Author: tianli

Chunarrom, Wannida published the artcileThe dielectric and polarization behavior of polyurethane-based polycarbonate diols with different content levels of fluorinated hard segments, Synthetic Route of 129301-42-4, the publication is Polymer Chemistry (2021), 12(8), 1136-1146, database is CAplus.

A novel series of polyurethane-based polycarbonate diols containing fluorinated hard segments in the main chain (FPU) were synthesized using a prepolymer method. The fluorinated hard segment content was varied to study the effects on the dielec. and polarization behaviors under an applied elec. field (P-E loop). The addition of a fluorinated chain notably improved the polarization via an induced dipole moment in the PU films and higher dielec. constant, including allowing the relaxation peak to move to a lower frequency. Paraelec. loop behavior was observed with thinner loops as the fluorinated group content was increased. The nature of the solvent used for the synthesis affected the H-bonding capabilities and fluorinated group content. FPU synthesized in DMF showed a higher dielec. constant than that synthesized in dimethylsulfoxide due to its higher fluorine content.

Polymer Chemistry published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Synthetic Route of 129301-42-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goncalves, Leticia C. P. published the artcileBoosting photobioredox catalysis by morpholine electron donors under aerobic conditions, Recommanded Product: 2-Morpholinoethanol, the publication is Catalysis Science & Technology (2019), 9(10), 2682-2688, database is CAplus.

Light-driven reduction of flavins, e.g. FAD or FMN, by sacrificial electron donors emerged as a convenient method to promote biocatalytic transformations. However, flavin activation has been restricted to oxygen-free conditions to prevent enzyme deactivation caused by reactive oxygen species (ROS). Herein, we show that the photoreduction of FMN by morpholines, including 3-(N-morpholino)propanesulfonic acid (MOPS), lessens the deactivation of the enoate reductase XenB from Pseudomonas sp. during the stereoselective asym. enzymic reduction of a model α,β-unsaturated diketone under aerobic conditions, leading to a 91% GC-yield and a stereoselectivity greater than 94%. The kinetic stability of the thermolabile XenB was increased by more than 20-fold in MOPS buffer compared to that in Tris-HCl buffer, and a pronounced pos. effect on the transition midpoint temperature was observed The reactive form of the FMN photocatalyst is stabilized by the formation of a ³[FMN^–̇-MOPS⁺̇] ensemble, which reduces the formation of hydrogen peroxide and other ROS in the presence of oxygen. These results contribute to broaden the application of photobiocatalytic transformations using flavin-dependent reductases.

Catalysis Science & Technology published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Wei-chen published the artcileReaction of HppE with Substrate Analogues: Evidence for Carbon-Phosphorus Bond Cleavage by a Carbocation Rearrangement, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Journal of the American Chemical Society (2013), 135(22), 8153-8156, database is CAplus and MEDLINE.

(S)-2-Hydroxypropylphosphonic acid ((S)-2-HPP) epoxidase (HppE) is an unusual mononuclear non-heme iron enzyme that catalyzes the oxidative epoxidation of (S)-2-HPP in the biosynthesis of the antibiotic fosfomycin. Recently, HppE has been shown to accept (R)-1-hydroxypropylphosphonic acid as a substrate and convert it to an aldehyde product in a reaction involving a biol. unprecedented 1,2-phosphono migration. In this study, a series of substrate analogs were designed, synthesized, and used as mechanistic probes to study this novel enzymic transformation. The resulting data, together with insights obtained from d. functional theory calculations, are consistent with a mechanism of HppE-catalyzed phosphono group migration that involves the formation of a carbocation intermediate. As such, this reaction represents a new paradigm for biol. C-P bond cleavage.

Journal of the American Chemical Society published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paalasmaa, Sanna published the artcileSynthesis and characterization of three homoleptic bismuth silanolates: [Bi(OSiR₃)₃] (R = Me, Et, iPr), Quality Control of 17877-23-5, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2005), 631(12), 2433-2438, database is CAplus.

The bismuth tris(triorganosilanolates) [Bi(OSiR₃)₃] (1, R = Me; 2, R = Et; 3, R = iPr) were prepared by reaction of R₃SiOH with [Bi(OtBu)₃]. Compound 1 crystallizes in the triclinic space group P1̅ with Z = 2 and a 10.323(1), b 13.805(1), c 21.096(1) Å and α 91.871(4), β 94.639(3), γ 110.802(3)°. In the solid state compound 1 is a trimer as result of weak intermol. bismuth-oxygen interactions with Bi-O distances in the range 2.686(6)-3.227(3) Å. The coordination at the bismuth atoms Bi(1) and Bi(3) is best described as 3 + 2 coordination whereas Bi(2) shows a 3 + 3 coordination. The intramol. Bi-O distances fall in the range 2.041(3)-2.119(3) Å. Compound 3 crystallizes in the orthorhombic space group Pbcm with Z = 4 and a 7.201(1), b 23.367(5) and c 20.893(1) Å whereas the triethylsilyl-derivative 2 is liquid In contrast to [Bi(OSiMe₃)₃] (1), compound 3 is monomeric in the solid state, but shows similar intramol. Bi-O distances in the range 1.998(2)-2.065(5) Å. The bismuth silanolates are highly soluble in common organic solvents and strongly moisture sensitive. Compound 1 shows the lowest thermal stability.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sindhu, S. published the artcileGC-MS determination of bioactive components of Polycarpaea corymbosa Lams. (Caryophyllaceae), Application of Triisopropylsilanol, the publication is Hygeia (2013), 5(1), 5-9, database is CAplus.

Plan: The investigation was carried out to determine the possible chem. components from Polycarpaea corymbosa Lam. root and aerial parts. Methodol.: GC-MS was analyzed using Agilent (Model 5975C) Gas Chromatog.-Mass Spectrometry. Outcome: GC-MS anal. of methanolic extract of root and aerial part led to identification of 30 and 24 compounds resp. The components were identified by comparing their retention indexes and mass spectra fragmentation patterns with those stored in the National Institute of Standards and Technol. (NIST) library. The major constituents reported are n-Hexadecanoic acid in methanolic aerial extract and 5-Hydroxymethyl furfural in methanolic root extract

Hygeia published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C5H5N3S, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stones, Duane published the artcileModular solid-phase synthetic approach to optimize structural and electronic properties of oligo-boronic acid receptors and sensors for the aqueous recognition of oligosaccharides, HPLC of Formula: 673456-16-1, the publication is Chemistry – A European Journal (2004), 10(1), 92-100, database is CAplus and MEDLINE.

This article describes the design and optimization of the first entirely modular, parallel solid-phase synthetic approach for the generation of well-defined polyamine oligo-boronic acid receptors and fluorescence sensors for complex oligosaccharides. The synthetic approach allows an effective building of the receptor polyamine backbone, followed by the controlled diversification of the amine benzylic side chains. This approach enabled the testing, in a modular fashion, of the effect of different aryl-boronic acid units substituted with un-encumbering para electron-withdrawing or electron-donating groups. The feasibility of this approach toward automated synthesis was also investigated with the assembly of a sub-library of receptors by means of the Irori MiniKan technol. Several sub-libraries of anthracene-capped sensors containing two or three aryl-boronic acids were synthesized, and their binding to a series of model disaccharides was examined in neutral aqueous media. The calculation of association constants by fluorescence titrations confirmed that subtle changes in the structures of the inter-amine spacers in the polyamine backbone can have a significant effect on the stability of the resulting complexes. Most importantly, this study led to the determination of the preferred electronic characteristics for the aryl-boronate units, and suggests that a new generation of receptors containing very electron-poor aryl-boronic acids could lead to a significant improvement of binding affinities.

Chemistry – A European Journal published new progress about 673456-16-1. 673456-16-1 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester,, name is 2-(2-(Bromomethyl)-4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C14H14N2O2, HPLC of Formula: 673456-16-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bagherzadeh, Sharareh published the artcileCatalyst Control of Selectivity in CO₂ Reduction Using a Tunable Heterobimetallic Effect, COA of Formula: C6H13BO3, the publication is Journal of the American Chemical Society (2015), 137(34), 10898-10901, database is CAplus and MEDLINE.

A tunable bimetallic effect on product selectivity in catalytic CO₂ reduction was identified using N-heterocyclic carbene-ligated Cu complexes. While the monometallic Cu-only system catalyzes hydroboration of CO₂ with pinacolborane to produce formate exclusively, introducing a bimetallic effect with analogous Cu-Fe, Cu-W, and Cu-Mo catalysts produces mixtures of formate and CO. Within a series of isosteric catalysts, the selectivity of CO vs. formate was controlled by tuning the electronic nature of the Cu/M pairing, with high selectivity for CO being achieved using a Cu-Mo catalyst.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, COA of Formula: C6H13BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Itagimatha, N. published the artcileRP-HPLC-UV method development and validation for simultaneous determination of terbutaline sulphate, ambroxol HCl and guaifenesin in pure and dosage forms, COA of Formula: C13H19Br2ClN2O, the publication is Annales Pharmaceutiques Francaises (2019), 77(4), 295-301, database is CAplus and MEDLINE.

The objective of the present work was to develop and validate a simple, sensitive, rapid and stable reverse-phase high performance liquid chromatog. (RP-HPLC) method for a combination of Terbutaline sulfate (TSL), Ambroxol hydrochloride (AML) and Guaifenesin (GFN).The combination of these drugs was analyzed by using Shimadzu LC 2010 CHT high performance liquid chromatog. (HPLC). Successful separation was achieved by isocratic elution on a reverse-phase C₁₈ column (sun fire) (250 mm, 4.6 mm, 5μg), using a mobile phase consisting of buffer: acetonitrile in the ratio 80: 20 (buffer – 0.1% volume/volume triethyleamine pH-3.0) followed by 1.0 mL/min flow rate. The wavelength of detection was at 220 nm.The chromatog. retention times were consistent at 3.0, 10.5 and 13.8 min for TSL, AML and GFN resp. For these three compounds, the lower limit of detection was 1.0, 1.25, and 1.5μg/mL and lower limit of quantification was 3.3, 4.1 and 5.0μg/mL resp. The linearity concentrations established for TSL, AML and GFN were 1.0-7.0, 1.5-7.5 and 4.0-14.0μg/mL resp. The correlation coefficients for all the drugs were found to be greater than 0.999. The relative standard deviation of inter- and intra-day were less than 2.0%.This method provides a necessary tool for quantification of the selected drugs for their assay. The proposed method is simple, accurate, reproducible and applied successfully to analyze three compounds in pure as well dosage form. This method provides a necessary tool for quantification of the selected drugs for their assay.

Annales Pharmaceutiques Francaises published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavallaro, Gennara published the artcileGlycosilated macromolecular conjugates of antiviral drugs with a polyaspartamide, Related Products of alcohols-buliding-blocks, the publication is Journal of Drug Targeting (2004), 12(9-10), 593-605, database is CAplus and MEDLINE.

Two new polymeric conjugates for specific liver targeting were prepared by conjugation of sugar moieties and antiviral drugs to α, β-poly[N-2-(hydroxyethyl)-dl-aspartamide] (PHEA). PHEA-galactopyranosylphenylthiocarbamide-mono-O-succinylganciclovir (conjugate 7) and PHEA-mannopyranosylphenylthiocarbamide-O-succinylacyclovir (conjugate 8) were synthesized according to a multi-step procedure which allowed for obtaining high product yield and process standardization. Conjugate 7 contained 7.5 and 8.5% of galactose and ganciclovir (substituent/repeating unit, mol/mol), resp., and conjugate 8 contained 14.2 and 10.8% of mannose and acyclovir, resp. In vitro studies demonstrated that both acyclovir and ganciclovir were released from the polymeric adducts at a release rate depending on the incubation medium. Though a detailed study evidenced that the two bioconjugates undergo different hydrolysis pathways, in both cases high drug release rate was found in plasma, while the glycosidic moiety was not released. Pharmacokinetic studies carried out by i.v. administration of the bioconjugates to Balb/c mice demonstrated that the conjugation of glycosidic moieties promoted the disappearance of the polymer from the blood stream. The two derivatives displayed a different pharmacokinetic profile. In particular, the mannosyl conjugation promoted the rapid disposition of the macromol. in the kidneys and in the liver, while prevented the accumulation in the spleen. On the contrary, the galactosyl derivative was found to dispose in the liver at the same extent of the naked polymer. Few considerations on the different behavior of the conjugates were reported.

Journal of Drug Targeting published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goswami, Lalit published the artcileBiological treatment of wastewater containing a mixture of polycyclic aromatic hydrocarbons using the oleaginous bacterium Rhodococcus opacus, SDS of cas: 86-48-6, the publication is Journal of Cleaner Production (2018), 1282-1291, database is CAplus.

Polycyclic aromatic hydrocarbons (PAHs), including naphthalene, phenanthrene and fluoranthene are commonly found in wastewaters from refineries and biomass gasification industries. This study investigated the simultaneous biodegradation of these PAHs along with lipid accumulation by Rhodococcus opacus in a ternary substrate system. A 2³ full factorial design of experiments was employed with the three PAHs at two different levels by varying their initial concentrations in the range 50-200 mg L^-1 each. A maximum removal of 91.6%, 82.3% and 80.7% was achieved for naphthalene, phenanthrene and fluoranthene, resp. The individual effect of PAH concentration was found to be more significant than 2-way and 3-way interaction effects on their degradation PAH biodegradation efficiency in the mixture was mainly affected by initial concentration and aromatic complexity of the PAHs. Identification of the PAH degradation metabolites was carried out using LC-MS anal., which clearly revealed that the PAHs were degraded primarily via the ortho/para pathway. This study demonstrates the potential utility of R. opacus for bioremediation and industrial wastewater treatment.

Journal of Cleaner Production published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts