Author: tianli

Torres, Talyta Mayara Silva published the artcilePhenolic compounds recovered from ora-pro-nobis leaves by microwave assisted extraction, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Biocatalysis and Agricultural Biotechnology (2022), 102238, database is CAplus.

Ora-pro-nobis is an ornamental plant, often used as food in some regions of Brazil, and Pereskia grandifolia is one of the less explored specie of this nutritional plant. To understand the antioxidant potential and phenolic profile of ora-pro-nobis leaves, the micro-wave assisted extraction (MAE) was held using the green solvents ethanol and water. An optimization was made using Box-Behnken exptl. design (32), with process time, temperature and solvent (% of water/ethanol) as variables. The evaluated responses were the process yield, combined with antioxidant capacity (DPPH, ABTS and FRAP methods) and total phenolic content (TPC) of the recovered extracts Soxhlet method with ethanol was performed for comparison purpose. The phenolic profile of extract samples was assessed by LC-ESI-MS/MS anal. High yield values were provided by 50% ethanol as solvent at 150°C. Best antioxidant potential from DPPH and FRAP methods were provided by ethanolic extracts at 110°C, while water extracts at 150°C provided best ABTS results. High TPC recovery was found in 50% ethanol samples at 70°C. Overall, 24 phenolic compounds were identified, within caffeic acid, ellagic acid, p-anisic acid, p-coumaric acid kaempferol and quercetin as the main components. Ellagic acid and p-anisic acid were firstly reported associated to ora-pro-nobis leaves. The optimization of the results indicates that 150°C, 12.5 min of MAE and ethanol as solvent provided the best combined responses. The use of MAE for ora-pro-nobis leaves is a novelty that must be followed to explore green methods to value natural products.

Biocatalysis and Agricultural Biotechnology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C18H34N4O5S, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Danielski, Renan published the artcileA non-conventional approach for obtaining phenolic antioxidants from red guava (Psidium guajava L.) by-products, Related Products of alcohols-buliding-blocks, the publication is Journal of Food Processing and Preservation (2022), 46(6), e16502, database is CAplus.

The recovery of phenolic antioxidants from agro-industrial byproducts using non-conventional techniques is a powerful tool to explore the bioactive potential of natural sources. Therefore, it is imperative to analyze the most suitable method to investigate a plant material’s phenolic composition This study used ultra-turrax (UTE), ultrasonic bath (BUAE), and pressurized liquid (PLE) for soluble phenolic extraction from guava’s pulp and processing waste. UTE at 25°C for 1 h yielded the highest concentration of total phenolics and flavonoids from guava pulp, while PLE for 30 min at 60°C/10 MPa presented the best performance for flavonoids and condensed tannins recovery from guava waste. PLE produced extracts with 39 phenolics and high antioxidant capacity. Besides, scopoletin, resveratrol, and naringin are being reported for the first time in this fruit. These results suggest possible alternatives for the recovery of bioactive compound, which may be used to develop nutraceuticals and/or functional foods. Practical applications : Upon guava processing, 30% of fruit’s total volume is lost in the form of byproducts (seeds, peels, and pulp leftovers). Evidence points out that this fraction, along with guava’s pulp, is rich in phenolics with antioxidant properties. An extraction procedure should be conducted to recover these compounds However, conventional techniques are laborious, time-consuming, and they generally use a large amount of toxic organic solvent. Ultra-turrax-UTE, ultrasonic bath-BUAE, and pressurized liquid-PLE are non-conventional approaches that make possible the reduction of solvents and the recovery of selected phenolics not possible with conventional techniques. These extracts could be further applied to lipid-rich foods as a natural antioxidant system and/or as an ingredient in the development of nutraceuticals and functional foods.

Journal of Food Processing and Preservation published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Palomino-Schatzlein, Martina published the artcileCombining metabolic profiling of plasma and faeces as a fingerprint of insulin resistance in obesity, Safety of 3-Hydroxyphenylacetic acid, the publication is Clinical Nutrition (2020), 39(7), 2292-2300, database is CAplus and MEDLINE.

Insulin resistance (IR) is one of the main risk factor for type 2 diabetes mellitus (T2DM). Nevertheless, its underlying pathophysiol. is not completely established because IR is triggered by a complex interconnection of numerous factors impairing metabolism, promoting metabolome changes. We used a metabolomics approach to identify plasma and faecal metabolites related to IR and obesity. We explored a cohort of 44 subjects at baseline, with 30 of them followed two years thereafter in a longitudinal study after an hypocaloric diet in the obese subjects. In all individuals as a whole, 11 plasma metabolites pos. associated with BMI (acetoacetate, creatinine, glycerol, glycerol of lipids, VLDL, fatty esters, myo-inositol, phenylalanine, threonine, tyrosine and valine) and one neg. (phosphocholine), with similar associations at baseline and follow-up. Four of these metabolites (myo-inositol, valine, acetoacetate and phosphocholine) remained significant within obese and non-obese groups. Thirteen faecal metabolites pos. associated with BMI at baseline and one neg. (glutamine). However, these correlations did not remain significant at follow-up. The correlations were not always consistent at baseline and at follow-up and the metabolites that showed significant correlations were different for the obese group compared with the control group. The percent change in plasma Δethanolamine, Δglucose, Δuracil and Δhypoxanthine were pos. associated with ΔBMI. The percent change in plasma Δphosphocholine and of faecal Δhydroxyphenylacetate, and Δ2-hydroxyphenylacetate were associated with ΔHOMA-IR in those patients that lost weight Faecal branched chain amino acids (BCAAs) in faeces were associated with IR, following a similar pattern to that described for plasma BCAAs. Choline derivates had an opposite behavior. The integration of plasma and faecal metabolites represents a valuable fingerprint that could help in the identification of patients at risk for IR and in the design of novel therapeutic strategies to prevent IR and the development of overt T2DM in the context of obesity. The results are coherent with diet having a much greater impact on faecal metabolomic profile than on plasma metabolome.

Clinical Nutrition published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Safety of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fent, Kenneth W. published the artcileFirefighters′ urinary concentrations of VOC metabolites after controlled-residential and training fire responses, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is International Journal of Hygiene and Environmental Health (2022), 113969, database is CAplus and MEDLINE.

Firefighters are exposed to volatile organic compounds (VOCs) during structural fire responses and training fires, several of which (e.g., benzene, acrolein, styrene) are known or probable carcinogens. Exposure studies have found that firefighters can absorb chems. like benzene even when self-contained breathing apparatus (SCBA) are worn, suggesting that dermal absorption contributes to potentially harmful exposures. However, few studies have characterized VOC metabolites in urine from firefighters. We quantified VOC metabolites in firefighters urine following live firefighting activity across two field studies. In two sep. controlled field studies, spot urine was collected before and 3 h after firefighters and firefighter students responded to simulated residential and training fires. Urine was also collected from instructors from the training fire study before the first and 3 h after the last training scenario for each day (instructors led three training scenarios per day). Samples were analyzed for metabolites of VOCs to which firefighters may be exposed. In the residential fire study, urinary metabolites of xylenes (2MHA), toluene (BzMA), and styrene (MADA) increased significantly (at 0.05 level) from pre- to post-fire. In the training fire study, MADA concentrations increased significantly from pre- to post-fire for both firefighter students and instructors. Urinary concentrations of benzene metabolites (MUCA and PhMA) increased significantly from pre- to post-fire for instructors, while metabolites of xylenes (3MHA+4MHA) and acrolein (3HPMA) increased significantly for firefighter students. The two highest MUCA concentrations measured post-shift from instructors exceeded the BEI of 500 μg/g creatinine. Some of the metabolites that were significantly elevated post-fire are known or probable human carcinogens (benzene, styrene, acrolein); thus, exposure to these compounds should be eliminated or reduced as much as possible through the hierarchy of controls. Given stringent use of SCBA, it appears that dermal exposure contributes in part to the levels measured here.

International Journal of Hygiene and Environmental Health published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Landge, Vinod G. published the artcilePalladium-Catalyzed Regioselective Arylation of Unprotected Allylamines, Recommanded Product: 2-Aminobutan-1-ol, the publication is JACS Au (2021), 1(1), 13-22, database is CAplus and MEDLINE.

A simple protocol for the arylation of cinnamylamines and the diarylation of terminal allylamines to generate a of 3,3-diarylallylamine products using a Pd^II precatalyst was described. Key features of the method were the ability to access relatively mild conditions that facilitate a broad substrate scope as well as direct diarylation of terminal allylamine substrates. In addition, several complex and therapeutically relevant mols. were included to demonstrate the utility of the transformation.

JACS Au published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Buta, Andriy published the artcileNovel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction, Name: 3-(Methylamino)phenol, the publication is Journal of Medicinal Chemistry (2015), 58(11), 4449-4461, database is CAplus and MEDLINE.

Acid sensing ion channels 1a (ASIC1a) are of crucial importance in numerous physiol. and pathol. processes in the brain. Here we demonstrate that novel 2-oxo-2H-chromene-3-carboxamidine derivative 5b, designed with mol. modeling approach, inhibits ASIC1a currents with an apparent IC₅₀ of 27 nM when measured at pH 6.7. Acidification to 5.0 decreases the inhibition efficacy by up to 3 orders of magnitude. The 5b mol. not only shifts pH dependence of ASIC1a activation but also inhibits its maximal evoked response. These findings suggest that compound 5b binds to pH sensor of ASIC1a acting as orthosteric noncompetitive antagonist. At 100 nM, compound 5b completely inhibits induction of long-term potentiation (LTP) in CA3-CA1 but not in MF-CA3 synapses. These findings support the knockout data indicating the crucial modulatory role of ASIC1a channels in the NMDAR-dependent LTP and introduce a novel type of ASIC1a antagonists.

Journal of Medicinal Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Name: 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alexis, Michael N. published the artcileSubunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell, Related Products of alcohols-buliding-blocks, the publication is European Journal of Biochemistry (1992), 204(1), 75-84, database is CAplus and MEDLINE.

Bifunctional reagents were used to exam. the subunit composition of the non-DNA-binding form of the rat and human glucocorticoid receptor. Treatment of intact cells and cell extracts with a reversible cross-linker, followed by electrophoretic anal. of immunoadsorbed receptor revealed that 3 proteins of apparent approx. mol. masses, 90, 53, and 14 kDa are associated with the receptor. The 1st of these was identified immunochem. as a 90-kDa heat-shock protein (hsp90). The complex isolated from HeLa cells contained 2.2 mol hsp90/mol steroid-binding subunit. Crosslinking of the receptor complex in the cytosol completely prevented salt-induced dissociation of the subunits. The cross-linked receptor was electrophoretically resolved into 2 oligomeric complexes of apparent mol. mass 288 kDa and 347 kDa, reflecting the association of the 53-kDa protein with a fraction of the receptor. Since no higher oligomeric complexes could be generated by crosslinking cell extracts under different conditions, it was concluded that most of the untransformed cytosolic receptor is devoid of addnl. components.

European Journal of Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mathis-Noel, Raymonde published the artcileSpectroscopic studies of hydrogen bonding in aliphatic and aromatic amino alcohols, Application of 2-(Benzyl(methyl)amino)ethanol, the publication is Bulletin de la Societe Chimique de France (1970), 3047-56, database is CAplus.

Inter- and intramol. H bonds were studied for a series of amino alcs., which included some aromatic substituted compounds The ir frequencies of the OH and NH bonds were observed for the pure compound and for several dilutions in CCl4. Further, the NMR shifts of these bonds were observed All compounds studied, with the one exception of 1-phenyl-2-N-methyl-N-ethylaminoethanol, showed various intermol. H-bonds in the pure phase, i.e., OH..A, NH…O, NH…N. Compounds with electron donor substituents on N showed intramol. H bonds (C. F. Douberet and Pariand, 1962). Such bonds are also observed for primary amines; they increase as the number of electron donors on the adjacent C increases. Substitution of an electron source or sink for a H on the C bearing the OH will always favor intramol. association Chelation will be suppressed by substitution of a H atom on N; this increases the H-bonding to the π-electrons of an aromatic system, observed at about 3541 cm-1.

Bulletin de la Societe Chimique de France published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Application of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nakanishi, Masako published the artcileDietary walnut supplementation alters mucosal metabolite profiles during DSS-induced colonic ulceration, Application of Triisopropanolamine, the publication is Nutrients (2019), 11(5), 1118, database is CAplus and MEDLINE.

Walnuts contain a complex array of natural compounds and phytochems. that exhibit a wide range of health benefits, including protection against inflammation and colon cancer. In this study, we assess effect of dietary supplementation with walnuts on colonic mucosal injury induced in mice by ulcerogenic agent, dextran sodium sulfate (DSS). C57Bl/6J mice were started on the Total Western Diet supplemented with freshly-ground whole walnuts (0, 3.5, 7 and 14% g/kg) 2 wk prior to a 5-day DSS treatment and walnut diets were continued throughout the entire exptl. period. In a sep. study, a discovery-based metabolite profiling anal. using liquid chromatog. tandem mass spectrometry was performed on fecal samples and colonic mucosa following two weeks of walnut supplementation. Dietary walnut supplementation showed significant effects in the 10-day post-DSS recovery-phase study, in which the extent of ulceration was significantly reduced (7.5% vs. 0.3%, p < 0.05) with 14% walnuts. In the metabolite-profiling anal., walnuts caused a significant increase in several polyunsaturated fatty acids, including docosahexaenoic acid and 9-oxo-10(E),12(E)-octadecadienoic acid (9-oxoODA), as well as kynurenic acid. In colon tissue samples, walnuts caused a significant increase in the levels of S-adenosylhomocysteine and betaine, important components of fatty acid β-oxidation These metabolite changes may contribute in part to the observed protection against DSS-induced inflammatory tissue injury.

Nutrients published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okuma, Kentaro published the artcileReaction of benzyne with 2-hydroxy-and 2-aminophenyl ketones. Synthesis of xanthenes and acridines, SDS of cas: 596-38-3, the publication is Fukuoka Daigaku Rigaku Shuho (2011), 41(1), 23-27, database is CAplus.

Reaction of benzyne with 2-hydroxybenzophenone afforded 9-phenyl-9-hydroxyxanthene, whereas reaction with 2-hydroxyacetophenone yielded 9-methylenexanthene. 9-Methyl-9-hydroxyxanthene, initial cycloadduct, further dehydrated to give exo-methylene xanthene. Reaction of benzyne with 2-aminophenyl ketones gave acridines in good yields.

Fukuoka Daigaku Rigaku Shuho published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, SDS of cas: 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts