Author: tianli

Varade, Vaibhav published the artcileBacteriorhodopsin based non-magnetic spin filters for biomolecular spintronics, Safety of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Physical Chemistry Chemical Physics (2018), 20(2), 1091-1097, database is CAplus and MEDLINE.

We discuss spin injection and spin valves, which are based on organic and biomols., that offer the possibility to overcome some of the limitations of solid-state devices, which are based on ferromagnetic metal electrodes. In particular, we discuss spin filtering through bacteriorhodopsin in a solid state biomol. spin valve that is based on the chirality induced spin selectivity (CISS) effect and shows a magnetoresistance of ∼2% at room temperature The device is fabricated using a layer of bacteriorhodopsin (treated with n-octyl-thioglucoside detergent: OTG-bR) that is adsorbed on a cysteamine functionalized gold electrode and capped with a magnesium oxide layer as a tunneling barrier, upon which a Ni top electrode film is placed and used as a spin analyzer. The bR based spin valves show an antisym. magnetoresistance response when a magnetic field is applied along the direction of the current flow, whereas they display a pos. sym. magnetoresistance curve when a magnetic field is applied perpendicular to the current direction.

Physical Chemistry Chemical Physics published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C6H12O2, Safety of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lesniak, Robert K. published the artcileHuman carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N^ε-trimethyllysine, Category: alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(2), 440-442, database is CAplus and MEDLINE.

N^ε-Trimethyllysine hydroxylase (TMLH) catalyzes the 1st step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism The stereochem. of the 3-hydroxy-N^ε-trimethyllysine product of TMLH has not been defined. Here, the authors report enzymic and asym. synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N^ε-trimethyllysine.

Chemical Communications (Cambridge, United Kingdom) published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arustamyan, Zh. S. published the artcileSynthesis and Anticonvulsant Activity of Amino Amides and Amino Esters Based on 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-cyclopentane-1-carboxylic Acid, Name: 2-Morpholinoethanol, the publication is Russian Journal of Organic Chemistry (2019), 55(6), 796-799, database is CAplus.

Alk. hydrolysis of 1-(2,3-dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carbonitrile gave the corresponding caroxylic acid which was converted to the carbonyl chloride. The latter reacted with N,N-di-alkylalkane-α,ω-diamines H₂N(CH₂)_nNR¹R² [R¹ = R² = Et, Me; R¹R² = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-; n = 2, 3] and (dialkylamino)alkanols HOCH(R³)CH₂NR⁴R⁵ [R³ = H, Me; R⁴ = R⁵ = Et, Me; R⁴R⁵ = -(CH₂)₄-, -(CH₂)₂O(CH₂)₂-, -(CH₂)₅-] to afford new amino amides I [R = NH(CH₂)_nNR¹R²] and amino esters I [R = OCH(R³)CH₂NR⁴R⁵] which were isolated as hydrochlorides. Anticonvulsant activity of the synthesized compounds was studied.

Russian Journal of Organic Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Name: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cohen, Yair published the artcileDirected Regioselective Carbometallation of 1,2-Dialkyl-Substituted Cyclopropenes, Computed Properties of 4410-99-5, the publication is Angewandte Chemie, International Edition (2021), 60(50), 26368-26372, database is CAplus and MEDLINE.

A regio- and diastereoselective copper-catalyzed carbomagnesiation of 1,2-dialkylated cyclopropenes I (R = H, Me; R¹ = Me, Et; R² = OH, Ph, OBn, etc.; R³ = Me, Ph, CH₂CH(CH₃)₂, etc.; n = 1-5) is reported. The regioselectivity is controlled by a subtle tethered Lewis basic moiety. The chelating moieties allow the differentiation between two electronically tantamount organometallic intermediates. Further functionalization grants access to polysubstituted stereodefined cyclopropanes II (R⁴ = H, allyl) and III bearing up to five alkyl groups.

Angewandte Chemie, International Edition published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kownacki, Ireneusz published the artcileTris(triorganosilyl)phosphites-New ligands controlling catalytic activity of Pt(0) complex in curing of silicone rubber, Category: alcohols-buliding-blocks, the publication is Applied Catalysis, A: General (2010), 380(1-2), 105-112, database is CAplus.

Applying novel and efficient method, new tris(triorganosilyl)phosphites were synthesized and further used for the preparation of new well-defined platinum complexes [Pt(DVTMDS){P(OSiR₃)₃}] (DVTMDS = (H₂C=CHSiMe₂)₂O, R₃ = Si₇O₉(ⁱOct)₇, ⁱPr₃, MePh₂, Ph₃, (O^tBu)₃, (OSiMe₃)₃) which were well characterized by spectroscopic methods. Structures of two platinum(0) complexes, [Pt{η⁴-(H₂C=CHSiMe₂)₂O}{P(OSiPh₃)₃}] (10) and [Pt{η⁴-(H₂C=CHSiMe₂)₂O}{P(OSi(O^tBu₃))₃}] (11) were determined by x-ray anal. The new complexes proved to be effective catalysts of a crosslinking of silicones via hydrosilylation at elevated temperature with relatively short cure time and the enthalpy of network formation similar to that of Pt-Karstedt’s/DAM (DAM = diallyl maleate) catalytic system. Addnl., the catalyzed silicone formulation had sufficiently long pot-life at room temperature

Applied Catalysis, A: General published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nunez-Delicado, Estrella published the artcileHydroperoxidase Activity of Lipoxygenase in the Presence of Cyclodextrins, Application of 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, the publication is Archives of Biochemistry and Biophysics (1999), 367(2), 274-280, database is CAplus and MEDLINE.

The oxidation of xenobiotics by the hydroperoxidase activity of lipoxygenase in the presence of cyclodextrins was studied. These produced an inhibitory effect on xenobiotics oxidation, based on their degree of hydrophobicity and the charge (isoproterenol < 4-methyl-catechol (4MC) < 4-tert-butylcatechol (TBC) < 4-tert-octylcatechol (TOC)). This inhibitory effect was due to the complexation of xenobiotics in the hydrophobic cavity of cyclodextrins. The complexation constant K_c was calculated by nonlinear regression of the inhibition curves obtained in the presence of cyclodextrins, and the values obtained were 400, 16,250, and 35,127 M^-1 for 4MC, TBC, and TOC, resp. The validity of these values was checked at different points of the Michaelis-Menten saturation curve, and a sigmoidal inhibition curve was obtained at the saturating concentration of the o-diphenol, TBC, with no change in the K_c value. This demonstrates the validity of the equations used to calculate K_c for the complete range of the Michaelis-Menten equation. (c) 1999 Academic Press.

Archives of Biochemistry and Biophysics published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Application of 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Li published the artcileDeveloping the large-area manganese-based catalytic ceramic membrane for peroxymonosulfate activation: Applications in degradation of endocrine disrupting compounds in drinking water, Quality Control of 80-09-1, the publication is Journal of Membrane Science (2022), 120602, database is CAplus.

Endocrine disrupting compounds (EDCs) in the aquatic systems are of growing concerns that could undermine drinking water safety. In this study, manganese (III) oxide (Mn2O3) based catalytic ceramic membrane (CCM) was developed for the activation of peroxymonosulfate (PMS), and its applicability has been tested in degrading the ten different EDCs (including bisphenol analogs (BPs)) in drinking water. The CCMs were synthesized at different calcination temperatures i.e., 850, 950, and 1150°C. Optimal performance of CCMs/PMS was achieved at a higher degree of calcination. The CCMs/PMS has shown a potential to effectively degrade the EDCs at higher concentrations (mg/L) to trace levels (ng/L). The CCMs/PMS system adopted a non-radical pathway of degrading the EDCs through the extensive generation of singlet oxygen (1O2), as confirmed using quenching experiments and ESR (EPR) spectroscopy. 1O2-based oxidation process showed special selectivity for the decontamination of phenols and bisphenols. The long-term performance of CCMs/PMS showed good stability in degradation of the EDCs in drinking water, also with efficient mineralization (TOC removal >55%) and negligible release of Mn (0.004 wt%Mn/min). CCMs/PMS system also showed high potential in improving water quality by reducing the disinfection byproducts (DBPs) formation potential, highest recorded for bromodichloromethane (CHCl2Br, 100%) and lowest for dichloroacetic acids (TCAA, ∼50%). The study provided a highly efficient catalytic ceramic membrane based advanced oxidation process (AOPs) for effective degradation multiple of EDCs in drinking water, and the findings of this work can be a baseline for full-scale water treatment applications.

Journal of Membrane Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Quality Control of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fernando, Roshan published the artcileRod-like oligomers incorporating 2,6-dialkylamino core-substituted naphthalene diimide as acceptors for organic photovoltaic, HPLC of Formula: 239075-02-6, the publication is Organic Electronics (2013), 14(6), 1683-1692, database is CAplus.

Core-substituted naphthalene diimides (core-substituted NDIs) were incorporated into rod-like mols. and oligomers through reaction at the imide nitrogen positions. N,N’-Di(4-bromophenyl)-2,6-di(N-alkylamino)-1,4,5,8-naphthalenetetracarboxydiimide was synthesized in only three steps, and used as a versatile platform to prepare extended structures by reaction with thiophene substrates using Suzuki-coupling conditions. The optoelectronic properties of the new compounds were examined by UV/vis absorption spectroscopy, fluorescence spectroscopy, cyclic voltammetry and theor. calculations The imide substituents had little effect on the optical and electrochem. properties of core-substituted NDIs in solution A bathochromic shift of the absorption was observed upon film formation, accompanied by quenching of fluorescence. These observations are consistent with increased inter-mol. interactions between core-substituted NDI moieties in the solid state. All compounds were tested in organic solar cells by blending with poly(3-hexylthiophene), and several showed a photovoltaic effect, demonstrating their potential as electron acceptors in organic solar cell. The best solar cell was observed for core-substituted NDI with 4-(thiophen-2-yl)phenyl imide substituents (5a), showing a power conversion efficiency of 0.57% and a large open circuit voltage of 0.87 V. This approach allows new structure-property relationship studies of non-fullerene acceptors in organic solar cells, where one can vary the imide substituent to optimize photovoltaic parameters while keeping the optical and electrochem. properties constant

Organic Electronics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, HPLC of Formula: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Na published the artcileLiquid chromatography-mass spectrometry based metabolic characterization of pleural effusion in patients with acquired EGFR-TKI resistance, Application of 3-Hydroxyphenylacetic acid, the publication is Journal of Pharmaceutical and Biomedical Analysis (2021), 114147, database is CAplus and MEDLINE.

Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) acquired resistance remains a major barrier in the clin. treatment of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations. Despite extensive efforts, mechanism of acquired resistance has not yet been elucidated clearly. The subject of this study was to characterize the metabolic signatures relevant to acquired EGFR-TKI resistance in pleural effusion (PE), and identify potential biomarkers in PE of patients with acquired EGFR-TKI resistance. PE from EGFR-TKI untreated group (n = 30) and EGFR-TKI resistant group (n = 18) was analyzed using liquid chromatog.-mass spectrometry (LC-MS) based metabolomic. Multivariate statistical anal. revealed distinctive diff ;erences between the groups. A total of 34 significantly differential metabolites in PE were identified, among which, the acquired EGFR-TKI resistant group had higher levels of L-lysine, taurine, ornithine and citrulline, and lower levels of L-tryptophan, kynurenine, L-phenylalanine, L-leucine, N-formyl-L-methionine, 3-hydroxyphenylacetic acid and N-acetyl-D-phenylalanine in PE than that of the EGFR-TKI untreated group. These metabolites are mainly involved in six amino acid metabolic pathways. In addition, 3-hydroxyphenylacetic acid and N-acetyl-D-phenylalanine showed the highest AUC values of 0.934 and 0.929 in receiver operating characteristic anal. Through LC-MS metabolomics, our study identified potential biomarkers in PE, differentiating EGFR-TKI resistant patients from untreated patients, as well as the mechanisms underlying acquired EGFR-TKI resistance; thus, providing novel insights into acquired EGFR-TKI resistance.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Application of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xin published the artcileSynthesis of 2-oxazolines from ring opening isomerization of 3-amido-2-phenyl azetidines, Product Details of C11H8O3, the publication is Molecules (2021), 26(4), 857, database is CAplus and MEDLINE.

In this paper, an efficient synthesis of 2-oxazolines I (R = Me, Ph, furan-2-yl, 1-hydroxynaphthalen-2-yl, etc.) has been achieved via the stereospecific isomerization of 3-amido-2-Ph azetidines II. The reactions were studied in the presence of both Bronsted and Lewis acids, and Cu(OTf)₂ were found to be the most effective.

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C2H3N3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts