Author: tianli

Hunter, Gordon A. published the artcileSynthesis of 3-hydroxythiophenes and thiophen-3(2H)-ones by pyrolysis of alkylsulfanylmethylene Meldrum’s acid derivatives, Name: Thiophen-3-ol, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1995), 1209-14, database is CAplus.

3-Hydroxythiophene [thiophen-3(2H)-one] and a range of its 2-substituted, 2,2-disubstituted and 5-substituted derivatives have been made by flash vacuum pyrolysis (FVP) of an appropriate alkylsulfanylmethylene derivatives of Meldrum’s acid. These compounds are readily obtained, either by reaction of methoxymethylene Meldrum’s acid with alkylthiols in refluxing acetonitrile, or via the bis(methylsulfanyl) compound I by known procedures. The pyrolysis proceeds by a hydrogen-transfer-cyclization mechanism in which there is extensive loss of configuration of a chiral center at the reaction site. The NMR and mass spectra of the Meldrum’s acid precursors and the mass spectra of the 3-hydroxythiophenes [thiophen-3(2H)-ones] are briefly discussed.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Name: Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hunter, Gordon A. published the artcileChemical and spectroscopic properties of the 3-hydroxythiophene [thiophen-3(2H)-one] system, Name: Thiophen-3-ol, the publication is New Journal of Chemistry (2010), 34(11), 2558-2563, database is CAplus.

3-Hydroxythiophene 1 spontaneously dimerizes to 4,5-dihydro-5-(3-hydroxythien-2-yl)thiophen-3(2H)-one 14. 3-Hydroxythiophenes 1E and 4-10E exist in solvent-dependent equilibrium with their thiophen-3(2H)-one 1K and 4-10K tautomers; the amount of hydroxy tautomer is greater than in the case of the corresponding 3-hydroxypyrroles. 3-Hydroxythiophenes are much less reactive to electrophiles than corresponding 3-hydroxypyrroles, but the 5-methylsulfanyl derivative 10 reacts at the 2-position with methoxymethylene Meldrum’s acid and undergoes Vilsmeier formylation. The enolates derived from 3-hydroxythiophenes by treatment with base can be O-alkylated and O-acylated with high regioselectivity. 2,2-Disubstituted thiophen-3(2H)-ones undergo equilibrium conjugate addition with nucleophiles, but the resulting adducts could not be isolated.

New Journal of Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Name: Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kazakov, Andrei published the artcileComputational Design of New Refrigerant Fluids Based on Environmental, Safety, and Thermodynamic Characteristics, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Industrial & Engineering Chemistry Research (2012), 51(38), 12537-12548, database is CAplus.

We present a systematic search for new classes of refrigerants that would possess low values of global warming potential (GWP), along with low to moderate flammability and suitable thermodn. characteristics. We developed new methods for estimating, solely from the mol. structure, the radiative efficiency (RE, a measure of radiative climate forcing) and atm. lifetime; the combination of RE and lifetime yields an estimate of the GWP. We also developed an estimate of the lower flammability limit (LFL) based on the enthalpy of formation. These estimation techniques, along with a previously developed technique for estimating critical temperature (T_c), are applied to a library of over 56,000 candidate mols. We select fluids with GWP <200; 300 K < T_c <550 K; and LFL >0.1 Kg/m³. Filters for toxicity and chem. stability based on functional groups are also applied to arrive at 1234 candidates for further study. The candidates that would be suitable for use in present types of refrigeration equipment (those with critical temperatures <400 K) are dominated by halogenated alkenes; addnl. chem. classes, including halogenated ethers and cyclic compounds, are identified among fluids with higher critical temperatures

Industrial & Engineering Chemistry Research published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Van de Sande, C. C. published the artcileMetastable ion characteristics. XXXVII. Structure and formation of stable C3H6O.+ ions, Application of 1-Methylcyclobutan-1-ol, the publication is Journal of the American Chemical Society (1975), 97(16), 4617-20, database is CAplus.

The C3H6O•+ isomeric ions I, II, CH2:CHOMe•+(III), C2H5CHO•+, CH3CH:CHOH•+, CH3COCH3•+, and CH2:CH(OH)CH3•+ are stable, with lifetimes >10-5 sec, and can be identified from their collisional activation (CA) spectra. Aliphatic terminal epoxides give a mixture of ions I and III, suggesting that the rearrangements involved are stepwise, not concerted. The C3H6O•+ ions formed by the loss of CH2O from the 2-methyl- and 4-methyl-1,3-dioxolane mol. ions have structure I; in a similar manner, 1,4-dioxane yields the cyclic ion II. The results show that the size of the cyclic transition state in hydrogen rearrangements is sensitive to a number of competing factors.

Journal of the American Chemical Society published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C17H20ClN3, Application of 1-Methylcyclobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Zhengmao published the artcileS-Nitrosation of Proteins by N-Methyl-N-nitrosoanilines, Product Details of C7H9NO, the publication is Bioorganic & Medicinal Chemistry Letters (1996), 6(5), 573-8, database is CAplus.

Substituted N-methyl-N-nitrosoanilines were found to function as stable, potent, nitrosating agents for S-nitrosation and inactivation of cysteine proteases such as papain, bromelain and aldehyde dehydrogenase under physiol. conditions in a time and concentration dependent manner. Spectroscopic studies on the reaction products have proved that the mechanism of the inactivation is the S-nitrosation of the protein.

Bioorganic & Medicinal Chemistry Letters published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Product Details of C7H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Lei published the artcileBio-based 1,5-Pentanediol as a Replacement for Petroleum-Derived 1,6-Hexanediol for Polyester Polyols, Coatings, and Adhesives, Synthetic Route of 111-29-5, the publication is ACS Sustainable Chemistry & Engineering, database is CAplus.

Amorphous and semi-crystalline polyester polyols based on a novel, low cost, bio-based 1,5-pentanediol (Bio-PDO) were synthesized and formulated into solvent-borne coatings and hot melt adhesives. Bio-PDO may provide a lower cost, more sustainable, and non-petroleum-based alternative to polyols based on 1,6-hexanediol (HDO). The polyester polyols were characterized for end group composition, monomer incorporation, and thermal transitions. Bio-PDO-based coatings exhibited performance, including hardness, flexibility, adhesion strength, and solvent resistance, similar to the coatings based on petroleum-derived HDO. Bio-PDO-based adhesives exhibited lower green strength (initial adhesion strength) and longer open time (workable time to bond substrates) than HDO-based adhesives. The effects of common bio-based impurities, including lactones and mono-alcs. (δ-valerolactone and tetrahydrofurfuryl alc. as examples of impurities), on polyester polyols were investigated. Hydroxyl functionalities of polyols were controlled by the excess diols in monomer feeds and were not impacted largely by the δ-valerolactone levels. High-level tetrahydrofurfuryl alc. terminated the polyester ends with unreactive functionality. Deleterious effects on polyol hydroxyl functionality are not expected at the low impurity levels (<2 weight %) found in leading bio-PDO processes.

ACS Sustainable Chemistry & Engineering published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C4H5F3N2O3S, Synthetic Route of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goosen, Andre published the artcileReactions of 9-hydroperoxy-9-phenylxanthene: the epoxidation of alkenes, Related Products of alcohols-buliding-blocks, the publication is South African Journal of Chemistry (1989), 42(3), 121-3, database is CAplus.

Alkyl-substituted alkenes have been epoxidized with 9-hydroperoxy-9-phenylxanthene in the presence of molybdenum(0) hexacarbonyl as catalyst, in moderate yields. Excellent yields of chalcone epoxides were obtained by epoxidizing a series of substituted chalcones with the hydroperoxide in basic nonaqueous medium.

South African Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goosen, Andre published the artcileReactions of 9-hydroperoxy-9-phenylxanthene: oxidation of sulfides, sulfoxides, and thiols, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is South African Journal of Chemistry (1989), 42(3), 107-12, database is CAplus.

Sulfides have been oxidized selectively to sulfoxides with 9-hydroperoxy-9-phenylxanthene at ambient and reflux temperatures resp. Excellent yields of dialkyl and aralkyl sulfoxides were obtained; diaryl sulfides gave moderate-to-poor yields of sulfoxides. Selective oxidation of allyl Ph sulfide to form sulfoxide without epoxidation was accomplished. These reactions have been proposed to proceed via a heterolytic path which does not involve the intermediacy of the hydroperoxy anion. Trifluoroacetic acid, benzyltrimethylammonium hydroxide, and molybdenum(0) hexacarbonyl catalyzed the oxidation reaction to give high yields of sulfoxides or sulfones, depending on the reaction conditions. Mechanistic aspects of these catalyzed oxidations have been discussed. Advantages of the reaction include the ease of separation of the peroxidic ancillary products from the formed sulfoxides and sulfones, as well as the relatively high stability of the hydroperoxide as compared to other known peroxide reagents.

South African Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leyden, Donald E. published the artcileEquilibrium isotope effects of tertiary amines by NMR and potentiometry, Formula: C10H15NO, the publication is Analytica Chimica Acta (1970), 49(1), 77-81, database is CAplus.

A comparative study of solvent isotope effects on the dissociation eonst. of amine salts, by means of potentiometric and NMR techniques was made. Agreement of the results of the 2 techniques was generally good. The magnetic resonance technique offers an advantage in cases in which the amine is insoluble in neutral or basic solutions An observed correlation between the isotopic shift of N-methyl proton chem. shift and the spin coupling between the Me protons and the N-H proton is mentioned.

Analytica Chimica Acta published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

McAfee, Seth M. published the artcileUtility of a heterogeneous palladium catalyst for the synthesis of a molecular semiconductor via Stille, Suzuki, and direct heteroarylation cross-coupling reactions, Synthetic Route of 239075-02-6, the publication is RSC Advances (2015), 5(33), 26097-26106, database is CAplus.

The com. available silica-supported heterogeneous catalyst SiliaCat DPP-Pd has proven to be highly active, robust, and reusable for the synthesis of a thiophene-phthalimide-based mol. semiconductor under microwave-irradiation reaction conditions. A Stille reaction protocol demonstrated that SiliaCat DPP-Pd outperformed well-known homogeneous catalysts, Pd(PPh₃)₄ and Pd(PPh₃)₂Cl₂, in terms of performance and catalyst loading, while also exhibiting tolerance to ambient reaction conditions and two-fold recyclability for the formation of product. The success established for SiliaCat DPP-Pd catalyzed Stille reactions via microwave irradiation was extended to optimize Suzuki coupling and direct heteroarylation protocols. Notably, direct heteroarylation with SiliaCat DPP-Pd exhibited excellent selectivity and perturbed the formation of homo-coupled aryl bromides, two side reactions that are known to plague this type of cross-coupling reaction.

RSC Advances published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Synthetic Route of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts