Author: tianli

Podjed, Nina published the artcileStructural diversity and magnetic properties of copper(II) quinaldinate compounds with amino alcohols, COA of Formula: C4H11NO, the publication is New Journal of Chemistry (2022), 46(15), 6899-6920, database is CAplus.

The reactions between [Cu(quin)₂(H₂O)] (quin^– = the anionic form of quinoline-2-carboxylic acid) and a series of aliphatic amino alcs. have yielded structurally very diverse copper(II) complexes, labeled a–g. Single-crystal X-ray structure anal. has revealed either intact amino alc. mols. or amino alcoholate ions serving as ligands. In type a complexes, the amino alcs. are bound in a monodentate manner via NH₂. Engagement of both functional groups in coordination was observed for types b and e (a bidentate chelating mode) and type c (a bidentate bridging one) complexes. In view of the strong bidentate chelating coordination of quinaldinate in [Cu(quin)₂(H₂O)], the formation of homoleptic amino alc. complexes e was not anticipated. Equally surprising was the transformation of a mononuclear starting material into a one-dimensional (1D) coordination polymer, [Cu(quin)₂]_n (g). Spontaneous deprotonation of some amino alcs. and coordination of, thus formed, amino alcoholates via both donors also took place. Dinuclear complexes (d) contained two bridging amino alcoholates, while bidentate chelating mode was observed for type f. Interestingly, the dinuclear complex exists as two isomers which differ in the position of quinaldinates with respect to the Cu(μ-OR)₂Cu core. DFT calculations on isolated syn- and anti-[Cu₂(quin)₂(3a1pO)₂] (3a1pO^– = anion of 3-amino-1-propanol) have shown the syn isomer to be more stable. The explanation lies in the intramol. π···π stacking of quinaldinates, possible only in this isomer. Magnetic susceptibility measurements revealed antiferromagnetic interactions between S = 1/2 copper(II) spins in all the studied compounds except in [Cu(quin)₂]_n (g) for which weak ferromagnetic couplings are detected.

New Journal of Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sheykhan, Mehdi published the artcileNovel access to carbonyl and acetylated compounds: the role of the tetra-n-butylammonium bromide/sodium nitrite catalyst, HPLC of Formula: 101-98-4, the publication is RSC Advances (2016), 6(56), 51347-51355, database is CAplus.

A novel aerobic oxidation of alcs. ArCH(OH)R (Ar = C₆H₅, 2-O₂N-3-CH₃-C₆H₃, 2-carbaldehydefuran-5-yl, etc.; R = H, CH₃) without the use of any oxidants was developed. An equimolar catalytic mixture of tetra-n-butylammonium bromide and sodium nitrite catalyzes the aerobic selective oxidation of benzylic alcs. under oxidant-free, base-free and metal-free conditions. The mild reaction conditions allow oxidation of a wide range of benzylic alcs., chemo-selectively to their carbonyl compounds ArC(O)R (68-93% isolated yields). More importantly, high selectivity among different kinds of alcs. (aromatic vs. aliphatic alcs., primary vs. secondary alcs. as well as alcs. having neutral rings vs. electron-deficient rings) is available by this approach. The method surprisingly switched over to be an efficient acetylation approach in the case of aliphatic alcs. without the use of any transition metal, phosphorus or other toxic reagents or any need for using toxic acyl halides, sulfonyl halides, anhydrides, etc. by the use of only acetic acid as a reagent.

RSC Advances published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C16H24BF4Ir, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Rui published the artcileFluorometric/electrochemical dual-channel sensors based on carbon quantum dots for the detection and information anti-counterfeiting, Synthetic Route of 90-64-2, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2022), 114118, database is CAplus.

Sensors used to detect Fe³⁺ and Cys are generally a single method. In this work, two methods of fluorescence and electrochem. are innovatively combined to detect Fe³⁺ and Cys, and the obtained Lod is basically the same. Carbon quantum dots (CQDs) with blue fluorescence were successfully prepared by hydrothermal methods using tryptophan (Trp) as carbon source, which can be used for fluorescence and electrochem. dual-channel probe quickly detecting iron ion (Fe³⁺) and cysteine (Cys). A series of studies have been carried out on its morphol., chem. structure, and optical properties through TEM, XRD, FT-IR, XPS, UV-vis absorption spectrum, and photoluminescence spectra. And the quantum yield of CQDs was up to 52.64%. It was also analyzed in the real sample, demonstrating the feasibility and reliability of detecting Fe³⁺ and Cys in the real sample. Furthermore, CQDs can also be used as fluorescent ink for information anti-counterfeiting due to their excellent fluorescent properties.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C5H10O2S, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Tengfei published the artcilePhotoelectrochemical Decomposition of Lignin Model Compound on a BiVO₄ Photoanode, Formula: C15H16O3, the publication is ChemSusChem (2020), 13(14), 3622-3626, database is CAplus and MEDLINE.

The photoelectrochem. decomposition of lignin model compounds at a BiVO₄ photoanode is demonstrated with simulated sunlight and an applied bias of 2.0 V. These prototypical lignin model compounds are photoelectrochem. converted into the corresponding aryl aldehyde and phenol derivatives in a single step with conversion of up to ≈64% over 20 h. Control experiments suggest that vanadium sites are electrocatalytically active, which precludes the need for a redox mediator in solution This feature of the system is corroborated by a layer of V₂O₅ deposited on BiVO₄ serving to boost the conversion by 10%. Our methodol. capitalizes on the reactive power of sunlight to drive reactions that have only been studied previously by electrochem. or catalytic methods. The use of a BiVO₄ photoanode to drive lignin model decomposition therefore provides a new platform to extract valuable aromatic chem. feedstocks using solar energy, electricity and biomass as the only inputs.

ChemSusChem published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Formula: C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stojanovic, Nikola M. published the artcileLemon balm (Melissa officinalis L.) essential oil and citronellal modulate anxiety-related symptoms – In vitro and in vivo studies, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of Ethnopharmacology (2022), 114788, database is CAplus and MEDLINE.

Besides psyche-related symptoms, patients with anxiety disorders can have a large number of somatic symptoms as well. Although the treatment of these disorders is mainly focused on resolving their mental component, one cannot neglect the need for the treatment of accompanying somatic symptoms. Melissa officinalis L. (lemon balm), in various formulations, has been extensively used as an ethnomedicinal remedy for the treatment of different psyche-related symptoms, and its use is considered relatively safe. Aim of the study: In the present study, the activity of M. officinalis (MO) essential oil was evaluated in several in vitro and in vivo models mimicking or involving anxiety-related somatic symptoms. To address the effect of MO essential oil on the gastrointestinal and heart-related symptoms accompanying anxiety disorders, in vitro models were utilized that follow the function of the isolated mouse ileum and atria tissues, resp., after exposure to MO essential oil. Effects of MO essential oil on BALB/c mice motor activity was estimated using the open field, rota-rod, and horizontal wire tests. Addnl., the essential oil was assayed for its potential in inhibiting acetylcholinesterase activity. The performance of mice treated with 25 mg/kg of the oil showed a statistically significant decrease in the motor impairment arising from acute anxiety (open field test), while there was a prolonged latency and a reduction of the frequency of falling from a rotating rod and/or a horizontal wire (signs of muscle weakness/spasms). Concentrations of the essential oil higher than 1 μg/mL were found to inhibit both spontaneous and induced ileum contractions. Moreover, the essential oil and citronellal were found to decrease isolated mouse atria contraction frequency, as well as contraction force. However, the oil was found to be a very weak acetylcholinesterase inhibitor. The modulation of anxiety-related symptoms by the oil was found not to be mediated through the inhibition of the acetylcholinesterase, nonetheless, the mechanistic studies involving the ileum and cardiac tissues, revealed that the activity of MO and citronellal might be related to the modification of either voltage-gated Ca2+ channels or muscarinic receptors. Mice locomotion, balance, and muscle strength were not impacted by the essential oil; however, its main constituent, citronellal, was found to exert a certain degree of muscle function inhibition. All these results suggest that the activity of MO essential oil arises from synergistic and/or antagonistic interactions of its constituents, and is not completely dependent on the oil main constituent.

Journal of Ethnopharmacology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C9H9NO, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Aghekyan, A. A. published the artcileSynthesis and Biological Activity of Arylcyclopentane-1-carboxylic Acids Aminoesters, Related Products of alcohols-buliding-blocks, the publication is Russian Journal of General Chemistry (2019), 89(5), 1051-1054, database is CAplus.

1-Arylcyclopentane-1-carboxylic acids were synthesized by alk. hydrolysis of the corresponding nitriles. Reactions of the acid chlorides with N,N-dialkylaminoalkyl-and hetarylalkylalkanols provided new amino ester derivatives of 1-arylcyclopentane-1-carboxylic acids. Sympatholytic and adrenolytic activity of the obtained amino esters hydrochlorides was studied.

Russian Journal of General Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Haga, Yuji published the artcileDiscovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Bioorganic & Medicinal Chemistry (2011), 19(2), 883-893, database is CAplus and MEDLINE.

The design, synthesis and structure-activity relationships of a novel class of N-phenylpyridone MCH1R antagonists are described. The core part of the N-phenylpyridone structure was newly designed and the side chain moieties that were attached to the core part were extensively explored. As a result of optimization of the N-phenylpyridone leads, we successfully developed the orally available, and brain-penetrable MCH1R selective antagonist 7c (I), exhibiting excellent anti-obese effect in diet-induced obese (DIO) mice.

Bioorganic & Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shirai, Fumiyuki published the artcileDesign and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer, Safety of 2-Morpholinoethanol, the publication is Journal of Medicinal Chemistry (2020), 63(8), 4183-4204, database is CAplus and MEDLINE.

Tankyrases (TNKS/TNKS2) belong to the poly(ADP-ribose) polymerase family. Inhibition of their enzymic activities attenuates the Wnt/β-catenin signaling, which plays an important role in cancer pathogenesis. We previously reported the discovery of RK-287107, a spiroindoline-based, highly selective, potent tankyrase inhibitor. Herein we describe the optimization process of RK-287107 leading to RK-582, which exhibits a markedly improved robust tumor growth inhibition in a COLO-320DM mouse xenograft model when orally administered. In addition to the dose-dependent elevation and attenuation of the levels of biomarkers AXIN2 and β-catenin, resp., results of the TCF reporter and cell proliferation studies on COLO-320DM are discussed.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H8O4, Safety of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tsuchiya, Tomoaki published the artcileThe factors that govern the allosteric chemical sensing of polythiophene chemosensors: scope and limitation toward signal-amplification sensing, HPLC of Formula: 239075-02-6, the publication is RSC Advances (2021), 11(48), 30472-30478, database is CAplus and MEDLINE.

The newly designed polythiophene chemosensors (PT1 and PT2) were synthesized via the Suzuki-Miyaura polymerization with appropriate yields. The photophys. properties of PTs thus obtained were examined by means of UV/vis, fluorescence, excitation spectroscopy, and time-correlated single-photon-counting method. The π-π* transitions around 400-600 nm and the emissions in the range of 400-650 nm were observed The binding behavior of PTs was also investigated upon the interaction of tetrabutylammonium or tetrabutylphosphonium isophthalate, affording the binding constants (K) of 5790-8310 M^-1, which were quite smaller than those observed in the corresponding repeating unit. The comprehensive analyses of the UV/vis data and theor. calculation supports revealed the origins of scope and limitation toward signal-amplification sensing. The present results obtained herein will guide the development of new amplification chemosensors.

RSC Advances published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C22H12F6O6S2, HPLC of Formula: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Miyoshi, Norikazu published the artcilePractical method for hydroxyl-group protection using strontium metal and readily available silyl chlorides, Category: alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(43), 6312-6315, database is CAplus and MEDLINE.

Smooth O-silylation of secondary aliphatic alcs. R¹CH(OH)R² was achieved by coupling with silyl chlorides R₃SiCl (R₃ = ^tBuMe₂, Et₃, ⁱPr₃, ^tBuPh₂, Ph₃) promoted by strontium metal in DMA, instead of use the expensive, yet more reactive, and commonly used silyl triflate. The reaction occurred almost completely with various alcs., giving silyl ethers R¹CH(OSiR₃)R².

Chemical Communications (Cambridge, United Kingdom) published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts