Author: tianli

Ogier, Sally Ann published the artcileNovel ligands for the affinity labeling of luteinizing hormone releasing hormone receptors, Safety of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biochemical Journal (1989), 258(3), 881-8, database is CAplus and MEDLINE.

A number of novel LH-RH analogs incorporating biotin together with potential covalent attachment sites were synthesized. Those based on the des-Gly¹⁰-[D-Lys⁶]-LH-RH ethylamide peptide backbone resulted in the most useful characteristics of binding to the LH-RH receptor in rat anterior pituitary gland membranes. Of these, des-Gly¹⁰-[biotinyl-aminoethylglycyl-D-Lys⁶]-LHRH ethylamide (XBAL) gave the best specific:nonspecific binding ratio, with 44% of total binding being specific with a K_d of 131 pM as determined by Scatchard anal. Two methods were used to covalently crosslink these analogs with the LH-RH receptor; photoaffinity labeling and the use of homobifunctional N-hydroxysuccinimide ester crosslinkers. The photoaffinity analogs gave poor specific:nonspecific binding ratios. Of the chem. crosslinkers tested, ethylene glycolbis(succinimidylsuccinate) (EGS) was the most efficient at covalently linking the ¹²⁵I-XBAL bound to the LH-RH receptor site. At an EGS concentration of 5 mM, 23% of the specific binding of ¹²⁵I-XBAL was covalently crosslinked.

Biochemical Journal published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Safety of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bladon, Christine M. published the artcilePreparation and use of biotinylated ligands for LHRH receptor purification, Related Products of alcohols-buliding-blocks, the publication is Tetrahedron Letters (1989), 30(11), 1401-4, database is CAplus.

The synthesis of biotinylated analogs of LH-RH is described in which the peptides simultaneously combine biotin and either a photolabile or an amino substituent. In rat anterior pituitary membranes, the conjugate [biotinyl-aminoethylglycyl-D-Lys⁶, des Gly¹⁰]-LH-RH ethylamide showed approx. 50% specific binding and could be covalently crosslinked to the LH-RH receptor site with ethylene glycol bis(succinimidylsuccinate).

Tetrahedron Letters published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Adam, Waldemar published the artcileHost-Guest Chemistry in a Urea Matrix: Catalytic and Selective Oxidation of Triorganosilanes to the Corresponding Silanols by Methyltrioxorhenium and the Urea/Hydrogen Peroxide Adduct, Recommanded Product: Triisopropylsilanol, the publication is Journal of the American Chemical Society (1999), 121(10), 2097-2103, database is CAplus.

The oxidation of silanes to silanols, catalyzed by methyltrioxorhenium (MTO), proceeds in high conversions and excellent selectivities in favor of the silanol (no disiloxane product) when the urea/hydrogen peroxide adduct (UHP) is used as oxygen source instead of 85% aqueous H₂O₂. It is proposed that this novel Si-H oxidation takes place in the helical urea channels, in which the urea matrix serves as host for the silane substrate, the H₂O₂ oxygen source, and the MTO metal catalyst as guests. In this confined environment, the metal catalyst is stabilized against decomposition, and this enhances higher conversions while condensation of the silanol to its disiloxane is avoided for steric reasons. The oxidation of the optically active silane (S)-(α-Np)PhMeSiH proceeds with retention of configuration in excellent yield. To date, no catalytic Si-H oxygen insertion has been reported for the preparation of optically active silanols. In analogy with the stereoselectivity in the dioxirane oxidation of (+)-(α-Np)PhMeSiH to (+)-(α-Np)PhMeSiOH, a concerted spiro-type transition-state structure is proposed for this novel Si-H oxidation Herewith, a valuable synthetic method for the preparation of silanols has been made available through catalytic and selective oxidation of silanes to silanols by the MTO/UHP system.

Journal of the American Chemical Society published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paul, Aparup published the artcileDNA/protein binding and molecular docking studies of two tetranuclear Cu(II) complexes with double-open-cubane core like structure, Product Details of C4H11NO, the publication is Inorganica Chimica Acta (2019), 119005, database is CAplus.

Two Cu(II) complexes [Cu₄(L)₂(HL)₂(H₂O)₂](pv)₂ (1) and [Cu₄(L)₂(HL)₂(H₂O)₂](ssal) (2) [H₂L = 2-ethoxy-6-[(1-hydroxymethyl-propylimino)-methyl]-phenol; pv = pivalate; ssal = 2-Hydroxy-5-sulfosalicylate] have been synthesized and characterized by X-ray structure determination Structure determination reveals that both the complexes are tetranuclear with double open cubane core framework, and C-H···π interactions results the formation of 1D supramol. structure. At room temperature 1 and 2 show fluorescence (λ_ex = 267 nm, λ_em = 329, 516 and 620 nm for 1; λ_ex = 277 nm, λ_em = 315 and 413 nm for 2) with fluorescence quantum yield 0.41 and 0.46, resp. Interactions of complexes with calf thymus DNA (CT-DNA), bovine serum albumin (BSA) and human serum albumin (HSA) were studied using UV-vis absorption and fluorescence spectroscopic techniques, and the calculated values of intrinsic binding constants of 1 and 2 with CT-DNA are 2.71(±0.07) × 10⁴ M^-1 and 1.58(±0.11) × 10⁴ M^-1, resp. Mol. docking technique has been used to determine the mode of interaction of complexes with CT-DNA and serum albumins. The docking studies suggest that both the complexes can interact with DNA through groove binding mode, and possible binding sites of complexes with BSA and HSA are in the proximity of Tyr149 and Tyr150, resp.

Inorganica Chimica Acta published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hurley, Michael D. published the artcileAtmospheric Chemistry of CF₃CH₂CH₂OH: Kinetics, Mechanisms and Products of Cl Atom and OH Radical Initiated Oxidation in the Presence and Absence of NO_x, Application In Synthesis of 2240-88-2, the publication is Journal of Physical Chemistry A (2005), 109(43), 9816-9826, database is CAplus and MEDLINE.

Relative rate techniques were used to study the kinetics of the reactions of Cl atoms and OH radicals with CF₃CH₂C(O)H and CF₃CH₂CH₂OH in 700 Torr of N₂ or air diluent at 296 ± 2 K. The rate constants determined were k(Cl+CF₃CH₂C(O)H) = (1.81 ± 0.27) x 10^-11, k(OH+CF₃CH₂C(O)H) = (2.57 ± 0.44) x 10^-12, k(Cl+CF₃CH₂CH₂OH) = (1.59 ± 0.20) x 10^-11, and k(OH+CF₃CH₂CH₂OH) = (6.91 ± 0.91) x 10^-13 cm³ mol.^-1 s^-1. Product studies of the chlorine initiated oxidation of CF₃CH₂CH₂OH in the absence of NO show the sole primary product to be CF₃CH₂C(O)H. Product studies of the chlorine initiated oxidation of CF₃CH₂CH₂OH in the presence of NO show the primary products to be CF₃CH₂C(O)H (81%), HC(O)OH (10%), and CF₃C(O)H. Product studies of the chlorine initiated oxidation of CF₃CH₂C(O)H in the absence of NO show the primary products to be CF₃C(O)H (76%), CF₃CH₂C(O)OH (14%), and CF₃CH₂C(O)OOH (≤10%). As part of this work, an upper limit of k(O₃+CF₃CH₂CH₂OH) < 2 × 10^-21 cm³ mol.^-1 s^-1 was established. Results are discussed with respect to the atm. chem. of fluorinated alcs.

Journal of Physical Chemistry A published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application In Synthesis of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mohan, C. Gopi published the artcileElectrostatic potential mapping using hybridization displacement charge: atomic parameters and transferability of charge and potential, Category: alcohols-buliding-blocks, the publication is International Journal of Quantum Chemistry (1998), 66(2), 149-156, database is CAplus.

Mol. electrostatic potential (MEP) maps and MEP-derived charges for certain mols. were studied by the ab initio approach using the 6-31G basis set. These results were used to obtain the parameters (K and ζ) for fluorine, sulfur, and chlorine required for the hybridization displacement charge (HDC) calculations employing the MNDO and AMI methods. The HDC combined with Loewdin charges, distributed continuously in three-dimension spherically and sym., were shown to reproduce ab initio MEP features of mols. fairly well. This method of computing the MEP was applied to two mols. of pharmacol. importance, namely, dimaprit and mustard gas. It is shown by studying the cis and trans forms of two amino acids that transferability of the MEP is appreciably less acceptable than that of charges in going from one conformation to the other.

International Journal of Quantum Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Muramatsu, Wataru published the artcilePerfectly Regioselective and Sequential Protection of Glucopyranosides, SDS of cas: 85618-21-9, the publication is European Journal of Organic Chemistry (2010), 827-831, S827/1-S827/67, database is CAplus.

A perfectly regioselective and sequential method for the preparation of orthogonally protected glucopyranosides has been developed. An acyl group was introduced at C(4)-OH by organocatalysis with >99 % regioselectivity. TBDPS, Boc, and BOM groups were sequentially introduced into the 4-O-acyl-glucopyranoside at C(6)-OH, C(2)-OH, and C(3)-OH, resp., with ca. 100 % regioselectivity in each step.

European Journal of Organic Chemistry published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Koohmareh, Gholam Ali published the artcileSynthesis, characterization, and optical properties of new pyridine- and thiophene-based copolymer bearing bulky naphthyl group, Synthetic Route of 239075-02-6, the publication is Polymer Bulletin (Heidelberg, Germany) (2015), 72(11), 2979-2990, database is CAplus.

A new copolymer was synthesized via reaction of new pyridine-containing dibromo compound, 2,6-bis(4-bromophenyl)-4-(naphthalen-1-yl) pyridine, with thiophene-based diboronic ester via Suzuki cross-coupling reactions. 2,6-Bis(4-bromophenyl)-4-(naphthalen-1-yl) pyridine was synthesized starting from condensation reactions of 4-bromoacetophenone and 1-naphthaldehyde. The synthesized monomer and polymer were characterized by FT-IR and NMR spectroscopy. The phys. properties of the polymer, including solubility and viscosity were studied, and the results showed good solubility and chain growth for polymer. Maximum absorption peak for polymer was 388 nm. The optical band gap energy of the polymers was determined by absorption onset and 2.38 eV for polymer.

Polymer Bulletin (Heidelberg, Germany) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Synthetic Route of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vantourout, Julien C. published the artcileSpectroscopic Studies of the Chan-Lam Amination: A Mechanism-Inspired Solution to Boronic Ester Reactivity, SDS of cas: 25240-59-9, the publication is Journal of the American Chemical Society (2017), 139(13), 4769-4779, database is CAplus and MEDLINE.

We report an investigation of the Chan-Lam amination reaction. A combination of spectroscopy, computational modeling, and crystallog. has identified the structures of key intermediates and allowed a complete mechanistic description to be presented, including off-cycle inhibitory processes, the source of amine and organoboron reactivity issues, and the origin of competing oxidation/protodeboronation side reactions. Identification of key mechanistic events has allowed the development of a simple solution to these issues: manipulating Cu(I)→Cu(II) oxidation and exploiting three synergistic roles of boric acid has allowed the development of a general catalytic Chan-Lam amination, overcoming long-standing and unsolved amine and organoboron limitations of this valuable transformation.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C24H29N5O3, SDS of cas: 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jorge, Miguel published the artcileNew Force-Field for Organosilicon Molecules in the Liquid Phase, Recommanded Product: Triethylsilanol, the publication is ACS Physical Chemistry Au (2021), 1(1), 54-69, database is CAplus and MEDLINE.

In this paper, we present a new mol. model that can accurately predict thermodn. liquid state and phase-change properties for organosilicon mols. including several functional groups (alkylsilane, alkoxysilane, siloxane, and silanol). These mols. are of great importance in geol. processes, biol. systems, and material science, yet no force field currently exists that is widely applicable to organosilicates. The model is parametrized according to the recent Polarization-Consistent Approach (PolCA), which allows for polarization effects to be incorporated into a nonpolarizable model through post facto correction terms and is therefore consistent with previous parametrizations of the PolCA force field. Alkyl groups are described by the United-Atom approach, bond and angle parameters were taken from previous literature studies, dihedral parameters were fitted to new quantum chem. energy profiles, point charges were calculated from quantum chem. optimizations in a continuum solvent, and Lennard-Jones dispersion/repulsion parameters were fitted to match the d. and enthalpy of vaporization of a small number of selected compounds Extensive validation efforts were carried out, after careful collection and curation of exptl. data for organosilicates. Overall, the model performed quite well for the d., enthalpy of vaporization, dielec. constant, and self-diffusion coefficient, but it slightly overestimated the magnitude of self-solvation free energies. The modular and transferable nature of the PolCA force field allows for further extensions to other types of silicon-containing compounds

ACS Physical Chemistry Au published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts