Author: tianli

Wei, Piao-piao published the artcileAnalysis of Metabolites from Direct Fermentation of D-Glucose to 2-Keto-L-Gulonic Acid by HPLC, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Guocheng Gongcheng Xuebao (2013), 13(4), 675-680, database is CAplus.

An HPLC-based method for quant. determination of the 4 metabolites of gluconic acid (GlcA), 2-keto-D-gluconic acid (2-KDG), 2,5-diketo-D-gluconic acid (2,5-DKG) and 2-keto-L-gulonic acid (2-KLG) from direct fermentation of D-glucose to 2-KLG by using HPLC was established. The optimum separation of the 4 substances could be achieved under the conditions of using Aminex HPX-87H column (size 300 mm x7.8 mm) with the temperature of 30 °C, sulfuric acid (50 mmol/L) as mobile phase at the flow rate of 0.2 mL/min, RID-10A detector, and malonic acid as internal standard The anal. results show that the method has average anal. deviation of 1.53%, 0.89% and 1.84% on 2-KDG 2,5-DKG and 2-KLG, resp.

Guocheng Gongcheng Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C20H19NO4, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Odoardi, Sara published the artcileMetabolism study and toxicological determination of mephtetramine in biological samples by liquid chromatography coupled with high-resolution mass spectrometry, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Drug Testing and Analysis (2021), 13(8), 1516-1526, database is CAplus and MEDLINE.

The emerging market of new psychoactive substances (NPSs) is a global-scale phenomenon, and their identification in biol. samples is challenging because of the lack of information about their metabolism and pharmacokinetic. In this study, we performed in silico metabolic pathway prediction and in vivo metabolism experiments, in order to identify the main metabolites of mephtetramine (MTTA), an NPS found in seizures since 2013. MetaSite software was used for in silico metabolism predictions and subsequently the presence of metabolites in the blood, urine, and hair of mice after MTTA administration was verified. The biol. samples were analyzed by liquid chromatog. coupled with high-resolution mass spectrometry (LC-HRMS) using a benchtop Orbitrap instrument. This confirmed the concordance between software prediction and exptl. results in biol. samples. The metabolites were identified by their accurate masses and fragmentation patterns. LC-HRMS anal. identified the dehydrogenated and demethylated-dehydrogenated metabolites, together with unmodified MTTA in the blood samples. Besides unmodified MTTA, 10 main metabolites were detected in urine. In hair samples, only demethyl MTTA was detected along with MTTA. The combination of Metasite prediction and in vivo experiment was a powerful tool for studying MTTA metabolism This approach enabled the development of the anal. method for the detection of MTTA and its main metabolites in biol. samples. The development of anal. methods for the identification of new drugs and their main metabolites is extremely useful for the detection of NPS in biol. specimens. Indeed, high throughput methods are precious to uncover the actual extent of use of NPS and their toxicity.

Drug Testing and Analysis published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Driess, Matthias published the artcileSynthesis and structure of siloxy-substituted ZnO aggregates having (ZnO)_n (n = 2, 4) and Zn₃O₄ cores, Application of Triisopropylsilanol, the publication is European Journal of Inorganic Chemistry (2000), 2517-2522, database is CAplus.

Convenient syntheses and x-ray crystallog. characterizations of the first bis(trimethylsilyl)amido-, Me-, and iodozinc triorganosiloxide aggregates 1–5 are described. They are accessible by the simple reaction of ZnR’₂ [R = Me, N(SiMe₃)₂] with the resp. silanols R₃SiOH (R = Me, Et, iPr), which affords the dimeric [(Me₃Si)₂NZnOSiR₃]₂ (1a: R = iPr; 1b: R = Et), trinuclear [(MeZn)₂Zn(OSiPrⁱ₃)₄] (2a), {[(Me₃Si)₂NZn]₂Zn(OSiR₃)₄} (2b: R = Et; 2c: R = Me), and tetranuclear heterocubanes [MeZnOSiR₃]₄ (3a: R = Me; 3b: R = Et), resp. The latter were oxidized with four equivalent of elemental I₂ to form the tetraiodo derivatives [IZnOSiR₃]₄ (4a: R = Me; 4b: R = Et) in 82 and 88% yield, resp. Due to the higher polarity of the Zn-I vs. Zn-C σ-bond, the Zn-O distances of the almost regular Zn₄O₄ core in 4a are 2-6 pm shorter than those observed in the less Lewis-acidic cluster 3b. However, the Zn-O distances in 3b and 4a are ∼10-15 pm longer than those in 1a, 2a, and 2c, due to different coordination numbers at Zn and the effects of ring strain. Remarkably, the iodo derivatives 4a,b undergo dissociation in THF to give the resp. dimeric THF solvates [IZn(THF)OSiR₃]₂ (5a: R = Me; 5b: R = Et), whereas the Zn₄O₄ cores in 3a and 3b are retained even in aprotic polar solvents.

European Journal of Inorganic Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Raju, Rekha published the artcilen-Octyl (thio)glycosides as potential cryoprotectants: Glass transition behaviour, membrane permeability, and ice recrystallization inhibition studies, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Australian Journal of Chemistry (2019), 72(8), 637-643, database is CAplus.

A series of eight n-octyl (thio)glycosides (1α, β-4α, β) with d-glucose or d-galactose-configured head groups and varying anomeric configuration were synthesized and evaluated for glass transition behavior, membrane permeability, and ice recrystallization inhibition (IRI) activity. Of these, n-octyl β-d-glucopyranoside (2β) exhibited a high glass transition temperatures (Tg), both as a neat sample and 20 wt-% aqueous solution Membrane permeability studies of this compound revealed cellular uptake to concentrations relevant to the inhibition of intracellular ice formation, thus presenting a promising lead candidate for further biophys. and cryopreservation studies. Compounds were also evaluated as ice recrystallization inhibitors; however, no detectable activity was observed for the newly tested compounds

Australian Journal of Chemistry published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Schmidt, Sebastian F. M. published the artcileSMM behaviour and magnetocaloric effect in heterometallic 3d-4f coordination clusters with high azide : metal ratios, Recommanded Product: Triisopropanolamine, the publication is Dalton Transactions (2017), 46(45), 15661-15665, database is CAplus and MEDLINE.

The authors present the synthesis and characterization of heterometallic compounds with a very large azide to metal ratio, (TBA)₃[Fe₃Gd₂(N₃)₁₅(OH)₃(tipaH₃)₂] (1) and (TBA)₂[Mn₄Dy₂(N₃)₁₂(teaH₂)₄] (2) (TBA = tetrabutylammonium, tipaH₃ = triisopropanolamine, teaH₃ = triethanolamine). Their interesting structures give rise to fascinating magnetic properties.

Dalton Transactions published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nannini, Giulia published the artcileFecal metabolomic profiles: a comparative study of patients with colorectal cancer vs adenomatous polyps, COA of Formula: C8H8O3, the publication is World Journal of Gastroenterology (2021), 27(38), 6430-6441, database is CAplus and MEDLINE.

BACKGROUND Colorectal cancer (CRC), the third most common cause of death in both males and females worldwide, shows a pos. response to therapy and usually a better prognosis when detected at an early stage. However, the survival rate declines when the diagnosis is late and the tumor spreads to other organs. Currently, the measures widely used in the clinic are fecal occult blood test and evaluation of serum tumor markers, but the lack of sensitivity and specificity of these markers restricts their use for CRC diagnosis. Due to its high sensitivity and precision, colonoscopy is currently the gold-standard screening technique for CRC, but it is a costly and invasive procedure. Therefore, the implementation of custom-made methodologies including those with minimal invasiveness, protection, and reproducibility is highly desirable. With regard to other screening methods, the screening of fecal samples has several benefits, and metabolomics is a successful method to classify the metabolite shift in living systems as a reaction to pathophysiol. influences, genetic modifications, and environmental factors. AIM To characterize the variation groups and potentially recognize some diagnostic markers, we compared with healthy controls (HCs) the fecal NMR (NMR) metabolomic profiles of patients with CRC or adenomatous polyposis (AP). METHODS Proton NMR spectroscopy was used in combination with multivariate and univariate statistical approaches, to define the fecal metabolic profiles of 32 CRC patients, 16 AP patients, and 38 HCs well matched in age, sex, and body mass index. RESULTS NMR metabolomic analyses revealed that fecal sample profiles differed among CRC patients, AP patients, and HCs, and some discriminatory metabolites including acetate, butyrate, propionate, 3-hydroxyphenylacetic acid, valine, tyrosine and leucine were identified. CONCLUSION In conclusion, we are confident that our data can be a forerunner for future studies on CRC management, especially the diagnosis and evaluation of the effectiveness of treatments.

World Journal of Gastroenterology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abellan, Alicia published the artcileIn utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts, Related Products of alcohols-buliding-blocks, the publication is Environment International (2022), 107178, database is CAplus and MEDLINE.

In utero exposure to bisphenols, widely used in consumer products, may alter lung development and increase the risk of respiratory morbidity in the offspring. However, evidence is scarce and mostly focused on bisphenol A (BPA) only. To examine the associations of in utero exposure to BPA, bisphenol F (BPF), and bisphenol S (BPS) with asthma, wheeze, and lung function in school-age children, and whether these associations differ by sex. We included 3,007 mother-child pairs from eight European birth cohorts. Bisphenol concentrations were determined in maternal urine samples collected during pregnancy (1999-2010). Between 7 and 11 years of age, current asthma and wheeze were assessed from questionnaires and lung function by spirometry. Wheezing patterns were constructed from questionnaires from early to mid-childhood. We performed adjusted random-effects meta-anal. on individual participant data. Exposure to BPA was prevalent with 90% of maternal samples containing concentrations above detection limits. BPF and BPS were found in 27% and 49% of samples. In utero exposure to BPA was associated with higher odds of current asthma (OR = 1.13, 95% CI = 1.01, 1.27) and wheeze (OR = 1.14, 95% CI = 1.01, 1.30) (p-interaction sex = 0.01) among girls, but not with wheezing patterns nor lung function neither in overall nor among boys. We observed inconsistent associations of BPF and BPS with the respiratory outcomes assessed in overall and sex-stratified analyses. This study suggests that in utero BPA exposure may be associated with higher odds of asthma and wheeze among school-age girls.

Environment International published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Han, Siyu published the artcileBiogas upgrading with various single and blended amines solutions: Capacities and kinetics, Category: alcohols-buliding-blocks, the publication is Energy (Oxford, United Kingdom) (2022), 124195, database is CAplus.

Biogas is an important renewable energy and biogas upgrading which sep. CH₄/CO₂ to increase the heating value of biogas is necessary for its utilization. Amine scrubbing is a promising biogas upgrading technol. In this study, we applied various single and blended amines solutions for biogas upgrading and reconsidered the evaluation method by comparing the equilibrium CO₂ absorption capacity (qe) and optimal CO₂ absorption capacity under 90 vol% or 95 vol% pure CH₄ requirement (q₉₀%CH₄, q₉₅%CH₄). Three apparent kinetic models and Fourier-transform IR spectroscopy (FT-IR) were applied to study the kinetics. The results showed that, compared with the qe, the new indicator q₉₀%CH₄ and q₉₅%CH₄ could better reveal the difference and improvements between various amines solutions and be more accordance with the real situation of biogas upgrading. The q₉₀%CH₄ increased from 0.15 to 0.82-1.70 mol/kg after adding other amines with methyldiethanolamine (MDEA), but qe was almost the same. For kinetics, the fitting results of Avrami model are the best among the three models. FT-IR anal. before and after absorption showed CO₂ formed different groups with different amine mols. This study provided a new perspective and method on evaluation of amine scrubbing for biogas upgrading, contributing to future research and industrial application.

Energy (Oxford, United Kingdom) published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kun, Jirui published the artcileCharacterization of the key compounds responsible for the fermented soybean-like cup aroma of raw Pu-erh tea using instrumental and sensory methods, Product Details of C10H18O, the publication is LWT–Food Science and Technology (2022), 113458, database is CAplus.

Cup aroma refers to the volatiles emitted from an empty cup after tea infusion. In this study, gas chromatog.-olfactometry (GC-O) and the odor activity value (OAV) approach were employed to investigate the composition of fermented soybean-like cup aroma from raw Pu-erh tea. Further, the aroma recombination and omission tests were performed, and the results demonstrated that 2-methylbutyric acid, acetic acid, 4-methyl-3-penten-2-one, Et isobutyrate, nonanoic acid, and phenylacetic acid exhibited relatively high aroma intensities (AI) and OAVs among the 12 odor-active compounds that were detected in the fermented soybean-like cup aroma. The aroma recombination, which was performed employing the 12 odorants with AI ≥1 successfully mimicked the overall aroma profile of the fermented soybean-like cup aroma. The omission test revealed that 2-methylbutyric acid contributed significantly to the fermented soybean-like cup aroma. And the enantiomeric ratio (ER) of the (S)- to (R)-forms of 2-methylbutyric acid was 67:33.

LWT–Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Teng, Shuang published the artcileTogni-II Reagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes, COA of Formula: C8H10S, the publication is Chinese Journal of Chemistry (2021), 39(12), 3429-3434, database is CAplus.

Based on the redox reactions of Togni-II reagent and thiols (such as propane-2-thiol, cyclohexanethiol, dodecan-1-thiol, p-toluenethiol, etc.), a thiol-tuned selective functionalization of unactivated olefins was disclosed. In combination with aryl thiol (p-toluenethiol), stoichiometric amount of Togni-II reagent prompted a hydrotrifluoromethylation of alkenes (such as N-allyl-benzamide, 1-phenyl-but-3-en-1-ol, 4-chloro-benzoic acid pent-4-enyl ester, etc.), in which, aryl thiol played as reductant and hydrogen source; while by utilization of alkyl thiols (such as propane-2-thiol, cyclohexanethiol, dodecan-1-thiol, etc.), catalytic amount of Togni-II reagent initiated thiol-ene and thiol-yne reactions. The reported applications are characterized by their operational simplicity and wide functional group tolerance.

Chinese Journal of Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C14H19NO8, COA of Formula: C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts