Author: tianli

Asadov, Ziyafaddin H. published the artcileEffects of head group on the properties of cationic surfactants containing hydroxyethyl- and hydroxyisopropyl fragments, SDS of cas: 122-20-3, the publication is Journal of Molecular Liquids (2019), 125-132, database is CAplus.

Cationic surfactants containing different head-groups have been synthesized by interaction of tetradecyl bromide and amines having hydroxyalkyl group (monoethanolamine, diethanolamine, triethanolamine, methylethanolamine, methyldiethanolamine, diethanolisopropanolamine, ethanoldiisopropanolamine, triisopropanolamine). Surfactivity parameters of the synthesized cationic surfactants have been determined by measurements of surface tension and electroconductance. The character of change of the colloidal-chem. parameters with an increase of the number of hydroxyethyl and hydroxyisopropyl groups in the head-group of the cationic surfactants has been established. The synthesized cationic surfactants possess effective antibacterial and antifungal properties.

Journal of Molecular Liquids published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhuang, Chunlin published the artcileRapid Identification of Keap1-Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search, Recommanded Product: 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, the publication is Journal of Medicinal Chemistry (2014), 57(3), 1121-1126, database is CAplus and MEDLINE.

In this study, rapid structure-based virtual screening and hit-based substructure search were utilized to identify small mols. that disrupt the interaction of Keap1-Nrf2. Special emphasis was placed toward maximizing the exploration of chem. diversity of the initial hits while economically establishing informative structure-activity relationship (SAR) of novel scaffolds. Our most potent noncovalent inhibitor exhibits three times improved cellular activation in Nrf2 activation than the most active noncovalent Keap1 inhibitor known to date.

Journal of Medicinal Chemistry published new progress about 518303-20-3. 518303-20-3 belongs to alcohols-buliding-blocks, auxiliary class Apoptosis,Bcl-2, name is 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, and the molecular formula is C7H13NO2, Recommanded Product: 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rodrigalvarez, Jesus published the artcileCatalytic C(sp³)-H bond activation in tertiary alkylamines, Formula: C4H11NO, the publication is Nature Chemistry (2020), 12(1), 76-81, database is CAplus and MEDLINE.

The development of robust catalytic methods to assemble tertiary alkylamines provides a continual challenge to chem. synthesis. In this regard, transformation of a traditionally unreactive C-H bond, proximal to the nitrogen atom, into a versatile chem. entity would be a powerful strategy for introducing functional complexity to tertiary alkylamines. A practical and selective metal-catalyzed C(sp³)-H activation facilitated by the tertiary alkylamine functionality, however, remains an unsolved problem. Here, we report a Pd(II)-catalyzed protocol that appends arene feedstocks to tertiary alkylamines via C(sp³)-H functionalization. A simple ligand for Pd(II) orchestrates the C-H activation step in favor of deleterious pathways. The reaction can use both simple and complex starting materials to produce a range of multifaceted γ-aryl tertiary alkylamines and can be rendered enantioselective. The enabling features of this transformation should be attractive to practitioners of synthetic and medicinal chem. as well as in other areas that use biol. active alkylamines.

Nature Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

McCallum, Megan M. published the artcileHigh-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe, Name: 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, the publication is Journal of Biomolecular Screening (2013), 18(6), 705-713, 9 pp., database is CAplus and MEDLINE.

Testing small mols. for their ability to modify cysteine residues of proteins in the early stages of drug discovery is expected to accelerate our ability to develop more selective drugs with lesser side effects. In addition, this approach also enables the rapid evaluation of the mode of binding of new drug candidates with respect to thiol reactivity and metabolism by glutathione. Herein, we describe the development of a fluorescence-based high-throughput assay that allows the identification of thiol-reactive compounds A thiol-containing fluorescent probe, MSTI, was synthesized and used to evaluate small mols. from the Library of Pharmacol. Active Compounds (LOPAC) collection of bioactive mols. LOPAC compounds that are known to react with sulfur nucleophiles were identified with this assay, for example, irreversible protease inhibitors, nitric oxide-releasing compounds and proton-pump inhibitors. The results confirm that both electrophilic and redox reactive compounds can be quickly identified in a high-throughput manner, enabling the assessment of screening libraries with respect to thiol-reactive compounds

Journal of Biomolecular Screening published new progress about 518303-20-3. 518303-20-3 belongs to alcohols-buliding-blocks, auxiliary class Apoptosis,Bcl-2, name is 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, and the molecular formula is C18H14BrNO5S2, Name: 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patchornik, Guy published the artcileTethered non-ionic micelles: a matrix for enhanced solubilization of lipophilic compounds, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Soft Matter (2012), 8(32), 8456-8463, database is CAplus.

A specific mechanism for tethering micelles composed of non-ionic detergents is presented. The mechanism does not require any precipitant, high ionic strength or temperature alterations. Rather, it relies on complexes between hydrophobic chelators embedded within the micelle and appropriate metal cations in the aqueous phase, serving as mediators. The approach was applied to: (i) four non-ionic detergents (tetraethylene glycol monooctyl ether (C8E4), n-dodecyl-β-D-maltoside (DDM), octyl β-D-1-thioglucopyranoside (OTG), and n-octyl-β-D-glucopyranoside (OG)), (ii) two hydrophobic chelators (bathophenanthroline and N-(1,10-phenanthrolin-5-yl)decanamide, Phen-C10) and (iii) five transition metals (Fe²⁺, Ni²⁺, Zn²⁺, Cd²⁺, and Mn²⁺). The mandatory requirement for a hydrophobic chelator and transition metals, capable of binding two (or more) chelators simultaneously, was demonstrated. The potential generality of the mechanism presented derives from the observation that different combinations of [detergent : chelator : metal] are able to induce specific micellar clustering. The greater solubilization capacity of tethered-micelles in comparison with untethered micelles was demonstrated when the water insoluble aromatic mol. fluorenone (8 mM = 1.44 mg mL^-1) and two highly lipophilic antibiotics: chloramphenicol (5 mM = 1.62 mg mL^-1) and tetracycline (1.5 mM = 0.66 mg mL^-1) were solubilized – only when the micelles were tethered.

Soft Matter published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mushtaq, Sajid published the artcileEfficient and Site-Specific ¹²⁵I-Radioiodination of Bioactive Molecules Using Oxidative Condensation Reaction, Formula: C8H19NO2, the publication is ACS Omega (2018), 3(6), 6903-6911, database is CAplus and MEDLINE.

In this report, the novel and site-specific radioiodination of biomols. by using aryl diamine and alkyl aldehyde condensation reaction in the presence of a Cu²⁺ catalyst under ambient conditions was reported. ¹²⁵I-labeled alkyl aldehyde was synthesized using a tin precursor with a high radiochem. yield (72 ± 6%, n = 5) and radiochem. purity (>99%). The utility of the radioiodinated precursor was demonstrated through aryl diamine-installed c[RGDfK(C)] peptide and human serum albumin (HSA). Radioiodinated c[RGDfK(C)] peptide and HSA protein were synthesized with high radiochem. yields and purity. ¹²⁵I-HSA protein showed excellent in vivo stability and negligible thyroid uptake as compared with directly radioiodinated HSA by using the tyrosine group. Excellent reaction kinetics and the in vitro and in vivo stabilities of ¹²⁵I-labeled alkyl aldehyde have suggested the usefulness of the strategy for the radioiodination of bioactive mols.

ACS Omega published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Munakala, Anandarao published the artcileSteric and Electronic Control Intramolecular [2 + 2]-Cycloaddition of Cyclohexadienone-Containing 1,7-Enynes, Category: alcohols-buliding-blocks, the publication is Organic Letters (2022), 24(3), 892-896, database is CAplus and MEDLINE.

Herein, authors have developed silver-catalyzed an electronic and steric control intramol. formal [2 + 2]-cycloaddition of alkyne-tethered cyclohexadienones. Substrates with electron-rich alkynes and less hindered quaternary carbon center afford tricyclic fused-cyclobutenes through 1,7-enyne cyclization. In contrast, the formation of dihydrofurans was observed from electron-deficient alkynes via proton abstraction/C-O bond cleavage. The synthetic potential of this method was also broadened with a gram-scale reaction and various transformations on cyclobutene.

Organic Letters published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Moriyama, Mizuki published the artcileDivergent asymmetric total synthesis of all four pestalotin diastereomers from (R)-glycidol, Related Products of alcohols-buliding-blocks, the publication is Molecules (2020), 25(2), 394, database is CAplus and MEDLINE.

All four chiral pestalotin diastereomers were synthesized in a straightforward and divergent manner from common (R)-glycidol. Catalytic asym. Mukaiyama aldol reactions of readily-available bis(TMSO)diene (Chan’s diene) with (S)-2-benzyloxyhexanal derived from (R)-glycidol produced a syn-aldol adduct with high diastereoselectivity and enantioselectivity using a Ti(iOPr)₄/(S)-BINOL/LiCl catalyst. Diastereoselective Mukaiyama aldol reactions mediated by catalytic achiral Lewis acids directly produced not only a (1’S,6S)-pyrone precursor via the syn-aldol adduct using TiCl₄, but also (1’S,6R)-pyrone precursor via the antialdol adduct using ZrCl₄, in a stereocomplementary manner. A Hetero-Diels-Alder reaction of similarly available mono(TMSO)diene (Brassard’s diene) with (S)-2-benzyloxyhexanal produced the (1’S,6S)-pyrone precursor promoted by Eu(fod)₃ and the (1’S,6R)-pyrone precursor Et₂AlCl. Debenzylation of the (1’S,6S)-precursor and the (1’S,6R)-precursor furnished natural (-)-pestalotin (99% ee, 7 steps) and unnatural (+)-epipestalotin (99% ee, 7 steps), resp. Mitsunobu inversions of the obtained (-)-pestalotin and (+)-epipestalotin successfully produced the unnatural (+)-pestalotin (99% ee, 9 steps) and (-)-epipestalotin (99% ee, 9 steps), resp., in a divergent manner. All four of the obtained chiral pestalotin diastereomers possessed high chem. and optical purities (optical rotations, 1H-NMR, 13C-NMR, and HPLC measurements).

Molecules published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Su, Xinluona published the artcileDiffusion of phenolic compounds within high-silica MFI-type zeolite in the mesitylene solution, Category: alcohols-buliding-blocks, the publication is Microporous and Mesoporous Materials (2021), 111044, database is CAplus.

The intracrystalline diffusivity of phenolic compounds (phenol, p-propylphenol and m-cresol) and toluene within silicalite-1 and MFI-type zeolite with Si/Al = 303 (H-MFI) in the liquid phase (solvent: mesitylene) in the temperature range from 313 to 353 K were measured by using the constant volumetric method. The amounts of phenol, p-propylphenol, and toluene adsorbed onto silicalite-1 at 313, 323 and 353 K were approx. the same, whereas less m-cresol was adsorbed because of its larger kinetic diameter Unlike adsorbed toluene, adsorbed of phenol displayed stronger interactions in H-MFI than in silicalite-1, indicating that hydrogen bonding between the OH group of phenol and Bronsted acid sites in H-MFI enhanced the adsorption of phenol. Whereas the intracrystalline diffusivity of phenol, p-propylphenol, and toluene within silicalite-1 are approx. the same, m-cresol exhibited lower intracrystalline diffusivity, indicating that the intracrystalline diffusivity was governed by geometrical limitation. The intracrystalline diffusivity of phenol was lower within H-MFI with acid sites than within silicalite-1. The residence time of phenol on the acid sites became longer than that of toluene, which led to a difference in the intracrystalline diffusivity between phenol and toluene within H-MFI.

Microporous and Mesoporous Materials published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C20H17FO4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kobayashi, Yuka published the artcileLactate sensors based on con A/LOx multilayer-modified electrodes, Related Products of alcohols-buliding-blocks, the publication is Chemical Sensors (1997), 13(Suppl. B), 29-32, database is CAplus.

Proteins multilayers composed of Con A and lactate oxidase (LOx) were prepared on the surface of a platinum electrode to construct electrochem. enzyme sensors sensitive to L-lactate, by means of a specific affinity between Con A and mannose. For this purpose, LOx was modified with mannose residues covalently by treating with an excess amount of 4-isothiocyanatephenyl-α-D-mannopyranose. By this treatment LOx was tagged with several residues of mannose. Con A and the mannose-modified LOx were deposited on the surface of a platinum electrode alternately, by immersing the electrode in the solutions of Con A and enzyme. It was found that Con A/LOx multilayers are formed in this simple procedure. A gravimetric study using a quartz-crystal microbalance and a spectrophotometric study also suggested a formation of the Con A/LOx multilayers. The Con A/LOx multilayer-modified electrodes exhibited an amperometric response to 10^-6-3×10^-2 M L-lactate, the size of the output current being dependent on the number of the enzyme layers.

Chemical Sensors published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts