 20880-92-6, the publication is Carbohydrate Research (2017), 7-13, database is CAplus and MEDLINE.

A mild acetolysis method for the regioselective removal of isopropylidene group from di-O-isopropylidene-protected hexopyranosides is reported. O-Isopropylidene-protected intermediates play an important role in carbohydrate chem., as they are often found in com. available furanosyl and pyranosyl materials, and some of them contain more than one O-isopropylidene groups. Methods that permit regioselective removal of O-isopropylidene groups are extremely valuable, as the number of steps in the total synthesis of complex oligosaccharides could be significantly decreased. Here we report that trifluoroacetic acid (TFA)/acetic anhydride (Ac₂O) can be used to regioselectively convert one of the two O-isopropylidene groups to vicinal di-O-acetates in the di-O-isopropylidene-protected galacto- and fructopyranosyl systems, and the reagent is compatible with some common functionalities such as sulfonate esters, bromide, azide etc.

Carbohydrate Research published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C8H5F3O2S, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khan, Ali published the artcileChange of the microemulsion structure with the hydrophile-lipophile balance of the surfactant and the volume fractions of water and oil, Quality Control of 70445-33-9, the publication is Journal of Physical Chemistry (1986), 90(22), 5799-801, database is CAplus.

In the 4-component system water/C₁₂H₂₅OCH₂CH₂SO₄Ca_1/2/C₄H₉CH(C₂H₅)CH₂O CH₂CH(OH)CH₂OH/C₁₀H₂₂ with 5 weight% total surfactant (surfactant + cosurfactant), 2 different microemulsion phases are formed when water and oil contents are both high, with only small differences in cosurfactant content. The structure of the microemulsions was investigated by the Fourier transform pulsed gradient spin-echo NMR technique and was found to be quite different (closed domains of oil in water, or water in oil, or bicontinuous) for different conditions (water-to-oil ratio, cosurfactant concentration). The microemulsion structure changes dramatically with small changes in cosurfactant concentration

Journal of Physical Chemistry published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Pengzhi published the artcileSynthesis of AD-Dihydrodipyrrins Equipped with Latent Substituents of Native Chlorophylls and (Bacterio)chlorophylls, Application of Pentane-1,5-diol, the publication is Journal of Organic Chemistry (2021), 86(17), 11794-11811, database is CAplus and MEDLINE.

Native chlorophylls and bacteriochlorophylls share a common trans-substituted pyrroline ring D (17-propionic acid, 18-methyl), whereas diversity occurs in ring A particularly at the 3-position. Two dihydrodipyrrins equipped with native-like D-ring substituents and A-ring substituents have been synthesized. The synthesis relies on a Schreiber-modified Nicholas reaction to construct the stereochem. defined precursor to ring D, a dialkyl-substituted pent-4-ynoic acid. The carboxylic acid group of the intact propionic acid proved unworkable, whereupon protected propionate (-CO₂^tBu) and several latent Pr ethers were examined The tert-butyldiphenylsilyl-protected propanol substituent proved satisfactory for reaction of the chiral N-acylated oxazolidinone, affording (2S,3S)-2-(3-((tert-butyldiphenylsilyl)oxy)propyl)-3-methylpent-4-ynoic acid in ~30% yield over 8 steps. Two variants for ring A, 2-tert-butoxycarbonyl-3-Br/H-5-iodo-4-methylpyrrole, were prepared via the Barton-Zard route. Dihydrodipyrrin formation from the pyrrole and pentynoic acid entailed Jacobi Pd-mediated lactone formation, Petasis methenylation, and Paal-Knorr-type pyrroline formation. The two AD-dihydrodipyrrins bear the D-ring Me and protected propanol groups with a stereochem. configuration identical to that of native (bacterio)chlorophylls, and a bromine or no substitution in ring A corresponding to the 3-position of (bacterio)chlorophylls. The analogous β-position of a lactone-pyrrole intermediate on the path to the dihydrodipyrrin also was successfully brominated, opening opportunities for late-stage diversification in the synthesis of (bacterio)chlorophylls.

Journal of Organic Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C9H8O4, Application of Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yamaguchi, Shigehiro published the artcileChanges of organized solution (microemulsion) structure with small change in amphiphile composition, Formula: C11H24O3, the publication is Yukagaku (1989), 38(2), 157-60, database is CAplus.

In the system of 8 weight% CaCl₂ aqueous/C₁₂H₂₅OCH₂CH₂SO₄Ca_0.5/iso-C₈H₁₇OCH₂CH(OH)CH₂OH/decane with only 3 weight% of total amphiphiles, it was possible to obtain only one phase region of microemulsion whose solvents swelled by 97 weight% (water + oil). The composition of water and oil varied over the entire range with slight changes in the amphiphile ratio from 0.38 to 0.42. Self-diffusion measurements indicated the microemulsion microstructure changed from O/W (hydrophilic) to W/O (lipophilic) by varying the HLB of the amphiphiles. A comparison of these results with change in temperature in a nonionic surfactant system showed that the change in the ratio of hydrophilic amphiphile and lipophilic amphiphile (from 0.38 to 0.42) had the same effect as that in HLB as making the temperature 30° in the nonionic surfactant system.

Yukagaku published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C44H28ClFeN4, Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kieburg, Christoffer published the artcileGlycodendrimer synthesis without using protecting groups, Quality Control of 96345-79-8, the publication is Tetrahedron Letters (1997), 38(22), 3885-3888, database is CAplus.

Oligoantennary neoglycoconjugates can act as powerful inhibitors of carbohydrate-protein interactions and thus serve as anti-adhesives in carbohydrate-based adhesion systems. They were obtained by a procedure that does not require protecting groups. Various unprotected NCS-functionalized saccharides were coupled with oligoamines in aqueous solution This versatile method is generally applicable to the synthesis of thiourea-bridged glycodendrimers.

Tetrahedron Letters published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Durben, Stefan published the artcileDithienophosphole-capped π-conjugated oligomers, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is New Journal of Chemistry (2010), 34(8), 1585-1592, database is CAplus.

The synthesis of a 2-monobrominated dithieno[3,2-b:2′,3′-d]phosphole has opened the access to a series of highly luminescent π-conjugated oligomers that link two dithienophosphole units via a variety of aromatic spacers. The nature of the linking mode was found to have a significant impact on the photophys. properties of the system as a whole, either considerably improving the molar absorptivity of the new extended chromophores, or providing luminescent materials with red-shifted emission features and substantial photoluminescence quantum yields.

New Journal of Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Quan, Wei published the artcileMetabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats, Computed Properties of 526-98-7, the publication is Food & Function (2022), 13(10), 5515-5527, database is CAplus and MEDLINE.

The present study aimed to investigate the metabolic perturbations and health impact of the co-accumulation of Maillard reaction products (MRPs), including acrylamide, harmane, and Nε-(carboxymethyl)lysine (CML), via serum biochem. and histopathol. examinations as well as metabolomic anal. Sprague-Dawley rats were treated with acrylamide (2 mg per kg body weight [bw]), harmane (1 mg per kg bw), CML (2 mg per kg bw), and combinations of these MRPs. Harmane did not cause adverse effects on the health of rats, whereas acrylamide and CML resulted in significantly (P < 0.05) decreased insulin sensitivity (HOMA-IR > 1), increased oxidative stress levels, and pathol. injuries to the pancreas, liver, and gastrocnemius. Owing to the antioxidant and anti-diabetic activities of harmane, the effects of the combination of the MRPs on oxidative stress levels, blood glucose metabolism, and pathol. injuries to the pancreas and gastrocnemius were relieved. However, new health problems, including pathol. injury of the kidneys and increased cancer risk, were observed Metabolomic anal. revealed that this may be related to the effects of MRPs on the arginine biosynthesis pathway, which resulted in the abnormal metabolism of fumaric acid and the tricarboxylic acid cycle. These results indicated that the mechanisms of the combined effect of MRPs and their effects on health cannot be predicted from the effects of individual MRPs.

Food & Function published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tuan, Nguyen Ngoc published the artcileCatabolism of 4-alkylphenols by Acinetobacter sp. OP5: Genetic organization of the oph gene cluster and characterization of alkylcatechol 2,3-dioxygenase, Quality Control of 1139-46-4, the publication is Bioresource Technology (2013), 420-428, database is CAplus and MEDLINE.

In this study, a specific PCR primer set was successfully designed for alkylcatechol 2, 3-dioxygenase genes and applied to detect the presence of this biomarker in 4-t-octylphenol-degrading Acinetobacter sp. strain OP5. A gene cluster (ophRBA1A2A3A4A5A6CEH) encoding multicomponent phenol hydroxylase and alkylcatechol 2,3-dioxygenase was then cloned from this strain and showed the highest homol. to those involved in the published medium-chain alkylphenol gene clusters. The pure enzyme of recombinant cell harboring ophB showed meta-cleavage activities for 4-methylcatechol (1,435%), 4-ethylcatechol (982%), catechol (100%), 4-t-butylcatechol (16.6%), and 4-t-octylcatechol (3.2%). The results suggest that the developed mol. technique is useful and easy in detection of medium/long-chain alkylphenol degradation gene cluster. In addition, it also provides a better understanding of the distribution of biodegradative genes and pathway for estrogenic-active long-chain alkylphenols in bacteria.

Bioresource Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C8H6N2O3, Quality Control of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts