Author: tianli

Gao, Ming published the artcileOptimization of fermentation conditions for two-step fermentation of vitamin C, Synthetic Route of 526-98-7, the publication is Shipin Gongye Keji (2012), 33(14), 235-238, database is CAplus.

The conversion process from L-sorbose to 2-keto-L-gulonic acid in vitamin C two-step fermentation was mixed culture fermentation by acid-producing strain (Gluconobacter oxydans) and companion bacterium (Bacillus subtilis). In order to promote the coordination between the two strains and make it reach the best state, the nutrient condition and the culture conditions were researched by orthogonal test and single factor experiment The result showed that the optimal conditions were as follows: 8% L-sorbose, 1.4% corn steep liquor, 1.2% urea, 0.5% CaCO₃, 0.02% MgSO₄, liquid volume in 100 mL flask with 10 mL, culture temperature 29°C, inoculation amount 15%. The yield of 2-KGA increased by 2.45% under the optimized culture medium conditions compared with the original medium. It reached the fermentation end after 60 h which was shortened by 16 h than before and the fermentation efficiency improved by 0.29 g/L·h.

Shipin Gongye Keji published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Synthetic Route of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Lin published the artcileTwo branched fructose modification improves tumor targeting delivery of liposomes to breast cancer in intro and in vivo, SDS of cas: 20880-92-6, the publication is Journal of Drug Delivery Science and Technology (2021), 102312, database is CAplus.

Breast cancer is the leading cause of cancer death for females and needs more specific treatments. D-fructose is a promising ligand targeting to glucose transporter 5 (GLUT5) on breast cancer cells, and single-branched fructose has been used for targeting nanoparticles. However, the impact of two-branched fructose on targeting delivery remains to be elucidated. In this study, we synthesized a two-branched fructose ligand, prepared fructose-decorating liposomes and evaluated them in vitro and in vivo. The results showed liposomes were approx. 102 nm-107 nm in size, with -3.19 mV to -3.61 mV zeta potential, and their encapsulation efficiency of paclitaxel (PTX) were 87% ∼ 91%. The liposomes decorated with two-branched fructose (Fru2-Lip) had the highest cellular uptake and cytotoxicity in 4T1 cells and MCF7 cells in vitro, and the strongest in vivo targeting delivery and accumulation in breast tumor sites, even compared with the liposomes decorated with two equivalent fructose. Further investigation of the mechanism underlying the increased targeting released the two-branched fructose had a 7.93 kcal/mol higher binding free energy to GLUT5, compared with the single-branched fructose. These results illustrated the two-branched fructose can significantly enhance the tumor-targeting of liposomes and supported the application of multi-branched ligands for the design of tumor-specific targeting delivery system.

Journal of Drug Delivery Science and Technology published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C3H9ClOS, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Wen published the artcileElectrochemically driven cross-electrophile coupling of alkyl halides, Product Details of C15H21BO2, the publication is Nature (London, United Kingdom) (2022), 604(7905), 292-297, database is CAplus and MEDLINE.

Here, electrochem. were used to achieve the differential activation of alkyl halides e.g., 2-(2-bromopropan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (I) by exploiting their disparate electronic and steric properties. Specifically, the selective cathodic reduction of a more substituted alkyl halide (I) gives rise to a carbanion, which undergoes preferential coupling with a less substituted alkyl halide via bimol. nucleophilic substitution to forge a new carbon-carbon bond. This protocol enables efficient cross-electrophile coupling of a variety of functionalized and unactivated alkyl electrophiles in the absence of a transition metal catalyst, and shows improved chemoselectivity compared with existing methods.

Nature (London, United Kingdom) published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C10H10O2, Product Details of C15H21BO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xin Rui published the artcileA photochromic thin film based on salicylideneaniline derivatives intercalated layered double hydroxide, COA of Formula: C17H12NNaO8S2, the publication is Chemical Physics Letters (2010), 493(4-6), 333-339, database is CAplus.

Optically transparent thin films with photochromic properties were fabricated by co-intercalation of azomethine-H anions (AMH) and 1-pentanesulfonate (PS) with different molar ratios into the galleries of a ZnAl layered double hydroxide (LDH). The photochromism of AMH occurred in a 2D confined inorganic matrix was studied by steady state and transient UV-visible spectroscopy. The AMH anion undergoes an excited-state intramol. proton transfer from the enol tautomer to trans-keto tautomer after UV excitation, and the relaxed back-isomerization to the ground state of enol tautomer was studied by transient UV-visible spectroscopy.

Chemical Physics Letters published new progress about 5941-07-1. 5941-07-1 belongs to alcohols-buliding-blocks, auxiliary class Salt,Benzene,Naphthalene,Phenol,Inhibitor, name is 8-Hydroxy-1-(salicylideneamino)naphthalene-3,6-disulfonic acid monosodium Salt, and the molecular formula is C8H10O2, COA of Formula: C17H12NNaO8S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yaping published the artcileSynthesis, characterization and catalytic oxidation of organosilanes with a novel multilayer polyoxomolybdate containing mixed-valence antimony, Recommanded Product: Triethylsilanol, the publication is Molecular Catalysis (2018), 167-174, database is CAplus.

Oxidation of organosilanes is one of the pivotal reactions in organic synthesis and the corresponding products of silanols are widely as raw materials in industrial processes. A new type of polyoxomolybdate containing mixed-valence Sb, [Sb(V)Sb(III)₄Mo₁₈O₆₆]^7- (1a), was isolated as tetra-Me ammonium salt in aqueous solution The compound was structurally characterized by FTIR, XPRD, TG, XPS, ESI-MS etc. It is the 1st time that the containing mixed-valence Sb polyoxomolybdate was used as a heterogeneous catalyst to efficaciously catalyze the oxidation of organosilanes to silanols under mild reaction conditions. Also, the catalyst was stable and maintained its catalytic activity after three reaction cycles.

Molecular Catalysis published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C12H13F2N3O4S, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaokang published the artcileDiscovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer’s disease, SDS of cas: 328-90-5, the publication is Acta Pharmaceutica Sinica B (2020), 10(4), 646-666, database is CAplus and MEDLINE.

The efficacy and discovery of new chem. entities, two series of NTZ-based derivatives I [R¹ = H, SMe, SO₂Me, etc.; R² = 2-OH, 3-OH, 4-OH, 2-OAc] and II [R³ = Me, cyclohexyl, 2-MeC₆H₄, etc.] were designed, synthesized and evaluated as autophagy activator against AD. All compounds I and II were screened by the inhibition of phosphorylation of p70S6K, which was the direct substrate of mammalian target of rapamycin (mTOR) and its phosphorylation level could reflect the mTOR-dependent autophagy level. Among these analogs, compound II [R³ = 3-OAc] exhibited excellent potency in promoting β-amyloid (Aβ) clearance, inhibiting tau phosphorylation, as well as stimulating autophagy both in vitro and in vivo. Compound II [R³ = 3-OAc] could effectively improved the memory and cognitive impairments in APP/PS1 transgenic AD model mice. These results demonstrated that II [R³ = 3-OAc] was a potential candidate for the treatment of AD.

Acta Pharmaceutica Sinica B published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Liu published the artcileLight-Promoted Nickel Catalysis: Etherification of Aryl Electrophiles with Alcohols Catalyzed by a Ni^II-Aryl Complex, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Angewandte Chemie, International Edition (2020), 59(31), 12714-12719, database is CAplus and MEDLINE.

A highly effective C-O coupling reaction of (hetero)aryl electrophiles with primary and secondary alcs. is reported. Catalyzed by a Ni^II-aryl complex under long-wave UV (390-395 nm) irradiation in the presence of a soluble amine base without any addnl. photosensitizer, the reaction enables the etherification of aryl bromides and aryl chlorides as well as sulfonates with a wide range of primary and secondary aliphatic alcs., affording synthetically important ethers. Intramol. C-O coupling is also possible. The reaction appears to proceed via a Ni^I-Ni^III catalytic cycle.

Angewandte Chemie, International Edition published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C3H12Cl2N2, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Jiacheng published the artcileCellular Uptake and Movement in 2D and 3D Multicellular Breast Cancer Models of Fructose-Based Cylindrical Micelles That Is Dependent on the Rod Length, Application In Synthesis of 20880-92-6, the publication is ACS Applied Materials & Interfaces (2016), 8(26), 16622-16630, database is CAplus and MEDLINE.

While the shape effect of nanoparticles on cellular uptake has been frequently studied, no consistent conclusions are available currently. The controversy mainly focuses on the cellular uptake of elongated (i.e., filaments or rod-like micelles) as compared to spherical (i.e., micelles and vesicles) nanoparticles. So far, there is no clear trend that proposes the superiority of spherical or nonspherical nanoparticles with conflicting reports available in the literature. One of the reasons is that these few reports available deal with nanoparticles of different shapes, surface chemistries, stabilities, and aspects ratios. Here, we investigated the effect of the aspect ratio of cylindrical micelles on the cellular uptake by breast cancer cell lines MCF-7 and MDA-MB-231. Cylindrical micelles, also coined rod-like micelles, of various length were prepared using fructose-based block copolymers poly(1-O-methacryloyl-β-D-fructopyranose)-b-poly(Me methacrylate). The critical water content, temperature, and stirring rate that trigger the morphol. transition from spheres to rods of various aspect ratios were identified, allowing the generation of different kinetically trapping morphologies. High shear force as they are found with high stirring rates was observed to inhibit the formation of long rods. Rod-like micelles with length of 500-2000 nm were subsequently investigated toward their ability to translocate in breast cancer cells and penetrate into MCF-7 multicellular spheroid models. It was found that shorter rods were taken up at a higher rate than longer rods.

ACS Applied Materials & Interfaces published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C19H21N3O3S, Application In Synthesis of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Usta, Hakan published the artcileSilole-based polymeric semiconductors for organic thin film transistors, Related Products of alcohols-buliding-blocks, the publication is PMSE Preprints (2007), 337-338, database is CAplus.

Four new silolearene-thiophene copolymers were synthesized and their properties in organic field-effect transistors (OFETs) were studied. Carrier mobilities ≤0.06 cm²/Vs and current on/off ratios of 10⁵-10⁶ for unaligned films were measured in devices functioning in ambient conditions. The silole-based systems can be synthesized in high yields, are environmentally stable, and yield solution-processable films which act as efficient hole transporters in FET devices.

PMSE Preprints published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C10H12O5, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Usta, Hakan published the artcileDithienosilole- and Dibenzosilole-Thiophene Copolymers as Semiconductors for Organic Thin-Film Transistors, Computed Properties of 239075-02-6, the publication is Journal of the American Chemical Society (2006), 128(28), 9034-9035, database is CAplus and MEDLINE.

The synthesis and physicochem. properties of a new class of thiophene/arenesilole-containing π-conjugated polymers are reported. Examples of this new polymer class include the following: poly(2,5-bis(3′,3”-dihexylsilylene-2′,2”-bithieno)thiophene) (TS6T1), poly(2,5′-bis(3”,3”’-dihexylsilylene-2”,2”’-bithieno)bithiophene) (TS6T2), poly(2,5′-bis(2”,2”’-dioctylsilylene-1”,1”’-biphenyl)thiophene) (BS8T1), and poly(2,5′-bis(2”,2”’-dioctylsilylene-1”,1”’-biphenyl)bithiophene) (BS8T2). Organic field-effect transistors (OFETs) with hole mobilities as high as 0.02-0.06 cm²/V s in air, low turn-on voltages, and current on/off ratios >10⁵-10⁶ are fabricated using solution processing techniques with the above polymers as the active channel layer. OFETs based on this polymer class exhibit excellent ambient operational stability.

Journal of the American Chemical Society published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C13H17BF3NO2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts