Author: tianli

Cao, Shengyan published the artcileComparison of application effect of ergometrine and carboprost tromethamine in patients with bleeding during cesarean section with placenta previa, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Guizhou Yiyao (2021), 45(5), 784-785, database is CAplus.

The efficacy of carboprost tromethamine and ergometrine in the treatment of bleeding patients with placenta previa during cesarean section was investigated. In the hemostatic treatment of patients with bleeding during cesarean section of placenta previa, the overall effect of ergometrine and carboprost tromethamine is equivalent, but considering the low cost of ergometrine, clin. prevention and treatment of puerperium is recommended. Ergometrine should be used for middle and postpartum hemorrhage.

Guizhou Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xia published the artcileBlue light-powered hydroxynaphthoic acid-titanium dioxide photocatalysis for the selective aerobic oxidation of amines, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Journal of Colloid and Interface Science (2021), 534-543, database is CAplus and MEDLINE.

Solar photocatalysis is the key to resolve many environmental challenges but is usually hard to achieve over a metal oxide semiconductor. Therefore, assembling π-conjugated mols. onto semiconductors becomes an efficient approach to solar conversion via ligand-to-metal charge transfer. Here, a rational design of ligands for titanium dioxide (TiO₂) is presented to produce robust visible light photocatalysts. Three hydroxynaphthoic acids (HNAs) were selected as ligands by extending an extra benzene ring of salicylic acid (SA) at 3,4 or 4,5 or 5,6 positions. These ligands could regulate the performance of TiO₂ in which 2-hydroxy-1-naphthoic acid (2H1NA) endows the best outcome. In detail, blue light-powered cooperative photocatalysis of 2H1NA-TiO₂ with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO, 5 mol%) inaugurates the expeditious formation of imines by oxidation of amines with atm. oxygen (O₂). Interestingly, the increase of the O₂ pressure from 1 atm to 0.4 MPa promoted the selective oxidation of benzylamine but thereafter declined with a further boost to 0.6 MPa. Notably, an electron transfer between the oxidatively quenched 2H1NA-TiO₂ and TEMPO is established, offering a new pathway for environmental applications. This work presents a strategy in designing cutting-edge visible light photocatalysts via altering semiconductors with surface ligands.

Journal of Colloid and Interface Science published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dong, Si published the artcileFunctional Amphiphilic Poly(2-oxazoline) Block Copolymers as Drug Carriers: the Relationship between Structure and Drug Loading Capacity, Recommanded Product: 2-Phenylethanethiol, the publication is Chinese Journal of Polymer Science (2021), 39(7), 865-873, database is CAplus.

Poly(2-oxazoline) (POx) is a kind of polymeric amides that can be viewed as conformational isomers of polypeptides with excellent cyto- and hemo-compatibility, and is promising to be used as drug carriers. However, the drug loading capacity (DLC) of POx for many drugs is still low except several hydrophobic ones including paclitaxel (PTX). Herein, we prepared a series of amphiphilic POx block copolymers with various functional groups, and investigated the relationship between functional structures and the DLC. Functional POxs with benzyl, carboxyl, and amino groups in the side-chain were synthesized based on a poly(2-methyl-2-oxazoline)-block-poly(2-butyl-2-oxazoline-co-2-butenyl-2-oxazoline) (PMeOx-P(nBuOx-co-ButenOx), PMBEOx) precursor, followed by click reaction between vinyl and the 2-phenylethanethiol, thioglycolic acid and cysteamine. Using thin-film hydration method, eight commonly used drugs with various characteristics were encapsulated within these functional POx polymers. We found that amine-containing drugs were more easily encapsulated by POx with carboxyl groups, while amine functionalities in POx enhanced the loading capacity of drugs with carboxyl groups. In addition, ;π;π interactions resulted in enhanced DLC of most drugs, except several hydrophobic drugs with aromatic to total carbon ratios less than 0.5. In general, we could successfully encapsulate all the selected drugs with a DLC% over 10% using properly selected functional POxs. The above results confirm that the DLC of polymeric carriers can be adjusted by modifying the functional groups, and the prepared series of functional POxs provide an option for various drug loadings.

Chinese Journal of Polymer Science published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Yu published the artcileSolution [2 + 2] photopolymerization of biomass-derived nonrigid biscinnamate monomers enabled by energy transfer catalysis, SDS of cas: 111-29-5, the publication is Polymer Chemistry (2022), 13(17), 2538-2544, database is CAplus.

The [2+2] photopolymerization has been known for more than fifty years and widely applied in many fields. However, this process is typically conducted in the solid state, while the corresponding [2 + 2] photopolymerization of simple non-rigid diolefinic monomers has been rarely achieved in solution under visible light, owing to the lack of monomer preassembly and low/no absorption of visible light. In fact, the [2 + 2] photopolymerization of simple biscinnamate monomers remains an unsolved problem. Here, we demonstrate that energy transfer catalysis could overcome the low efficiency in the intersystem crossing to the triplet states of monomers and enable the [2 + 2] photopolymerization of biomass-derived biscinnamate monomers in solution for the first time. As no preassembly is required, this solution polymerization protocol is applicable to biscinnamate monomers with different linker structures and allows copolymerization between different biscinnamate monomers to regulate polymer mech. properties. A series of cyclobutane-imbedded polyesters (Mw ranged from 25.3 kDa to 61.3 kDa) became accessible, which showed excellent solubility in organic solvents and good processability, in sharp contrast to the properties of the biscinnamate polymers obtained before via solid state photopolymerization methods.

Polymer Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kong, Xu-Dong published the artcileA Smart Library of Epoxide Hydrolase Variants and the Top Hits for Synthesis of (S)-β-Blocker Precursors, Name: 4-Morpholino-1,2,5-thiadiazol-3-ol, the publication is Angewandte Chemie, International Edition (2014), 53(26), 6641-6644, database is CAplus and MEDLINE.

Microtuning of the enzyme active pocket has led to a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots. This study represents a breakthrough in protein engineering of epoxide hydrolases and resulted in enhanced activity toward bulky substrates.

Angewandte Chemie, International Edition published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Name: 4-Morpholino-1,2,5-thiadiazol-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Tingting published the artcileAtomically Dispersed Pt-N₃C₁ Sites Enabling Efficient and Selective Electrocatalytic C-C Bond Cleavage in Lignin Models under Ambient Conditions, Product Details of C15H16O3, the publication is Journal of the American Chemical Society (2021), 143(25), 9429-9439, database is CAplus and MEDLINE.

Selective cleavage of C-C linkages is the key and a challenge for lignin degradation to harvest value-added aromatic compounds To this end, electrocatalytic oxidation presents a promising technique by virtue of mild reaction conditions and strong sustainability. However, the existing electrocatalysts (traditional bulk metal and metal oxides) for C-C bond oxidative cleavage suffer from poor selectivity and low product yields. We show for the first time that atomically dispersed Pt-N₃C₁ sites planted on nitrogen-doped carbon nanotubes (Pt₁/N-CNTs), constructed via a stepwise polymerization-carbonization-electrostatic adsorption strategy, are highly active and selective toward C_α-C_β bond cleavage in β-O-4 model compounds under ambient conditions. Pt₁/N-CNTs exhibits 99% substrate conversion with 81% yield of benzaldehyde, which is exceptional and unprecedented compared with previously reported electrocatalysts. Moreover, Pt₁/N-CNTs using only 0.41 weight % Pt achieved a much higher benzaldehyde yield than those of the state-of-the-art bulk Pt electrode (100 weight % Pt) and com. Pt/C catalyst (20 weight % Pt). Systematic exptl. investigation together with d. functional theory (DFT) calculation suggests that the superior performance of Pt₁/N-CNTs arises from the atomically dispersed Pt-N₃C₁ sites facilitating the formation of a key C_β radical intermediate, further inducing a radical/radical cross-coupling path to break the C_α-C_β bond. This work opens up opportunities in lignin valorization via a green and sustainable electrochem. route with ultralow noble metal usage.

Journal of the American Chemical Society published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Product Details of C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shao, Jun published the artcileCharacterization of a mannosylphospholipid liposome system for drug targeting to alveolar macrophages, Quality Control of 96345-79-8, the publication is Drug Delivery (1997), 4(1), 43-48, database is CAplus.

The potential that mannose receptors on alveolar macrophages (AMs) may be targeted using mannose-conjugated liposomes for intracellular drug delivery to AMs was investigated. A mannosylphospholipid was synthesized via the reaction of α-D-mannopyranosylphenylisothiocyanate with dipalmitoyl phosphatidylethanolamine, and the product was identified using thin-layer chromatog. and NMR spectroscopy. Liposomes containing this mannosylated phospholipid were made using a high-pressure homogenization method and analyzed using freeze-etch electron transmission microscopy. These liposomes were shown to exhibit unilamellar structure with a mean diameter of 140 ± 59 nm. The uptake of liposomes by rat alveolar macrophages, by measurement of internalized, liposome-encapsulated fluorescein, was found to be both dose and time dependent. The uptake of liposomes containing 40% mannosylphospholipid was 3.6-fold higher than that of liposomes without the mannosylated lipid (16% to 4.5%). Fluorescein in solution was not internalized by AMs. The enhancement of uptake by conjugation of mannose onto the liposome surface was markedly inhibited by the addition of free mannose at various concentrations, indicating an uptake process involving mannose receptor-mediated endocytosis.

Drug Delivery published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C11H8O3, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Du, Xiangsha published the artcileSingle-electron charging and ultrafast dynamics of bimetallic Au_144-xAg_x(PET)₆₀ nanoclusters, Application of 2-Phenylethanethiol, the publication is Nano Research (2022), 15(9), 8573-8578, database is CAplus.

Alloying is an important strategy in tailoring the functionality of materials. In metal nanoclusters (NCs), the introduction of a heterometal leads to alloy nanoclusters that often outperform the homometal ones in terms of the phys. and chem. properties. In this work, a series of four M₁₄₄(PET)₆₀ alloy NCs (where, M = Au/Ag, PET = -SCH₂CH₂Ph) are synthesized and characterized. The silver doping into the homogold template (Au₁₄₄) leads to more prominent optical absorption features in the steady-state spectrum in the visible range. Femtosecond transient absorption spectroscopy reveals the effect of Ag doping on the electronic relaxation dynamics compared to Au₁₄₄ and the pump fluence independent dynamics. Electrochem. results reflect a narrowing of HOMO-LUMO gap (Eg) induced by Ag doping. A temperature dependence of the single-electron charging is also observed for the series of alloy NCs, in which the E_g values of the alloy NCs enlarge as the temperature decreases, which is characteristic of semiconducting behavior. [graphic not available: see fulltext]

Nano Research published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Xingye published the artcileOptical Control of CRAC Channels Using Photoswitchable Azopyrazoles, Computed Properties of 328-90-5, the publication is Journal of the American Chemical Society (2020), 142(20), 9460-9470, database is CAplus and MEDLINE.

The Ca²⁺ release-activated Ca²⁺ (CRAC) channels control many Ca²⁺-modulated physiol. processes in mammals. Hyperactivating CRAC channels are known to cause several human diseases, including Stormorken syndrome. Here, we show the design of azopyrazole-derived photoswitchable CRAC channel inhibitors (designated piCRACs), which enable optical inhibition of store-operated Ca²⁺ influx and downstream signaling. Moreover, piCRAC-1 has been applied in vivo to alleviate thrombocytopenia and hemorrhage in a zebrafish model of Stormorken syndrome in a light-dependent manner.

Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C26H45N5O7Si2, Computed Properties of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

An, Zhi-min published the artcileStructural changes of 2-keto-L-gulonic acid studied by NMR spectroscopy, Formula: C6H10O7, the publication is Bopuxue Zazhi (2014), 31(3), 407-414, database is CAplus.

2-Keto-L-gulonic acid (2-KLG) changes its mol. structure in many solvents at room temperature A five-membered intramol. ring structure can easily be formed by the 2,5-hemiacetal reaction after the opening of the carbonyl group in 2-KLG (-C=O) to form a O-C-O interlinkage. In this study, we showed that the ¹³C chem. shift of the carbonyl changed from δ200 towards high field to about δ96 after forming the intramol. ring. Two-dimensional HMBC experiments revealed that 2-keto-L-gulonic acid formed five-membered ring 2,5-hemiacetal derivatives in seven solvents, instead of six-membered 2,6-hemiacetal derivatives

Bopuxue Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts