Author: tianli

Li, Wei published the artcileAnalysis of clinical efficacy of pituitrin combined with carboprost tromethamine in treatment of massive hemorrhage after placental abruption, Related Products of alcohols-buliding-blocks, the publication is Hebei Yixue (2016), 22(2), 221-223, database is CAplus.

Objective: To explore the clin. effect of pituitrin combined with carboprost tromethamine in the treatment of massive hemorrhage after placental abruption. Methods: A total of 116 patients with postpartum hemorrhage caused by premature abruption of placenta were selected and randomly divided into a control group and an observation group with 58 cases in each group. Both groups were treated with carboprost tromethamine, patients in the observation group were given pituitrin injection at the same time, and the time to hemostasis, total bleeding and the incidence of adverse events in the two groups were compared, and clin. summary and anal. were performed. Results: The observation group had bleeding volume 15min after delivery (224.7 ± 11.9) mL, bleeding volume 30min after delivery (254.8 ± 12.1) mL, bleeding volume 2h after delivery (275.2 ± 14.9) mL, bleeding volume 24h after delivery (291.7 ± 17.6) mL, postpartum hemostasis time (18.7 ± 5.9) min, hysterectomy rate 1.7%, neonatal asphyxia rate 6.9%, and no blood transfusion or death occurred, which were significantly better than the control group with statistical significance (P < 0.05). Conclusion: For patients with massive hemorrhage after premature abruption of placenta, the treatment of carboprost tromethamine combined with pituitrin can quickly inhibit the bleeding and improve the safety of mother and child.

Hebei Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Zhenzhen published the artcileEfficacy of carboprost trometamol vs. misoprostol in preventing hemorrhage after cesarean section, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Jianyan Yixue Yu Linchuang (2016), 13(22), 3258-3260, database is CAplus.

Objective: To investigate the efficacy of carboprost trometamol vs. misoprostol in preventing hemorrhage after cesarean section. Methods: 114 cases of high-risk parturient women were divided into group A and group B, which received carboprost trometamol and misoprostol after cesarean section, resp. Results: There was no significant difference of postpartum hemorrhage rate between the two groups, but the 2 h hemorrhage and 24 h hemorrhage in group A were significantly lower than those in group B. Conclusion: Carboprost trometamol shows a better preventive effect on hemorrhage after cesarean section than misoprostol.

Jianyan Yixue Yu Linchuang published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Yinghua published the artcileImaging of lysosomal oxidative stress during autophagy with a ratiometric probe featuring a large probe-product spectral separation, Recommanded Product: 2-Morpholinoethanol, the publication is Sensors and Actuators, B: Chemical (2021), 129713, database is CAplus.

Autophagy is a physiol. process governing proteostasis and implicated in many diseases. Enhanced ROS levels was known to be associated with lysosomal autophagy and therefore a lyso-specific ROS probe could find applications in autophagy related studies. Following the probe-design principle of bridging-group modification, we previously developed a ROS probe capable of detect a broader range of reactive species than the existing probes. Addnl. merits of the probe include ratiometry-capability, minimal probe-product spectral crosstalk, resistance toward autoxidation at lysosomal acidity, and structural simplicity. It is the aim of this manuscript to render this probe lyso-specificity and examine its potentials to monitor autophagy-related ROS generation in HeLa cells treated by H2O2 or 6-OHDA.

Sensors and Actuators, B: Chemical published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Zhuangqing published the artcileSelective hydrogenolysis of tetrahydrofurfuryl alcohol to 1,5-pentanediol over PrO_x promoted Ni catalysts, SDS of cas: 111-29-5, the publication is Catalysis Today (2022), 79-87, database is CAplus.

Catalytic conversion of furfural and its derivatives to value-added C₅ mols. has attractive much attention in the field of biomass conversion. In this paper, the selective hydrogenolysis of tetrahydrofurfuryl alc. to 1,5-pentanediol has been studied over a series of PrO_x promoted Ni/Al₂O₃ catalysts. The catalytic performances and the promoting effects of PrO_x, as well as the role of Ni and PrO_x species have been discussed. The surface properties and structure of catalysts were examined by TEM, XRD, XPS, H₂-TPR, H₂-TPD, in-situ DRIFTS, etc. The presence of PrO_x species promotes the reaction rate and changes product selectivity significantly, and a 79.2% 1,5-pentanediol selectivity can be obtained at 88.4% conversion over the NiPr_1.2/Al₂O₃ catalyst. The synergistic effect between defect-rich PrO_x and the adjacent active Ni species has been confirmed to contribute to the superior catalytic performances. These results provide useful knowledge for the activation of cyclic ether bonds and the design of heterogeneous catalysts with lanthanide oxide supports.

Catalysis Today published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C9H6FNO, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xi published the artcileNickel-catalyzed allylic defluorinative alkylation of trifluoromethyl alkenes with reductive decarboxylation of redox-active esters, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Chemical Science (2019), 10(3), 809-814, database is CAplus and MEDLINE.

An efficient method was developed for the synthesis of functionalized gem-difluoroalkenes I [R = c-hexyl, 4-BrC₆H₄(CH₂)₂, 4-CNC₆H₄O(CH₂)₂C(Me)₂, etc.; Ar = 3,4-(OMe)₂C₆H₃, 4-PhC₆H₄, 2-naphthyl, etc.] via nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with redox-active esters. The present reaction involved C(sp³)-F bond cleavage and C(sp³)-C(sp³) bond formation under very mild reaction conditions, while tolerating many sensitive functional groups and requiring minimal substrate protection. Therefore, this method provided an efficient and convenient approach for late-stage modification of biol. interesting mols.

Chemical Science published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Application of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Cui-hua published the artcileEfficacy and safety of carboprost tromethamine combined with low B-Lynch suture in treatment of refractory placenta previa postpartum hemorrhage, Computed Properties of 58551-69-2, the publication is Zhongguo Linchuang Yanjiu (2016), 29(4), 541-543, database is CAplus.

Objective: To explore the clin. efficacy and safety of carboprost tromethamine combined with low B-Lynch suture in the treatment of refractory placenta previa and postpartum hemorrhage (PPH). Methods: Using retrospective research methods, 108 patients with refractory placental previa PPH admitted from May 2011 to May 2015 were divided into control group (n=53) and observation group (n=55) according to the treatment method. . Both groups were given cesarean section for delivery. The control group was given oxytocin, and the placenta was dissected with 8 intermittent suture. The observation group was treated with carboprost tromethamine combined with low B-Lynch suture. The clin. efficacy, intraoperative blood loss, vaginal bleeding 2h postoperatively, vaginal bleeding 24h postoperatively, and the incidence of adverse reactions were compared between the two groups. If the hemostasis is ineffective, the two groups of patients will be treated with catheter arterial embolization (TAE) to stop the bleeding. If the TAE fails to stop the bleeding, hysterectomy will be performed. Results: (1) After treatment, the number of markedly effective, effective and ineffective cases in the observation group were 34, 19 and 2 resp., and the total clin. effective rate was 96.36% (53/55), the number of markedly effective, effective and ineffective cases in the control group were resp. 15 cases, 24 cases and 14 cases, and the total clin. effective rate was 73.58% (39/53). The difference in efficacy between the two groups was statistically significant (P<0.05). (2) There was no statistically significant difference in intraoperative blood loss between the two groups (P>0.05), but the vaginal bleeding in the observation group was significantly less than that in the control group at 2h and 24h after surgery (P<0.01). (3) The incidence of adverse reactions after treatment in the control group was 22.64% (12/53), and the observation group was 7.27% (4/55). The difference in the incidence of adverse reactions between the two groups was statistically significant (P<0.01). Conclusion: Carboprost tromethamine combined with low B-Lynch suture in the treatment of refractory placenta previa postpartum hemorrhage has a significant clin. effect and a low incidence of postoperative adverse reactions.

Zhongguo Linchuang Yanjiu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C37H30ClIrOP2, Computed Properties of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xue-Zhen published the artcileSynthesis, Structures, and Fluorescence Properties of Dimeric Aluminum Oxo Clusters, COA of Formula: C11H8O3, the publication is Inorganic Chemistry (2021), 60(10), 7089-7093, database is CAplus and MEDLINE.

Aluminum is an important component for luminescence. However, the fluorescent aluminum complex with unambiguous structural information is still limited. Herein, we report a series of fluorescence aluminum oxo clusters (AlOCs). By introducing an addnl. coordination site to the aromatic conjugation ligand, cluster nuclearity increment and fluorescence variation are observed Al₈(OH)₂(μ₄-O)₂(1-NA)₂(OEt)₁₆ (AlOC-41, 1-NA = 1-naphthoic acid, OEt = ethanol) is made up of two tetrahedral subunits. By introducing an addnl. coordination site to the aromatic conjugation ligand, we isolate a high nuclearity compound Al₁₀(μ₃-O)₂(3-HNA)₂(OEt)₂₂ (AlOC-47, 3-HNA = 3-hydroxy-2-naphthoic acid). Correspondingly, their luminescence performance is different (blue fluorescence in AlOC-41 and green in AlOC-47). Present herein is a platform to illustrate the relationship between synthesis, structure, and fluorescence properties.

Inorganic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C23H43NP2, COA of Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tang, Jiaqi published the artcileThe first observation that metal chalcogenide supertetrahedral cluster is corner-coordinated by neutral amine group, COA of Formula: C4H11NO, the publication is Journal of Solid State Chemistry (2022), 122935, database is CAplus.

Reported here is a new organic-inorganic hybrid compound {[(Ga₁₀S₁₇)(H⁺-AEP)₂]·(H⁺-AEP)₂} (1) with an one-chain structure and an unprecedented corner-coordination mode between the amine group from the 1-(2-aminoethyl)piperazine ligand and gallium ions in metal chalcogenide supertetrahedral cluster. This is the first observation that a metal chalcogenide supertetrahedral cluster is corner-coordinated by an amine group from alicyclic ammonia. The characterization of UV-Vis diffuse reflectance spectroscopy and optoelectronic properties on 1 indicated its potential application in semiconductor devices and photoelec. sensors.

Journal of Solid State Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C9H22OSi, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pan, Mingshi published the artcileRuthenium-catalyzed acceptorless dehydrogenative coupling of amino alcohols and ynones to access 3-acylpyrroles, Application In Synthesis of 96-20-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(14), 2379-2382, database is CAplus and MEDLINE.

Herein, a new strategy for the direct synthesis of functionalized pyrroles from β-amino alcs. and ynones via ruthenium-catalyzed acceptorless dehydrogenative coupling was demonstrated. This developed methodol. proceeded in an atom- and step-economic fashion together with the merits of broad substrate scope, operational simplicity, with water and hydrogen gas as the sole byproducts, which provided an alternative and sustainable way to access functionalized pyrroles. Further, this method was applied to the rapid synthesis of the COX-1/COX-2 inhibitor and boron dipyrromethene derivative successfully.

Chemical Communications (Cambridge, United Kingdom) published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Hongbo published the artcileComparison of the efficacy of ambroxol hydrochloride and N-acetylcysteine in the treatment of children with bronchopneumonia and their influence on prognosis, Computed Properties of 23828-92-4, the publication is Experimental and Therapeutic Medicine (2020), 20(6), 130, database is CAplus and MEDLINE.

The aim of the present study was to compare the efficacy of ambroxol hydrochloride and N-acetylcysteine in the treatment of children with bronchial pneumonia and their influence on prognosis. A total of 120 children with bronchial pneumonia, admitted to The Affiliated Yantai Yuhuangding Hospital of Qingdao University from July 2015 to August 2018, were enrolled in the study. Among them, 58 children were treated with N-acetylcysteine and comprised the exptl. group, and 62 children were treated with ambroxol hydrochloride and comprised the control group. Children’s phys. signs (such as fever, short breath, cough and pulmonary rales) and the adverse reactions to treatment were observed, and the disappearance time of the signs was recorded. In addition, the cellular immune function indicators and the quality of life after treatment were investigated. There was no significant difference in clin. data between the two groups (P>0.05). The effective rate in the exptl. group was significantly higher than that in the control group (P<0.05). The disappearance time of symptoms, such as fever, cough, asthma and rales in the lung, was significantly shorter in the exptl. group than that in the control group (P<0.05). The hospitalization time of patients in the exptl. group was shorter than that in the control group (P<0.05). After treatment, IgA (IgA), IgG (IgG), IgM (IgM) and complement C3 were significantly increased in the exptl. group (P<0.01), and the IgA and IgG in the exptl. group were significantly higher than those in the control group (P<0.01). The incidence of adverse reactions in the exptl. group was significantly lower than that in the control group (P<0.05). In conclusion, N-acetylcysteine has a significant effect on the treatment of bronchopneumonia in children providing a quick relief from symptoms, such as lung rales, and therefore is worthy of use in clinic.

Experimental and Therapeutic Medicine published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Computed Properties of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts