Author: tianli

Rundel, Kira published the artcileNaphthalene diimide-based small molecule acceptors for organic solar cells, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2017), 5(24), 12266-12277, database is CAplus.

This work introduces six novel naphthalene diimide (NDI) mol. acceptors for evaluation in organic solar cells based on two different chem. architectures: a star-shaped structure with a triarylamine core flanked by three NDI moieties and a linear mol. composed of a bithiophene bridge between two NDI moieties. For each mol. structure, three different side chains are examined, with alkyl chains linked to the NDI core either through oxygen, sulfur, or nitrogen substituents. Both the chem. structure and the side-chain heteroatom substitution were found to influence the optoelectronic and photovoltaic properties of these mol. acceptors. Organic solar cells were fabricated with each acceptor, utilizing PBDTTT-EFT (also known as PTB7-Th) as the donor material in inverted bulk-heterojunction devices. Nitrogen was observed to lower the solar cell performance for these acceptors by significantly decreasing the short circuit c.d. (J_SC), while sulfur increased the J_SC and, in the star configuration, led to the highest power conversion efficiency (PCE) of 2.8% – which is amongst the highest for any mol. NDI-based acceptor to date. Grazing incidence wide-angle x-ray scattering (GIWAXS) measurements of the star-shaped materials showed the side-chain substitutional atom significantly alters the material’s packing configuration in neat films, with films blended with PBDTTT-EFT showing features characteristic of the neat donor and acceptor materials, indicating that the small mols. do not disrupt the packing of PBDTTT-EFT (and vice versa). Resonant soft x-ray scattering (R-SoXS) measurements indicate the PBDTTT-EFT:star-shaped acceptor blends are not subject to coarse phase-separation, with the average domain size for all three star-shaped acceptor blends typically being <100 nm. This is confirmed by similar topog. for blended films in AFM images amongst the three acceptors. Photoluminescence (PL) quenching measurements, however, found large differences in PL quenching efficiency which were attributed to differences in the driving force for charge transfer, with the nitrogen substituted compound showing the lowest PL quenching and the sulfur replacement showing the highest.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beyzavi, Hudson published the artcile¹⁸F-Deoxyfluorination of Phenols via Ru π-Complexes, Formula: C10H13NO2, the publication is ACS Central Science (2017), 3(9), 944-948, database is CAplus and MEDLINE.

The deficiency of robust and practical methods for ¹⁸F-radiofluorination is a bottleneck for positron emission tomog. (PET) tracer development. Here, we report the first transition-metal-assisted ¹⁸F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atm., large substrate scope, and translatability to generate doses appropriate for PET imaging.

ACS Central Science published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nurjuliana, M. published the artcileRapid identification of pork for halal authentication using the electronic nose and gas chromatography mass spectrometer with headspace analyzer, SDS of cas: 17236-59-8, the publication is Meat Science (2011), 88(4), 638-644, database is CAplus and MEDLINE.

The volatile compounds of pork, other meats and meat products were studied using an electronic nose and gas chromatog. mass spectrometer with headspace analyzer (GCMS-HS) for halal verification. The zNose was successfully employed for identification and differentiation of pork and pork sausages from beef, mutton and chicken meats and sausages which were achieved using a visual odor pattern called VaporPrint, derived from the frequency of the surface acoustic wave (SAW) detector of the electronic nose. GCMS-HS was employed to sep. and analyze the headspace gases from samples into peaks corresponding to individual compounds for the purpose of identification. Principal component anal. (PCA) was applied for data interpretation. Anal. by PCA was able to cluster and discriminate pork from other types of meats and sausages. It was shown that PCA could provide a good separation of the samples with 67% of the total variance accounted by PC1.

Meat Science published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, SDS of cas: 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shkodin, N. E. published the artcileTesting of anthelmintics during experimental and spontaneous nematodosis of sheep, Quality Control of 3818-50-6, the publication is Trudy Kirgizskogo Nauchno-Issledovatel’skogo Instituta Zhivotnovodstva i Veterinarii (1975), 20-1, database is CAplus.

Nephthamon (I) [3818-50-6] (0.5 g/kg) or copper sodium carbonatoarsenate [65722-74-9] (0.1 g/kg) given orally to sheep exptl. infested with lung nematodes daily for 6 days gave complete control of the parasites. I also gave 100% control in spontaneously infested sheep, whereas Cu Na carbonatoarsenate was about 95% effective.

Trudy Kirgizskogo Nauchno-Issledovatel’skogo Instituta Zhivotnovodstva i Veterinarii published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C12H16O3, Quality Control of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Koeckerling, Martin published the artcileStructural and Kinetic Considerations for the Application of the Traceless Staudinger Ligation to Future ¹⁸F Radiolabeling Using XRD and ¹⁹F NMR, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is International Journal of Chemical Kinetics (2018), 50(1), 31-40, database is CAplus.

A 4-fluorobenzoate-functionalized phosphane was synthesized and reacted with different azides using the traceless Staudinger ligation as a representative sample reaction for future radiolabeling purposes with short-lived radionuclides like fluorine-18. For this purpose, the reaction rate was evaluated at different temperatures The effect of starting material concentrations and the influence of the steric effect coming from the applied azides were investigated. ¹⁹F NMR was used to determine the reaction half-live (τ_1/2) and the reaction rate constant (k_obs) of this ligation under mild reaction conditions in a water-acetonitrile mixture Furthermore, the phosphane key compound I (orthorhombic, space group Pna2₁, a = 18.6363(9), b = 8.3589(4), c = 18.5480(9) Å, V = 2889.4(2) ų, Z = 8, D_obs = 1.277 g/cm³), which acts as starting material for all subsequent syntheses, and the fluorine-containing phosphane II (monoclinic, space group P2₁/c, a = 8.321(2), b = 16.160(4), c = 14.940(4) Å, β = 99.51(1)°, V = 1981.4(8) ų, Z = 4, D_obs = 1.342 g/cm³) were analyzed by single-crystal XRD.

International Journal of Chemical Kinetics published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sanceau, Jean-Yves published the artcileTotal Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX, Name: (R)-Oxiran-2-ylmethanol, the publication is Journal of Organic Chemistry (2019), 84(2), 495-505, database is CAplus and MEDLINE.

The first total synthesis of a lipid mediator derived from natural ω-3-fatty acid docosahexaenoic acid (DHA), 10S,17S-diHDHA (also referred to as protectin DX/PDX), was achieved in a convergent route (29 steps). The two chiral hydroxyl groups at C-10 and C-17 were derived from readily available (S)-1,2,4-butanetriol and (R)-glycidol, resp. The two stereodefined E-double bonds were generated by a Takai olefination, and the skipped diene side chain was introduced with a stereocontrolled Wittig olefination. Importantly, the sensitive conjugated E,Z,E-triene intermediate was generated by a Boland reduction of the central triple bond of a E,E-dienyne. Overall, this synthetic strategy should allow the preparation of a larger quantity of PDX, which is inaccessible via previously reported biosynthetic approaches.

Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Name: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Riggs, Daniel W. published the artcileEnvironmental exposure to volatile organic compounds is associated with endothelial injury, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Toxicology and Applied Pharmacology (2022), 115877, database is CAplus and MEDLINE.

Volatile organic compounds (VOCs) are airborne toxicants abundant in outdoor and indoor air. High levels of VOCs are also present at various Superfund and other hazardous waste sites; however, little is known about the cardiovascular effects of VOCs. We hypothesized that ambient exposure to VOCs exacerbate cardiovascular disease (CVD) risk by depleting circulating angiogenic cells (CACs). In this cross-sectional study, we recruited 603 participants with low-to-high CVD risk and measured 15 subpopulations of CACs by flow cytometry and 16 urinary metabolites of 12 VOCs by LC/MS/MS. Associations between CAC and VOC metabolite levels were examined using generalized linear models in the total sample, and sep. in non-smokers. In single pollutant models, metabolites of ethylbenzene/styrene and xylene, were neg. associated with CAC levels in both the total sample, and in non-smokers. The metabolite of acrylonitrile was neg. associated with CD45^dim/CD146⁺/CD34⁺/AC133⁺ cells and CD45⁺/CD146⁺/AC133⁺, and the toluene metabolite with AC133⁺ cells. In anal. of non-smokers (n = 375), multipollutant models showed a neg. association with metabolites of ethylbenzene/styrene, benzene, and xylene with CD^45dim/CD146⁺/CD34⁺ cells, independent of other VOC metabolite levels. Cumulative VOC risk score showed a strong neg. association with CD45^dim/CD146⁺/CD34⁺ cells, suggesting that total VOC exposure has a cumulative effect on pro-angiogenic cells. We found a non-linear relationship for benzene, which showed an increase in CAC levels at low, but depletion at higher levels of exposure. Sex and race, hypertension, and diabetes significantly modified VOC associated CAC depletion. Low-level ambient exposure to VOCs is associated with CAC depletion, which could compromise endothelial repair and angiogenesis, and exacerbate CVD risk.

Toxicology and Applied Pharmacology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lubeck, Josephine S. published the artcileSupercritical fluid chromatography for the analysis of oxygenated polycyclic aromatic compounds in unconventional oils, Name: 1-Hydroxy-2-naphthoic acid, the publication is Journal of Chromatography A (2019), 162-172, database is CAplus and MEDLINE.

Unconventional oil feeds can be rich in oxygenated organic compounds that will neg. affect the fuel properties if they are not removed during refining. In this study, supercritical fluid chromatog. (SFC) was utilized for the combined anal. of polycyclic aromatic hydrocarbons (PAHs) and oxygenated polycyclic aromatic compounds (OPACs). One objective was to chromatog. sep. PAHs from OPACs; another to reach a high peak capacity, improved peak shapes and high signal-to-noise ratios (S/N) for OPACs. These objectives were set to establish a non-target anal. method for oxygenated compounds in unconventional oils by SFC hyphenated to a UV detector and a quadrupole time-of-flight mass spectrometer (QTOF-MS) with neg. electrospray ionization (ESI^–). Highest peak capacities were observed with a 2-picolylamine column with methanol as modifier, however, a better resolution and S/N were obtained with ethanol and 0.1% formic acid. The elution order for OPACs on all columns followed mainly the polarity of the analytes: furans < aldehydes ≤ ketones < phenols ≤ carboxylic acids. Best separation between PAHs and OPACs was achieved with the ethylene-bridged silica column. The optimized SFC-UV-ESI^–-QTOF-MS method was tested on a coal tar middle distillate and a pyrolysis oil where a number of homologous series (e.g. hydroxy-naphthalenes and -benzaldehydes) was tentatively identified.

Journal of Chromatography A published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Name: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Antharavally, Babu S. published the artcileEfficient removal of detergents from proteins and peptides in a spin column format, Synthetic Route of 85618-21-9, the publication is Analytical Biochemistry (2011), 416(1), 39-44, database is CAplus and MEDLINE.

Detergents are commonly used in protein-chem. protocols and may be necessary for protein extraction, solubilization, and denaturation; however, their presence interferes with many downstream anal. techniques, including mass spectrometry (MS). To enable downstream anal., it is critical to remove unbound detergents from protein and peptide samples. In this study, the authors describe a high-performance resin that offers exceptional detergent removal for proteins and peptides. When used in a spin column format, this resin dramatically improves protein and peptide MS results by more than 95% removal of 1-5% detergents, including SDS, sodium deoxycholate, Chaps, Triton X-100, Triton X-114, NP-40, Brij-35, octyl glucoside, octyl thioglucoside, and lauryl maltoside, with high recovery of proteins and peptides. Postcolumn liquid chromatog.-tandem MS (LC-MS/MS) anal. of trypsin digests of bovine serum albumin (BSA) and HeLa cell lysate revealed excellent sequence coverage, indicating successful removal of detergent from the peptides. Matrix-assisted laser desorption/ionization (MALDI)-MS anal. of unprocessed and processed samples further confirmed efficient removal of detergents. The advantages of this method include speed (<15 min), efficient detergent removal, and high recovery of proteins and peptides.

Analytical Biochemistry published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Larcombe, Chloe N. published the artcileAccessing Diverse Cross-Benzoin and α-Siloxy Ketone Products via Acyl Substitution Chemistry, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Organic Chemistry (2022), 87(14), 9408-9413, database is CAplus and MEDLINE.

An approach to diverse cross-benzoin and α-siloxy ketone products which leverages a simple yet underutilized C-C bond disconnection strategy is reported. Acyl substitution of readily accessible α-siloxy Weinreb amides with organolithium compounds enables access to a broad scope of aryl, heteroaryl, alkyl, alkenyl, and alkynyl derivatives Enantiopure benzoins can be accessed via a chiral pool approach, and the utility of accessible cross-benzoins and α-siloxy ketones is highlighted in a suite of downstream synthetic applications.

Journal of Organic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts