Author: tianli

Itoh, Hiroshi published the artcileUV absorption of n-alkyl 1-thio-β-D-glucopyranosides and its utilization in chromatographic separation, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Tetrahedron Letters (2017), 58(37), 3678-3680, database is CAplus.

The UV absorption of n-alkyl β-D-glucopyranosides was not used so far for their detection which is usually performed by the refractive index detector. The authors demonstrate the HPLC separation of several n-alkyl β-D-glucopyranosides with linear gradient by using UV detector and support the authors’ findings with time-dependent d. functional theory calculations

Tetrahedron Letters published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sokolova, Daria published the artcileEnantioselective Tail-to-Head Terpene Cyclizations by Optically Active Hexameric Resorcin[4]arene Capsule Derivatives, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Angewandte Chemie, International Edition (2022), 61(25), e202203384, database is CAplus and MEDLINE.

Mol. capsules enabled the conversion of substrates inside a closed cavity, mimicking to some extent enzymic catalysis. Chirality transfer from the mol. capsule onto the encapsulated substrate was only studied in a few cases. Here the chirality transfer was possible inside a rather large mol. container of approx. 1400 S3 was demonstrated. Specifically, the first examples of optically active hexameric resorcin[4]arene capsules such as I [R = Et, n-Pr, n-Bu], their ability to enantioselectively catalyze tail-to-head terpene cyclizations, and the surprisingly high sensitivity of enantioselectivity on the structural modifications was presented.

Angewandte Chemie, International Edition published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C7H6O3, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Uroz, Stephane published the artcileDual transcriptomics and proteomics analyses of the early stage of interaction between Caballeronia mineralivorans PML1(12) and mineral, Computed Properties of 526-98-7, the publication is Environmental Microbiology (2020), 22(9), 3838-3862, database is CAplus and MEDLINE.

Summary : Minerals and rocks represent essential reservoirs of nutritive elements for the long-lasting functioning of forest ecosystems developed on nutrient-poor soils. While the presence of effective mineral weathering bacteria was evidenced in the rhizosphere of different plants, the mol. mechanisms involved remain uncharacterized. To fill this gap, we combined transcriptomic, proteomics, geo-chem. and physiol. analyses to decipher the potential mol. mechanisms explaining the mineral weathering effectiveness of strain PML1(12) of Caballeronia mineralivorans. Considering the early-stage of the interaction between mineral and bacteria, we identified the genes and proteins differentially expressed when: (i) the environment is depleted of certain essential nutrients (i.e., Mg and Fe), (ii) a mineral is added and (iii) the carbon source (i.e., glucose vs mannitol) differs. The integration of these data demonstrates that strain PML1(12) is capable of (i) mobilizing iron through the production of a non-ribosomal peptide synthetase-independent siderophore, (ii) inducing chemotaxis and motility in response to nutrient availability and (iii) strongly acidifying its environment in the presence of glucose using a suite of GMC oxidoreductases to weather mineral. These results provide new insights into the mol. mechanisms involved in mineral weathering and their regulation and highlight the complex sequence of events triggered by bacteria to weather minerals.

Environmental Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C3H5BN2O2, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pan, Haijuan published the artcileObservation on effect of carboprost tromethamine in prevention of postoperative bleeding during cesarean section with placenta previa, Quality Control of 58551-69-2, the publication is Guizhou Yiyao (2021), 45(7), 1064-1065, database is CAplus.

Objective: To investigate the effect of carboprost tromethamine in the prevention of postoperative bleeding during cesarean section with placenta previa. Methods: A controlled study was conducted on 88 puerperae with placenta previa who underwent cesarean section in our hospital from 2017.5 to 2019.5, and they were divided into observation group (carboprost tromethamine) and control group (oxytocin) 44 cases in each group, and the grouping method was random number table method to explore the effect of different treatments on postpartum hemorrhage and adverse reactions of puerperae. Results: The research objects in this paper were compared in terms of intraoperative blood loss, postoperative 12-h blood loss and postoperative 24-h blood loss. The observation group was significantly lower than the control group, and the difference was statistically significant (P < 0.05). Compared with the total effective rate, the observation group (97.73%) was significantly higher than the control group (86.36%), and the difference was statistically significant (P < 0.05). The observation group (2.27%, 9.09%) was significantly lower than the control group (15.91%, 27.27%), and the difference was statistically significant (P < 0.05). CONCLUSION: The application of carboprost tromethamine to pregnant women undergoing cesarean section with placenta previa could significantly reduce intraoperative and postoperative blood loss, with definite curative effect, less adverse reactions and high safety. This method was worthy of application and promotion.

Guizhou Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lowenthal, Mark S. published the artcileDeveloping qualitative LC-MS methods for characterization of Vaccinium berry Standard Reference Materials, HPLC of Formula: 526-98-7, the publication is Analytical and Bioanalytical Chemistry (2013), 405(13), 4451-4465, database is CAplus and MEDLINE.

Standard Reference Materials (SRMs) offer the scientific community a stable and homogeneous source of material that holds countless application possibilities. Traditionally, the National Institute of Standards and Technol. (NIST) has provided SRMs with associated quant. information (certified values) for a select group of targeted analytes as measured in a solution or complex matrix. While the current needs of the SRM community are expanding to include non-quant. data, NIST is attempting to broaden the scope of how and what information is offered to the SRM community by providing qual. information about biomaterials, such as chromatog. fingerprints and profiles of untargeted identifications. In this work, metabolomic and proteomic profiling efforts were employed to characterize a suite of six Vaccinium berry SRMs. In the discovery phase, liquid chromatog.-tandem mass spectrometry (LC-MS/MS) data was matched to mass spectral libraries; a subsequent validation phase based on multiple-reaction monitoring LC-MS/MS relied on both retention time matching of authentic standards along with fragmentation data for a qual. overview of the most prominent organic compounds present. Definitive and putative identifications were determined for over 70 metabolites based on reporting guidelines set forth by the Metabolomics Standards Initiative (Metabolomics 3(3):211-221, 2007), and the capability of electrospray ionization mass spectrometry (ESI-MS) to profile untargeted metabolites within a complex matrix using mass spectral matching is demonstrated. Bottom-up proteomic analyses were possible using peptide databases translated from expressed sequence tags (ESTs). Homol. searches provided identification of novel Vaccinium proteins based on homol. to related genera. Chromatog. fingerprints of these berry materials were acquired for supplemental qual. information to be provided to users of these SRMs. An unbounded set of qual. data about a biomaterial is a valuable complement to quant. information traditionally provided in NIST Certificates of Anal.

Analytical and Bioanalytical Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zeng, Zhuo published the artcilePolyfluoroalkyl, Polyethylene Glycol, 1,4-Bismethylenebenzene, or 1,4-Bismethylene-2,3,5,6-Tetrafluorobenzene Bridged Functionalized Dicationic Ionic Liquids: Synthesis and Properties as High Temperature Lubricants, Quality Control of 129301-42-4, the publication is Chemistry of Materials (2008), 20(8), 2719-2726, database is CAplus.

A new class of geminal dicationic ionic liquids was formed with a bridging moiety, such as a polyalkyl ether, polyfluoroalkyl, 1,4-bismethylenebenzene, or 1,4-bismethylene-2,3,5,6-tetrafluorobenzene link, between alkyl-substituted imidazolium rings. Their properties were modified by varying the linker chains and/or alkyl substituents on the imidazolium ring. The polyfluoroalkyl bridged dicationic ionic liquids exhibit the highest densities and viscosities. Although m.ps. are directly proportional to the length of the alkyl substituent, the densities decrease concomitantly. With 1,4-bismethylene-2,3,5,6-tetrafluorobenzene as the linking chain and with longer alkyl substituents on the imidazolium rings, the nonpolar character of the ionic liquid greatly increases, e.g., the solubilities in toluene of dicationic ionic liquids 36 and 37, where the ring substituents are C₁₀H₂₁ and C₁₄H₂₉, increase markedly. Some of the salts exhibit higher conductivities than an equimolar tetrabutylammonium iodide solution in acetonitrile/toluene. These new ionic liquids (except with PF₆^– as anion) display outstanding tribol. properties in temperature ramp tests by performing very well at 300 °C, thus meeting one criterion for high-temperature lubricants.

Chemistry of Materials published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C2H4ClNO, Quality Control of 129301-42-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ramurthy, Savithri published the artcileDiscovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors, Computed Properties of 371-99-3, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(4), 126930, database is CAplus and MEDLINE.

Glycogen synthase kinase-3 plays an essential role in multiple biochem. pathways in the cell, particularly in regards to energy regulation. As such, Glycogen synthase kinase-3 is an attractive target for pharmacol. intervention in a variety of disease states, particularly non-insulin dependent diabetes mellitus. However, due to homol. with other crucial kinases, such as the cyclin-dependent protein kinase CDC2, developing compounds that are both potent and selective is challenging. A novel series of derivatives of 5-nitro-N2-(2-(pyridine-2-ylamino)ethyl)pyridine-2,6-diamine were synthesized and potently inhibit glycogen synthase kinase-3 (GSK3). Potency in the low nanomolar range was obtained along with remarkable selectivity. The compounds activate glycogen synthase in insulin receptor-expressing CHO-IR cells and in primary rat hepatocytes, and have acceptable pharmacokinetics and pharmacodynamics to allow for oral dosing. The x-ray co-crystal structure of human GSK3-β in complex with compound 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one is reported and provides insights into the structural determinants of the series responsible for its potency and selectivity.

Bioorganic & Medicinal Chemistry Letters published new progress about 371-99-3. 371-99-3 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2-((2,2,2-Trifluoroethyl)amino)ethanol, and the molecular formula is C4H8F3NO, Computed Properties of 371-99-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kochansky, Jan published the artcileScreening additional antibiotics for efficacy against American foulbrood, Category: alcohols-buliding-blocks, the publication is Journal of Apicultural Research (2005), 44(1), 24-28, database is CAplus.

The sensitivity of Paenibacillus larvae larvae (American foulbrood, AFB) to 35 antibiotics and synthetic antimicrobials, including two previously reported, was investigated. All compounds but one are currently approved by the US Food and Drug Administration for agricultural uses. The most active approved antibiotics screened were pirlimycin, tiamulin, and the polyether ionophores, particularly narasin, lasalocid, salinomycin, laidlomycin, and maduramicin. Pirlimycin and tiamulin show high activity in vitro, but share the mode of action of tylosin and lincomycin (inhibition of ribosomal peptide synthesis), and therefore have no advantage over it. While the ionophores have high in vitro activity and a completely different mode of action (interference with cation transport across cell membranes) and therefore seemed to represent potential alternative treatments for AFB, they were inactive in the field.

Journal of Apicultural Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ryba, O. published the artcileAntioxidants and stabilizers. IV. Influence of structure on polarographic half-wave potentials of alkylated hydroquinones, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Collection of Czechoslovak Chemical Communications (1965), 30(3), 843-52, database is CAplus.

cf. CA 60, 6772f, 7429d; 61, 5545d. E_1/2 values were determined with a dropping Hg electrode for hydroquinone and for its 21 alkyl derivatives in acetate buffer solutions in 50% EtOH, and were tabulated. The slope of the polarographic waves corresponded to a reversible 2-electron oxidation Substitution in the 2-or 2,5-positions caused a shift of E_1/2 towards neg. values; this shift is a linear function of the sum of steric substitution constants With substitution in the 2,6-positions, the influence of individual substituents is not additive. 37 references.

Collection of Czechoslovak Chemical Communications published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Recommanded Product: 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ryba, O. published the artcileAntioxidants and stabilizers. VII. Influence of structure on polarographic half-wave potentials of alkylated pyrocatechols, Related Products of alcohols-buliding-blocks, the publication is Collection of Czechoslovak Chemical Communications (1965), 30(7), 2157-63, database is CAplus.

cf. CA 63, 10648b. The influence of substituents in various positions in pyrocatechol on E_1/2 values was discussed in terms of polar, mesomeric, and steric effects of these groups. The pyrocatechol derivatives yielded best developed polarographic waves in acetate buffers, the dependence of E_1/2 on pH being the same for all substances studied: E_1/2 = E₀ – 0.059 pH at 25°. The E₀ values were determined with an accuracy of ±2 mv. and tabulated. The logarithmic analysis of the waves indicates a reversible 2-electron oxidation 20 references.

Collection of Czechoslovak Chemical Communications published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts