Author: tianli

Nischang, Ivo published the artcileHydrodynamic Analysis Resolves the Pharmaceutically-Relevant Absolute Molar Mass and Solution Properties of Synthetic Poly(ethylene glycol)s Created by Varying Initiation Sites, Product Details of C12H20O6, the publication is Analytical Chemistry (Washington, DC, United States) (2017), 89(2), 1185-1193, database is CAplus and MEDLINE.

The solution behavior originating from mol. characteristics of synthetic macromols. plays a pivotal role in many areas, in particular the life sciences. This situation necessitates the use of complementary hydrodynamic anal. methods as the only means for a complete structural understanding of any macromol. in solution To this end, we present a combined hydrodynamic approach for studying inhouse prepared, low dispersity poly(ethylene glycols)s (PEGs), also known as poly (ethylene oxide)s (PEOs) depending on the classification used, synthesized from varying initiation sites by living anionic ring opening polymerization The series of linear PEGs in the molar mass range of only a few thousand to 50 000 g mol-1 were studied in detail via viscometry, and sedimentation-diffusion anal. by anal. ultracentrifugation. The obtained estimations for intrinsic viscosity, diffusion coefficients, and sedimentation coefficients of the macromols. in the solution-based anal. clearly showed self-consistency of the followed hydrodynamic approach. This self-consistency is underpinned by appropriate and phys.-sound values of hydrodynamic invariants, indicating adequate values of derived absolute molar masses. The classical scaling relations of Kuhn-Mark-Houwink-Sakurada of all molar-mass dependent hydrodynamic estimates show linear trends, allowing for interrelation of all parametric macromol. characteristics. Differences among these are ascribed to the observation of α-end and chain-length dependent solvation of the macromols., identified from viscometric studies. This important information al-lows for anal. tracing of variations of scaling relationships and a phys.-sound estimation of hydrodynamic characteristics. The demonstrated self-sufficient methodol. paves an important way for a complete structural understanding and potential replacement of pharmaceutically-relevant PEGs by alternative macromols. offering a suite of similar or tractably distinct physicochem. properties.

Analytical Chemistry (Washington, DC, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Bhavesh H. published the artcileCommon origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism, Synthetic Route of 6346-09-4, the publication is Nature Chemistry (2015), 7(4), 301-307, database is CAplus and MEDLINE.

A minimal cell can be thought of as comprising informational, compartment-forming and metabolic subsystems. To imagine the abiotic assembly of such an overall system, however, places great demands on hypothetical prebiotic chem. The perceived differences and incompatibilities between these subsystems have led to the widely held assumption that one or other subsystem must have preceded the others. Here we exptl. investigate the validity of this assumption by examining the assembly of various biomol. building blocks from prebiotically plausible intermediates and one-carbon feedstock mols. We show that precursors of ribonucleotides, amino acids and lipids can all be derived by the reductive homologation of hydrogen cyanide and some of its derivatives, and thus that all the cellular subsystems could have arisen simultaneously through common chem. The key reaction steps are driven by UV light, use hydrogen sulfide as the reductant and can be accelerated by Cu(I)-Cu(II) photoredox cycling.

Nature Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xin-ni published the artcileEfficacy of preventive intrauterine injection of carboprost tromethamine in cesarean section of pregnant women with critical risk of postpartum hemorrhage, SDS of cas: 58551-69-2, the publication is Guangdong Yixue (2012), 33(5), 696-697, database is CAplus.

Objective: To observe the clin. efficacy of preventive intrauterine injection of carboprost tromethamine in cesarean section of pregnant women with critical risk of postpartum hemorrhage. Methods: Ninety-eight critical pregnant women receiving cesarean section with probability of postpartum hemorrhage were divided into an observation group (n=50) and a control group (n=48). The patients in the observation group were given conventional intrauterine injection of oxytocin and carboprost tromethamine for prevention of postpartum hemorrhage after parturition, and the patients in the control group were given oxytocin, misoprostol, pituitrin and calcium gluconate. The indexes of 2, 24 h hemorrhage volume, incidence of postpartum hemorrhage, hemostasis time, transfusion rate and complications in long or short term were compared between the two groups after parturition. Results: The 2, 24 h hemorrhage volume, incidence of postpartum hemorrhage, hemostasis time, transfusion rate and uterectomy rate in the observation group were significantly lower compared with the control group (P<0.05). Conclusion: Preventive intrauterine injection of carboprost tromethamine in cesarean section reduces hemorrhage volume, decreases the incidence of postpartum hemorrhage, transfusion rate and complications in long and short term for pregnant women with critical risk of postpartum hemorrhage, and the earlier of time selection, the better of the efficacy, which is valuable to popularize in basis hospitals.

Guangdong Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H10BNO3, SDS of cas: 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tong, Zhou published the artcileCu(I)-Catalyzed C-H Alkenylation of Tertiary C(sp³)-H Bonds of 3-Aryl Benzofuran-2(3H)-ones to Give Z- and E-Styrene Containing Quaternary Carbon Centers with 99/1 Regioselectivity, Computed Properties of 90-64-2, the publication is Journal of Organic Chemistry (2022), 87(9), 6064-6074, database is CAplus and MEDLINE.

The synthesis of isomerically pure olefins containing all-carbon quaternary centers is a challenging issue. Herein, authors developed an efficient protocol for the synthesis of (Z)-olefins (27 examples, yield up to 97%, Z/E up to 99/1) and (E)-olefins (16 examples, yield up to 94%, E/Z up to 99/1) containing all-carbon quaternary centers. This protocol is adopted for the copper-catalyzed regioselective C-H alkenylation of the tertiary C(sp³)-H bond of 3-aryl benzofuran-2(3H)-ones with alkyne and alkenes. A diverse range of functional groups in the substrates is well-tolerated, such as F, Cl, Br, Me, OMe, ester, CF₃, etc. A gram scale experiment was performed in good yield, and the radical mechanisms are also proposed based on the control experiments

Journal of Organic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C9H9BO2, Computed Properties of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, Fucheng published the artcileRhodium(III)-catalyzed Cleavage of C-C Bond and C-H Bond Cascaded by Michael Addition for the Conversion of α-Hydroxy Ketones to Phthalides and Isocoumarins, Name: 2-Hydroxy-2-phenylacetic acid, the publication is Asian Journal of Organic Chemistry (2022), 11(4), e202200024, database is CAplus.

A protocol for Rh(III)-catalyzed cleavage of C-C bond and C-H bond cascaded by Michael addition of α-hydroxy ketones was established. The method allows the rapid construction of phthalides and isocoumarins skeleton. A total of 62 phthalides and isocoumarins were obtained with yields up to 91% demonstrating the broad applicability of the protocol. This efficient cascade catalysis can be applied to the total synthesis of the natural products isoochracinic acid and sparstolonin B. The reaction mechanism, especially the dimerization process of the α-hydroxyketone, is unique. Further studies of the reaction using control experiments, in situ NMR anal., cyclic voltammogram and isotope tracking experiments have provided insight into the reaction mechanism.

Asian Journal of Organic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C4H6O3, Name: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Qiu-hong published the artcileClinical effect of the combined application of carboprost tromethamine injection and gauze on patients with previa placenta underwent cesarean section, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Linchuang Yixue (2016), 36(2), 24-25, database is CAplus.

The aim of this paper is to investigate the clin. effects of combined application of Carboprost tromethamine injection and gauze on patients with previa placenta underwent cesarean section. From March 2013 to March 2015, forty-two patients with previa placenta underwent cesarean section were selected in the sixth people’s hospital of Nanhai district, all patients were randomly divided into observation group and control group. The patients in observation group were given Carboprost tromethamine injection and gauze to stop bleeding, while the patients in control group were managed with gauze only. The operation situations(bleeding volume, operation time, transfusion rate, and uterus resection rate), the bleeding volume after operation(2 h, 4 h, 8 h, 12 h), and adverse effects after operation of the two groups were observed The bleeding volume in operation of observation group and control group was resp.(361.3±69.9) ml vs. (552.0±59.6) ml, and there was significant difference(P<0.05). No significant difference was observed in operation time, transfusion rate, uterus resection rate or adverse effects after operation between the two groups(P>0.05). The effects of hemostasis of the combined application of carboprost tromethamine injection and gauze are better than gauze only on patients with previa placenta underwent cesarean section.

Linchuang Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Straker, R. N. published the artcileComputational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Nature Communications (2016), 10109, database is CAplus and MEDLINE.

Many diastereoselective (substrate stereocontrol), and enantioselective (catalyst stereocontrol) cycloisomerizations was developed. However, asym. cycloisomerizations where a chiral catalyst specifies the stereochem. outcome of the cyclization of a single enantiomer substrate-regardless of its inherent preference-were unknown. A combined theor. and exptl. approach enables the design of a highly reactive rhodium catalyst for the stereoselective cycloisomerization of ynamide-vinylcyclopropanes to [5.3.0]-azabicycles was showed. Highly diastereoselective cycloisomerizations using an achiral catalyst, and then explored phosphoramidite-complexed rhodium catalysts in the enantioselective variant, where theor. investigations uncovered an unexpected reaction pathway in which the electronic structure of the phosphoramidite dramatically influences reaction rate and enantioselectivity was established. A marked enhancement of both was observed using the optimal theory-designed ligand, which enabled double stereodifferentiating cycloisomerizations in both matched and mismatched catalyst-substrate settings.

Nature Communications published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C20H22ClN3O3, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaozhou published the artcileKlebsiella sp. PD3, a phenanthrene (PHE)-degrading strain with plant growth promoting properties enhances the PHE degradation and stress tolerance in rice plants, SDS of cas: 86-48-6, the publication is Ecotoxicology and Environmental Safety (2020), 110804, database is CAplus and MEDLINE.

Phenanthrene (PHE) is harmful to human health and is difficult to be eliminated from environment. In this study, an aerobic bacterium capable of use PHE as a sole carbon source and energy was isolated and classified as Klebsiella sp. PD3 according to 16S rDNA anal. The degradation efficiency of PHE reached to about 78.6% after 12 days of incubation with strain PD3. Identification of metabolites formed during PHE degradation process by this strain was carried out by GC-MS. The first degradation step of PHE by PD3 was proposed to generate 1-hydroxy-2-naphthoic acid. PD3 significantly improved growth performance, biomass production, seed germination rate, photosynthetic capacity, antioxidant levels, relative water content and chlorophyll accumulation in rice (Oryza sativa L.) plants under PHE stress conditions in comparison with non-inoculation treatment. Moreover, PD3-inoculated rice showed lower ROS accumulation, ethylene production, ACC content, ACC oxidase activity and electrolyte leakage under PHE treatment compared to non-inoculated ones. The combination use of rice plants and strain PD3 was also shown to enhance the removal efficiency of PHE from the soil and decline the PHE accumulation in plants. Synergistic use of plants and bacteria with PHE degradation ability and PGPR attributes to remediate the PHE-contaminated soil will be an important and effective way in the phytoremediation of PHE-contaminated soils.

Ecotoxicology and Environmental Safety published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gagauzov, I. published the artcileDerivatives of 1,3-dimethylxanthine. I. Direct condensation of 1,3-dimethylxanthine with alkanolamines, Safety of 2-(Benzyl(methyl)amino)ethanol, the publication is Farmatsiya (Sofia, Bulgaria) (1977), 27(2), 1-6, database is CAplus.

Direct condensation of theophylline (I) with 1 equivalent HOCH₂CH2NRR¹ (R = Me, Et, Pr, Bu, CH₂CH₂CHMe₂, CH₂Ph, CH₂CH₂OH, CH₂CH₂OAc, CH₂CH₂OBz; R¹ = CH₂Ph, CH₂CH₂OH, CH₂CH₂OAc, CH₂CH₂OBz, CH₂CH₂O₂CH:CHPh) at 250-320° in a salt bath 50-90 min gave resinous II, which were taken up in EtOH and precipitated as the tartrates or saccharinates in 42-74% yield. The salts were H₂O-soluble and had bronchodilating, antihistaminic and diuretic effects, but were more toxic than I.

Farmatsiya (Sofia, Bulgaria) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Safety of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Empel, Claire published the artcileProton or Carbene Transfer? On the Dark and Light Reaction of Diazoalkanes with Alcohols, HPLC of Formula: 2240-88-2, the publication is Chemistry – A European Journal (2022), 28(15), e202104397, database is CAplus and MEDLINE.

A fundamental understanding of the reaction of diazoalkanes with alcs. to made this transformation amenable to a generalized approach towards formal alkylation reactions of alcs. with diazoalkanes was aimed. Exptl. and theor. studies suggested a direct proton transfer only in exceptional cases. In a more general setting, such O-H functionalization proceeded both under dark and photochem. conditions via a key hydrogen-bonded singlet carbene intermediate that underwent a protonation-addition mechanism. Applications of this approach in O-H functionalization reactions of alcs., including simple fluorinated, halogenated and aliphatic alcs. and showcase functional-group tolerance of this method in the reaction of biol. active and pharmaceutically relevant alcs. was concluded.

Chemistry – A European Journal published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, HPLC of Formula: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts