Author: tianli

Felix e Silva, Altiery published the artcileAntibacterial and antibiofilm activities and synergism with florfenicol from the essential oils of Lippia sidoides and Cymbopogon citratus against Aeromonas hydrophila, HPLC of Formula: 106-25-2, the publication is Journal of Applied Microbiology (2022), 132(3), 1802-1812, database is CAplus and MEDLINE.

Aeromonas hydrophila is an opportunistic bacterium, with a high capacity for biofilm production, which can cause severe damage in aquaculture. The objective of this study was to identify the chem. compounds of the essential oils of Lippia sidoides (EOLS) and Cymbopogon citratus (EOCC), and to evaluate the biocidal, antibiofilm and synergistic action with the antimicrobial florfenicol of these essential oils (EOs) against A. hydrophila. The antibacterial activity of EOLS and EOCC was verified by the min. bactericidal concentration and by the action of these EOs against both forming and consolidated biofilms. The synergistic activity of EOs with florfenicol was performed using the checkerboard technique. The main component of EOLS and EOCC was carvacrol (44.50%) and α-citral (73.56%), resp. Both EOs showed weak inhibitory activity (≥3125.00 μg ml-1). Two bacterial isolates were able to produce biofilm, and EOLS and EOCC acted upon the bacterial isolates to prevent biofilm formation. A bactericidal effect was verified for EOLS in the previously consolidated biofilm for both isolates and for EOCC in only one of the isolates. In general, EOLS had a synergistic effect with florfenicol, while EOCF had an additive effect. Both EOs were able to interfere with biofilm formation and did not have an antagonistic effect in combination with florfenicol. The best results were found for EOLS, which showed a synergistic effect with florfenicol and the ability to interfere in the formation of consolidated biofilm. This study highlights the potential of EOLS and EOCC to interfere in biofilm and act in synergy with florfenicol to reduce the occurrence of A. hydrophila. Development of these compounds may contribute to the development of herbal medicines in aquaculture.

Journal of Applied Microbiology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, HPLC of Formula: 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Feng published the artcileAlkanolamines as activators in no-clean flux systems: investigation of humidity robustness and solderability, Recommanded Product: Triisopropanolamine, the publication is Journal of Materials Science: Materials in Electronics (2021), 32(4), 4961-4981, database is CAplus.

This paper systematically investigates the humidity robustness and solderability of five alkanolamines used as activators in flux systems, and their effect was assessed along with the influence of soldering temperature Electrochem. impedance spectroscopy and chronoamperometry techniques were used to obtain a better understanding of water adsorption, absorption, and protonation tendencies of alkanolamine candidates. Potentiodynamic polarization, hot plate spreading test, and wetting balance test were adapted for the etching ability and solderability evaluation. Thermal degradation of alkanolamine compounds was analyzed using thermogravimetric anal. (TGA) and Fourier-transform IR spectroscopy (FT-IR). The combined results indicate a strong water absorption and protonation of diethanolamine (DEA), triethanolamine (TEA), and triisopropanolamine (TIPA), rendering them not reliable and not feasible as activators. Poor solderability of alkanolamine-based fluxes was inferred based on their thermal degradation behavior and poor oxide removal ability under the soldering conditions.

Journal of Materials Science: Materials in Electronics published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Munoz-Gonzalez, Rodrigo published the artcileElucidation of antimicrobial and antioxidant activities of selected plant-based mayonnaise-derived essential oils against lactic acid bacteria, Formula: C10H18O, the publication is Journal of Food Processing and Preservation (2022), 46(3), e16339, database is CAplus.

There is significant growth in the market for plant-based products at the com. level in recent times. One of the biggest challenges of this industry is to find consumer-approved natural preservatives that can control the microorganism proliferation found in plant-based products. In this study, we investigated the antimicrobial and antioxidant activities of several essential oils against Lactobacillus parabuchneri, a lactic acid bacterium found in plant-based mayonnaise. We show that the oregano-derived essential oil had the highest in vitro and in food antimicrobial activity against L. parabuchneri and had minimal impact on the organoleptic properties of mayonnaise. Physicochem. anal. of the oils revealed volatile compounds to be the most prominent ingredients. Addnl., the clove and cinnamon essential oils showed the highest antioxidant activity, which could be attributed to their degrees of phenolic content. These results collectively indicated the potential application of essential oils as preservatives for plant-based mayonnaises. Novelty impact statement : The market for plant-based products is growing sustained and consumers are increasingly concerned with quality and demand clean labeling. The present research shows an alternative based on essential oils for the control of lactic acid bacteria in mayonnaise-like dressings to avoid deterioration and offer a clean label.

Journal of Food Processing and Preservation published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonec, Tomas published the artcileAntistaphylococcal Activities and ADME-Related Properties of Chlorinated Arylcarbamoylnaphthalenylcarbamates, Name: 1-Hydroxy-2-naphthoic acid, the publication is Pharmaceuticals (2022), 15(6), 715, database is CAplus and MEDLINE.

Pattern 1-hydroxy-N-(2,4,5-trichlorophenyl)-2-naphthamide and the thirteen original carbamates derived from it were prepared and characterized. All the compounds were tested against Staphylococcus aureus ATCC 29213 as a reference and quality control strain and in addition against three clin. isolates of methicillin-resistant S. aureus (MRSA). Moreover, the compounds were evaluated against Enterococcus faecalis ATCC 29212, and preliminary in vitro cytotoxicity of the compounds was assessed using the human monocytic leukemia cell line (THP-1). The lipophilicity of the prepared compounds was exptl. determined and correlated with biol. activity. While pattern anilide had no antibacterial activity, the prepared carbamates demonstrated high antistaphylococcal activity comparable to the used standards (ampicillin and ciprofloxacin), which unfortunately were ineffective against E. feacalis. 2-[(2,4,5-Trichlorophenyl)carba- moyl]naphthalen-1-yl ethylcarbamate (2) and 2-[(2,4,5-trichlorophenyl)carbamoyl]naphthalen-1-yl butylcarbamate (4) expressed the nanomolar min. inhibitory concentrations (MICs 0.018-0.064 μM) against S. aureus and at least two other MRSA isolates. Microbicidal effects based on the min. bactericidal concentrations (MBCs) against all the tested staphylococci were found for nine carbamates, while 2-[(2,4,5-trichlorophenyl)carbamoyl]naphthalen-1-yl heptylcarbamate (7) and 2-[(2,4,5-trichlorophenyl)carbamoyl]naphthalen-1-yl (4-phenylbutyl)carbamate (14) demonstrated MBCs in the range of 0.124-0.461 μM. The selectivity index (SI) for most investigated carbamates was >20 and for some derivatives even >100. The performed tests did not show an effect on the damage to the bacterial membrane, while the compounds were able to inhibit the respiratory chain of S. aureus.

Pharmaceuticals published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Name: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Azzena, Ugo published the artcileGeneration and reactivity of α-amino-substituted arylmethyllithium organometallics, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Tetrahedron (2000), 56(23), 3775-3780, database is CAplus.

Reductive cleavage of open chain and cyclic α-N,N-dialkylamino-substituted benzyl alkyl ethers with a dispersion of Li metal and a catalytic amount of naphthalene in THF allowed easy access to a wide array of α-N,N-dialkylamino-substituted benzyllithium derivatives Reaction of these organometallics with various electrophiles afforded the expected products in satisfactory yields.

Tetrahedron published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sadowsky, Jack D. published the artcileDevelopment of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates, Quality Control of 73303-88-5, the publication is Bioconjugate Chemistry (2017), 28(8), 2086-2098, database is CAplus and MEDLINE.

Conjugation of small mol. payloads to specific cysteine residues on proteins via a disulfide bond represents an attractive strategy to generate redox-sensitive bioconjugates, which have value as potential diagnostic reagents or therapeutics. Advancement of such “direct-disulfide” bioconjugates to the clinic necessitates chem. methods to form disulfide connections efficiently, without byproducts. The disulfide connection must also be resistant to premature cleavage by thiols prior to arrival at the targeted tissue. We show here that commonly-employed methods to generate direct disulfide-linked bioconjugates are inadequate for addressing these challenges. We describe our efforts to optimize direct-disulfide conjugation chem., focusing on the generation of conjugates between cytotoxic payloads and cysteine-engineered antibodies (i.e., THIOMAB antibody-drug conjugates, or TDCs). This work culminates in the development of novel, high-yielding conjugation chem. for creating direct payload disulfide connections to any of several Cys mutation sites in THIOMAB antibodies or to Cys sites in other biomols. (e.g., human serum albumin and cell-penetrating peptides). We conclude by demonstrating that hindered direct disulfide TDCs with two Me groups adjacent to the disulfide, which have heretofore not been described for any bioconjugate, are more stable and more efficacious in mouse tumor xenograft studies than less hindered analogs.

Bioconjugate Chemistry published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Quality Control of 73303-88-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rossi, Kyllikki published the artcileCarbon-13 NMR chemical shifts and ring conformations of 2-hydroxy-1,3,2-dioxaborolane and 2-hydroxy-1,3,2-dioxaborinane and their methyl derivatives, Computed Properties of 25240-59-9, the publication is Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1985), B39(8), 671-83, database is CAplus.

The ¹³C NMR chem. shifts of 2-hydroxy-1,3,2-dioxaborolane (half-chair) and -borinane (chair) and their Me derivatives are reported. Substituent effects on the chem. shifts have been derived, and their type and magnitude are closely related to the ring size, geometry, and other conformational aspects. ¹H NMR data for some 2-hydroxy-1,3,2-dioxaborinanes have been used to confirm the populations of their interconverting chair forms as deduced from the ¹³C NMR chem. shift correlations.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Computed Properties of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tuokko, Sakari published the artcilePalladium on Charcoal Catalyzed 3,4-Hydroperoxidation of α-Substituted Enals with Triethylsilane and Water, Computed Properties of 597-52-4, the publication is Synlett (2016), 27(11), 1649-1652, database is CAplus.

Aldehyde α-hydroperoxides can be accessed from α-substituted acroleins with triethylsilane and water under Pd/C catalysis and aerobic conditions. The reaction is composed of a Pd/C-catalyzed conjugate reduction step and a hydroperoxidn. step. The hydroperoxidn. takes place via autoxidation of sufficiently stable enols formed in situ by transfer hydrogenation. Upon reduction, 2,2-disubstituted 1,2-diols are obtained directly from aldehydes.

Synlett published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C7H8O3, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

McBee, E. T. published the artcileThe preparation and properties of some compounds containing the 4,4,4-trifluorocrotyl group, COA of Formula: C4H5F3O, the publication is Journal of the American Chemical Society (1954), 3725-8, database is CAplus.

The preparation and reactions of several compounds containing the CF₃CH:CHCH₂ group are described, and an unusual reaction of LiAlH₄, the reduction of CF₃CHBrCHBrCO₂Et (I) to CF₃CH:CHCH₂OH (II) at about -80°, is reported. CF₃CH:CHCO₂Et (IIa) (76 g.) in 150 cc. CCl₄ refluxed, the mixture treated dropwise with 90 g. Br with the occasional addition of 150 cc. CCl₄ in portions to keep the Br in solution, the mixture refluxed 24 hrs. while illuminating with a 100-watt bulb, the excess Br and CCl₄ distilled off at atm. pressure, the residue distilled, b₁₅ 65-92°, and the distillate rectified yielded 125 g. (84.5%) I, b₁₅ 90.0-2.0°, n²⁰_D 1.4448, d₂₅ 1.823. I treated with PhCH₂NH₂ (III) gave only III. HBr, m. 220°. CF₃CH:CHCO₂H (IV) (20 g.) and 60 g. BzCl slowly heated to 195° while distilling the acid chloride from the mixture, and the distillate, b. 64-72°, rectified gave 11.5 g. (50%) CF₃CH:CHCOCl (V), m. 77.0-7.5°, n²⁰_D 1.3703, d₂₅ 1.362; it gave with MeNH₂ the N-Me amide of IV, m. 110°. BzCl (300 g.)treated with IV at 150-60° (obtained as the residue from the acidolysis of 100 g. IIa with HCO₂H) dropwise while slowly distilling the acid chloride from the reactor, the residual mixture treated with 100 g. BzCl and heated until no more chloride distilled, and the crude distillate rectified yielded 65.0 g. (67%) V. CF₃CH(OH)CH₂CO₂Et (46.5 g.) in an equal volume Et₂O added dropwise with cooling during 0.5 hr. to 12.0 g. LiAlH₄ in 200 cc. dry Et₂O, the mixture stirred 12 hrs. at room temperature, the excess hydride destroyed with 95% EtOH, the mixture treated with 50 cc. concentrated H₂SO₄ and 250 g. ice, the acid layer extracted twice with 100-cc. portions Et₂O, the combined organic layer and extract distilled, and the residue dried azeotropically with C₆H₆ and distilled yielded 30 g. (83%) CF₃CH(OH)CH₂CH₂OH, b₂₀ 104-5°, viscous cloudy liquid which solidified during several hrs. at 0° to give a white, crystalline and deliquescent solid. I (163 g.) in 200 cc. Et₂O added dropwise with stirring at about -80° to 20 g. LiAlH₄ in 400 cc. dry Et₂O, the mixture stirred 20 hrs. at about -80°, the excess hydride destroyed with 95% EtOH, the reaction complex poured into 100 cc. concentrated H₂SO₄ and 1 kg. ice, the acid layer washed with two 100-cc. portions Et₂O, the combined organic layer and extract dried with Drierite and evaporated, the residue dried azeotropically with 25 cc. C₆H₆ and distilled, and the distillate, b₂₈ 35-54° rectified yielded 33.0 g. (50%) II, b. 128.0-8.5°, n²⁰_D 1.3578, d₂₅ 1.256; phenylurethan, m. 63.0°. B(OMe)₃ (73.0 g.) added dropwise to 18.0 g. NaH in 750 cc. dry, refluxing tetrahydrofuran, the mixture refluxed 2 hrs., cooled, let settle, and filtered under N pressure through glass wool, the filtrate treated with 52.0 g. V in 150 cc. dry tetrahydrofuran, the mixture stirred 2 hrs., treated cautiously with H₂O, and poured into 50 cc. concentrated H₂SO₄ and 1 kg. ice, the resulting homogeneous solution extracted with about 1500 cc. Et₂O in portions, the extract dried with Na₂SO₄, the solvents distilled off, and the residue rectified yielded 12.0 g. (33%) II. IIa (33.5 g.) in an equal volume Et₂O added with cooling during 1 hr. to iso-PrMgBr from 74 g. iso-PrBr and 14.4 g. Mg, the mixture hydrolyzed with ice-cold 10% aqueous H₂SO₄, and the product rectified yielded 17.0 g. (40%) Me₂CHCH(CF₃)CH₂CO₂Et, b₆₅ 98.0-9.0°, n²⁰_D 1.3850, d²⁵ 1.113; Me₂CHCH(CF₃)CH₂CO₂NHNH₂, m. 41.0°; apparently this is the m.p. of a hydrate; after drying in an Abderhalden pistol over P₂O₅ the material turned liquid in air, then solidified to the 41.0° material; Me₂CHCH(CF₃)CH₂CONHPh, m. 129.0°. IIa (33.5 g.) added to EtMgI from 93 g. EtI and 14.4 g. Mg, the mixture hydrolyzed with saturated aqueous NH₄Cl, the aqueous layer extracted with Et₂O, and the combined organic layer and extract distilled gave 15.9 g. (40%) CF₃CHEtCH₂CO₂Et, b₂₅ 62.0-5.0°, n²⁰_D 1.3750, d₂₅ 1.110. Freshly distilled (iso-PrO)₃Al (5.5 g.) and 10 g. II heated slowly at 65-70° and 100 mm. pressure, the mixture kept 1 hr. at this temperature while slowly distilling off some iso-PrOH, heated to 110° to remove all iso-PrOH, and distilled at 20 mm. to remove 1.3 g. II, the residue treated at 65° and 100 mm. dropwise with 16.3 g. p-MeOC₆H₄CHO, and the mixture distilled gave 3.0 g. CF₃CH:CHCHO, clear, water white liquid, b₇₀ 70-6°; 2,4-dinitrophenylhydrazone, m. 226.0°.

Journal of the American Chemical Society published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, COA of Formula: C4H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kelemen, Vanja published the artcileBrown rice proteins as delivery system of phenolic and volatile compounds of raspberry juice, Related Products of alcohols-buliding-blocks, the publication is International Journal of Food Science and Technology (2022), 57(4), 1866-1874, database is CAplus.

Development of novel food ingredients with health benefits as well as desired sensory attributes is of great importance for food industry. For that purpose, complexes (BRP/R) between brown rice proteins (amounts varied; 2%, 6% and 10%) and raspberry juice were prepared Obtained complexes were evaluated for the amount of volatile compounds, phenolic content, anthocyanin content and antioxidant activity. Those parameters depended on proteins amount The highest adsorption of total phenolics and anthocyanins (18.18 mg g^-1 and 4.59 mg g^-1, resp.) was observed on complexes obtained with the lowest amount of proteins (2%). Regarding volatiles, dominant flavor note in raspberry juice was berry (40% of overall flavor), followed by citrus and woody notes (each around 18%), while dominant flavor note on complexes was citrus note (60%) followed by green note (15%). These results suggest an efficient plant-based approach to produce value-added protein-based complexes with possible utility as food colorant and flavoring.

International Journal of Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts