Author: tianli

Aono, Toshiaki published the artcileThe effect of oxygen insulation on the stability of image dyes of a color photographic print and the behavior of alkylhydroquinones as antioxidants, Application of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Journal of Applied Photographic Engineering (1982), 8(5), 227-31, database is CAplus.

Studies concerning the light fading of color prints due to oxidation by O from the ambient atm. are described. From studying the effects of O insulation by various techniques of polymer film lamination, it has been found that O mols., which greatly accelerate the light fading of magenta and yellow dyes in color prints, penetrate most easily through a polyethylene-coated paper support. The acceleration of light fading of the dye image by the migrating O is restrained not only by alkylhydroquinone but also by alkylbenzoquinone, incorporated in the dye image layer. This result can be explained in terms of a photochem. reaction mechanism, namely, alkylbenzoquinone reacts to form alkylhydroquinone derivatives upon exposure to light.

Journal of Applied Photographic Engineering published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Application of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kanda, Yuzuru published the artcileTwo-Phase Synthesis of Taxol, Related Products of alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2020), 142(23), 10526-10533, database is CAplus and MEDLINE.

Taxol is widely regarded as amongst the most famed natural isolates ever discovered, and has been the subject of innumerable studies in both basic and applied science. Its documented success as an anticancer agent, coupled with early concerns over supply, stimulated a furious worldwide effort from chemists to provide a solution for its preparation through total synthesis. Those pioneering studies proved the feasibility of retrosynthetically-guided access to synthetic Taxol, albeit in minute quantities and with enormous effort. In practice, all medicinal chem. efforts and eventual commercialization have relied upon natural-(plant material) or biosynthetically-derived (synthetic biol.) supplies. Here we show how a complementary divergent synthetic approach that is holistically patterned off of biosynthetic machinery for terpene synthesis can be used to arrive at Taxol.

Journal of the American Chemical Society published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ooguri, Akihiro published the artcileNickel-Catalyzed Cycloaddition of Salicylic Acid Ketals to Alkynes via Elimination of Ketones, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2009), 131(37), 13194-13195, database is CAplus and MEDLINE.

An intermol. nickel-catalyzed addition reaction has been developed where salicylic acid ketals react with alkynes to afford substituted chromones. A mechanistic rationale is proposed, implying β-elimination of ketone from ring strained seven-membered nickelacycle to generate a five-membered oxa-nickelacycle intermediate.

Journal of the American Chemical Society published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Matsui, Kazuki published the artcilePotential pharmacokinetic interaction between orally administered drug and osmotically active excipients in pediatric polypharmacy, Application In Synthesis of 23828-92-4, the publication is European Journal of Pharmaceutical Sciences (2021), 105934, database is CAplus and MEDLINE.

Poorly absorbable sugar alcs. (e.g., mannitol, sorbitol, and maltitol) are the excipients frequently contained in pediatric dosage forms. Due to their osmotically active properties, certain amount of sugar alcs. reportedly reduces oral bioavailability of concomitant drugs. This fact implies the possible pharmacokinetic interaction between orally administered drug and sugar alcs. which are present in other concomitant medications. The purpose of this study was to identify the possibility and likeliness of the osmotically active excipient-induced pharmacokinetic interaction in pediatric polypharmacy. Previously developed in silico model that captured the osmotic effect of sugar alcs. in adults was expanded to pediatric population. This math. model successfully explained the impaired bioavailability of lamivudine by the co-administered sorbitol in other dosage forms. In the meantime, sugar alc. contents in marketed pediatric dosage forms were investigated by reverse engineering technol. Considering the critical administration dose of sugar alcs. estimated by in silico model, it was revealed that 25 out of 153 pediatric dosage forms were identified as possible perpetrators even under the approved administration and dosage in Japan. This study shed light on the potential pharmacokinetic interaction that cannot be dismissed throughout the pediatric pharmaceutical dosage form design and development.

European Journal of Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tanaka, Masamichi published the artcileBoronic-Acid-Catalyzed Regioselective and 1,2-cis-Stereoselective Glycosylation of Unprotected Sugar Acceptors via S_Ni-Type Mechanism, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of the American Chemical Society (2018), 140(10), 3644-3651, database is CAplus and MEDLINE.

Regio- and 1,2-cis-stereoselective chem. glycosylation of unprotected glycosyl acceptors has been in great demand for the efficient synthesis of natural glycosides. However, simultaneously regulating these selectivities has been a longstanding problem in synthetic organic chem. In nature, glycosyl transferases catalyze regioselective 1,2-cis-glycosylations via the S_Ni mechanism, yet no useful chem. glycosylations based on this mechanism have been developed. In this paper, we report a highly regio- and 1,2-cis-stereoselective S_Ni-type glycosylation of 1,2-anhydro donors and unprotected sugar acceptors using p-nitrophenylboronic acid (10e) as a catalyst in the presence of water under mild conditions. Highly controlled regio- and 1,2-cis-stereoselectivities were achieved via the combination of boron-mediated carbohydrate recognition and the S_Ni-type mechanism. Mechanistic studies using the KIEs and DFT calculations were consistent with a highly dissociative concerted S_Ni mechanism. This glycosylation method was applied successfully to the direct glycosylation of unprotected natural glycosides and the efficient synthesis of a complex oligosaccharide with minimal protecting groups.

Journal of the American Chemical Society published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H9NO6S, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Albozahid, Muayad published the artcileEffect of dispersion methods on the performance of novel rigid copolymer polyurethane nanocomposites based on graphene nanofillers, Application In Synthesis of 111-29-5, the publication is Polymer-Plastics Technology and Materials (2022), 61(4), 426-440, database is CAplus.

The Rigid Copolymer Polyurethanes (RCPUs) as nanocomposites were synthesized by in-situ polymerization (ISP), melt compounding (MC), and solution mixing (SM) with wide range of weight ratios of graphite nanoplatelets (GNP). The blending process was utilized to obtain well- dispersed of GNP and thus strong interaction, leading to an effective performance of the RCPU/GNP nanocomposites. The structure of RCPU/GNP nanocomposites was studied using FTIR test. The thermal stability of RCPU nanocomposites was seen by TGA anal., showing an increase with addition of GNP nanofillers. Rheol. anal. revealed network formation with well-dispersed GNP regarding different dispersion approaches. Thermal and elec. tests were also conducted, approving that dispersion and interaction of GNP can play a crucial role for enhancing the thermal and elec. properties. Such a significant improvement in RCPU matrix performance could lead to the use of this material for different application.

Polymer-Plastics Technology and Materials published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Albozahid, Muayad published the artcileStudy on the effect of tailoring the hard copolymer polyurethane on the thermal, mechanical and electrical properties of hard copolymer polyurethane/multi-walled carbon nanotubes nanocomposites, SDS of cas: 111-29-5, the publication is Journal of Composite Materials (2022), 56(10), 1467-1480, database is CAplus.

This study focusses on the effect of the addition of multi-walled carbon nanotubes (MWCNTs) on the morphol. and thermal, rheol. and elec. properties of hard copolymer polyurethane (HCPU) using 1,5 pentane-diols as a chain extender, containing 85% of hard segment blocks. Step-growth polymerization was used to synthesize a HCPU polymer matrix, followed by melt compounding to prepare the nanocomposites. SEM investigation of the neat HCPU structure and its nanocomposites indicated the uniform dispersion of MWCNTs within the polymer matrix; further TEM morphol. investigation showed some agglomeration regions, attributed to the high MWCNT content (2 wt%). An XRD test confirmed a homogeneous distribution of MWCNTs by observing the remaining location of the highest peaks of MWCNTs and amorphous peaks of the HCPU matrix. Anal. of the melt rheol. test results showed an improvement in complex viscosity combined with an increase in the G’ and G” of nanocomposites from those of pure HCPU due to the presence of MWCNTs. Finally, elec. conductivity of nanocomposites demonstrated a significant improvement in its value at high loading of MWCNTs from that of pure HCPU matrix.

Journal of Composite Materials published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Albozahid, Muayad published the artcileEffect of OMMT reinforcement on morphology and rheology properties of polyurethane copolymer nanocomposites, Related Products of alcohols-buliding-blocks, the publication is Journal of Elastomers & Plastics (2021), 53(8), 992-1014, database is CAplus.

The remarkable structural features of organic modified montmorillonite particles (OMMT) enable them to complete their important role in enhancing different properties of polyurethane copolymer with 75 weight% hard segments (PUC/75). Based on the melt intercalation approach, various amounts of OMMT were incorporated into PUC/75 solution followed by the injection molding process. It is essential to mention that the synthesized PUC/75 in this work relied on using 1,5-Pentanediol as a chain extender in order to produce a long-term and thermal-stable PUC successfully. The effect of incorporating various loading of OMMT on rheol. properties of neat PUC/75 and its nanocomposites was investigated. The structure of PUC/OMMT was studied using X-ray diffraction (XRD) and SEM. Addnl., differential scanning calorimetry (DSC) thermograms were utilized to investigate OMMT effect on the thermal transitions and crystallinity of resultant PUC nanocomposites. Interestingly, the dynamic rheol. anal. exhibited a remarkable increase in melt rheol. behavior with increasing OMMT loading compared to neat PUC/75. This could imply a good interaction between the functional group on the surface of OMMT and PUC/75 domains; particularly hard domains, herein the DSC results showed moderate improvement in melt temperature (T_m) of PUC/OMMT nanocomposite. However, a decline in crystalline temperature (T_c) was also seen due to aggregation of OMMT, especially at higher OMMT loading. While XRD results exhibited a slight shifting in crystalline peaks of PUC nanocomposites relative to neat PUC/75.

Journal of Elastomers & Plastics published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Albozahid, Muayad published the artcileEnhanced mechanical, crystallisation and thermal properties of graphene flake-filled polyurethane nanocomposites: the impact of thermal treatment on the resulting microphase-separated structure, Quality Control of 111-29-5, the publication is Journal of Polymer Research (2021), 28(8), 302, database is CAplus.

The present work investigates the combined effect of the addition of graphite nanoplatelets (xGNPs) to polyurethane copolymer (PUC) and thermal treatment was employed. The PUC reinforced by xGNP were synthesized by in-situ polymerization, which leads to an effective performance of the PUC/xGNP system. Meanwhile, X-ray diffraction and Raman spectroscopy tests displayed the inter-spacing planar quality of xGNP nanofillers. The thermal stability of PUC was seen to increase with addition of xGNP. Addnl., the dynamic storage modulus (E’) showed better performance after thermal treatment than in the untreated samples. However, a relationship between the microphase-separated morphol. of PUC induced by thermal treatment and the addition of xGNP has been observed Consequently, the crystallinity percentage increased after thermal treatment @ 80 C for 4 days, presuming a re-ordering of amorphous hard segments during the heating in a packed microphase conformation. On the other hand, better dispersion and interaction of xGNP can play a crucial role in enhancing the thermal and mech. properties, and thus a significant reinforcement for PUC. The tensile properties such as modulus and tensile strength showed significant enhancement with xGNP incorporation, while the elongation steeply dropped. On the contrary, a deterioration in modulus and tensile strength resulted from thermal treatment, likely due to the restacking of xGNP during segmental movement and thus increasing the amorphous phase rather than the crystalline phase. A modified Halpin-Tsai model was utilized to predict the mismatch between the empirical and theor. results. Consequently, the findings displayed the divergence of the nanocomposite modulus of PUC with greater amounts of xGNP nanofillers.

Journal of Polymer Research published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hosseini-Sarvari, M. published the artcileNano-sulfated titania as a heterogeneous solid acid catalyst for the synthesis of pyrroles by Clauson-Kaas condensation under solvent-free conditions, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2014), 49(12), 1732-1739, database is CAplus.

A new and environmentally benign method for the preparation of N-substituted pyrroles from one-pot condensation reaction of 2,5-dimethoxytetrahydrofuran with amines and diamines in the presence of nano sulfated titania under solvent-free conditions was presented. This new protocol features simple operation, easy availability, stability, and eco-friendliness of catalyst, as well as high to excellent yields of products. In addition, we report for the first time an alternative method for the synthesis of pyrroles from aromatic amines containing the β-lactam fragment using nano sulfated titania as catalyst.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts