Author: tianli

Shi, Lei published the artcileRapid and Efficient Microwave-Assisted Amination of Electron-Rich Aryl Halides without a Transition-Metal Catalyst, Related Products of alcohols-buliding-blocks, the publication is Organic Letters (2003), 5(19), 3515-3517, database is CAplus and MEDLINE.

A rapid and direct amination of aryl halides has been developed, in good to high yields, under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines, e.g., I, from ortho- or para-substituted Ph halides. The proposed mechanism proceeds through a benzyne intermediate.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C15H18BF3O4, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Qiong-lin published the artcilePreventive efficacy of carboprost tromethamine on delivery woman having risk factors of postpartum hemorrhage, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhongxiyi Jiehe Zazhi (2013), 22(23), 2538-2540, database is CAplus.

The purpose is to investigate clin. efficacy and safety of carboprost tromethamine in prevention of postpartum hemorrhage after high-risk pregnancy cesarean section. 200 Cases of delivery primiparous mothers underwent cesarean section were selected, and randomly divided into observation group and control group, n=100. Patients in the observation group after the babies were delivered were immediately injected with oxytocin 20IU in uterine body, then were injected with carboprost tromethamine 250 μg in uterine body, patients in the control group after the babies were delivered were immediately injected with oxytocin 20IU in uterine body, meanwhile i.v. injected with oxytocin 10 IU. Operative time, bleeding in operation, postpartum hemorrhage, postpartum hemorrhage incidence, postpartum lochia duration time, postpartum anemia incidence and other conditions of delivery women in two groups were observed There were effective 95 cases and ineffective 5 cases in the observation group, the total effective rate was 95%; there were effective 89 cases and ineffective 13 cases in the control group, the total efficiency was 87%; there was a significant difference in clin. efficacy of two groups (P<0.05). The average operation time and average bleeding amount of the observation group were 37.86 min, and 300.35 mL; the average operation time and average bleeding amount of the control group were 48.19min and 415.66mL; and there were significant differences between two groups (P<0.05). The postpartum hemorrhage amount of delivery woman in the observation group was 368.41 mL, the incidence of postpartum hemorrhage was 5%, the postpartum lochia duration time was (17.32±5.01) d, the incidence of postpartum anemia was 6%; the postpartum hemorrhage amount of delivery woman in the control group was 473.55 mL, the incidence of postpartum hemorrhage was 13%, the postpartum lochia duration time was (23.29±7.91) d, the incidence of postpartum anemia was 15%; and there were significant differences between two groups (P<0.05). Carboprost tromethamine for prevention of postpartum hemorrhage in high-risk pregnancy cesarean section women, is safe and effective, has mild adverse reactions, and is worthy of clin. application.

Xiandai Zhongxiyi Jiehe Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C4H3Cl2NS, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang, Hao published the artcileSelective Electrochemical Hydrolysis of Hydrosilanes to Silanols via Anodically Generated Silyl Cations, Synthetic Route of 17877-23-5, the publication is Angewandte Chemie, International Edition (2021), 60(4), 1839-1844, database is CAplus and MEDLINE.

The first electrochem. hydrolysis of hydrosilanes to silanols under mild and neutral reaction conditions is reported. The practical protocol employs com. available and cheap NHPI as a hydrogen-atom transfer (HAT) mediator and operates at room temperature with high selectivity, leading to various valuable silanols in moderate to good yields. Notably, this electrochem. method exhibits a broad substrate scope and high functional-group compatibility, and it is applicable to late-stage functionalization of complex mols. Preliminary mechanistic studies suggest that the reaction appears to proceed through a nucleophilic substitution reaction of an electrogenerated silyl cation with H₂O.

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kang, Iou-Jiun published the artcileDesign, synthesis, and anti-HCV activity of thiourea compounds, Formula: C10H9NO, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(7), 1950-1955, database is CAplus and MEDLINE.

A series of thiourea derivatives, e.g., I, were synthesized and their antiviral activity was evaluated in a cell-based HCV subgenomic replicon assay. SAR studies revealed that the chain length and the position of the alkyl linker largely influenced the in vitro anti-HCV activity of this class of potent antiviral agents. Among this series of synthesized compounds, the thiourea derivative with a six-carbon alkyl linker at the meta-position of the central Ph ring was identified as the most potent anti-HCV inhibitor (EC₅₀ = 0.047 μM) with a selectivity index of 596.

Bioorganic & Medicinal Chemistry Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Su, Chang published the artcileSyntheses and properties of pyrrole derivative as a cathode material for Li-ion batteries, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Applied Mechanics and Materials (2012), 731-735, database is CAplus.

A copolymer of 4-(1H-pyrrol-1-yl)phenol (PLPY) and pyrrole (P(PLPY-co-Py))was synthesized. And the chem. structure and battery performance of the prepared materials were characterized comparably by 1H NMR, FT-IR spectra and galvanostatic charge-discharge testing using simulant lithium ion half-cell method, resp. The results shows that the introduction of the phenol group to the pyrrole as a rigid side chain could prevent the polymer from agglomeration and optimize the particle morphol. of the resulting polymers, all of which made it demonstrate a significantly improved specific capacity (73.9 mAh·g^-1) compared with PPy (21.4 mAh·g^-1).

Applied Mechanics and Materials published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C8H10BNO3, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Su, Chang published the artcileSynthesis of a novel ferrocene-contained polypyrrole derivative and its performance as a cathode material for Li-ion batteries, Quality Control of 23351-09-9, the publication is Electrochimica Acta (2013), 302-307, database is CAplus.

A novel ferrocene-contained pyrrole, 4-(1H-pyrrol-1-yl)-Ph-ferrocenecarboxylate (FcPy) was synthesized by esterification of 4-(1H-pyrrol-1-yl)-phenol (PLPY) and ferrocenecarboxylic acid. Then the homopolymer of FcPy (PFcPy), copolymer of FcPy and pyrrole (P(FcPy-co-Py)), polypyrrole (PPy) were prepared by chem. oxidative polymerization And the structure, morphol., electrochem. properties of prepared polymers were characterized by FTIR spectroscopy, SEM, cyclic voltammograms (CV) and electrochem. impedance spectra (EIS), resp. Also, the charge/discharge properties of the prepared polymers were studied by galvanostatic charge-discharge testing. The introduction of ferrocene to polypyrrole obviously improved the specific capacity of PPy cathode and gave a well-defined plateau at the potential rang of ∼3.5 V. Under the authors’ exptl. conditions, the discharge capacity of undoped PPy-based electrodes only presented 16.5 mAh g^-1 at 20 mA g^-1 between 2.5 and 4.2 V, while PFcPy-based electrodes exhibited an initial discharge capacity of up to 43.2 mAh g^-1. Specially, the P(FcPy-co-Py)-based electrodes even showed a discharge capacity of 68.1 mAh g^-1 and the improved discharge platform, which were ascribed to the resonance doping effect of pendant group, the advanced electrochem. nature of ferrocene moiety and the loose morphol. of copolymer.

Electrochimica Acta published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C7H7BN2O2, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Lei published the artcileCobalt-Catalyzed Diastereo- and Enantioselective Reductive Allyl Additions to Aldehydes with Allylic Alcohol Derivatives via Allyl Radical Intermediates, Recommanded Product: (E)-4,4,4-Trifluorobut-2-en-1-ol, the publication is Journal of the American Chemical Society (2021), 143(32), 12755-12765, database is CAplus and MEDLINE.

Herein an unprecedented cobalt-catalyzed highly site-, diastereo- and enantioselective protocol for stereoselective formation of nucleophilic allyl-Co(II) complexes followed by addition to aldehydes RCHO (R = Ph, 2-furyl, cyclohexyl, etc.) is presented. The reaction features diastereo- and enantioconvergent conversion of easily accessible allylic alc. derivatives, e.g., 2-(3,4-dihydro-1(2H)-naphthalenylidene)ethanol to diversified enantioenriched homoallylic alcs. e.g., I with remarkably broad scope of allyl groups that can be introduced. Mechanistic studies indicated that allyl radical intermediates were involved in this process. These new discoveries establish a new strategy for development of enantioselective transformations through capture of radicals by chiral Co complexes, pushing forward the frontier of Co complexes for enantioselective catalysis.

Journal of the American Chemical Society published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C10H10O3, Recommanded Product: (E)-4,4,4-Trifluorobut-2-en-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Huihui published the artcileCobalt Nanoparticles-Catalyzed Widely Applicable Successive C-C Bond Cleavage in Alcohols to Access Esters, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol, the publication is Angewandte Chemie, International Edition (2020), 59(43), 19268-19274, database is CAplus and MEDLINE.

Selective cleavage and functionalization of C-C bonds have important applications in organic synthesis and biomass use. However, functionalization of C-C bonds by controlled cleavage remains difficult and challenging because they are inert. Herein, the authors describe an unprecedented efficient protocol for the breaking of successive C-C bonds in alcs. to form esters with one or multiple carbon atoms less using heterogeneous cobalt nanoparticles as catalyst with dioxygen as the oxidant. A wide range of alcs. including inactive long-chain alkyl aryl alcs. undergo smoothly successive cleavage of adjacent -(C-C)_n– bonds to afford the corresponding esters. The catalyst was used for seven times without any decrease in activity. Characterization and control experiments disclose that cobalt nanoparticles are responsible for the successive cleavage of C-C bonds to achieve excellent catalytic activity, while the presence of Co-N_x has just the opposite effect. Preliminary mechanistic studies reveal that a tandem sequence reaction is involved in this process.

Angewandte Chemie, International Edition published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Huihui published the artcileNitrogen-Doped Carbon-Modified Cobalt-Nanoparticle-Catalyzed Oxidative Cleavage of Lignin β-O-4 Model Compounds under Mild Conditions, Quality Control of 70110-65-5, the publication is ACS Sustainable Chemistry & Engineering (2018), 6(11), 14188-14196, database is CAplus.

A noble-metal-free Co-based catalyst, derived from pyrolysis of natural vitamin B₁₂ on activated carbon, is developed for the first time for one-pot oxidative cleavage of lignin linkages to phenols and aromatic esters with mol. oxygen as the oxidant under mild reaction conditions. High yields of phenol were obtained, and no oxidative coupling of phenol was produced based on the present cobalt catalyst. Compared to the previous report, the present catalyst can achieve the oxidative cleavage of β-O-4 ketones even at room temperature using a dioxygen balloon. The heterogeneous catalyst shows robust recyclability and can be conveniently recovered and reused up to eight times without an appreciable loss of catalytic activity. Moreover, this catalyst system can realize the bond cleavage of organosolv lignin. The evidence of depolymerization was given by two-dimensional heteronuclear single quantum coherence NMR and gel permeation chromatog. Characterization of the catalyst by inductively coupled plasma, N₂ adsorption-desorption, Raman spectroscopy, SEM, transmission electron microscopy (TEM), high-resolution TEM, high-angle angular dark-field scanning TEM, energy-dispersive X-ray spectroscopy, XPS, and control experiments provide a fundamental understanding of the catalytic materials and the reaction pathway. Co₃O₄ in situ supported on a N-doped carbon matrix by the way of high-temperature pyrolysis might be a catalytically active species. Two reaction intermediates are detected and confirmed by gas chromatograph-mass spectrometry.

ACS Sustainable Chemistry & Engineering published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, Quality Control of 70110-65-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Zhipeng published the artcilePotential mechanisms of the anti-hypertensive effects of RVPSL on spontaneously hypertensive rats using non-targeted serum metabolomics, Recommanded Product: 4-Propylphenol, the publication is Food & Function (2021), 12(18), 8561-8569, database is CAplus and MEDLINE.

The study aimed to investigate potential mechanisms for the anti-hypertensive effects of RVPSL on spontaneously hypertensive rats (SHRs) using a non-targeted metabonomic approach. In this study, UPLC/MS-based non-targeted metabolomics was performed to discover metabolite variation of serum in SHRs with RVPSL treatment. As a result, the serum metabolites of SHRs that were administered RVPSL for four weeks exhibited distinct alterations. Nine potential biomarkers, i.e., choline, adenosine, adrenic acid, L-tryptophan, niacinamide, glycocholic acid, propiolic acid, D-glyceraldehyde 3-phosphate, and phosphoglycolic acid, were significantly altered, which were mainly involved in lipid metabolism, vitamin and amino acid metabolism, purine metabolism, the MAPK signaling pathway, and the renin-angiotensin system. This study suggested that RVPSL potentially exerted potent effects of alleviating hypertension in the SHRs mainly via integrated regulations of metabolism and production of choline, L-tryptophan, nicotinamide, and adenosine.

Food & Function published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is Al2H32O28S3, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts