Author: tianli

Cheng, Jing-Zhao published the artcileAchieving an unprecedented hydrogen evolution rate by solvent-exfoliated CPP-based photocatalysts, Computed Properties of 239075-02-6, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2020), 8(12), 5890-5899, database is CAplus.

How to prompt higher photocatalytic hydrogen production (PHP) efficiency from water to achieve practical applications still remains a big challenge with conjugated porous polymers (CPP)-based photocatalysts. Herein, a simple and efficient cosolvent-assisted strategy is developed to significantly improve the photocatalytic efficiency of CPP-based photocatalysts by introducing water-soluble aprotic bipolar co-solvents, including N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMAc), and N-Me pyrrolidone (NMP). The PHP activity of the pyrene-bithiophene-based CPP (named CP-St) using ascorbic acid (AA) as a sacrificial electron donor could be excellently accelerated in the presence of an aprotic bipolar NMP solvent. CP-St dispersed in an NMP/H₂O/AA mixed solution under visible-light (λ > 420 nm) irradiation without the aid of a Pt cocatalyst achieved an unprecedented hydrogen evolution rate (HER) of 190.7 mmol h^-1 g^-1. As a result, 6 mg CP-St amazingly produced 128.1 mL H₂ (∼5.72 mmol) under visible-light irradiation for only 5 h. Excitingly, by introducing 0.5 wt% Pt cocatalyst into the NMP/H₂O/AA system, the HER of CP-St could be further boosted to 303.7 mmol h^-1 g^-1 (1.82 mmol h^-1/6 mg), which represents the highest photocatalytic HER ever reported. This outstanding photocatalytic performance is mainly ascribed to the enhanced dispersity, strong hydrogen-bond interactions, and exfoliation effect by the NMP solvent. This study provides us with some new design ideas and opportunities for effectively catering to the actual hydrogen production demand.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Cai-Yun published the artcileIdentification and validation of four novel promoters for gene engineering with broad suitability across species, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Microbiology and Biotechnology (2021), 31(8), 1154-1162, database is CAplus and MEDLINE.

The transcriptional capacities of target genes are strongly influenced by promoters, whereas few studies have focused on the development of robust, high-performance and cross-species promoters for wide application in different bacteria. In this work, four novel promoters (Pk.rtufB, Pk.r1, Pk.r2, and Pk.r3) were predicted from Ketogulonicigenium robustum and their inconsistency in the -10 and -35 region nucleotide sequences indicated they were different promoters. Their activities were evaluated by using green fluorescent protein (gfp) as a reporter in different species of bacteria, including K. vulgare SPU B805, Pseudomonas putida KT2440, Paracoccus denitrificans PD1222, Bacillus licheniformis and Raoultella ornithinolytica, due to their importance in metabolic engineering. Our results showed that the four promoters had different activities, with Pk.r1 showing the strongest activity in almost all of the exptl. bacteria. By comparison with the commonly used promoters of E. coli (tufB, lac, lacUV5), K. vulgare (Psdh, Psndh) and P. putida KT2440 (JE111411), the four promoters showed significant differences due to only 12.62% nucleotide similarities, and relatively higher ability in regulating target gene expression. Further validation experiments confirmed their ability in initiating the target minCD cassette because of the shape changes under the promoter regulation. The overexpression of sorbose dehydrogenase and cytochrome c551 by Pk.r1 and Pk.r2 resulted in a 22.75% enhancement of 2-KGA yield, indicating their potential for practical application in metabolic engineering. This study demonstrates an example of applying bioinformatics to find new biol. components for gene operation and provides four novel promoters with broad suitability, which enriches the usable range of promoters to realize accurate regulation in different genetic backgrounds.xxxxxxxxxxxxx.

Journal of Microbiology and Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C12H10O4S, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Ying-Jie published the artcileRegioselective synthesis and anticancer evaluation of H₂O₂-activable nucleosides, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(48), 6484-6487, database is CAplus and MEDLINE.

We describe here the design, synthesis, and biol. evaluation of H₂O₂-activatable dioxaboronalyl nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biol. evaluation of a H₂O₂-specific responsive prodrug of gemecitabin demonstrates an extremely fast activation, low toxicity and enhanced anticancer effects in two cell lines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C18H17N5O3, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stanisic, Danijela published the artcileNew sustainable process for hesperidin isolation and anti-aging effects of hesperidin nanocrystals, Formula: C11H24O3, the publication is Molecules (2020), 25(19), 4534, database is CAplus and MEDLINE.

Hesperidin, a secondary orange (Citrus sinensis) metabolite, was extracted from orange bagasse. No organic solvents or addnl. energy consumption were used in the clean and sustainable process. Hesperidin purity was approx. 98% and had a yield of 1%. Hesperidin is a known supplement due to antioxidant, chelating, and anti-aging properties. Herein, hesperidin application to eliminate dark eye circles, which are sensitive and thin skin regions, was studied. In addition, the proposed method for its aqueous extraction was especially important for human consumption. Further, the most effective methods for hesperidin nanonization were explored, after which the nanoemulsions were incorporated into a cream formulation that was formulated for a tropical climate. Silky cream formulations (oil in water) were tested in vitro on artificial 3D skin from cultured cells extracted from skin residues after plastic surgery. The proposed in vitro assay avoided tests of the different formulations in human volunteers and animals. It was shown that one of the nanonized hesperidin formulations was the most skin-friendly and might be used in cosmetics.

Molecules published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C7H5ClN2S, Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Xiaowei published the artcileSugar and organic acid availability modulate soil diazotroph community assembly and species co-occurrence patterns on the Tibetan Plateau, Related Products of alcohols-buliding-blocks, the publication is Applied Microbiology and Biotechnology (2021), 105(21-22), 8545-8560, database is CAplus and MEDLINE.

Metabolites can mediate species interactions and the assembly of microbial communities. However, how these chems. relate to the assembly processes and co-occurrence patterns of diazotrophic assemblages in root-associated soils remains largely unknown. Here, we examined the diversity and assembly of diazotrophic communities and further deciphered their links with metabolites on Tibetan Plateau. We found that the distribution of sugars and organic acids in the root-associated soils was significantly correlated with the richness of diazotrophs. The presence of these two soil metabolites explains the variability in diazotrophic community compositions The differential concentrations of these metabolites were significantly linked with the distinctive abundances of diazotrophic taxa in same land types dominated by different plants or dissimilar soils by same plants. The assembly of diazotrophic communities is subject to deterministic ecol. processes, which are widely modulated by the variety and amount of sugars and organic acids. Organic acids, for instance, 3-(4-hydroxyphenyl)propionic acid and citric acid, were effective predictors of the characteristics of diazotrophic assemblages across desert habitats. Diazotrophic co-occurrence networks tended to be more complex and connected within different land types covered by the same plant species. The concentrations of multiple sugars and organic acids were coupled significantly with the distribution of keystone species, such as Azotobacter, Azospirillum, Bradyrhizobium, and Mesorhizobium, in the co-occurrence network. These findings provide new insights into the assembly mechanisms of root-associated diazotrophic communities across the desert ecosystems of the Tibetan Plateau.

Applied Microbiology and Biotechnology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Xi-Shou published the artcileThe synthesis, structure and activity evaluation of secnidazole derivatives as Helicobacter pylori urease inhibitors, Application In Synthesis of 328-90-5, the publication is Current Bioactive Compounds (2011), 7(4), 268-280, database is CAplus.

Various secnidazole derivatives were synthesized and evaluated for Helicobacter pylori (H. pylori) urease inhibitory activities and anti-inflammatory activities. The most potent urease inhibitory activities and anti-inflammatory activities were in the range of IC₅₀ = 1.0-2.0 μM and 59-72% inhibition, resp. Docking simulation was performed with one of the compounds into the urease active site to determine the probable binding model. The compounds with potent inhibitory activity against H. pylori may be potential antibacterial agents.

Current Bioactive Compounds published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application In Synthesis of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Guanyi published the artcileInvestigation on catalytic hydrodeoxygenation of eugenol blend with light fraction in bio-oil over Ni-based catalysts, Safety of 4-Propylphenol, the publication is Renewable Energy (2020), 456-465, database is CAplus.

In this work, HZSM-5, Al-SBA-15 and Al-SBA-15/HZSM-5 were adopted as supporting materials for the nickel-based catalysts used in hydrodeoxygenation process. Incipient wetness impregnation method was employed to load nickel species onto these materials. The physicochem. characterization was carried out using advanced instruments. The effect of composition of nickel-based catalysts on hydrodeoxygenation (HDO) reaction was studied. Support materials of nickel-based catalyst have a significantly impact on HDO activity. The highest selectivity (67.9%) of propyl-cyclohexane was obtained over nickel based Al-SBA-15/HZSM-5 catalyst, and nearly all the eugenol was completely hydrodeoxygenated after reaction. The impact of light fractions existed in bio-oil on phenols upgrading process was investigated. The conversion of eugenol mixed with light fractions reached nearly 100% for all the reactions. Eugenol mixed with light fractions as reactant could reduce ring break reaction during hydrodeoxygenation process. The selectivity of alkanes remained nearly unchanged after adding ethylene glycol into the reactant. However, the selectivity of propyl-cyclohexane was significantly decreased by mixing furfural or acetic acid with eugenol as reactant.

Renewable Energy published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Safety of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Steiman, Talia J. published the artcileSynthesis of β-Phenethylamines via Ni/Photoredox Cross-Electrophile Coupling of Aliphatic Aziridines and Aryl Iodides, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of the American Chemical Society (2020), 142(16), 7598-7605, database is CAplus and MEDLINE.

A photoassisted Ni-catalyzed reductive cross-coupling between tosyl-protected alkyl aziridines and com. available (hetero)aryl iodides is reported. This mild and modular method proceeds in the absence of stoichiometric heterogeneous reductants and uses an inexpensive organic photocatalyst to access medicinally valuable β-phenethylamine derivatives Unprecedented reactivity was achieved with the activation of cyclic aziridines. Mechanistic studies suggest that the regioselectivity and reactivity observed under these conditions are a result of nucleophilic iodide ring opening of the aziridine to generate an iodoamine as the active electrophile. This strategy also enables cross-coupling with Boc-protected aziridines.

Journal of the American Chemical Society published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C7H7ClN2S, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zou, Wei published the artcileReview on the application of genome-based approaches on the vitamin C producing industrial strains, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Jiyinzuxue Yu Yingyong Shengwuxue (2012), 31(5), 513-521, database is CAplus.

A review with 40 references Vitamin C is one of the main fermentation products in China and its annual production accounts for more than 80% of total yields in the world. It is manufactured by a two-step fermentation process, which uses two fermentation steps to transform L-sorbose into 2-keto-L-gulonic acid, the precursor of vitamin C. This paper reviews the latest progress that has been achieved to study the key problems existing in the two-step fermentation process with emphasis on the important role played by the genome-based system biol. approaches during this process. Further, certain suggestions on how to improve the productivity of other fermentation products are also provided in this paper.

Jiyinzuxue Yu Yingyong Shengwuxue published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C20H17FO4S, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Yibo published the artcileSporulation and spore stability of Bacillus megaterium enhance Ketogulonigenium vulgare propagation and 2-keto-L-gulonic acid biosynthesis, Product Details of C6H10O7, the publication is Bioresource Technology (2012), 399-404, database is CAplus and MEDLINE.

Bacillus spp. is widely used as the companion bacterium in the two-step biosynthesis of 2-keto-L-gulonic acid (2-KLG), which is the direct precursor in the production of vitamin C by Ketogulonigenium vulgare. To understand the effects of sporulation and spore stability on 2-KLG production, the spo0A and spoVFA deletion mutants of Bacillus megaterium were constructed. The sorbose conversion rates of spo0A and spoVFA mutant co-culture systems were 33% and 70% lower, resp., than that of the wild-type co-culture system. In addition, K. vulgare cell numbers in the two mutant systems declined by 15% and 49%, resp., compared to the value in the wild-type system. Correlation anal. indicated that the 2-KLG concentration is pos. related to sorbose dehydrogenase activity and the K. vulgare cell number This study demonstrated that sporulation and spore stability of the wild-type companion play key roles in the enhancement of K. vulgare propagation and 2-KLG biosynthesis.

Bioresource Technology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C38H74Cl2N2O4, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts