Author: tianli

Shiraki, Tadashi published the artcileMass treatment of trichuriasis with several anthelmintics, especially on the statistical criteria for the evaluation of egg-diminishing effects of the drug, Product Details of C28H29NO4, the publication is Acta Medica et Biologica (Niigata, Japan) (1973), 21(1), 11-27, database is CAplus.

A single oral dose of paromomycin sulfate [1263-89-4] (3g), tetrachlorethylene [127-18-4] (1.5 g), bithional [97-18-7] (1.5 g), biphenium hydroxynaphthoate [3818-50-6] (1.4 g), 1-bromo-2-naphthol [573-97-7] (4 g), piperazine [110-85-0] (3 g), and a santonin-kainic acid mixture [51990-05-7] (50 mg-5 mg) given to whipworm (Trichuris trichiura) infested school children gave a 60.0, 52.6, 42.9, 42.9, 33.4, 28.6, and 0% decrease, resp., in the number of eggs in stool samples. Tetrachloroethylene and 1-bromo-2-naphthol completely eliminated eggs from, respectively, 26.3 and 16.7% of the children treated.

Acta Medica et Biologica (Niigata, Japan) published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C4H4N2O2, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Eitzinger, Andreas published the artcileEnantioselective Bifunctional Ammonium Salt-Catalyzed Syntheses of 3-CF₃S-, 3-RS-, and 3-F-Substituted Isoindolinones, COA of Formula: C8H10S, the publication is Advanced Synthesis & Catalysis (2021), 363(7), 1955-1962, database is CAplus and MEDLINE.

Herein, ammonium salt-catalyzed synthesis of chiral 3,3-disubstituted isoindolinones, e.g., I bearing a heteroatom functionality in the 3-position was reported. A broad variety of differently substituted CF₃S- and RS-derivatives were obtained with often high enantioselectivities when using Maruoka’s bifunctional chiral ammonium salt catalyst. In addition, a first proof-of-concept for the racemic synthesis of the analogous F-containing products was obtained as well, giving access to one of the rare examples of a fairly stable α-F-α-amino acid derivative

Advanced Synthesis & Catalysis published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, COA of Formula: C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patil, Ujwal S. published the artcileCleavable ester-linked magnetic nanoparticles for labeling of solvent-exposed primary amine groups of peptides/proteins, Quality Control of 70539-42-3, the publication is Analytical Biochemistry (2015), 18-20, database is CAplus and MEDLINE.

To study the solvent-exposed lysine residues of peptides/proteins, we previously reported disulfide-linked N-hydroxysuccinimide ester-modified silica-coated iron oxide magnetic nanoparticles (NHS-SS-SiO₂@Fe₃O₄ MNPs). The presence of a disulfide bond in the linker limits the use of disulfide reducing agent during protein digestion and allows unwanted disulfide formation between the MNPs and protein. In the current work, the disulfide bond was replaced with a cleavable ester group to synthesize NHS ester-modified SiO₂@Fe₃O₄ MNPs. Use of the cleavable ester group provides an improved method for protein labeling and allows the use of disulfide reducing agents during protein digestion.

Analytical Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Quality Control of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chamorro-Arenas, Delfino published the artcileSelective, Catalytic, and Dual C(sp³)-H Oxidation of Piperazines and Morpholines under Transition-Metal-Free Conditions, Application In Synthesis of 622-40-2, the publication is Journal of Organic Chemistry (2018), 83(24), 15333-15346, database is CAplus and MEDLINE.

By using cheap and innocuous reagents, such as NaClO₂, NaOCl, and catalytic amounts of TEMPO, a new environmentally friendly protocol for the selective and catalytic TEMPO C(sp³)-H oxidation of piperazines and morpholines to 2,3-diketopiperazines (2,3-DKP) and 3-morpholinones (3-MPs), resp., has been developed. This novel direct access to 2,3-DKP from piperazines provides significant advantages over the traditional N-monoacylation/intramol. C-N cyclization procedure. Addnl., by modulating the amounts of TEMPO, 2-alkoxyamino-3-morpholinone can be prepared from morpholine derivatives, which would enable further functionalization at the C2 position of the morpholine skeleton.

Journal of Organic Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application In Synthesis of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lyle, Steven J. published the artcileMultistep Solid-State Organic Synthesis of Carbamate-Linked Covalent Organic Frameworks, COA of Formula: C6H13BO3, the publication is Journal of the American Chemical Society (2019), 141(28), 11253-11258, database is CAplus and MEDLINE.

Herein, we demonstrate the first example of a multi-step solid-state organic synthesis, in which a new imine-linked two-dimensional covalent organic framework (COF-170, 1) was transformed through three consecutive postsynthetic modifications into porous, crystalline cyclic carbamate and thiocarbamate-linked frameworks. These linkages are previously unreported and inaccessible through de novo synthesis. While not altering the overall connectivity of the framework, these chem. transformations induce significant conformational and structural changes at each step, highlighting the key importance of noncovalent interactions and conformational flexibility to COF crystallinity and porosity. These transformations were assessed using ¹⁵N multi-CP-MAS NMR spectroscopy, providing the first quantitation of yields in COF postsynthetic modification reactions, as well as of amine defect sites in imine-linked COFs. This multi-step COF linkage postsynthetic modification represents a significant step toward bringing the precision of organic solution-phase synthesis to extended solid-state compounds

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, COA of Formula: C6H13BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Michinobu, Tsuyoshi published the artcileSynthesis and properties of 1,8-carbazole-based conjugated copolymers, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Polymers (Basel, Switzerland) (2010), 2(3), 159-173, database is CAplus.

A new series of conjugated carbazole polymers based on the 1,8-carbazolylene unit was synthesized by the Pd-catalyzed polycondensation between the 1,8-diiodocarbazole derivative and various bifunctional counter comonomers. An alkyne spacer was found to be a key to increasing the mol. weight of the resulting polymers. All the obtained polymers showed good solubilities in the common organic solvents, and they were fully characterized by Gel permeation chromatog. (GPC), and ¹H NMR and IR spectroscopies. The UV-vis absorption and fluorescence spectra revealed the relationship between the chem. structure and effective conjugation length. The efficiency order of the carbazole connectivity was 2,7-carbazolylene > 1,8-carbazolylene > 3,6-carbazolylene. The electrochem. properties of these polymers suggested the relatively facile oxidation at ca. +0.5-0.7 V vs. Fc/Fc⁺ or a high potential as p-type semiconductors. The combination of the electrochem. oxidation potentials and the optical band gaps allowed us to estimate the HOMO and LUMO levels of the polymers. It was shown that the energy levels of the 1,8-carbazole-based conjugated polymers can be tunable by selecting the appropriate comonomer structures.

Polymers (Basel, Switzerland) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Katane, Masumi published the artcileIdentification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Journal of Medicinal Chemistry (2013), 56(5), 1894-1907, database is CAplus and MEDLINE.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rodriguez-Alba, Efrain published the artcileDesign of novel well-defined oligothiophenes bearing donor-acceptor groups (pyrene-porphyrin): Synthesis, characterization, optical properties and energy transfer, Quality Control of 239075-02-6, the publication is Journal of Molecular Structure (2019), 28-36, database is CAplus.

Novel thiophene monomers containing porphyrin units attached via di(ethylene glycol) and tetra(ethylene glycol) spacers were synthesized: 3-methyl-4-(4-(1-(5-phenyl-10,15,20-triphenylporphyrin)) diethoxy) thiophene (M2PPh) and 3-methyl-4-(4-(1-(5-phenyl-10,15,20-triphenylporphyrin)) tetraethoxy) thiophene (M4PPh). These monomers and other co-monomers with pyrene units 3-methyl-4-(diethoxy) thiophene (M2) and 3-methyl-4-(tetraethoxy) thiophene (M4) previously reported by us, were linked to thiophene and bithiophene via a Suzuki coupling reaction to give the corresponding terthiophenes and quaterthiophenes: [3-diethoxypyrene, 3-diethoxyporphyrin, 4,4”’ di-Me – 2,2:5’2″- terthiophene (TT2PY-PPh)], [3-tetraethoxypyrene, 3-tetraethoxyporphyrin, 4, 4”’dimethyl-2,2:5’2″-terthiophene (TT4PY-PPh)], [3′-diethoxypyrene, 3′-diethoxyporphyrin, 4,4”’methyl-2,2′:5′:2”:5”,2”’-quaterthiophene (QT2PY-PPh)], and [3′-tetraethoxypyrene, 3′-tetraethoxyporphyrin,4,4”’methyl-2,2′:5′:2”:5”,2”’-quaterthiophene (QT4PY-PPh)]. The synthesized compounds were characterized by ¹H NMR, ¹³C NMR and MALDI-TOF mass spectrometry; their optical properties were studied by absorption and fluorescence spectroscopy. The emission spectra of the oligothiophenes bearing pyrene-porphyrin units showed a significant decrease in the pyrene monomer emission and the appearance of a new emission band at 650 nm, arising from the porphyrin, which revealed that a FRET phenomenon is occurring from the excited pyrene to the porphyrin. The obtained FRET efficiencies were between 93 and 98% depending on the oligomer structure.

Journal of Molecular Structure published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rodriguez-Alba, Efrain published the artcileSynthesis, characterization and optical properties of novel oligothiophenes bearing pyrene units attached via well defined oligo(ethylene glycol) spacers, Quality Control of 239075-02-6, the publication is Synthetic Metals (2015), 92-105, database is CAplus.

Two new thiophene monomers bearing pyrene units attached via di(ethylene glycol) and tetra(ethylene glycol) spacers were synthesized, 3-methyl-4-(diethoxy) thiophene (M2) and 3-methyl-4-(tetraethoxy) thiophene (M4). These monomers were linked to thiophene and bithiophene via a Suzuki coupling reaction to give the corresponding terthiophenes and quaterthiophenes: [3,3-(di (diethoxypyrene)), 4,4”’dimethyl-2,2: 5#14-15#-terthiophene (TT2)], [3,3-(di(tetraethoxypyrene)), 4,4”’dimethyl-2,2:5#14-15#-terthiophene (TT4)], [3,3”’-di(diethoxypyrene), 4,4”’methyl-2,2′:5′: 2”:5”,2”’-quaterthiophene (QT2)], and [3,3”’-di(tetraethoxypyrene), 4,4”’methyl -2,2′:5′:2”:5”,2”’-quaterthiophene (QT4)]. The obtained oligothiophenes were characterized by ¹H, ¹³C NMR spectroscopies and MALDI-TOF mass spectrometry. The optical properties of these compounds were studied by absorption and fluorescence spectroscopy. The absorption spectra of these compounds exhibited a broad absorption band at λ_max = 350 nm arising from the S₀ → S₂ transition of the pyrene group. This broadening is an indication of the presence of pyrene-pyrene interactions in the ground state. A discrete band at ca λ = 385 due to the S₀ → S₁ transition (n-π*) of the oligothiophene backbone was also observed The emission spectra of oligomers TT2, TT4, QT2 and QT4 showed a “monomer emission” band at λ_M = 379-450 nm followed by an intense excimer emission band at λ_E = 570 nm due to intramol. pyrene-pyrene interactions. The effect of the flexible spacer length and that of the oligomer backbone influences significantly the formation of pyrene-pyrene complexes.

Synthetic Metals published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sorrentino, Jacob P. published the artcileAcid-Catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers, Recommanded Product: 2-Phenylethanethiol, the publication is Journal of Organic Chemistry (2021), 86(3), 2297-2311, database is CAplus and MEDLINE.

The substitution of hydrogen atoms with fluorine in bioactive mols. can greatly impact physicochem., pharmacokinetic, and pharmacodynamic properties. However, current synthetic methods cannot readily access many fluorinated motifs, which impedes utilization of these groups. Thus, the development of new methods to introduce fluorinated functional groups was critical for developing the next generation of biol. probes and therapeutic agents. The synthesis of one such substructure, the α,α-difluoroalkylthioether, typically requires specialized conditions that necessitate early-stage installation. A late-stage and convergent approach to access α,α-difluoroalkylthioethers could involve nucleophilic addition of thiols across gem-difluorostyrenes. Unfortunately, under basic conditions, nucleophilic addition to gem-difluorostyrenes generates an anionic intermediate that can undergo facile elimination of fluoride to generate α-fluorovinylthioethers. To overcome this decomposition,acid-based catalyst system to facilitate simultaneous nucleophilic addition and protonation of the unstable intermediate. Ultimately, the optimized mild conditions afford the desired α,α-difluoroalkylthioethers in high selectivity and moderate to excellent yields. These α,α-difluoroalkylthioethers were less nucleophilic and more oxidatively stable relative to nonfluorinated thioethers, suggesting the potential application of this unexplored functional group in biol. probes and therapeutic agents.

Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C3H5F3O, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts