Author: tianli

Berger, R. M. published the artcileStable cation formation and luminescence on inorganic oxide surfaces: 9-phenylxanthenyl cation, Application of 9-Phenyl-9H-xanthen-9-ol, the publication is Chemical Physics Letters (1990), 169(3), 213-17, database is CAplus.

The alc. 9-phenylxanthen-9-ol (I) was adsorbed on silica gel and alumina surfaces. Under room temperature conditions the 9-phenylxanthenyl cation (II) was formed and stabilized on silica gel. Steady state fluorescence studies show II fluoresces with λ_max = 210 nm and that this luminescence occurs via both direct excitation of II as well as adiabatic dehydroxylation of the excited singlet of I. Time-resolved experiments show II has a fluorescence lifetime on silica gel of 37 ± 2 ns and is quenched by oxygen at a rate of 1.5 × 10⁴ torr^-1 s^-1.

Chemical Physics Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Application of 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Toelle, Nina published the artcileLight-mediated total synthesis of 17-deoxyprovidencin, COA of Formula: C3H6O2, the publication is Angewandte Chemie, International Edition (2014), 53(15), 3859-3862, database is CAplus and MEDLINE.

An asym. synthesis of the diterpenoid 17-deoxyprovidencin I is described. Key steps include an aldol addition, a base-catalyzed Wipf-type furan formation, a Z-selective ring-closing metathesis for macrocyclization, a photochem. E/Z isomerization to a highly strained and conformationally restricted ring system, and the stereoselective formation of two epoxides on the ring.

Angewandte Chemie, International Edition published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C8H7ClO3, COA of Formula: C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qureshi, Zafar published the artcileApplication of the Palladium-Catalyzed Norbornene-Assisted Catellani Reaction Towards the Total Synthesis of (+)-Linoxepin and Isolinoxepin, Safety of (R)-Oxiran-2-ylmethanol, the publication is European Journal of Organic Chemistry (2014), 2014(19), 4053-4069, database is CAplus.

The authors’ ongoing effort towards the development of highly selective transition-metal-catalyzed carbon hydrogeb bond (C-H bond) activation processes has led to the expansion of a Catellani reaction. In a Pd⁰/Pd^II/Pd^IV-catalyzed tandem reaction (domino reaction), an aryl iodide, alkyl iodide and tert-Bu acrylate were combined to synthesize a carbon framework of the novel lignan (+)-linoxepin. The enantioselective synthesis highlights the work accomplished in the authors’ group and provides an excellent procedure for a reliable and scalable synthesis of architecturally complex scaffolds. This report outlines the synthetic approaches towards this interesting class of biol. active mols. After a key Catellanireaction/Heck reaction, the synthesis features a Leimeux-Johnson oxidation and a titanium tetrachloride mediated aldol condensation. Finally, a tuneable Mizoroki-Heck reaction was performed to furnish not only the natural product (+)-linoxepin but also its isoform, which we have named isolinoxepin. The synthesis of the target compounds was achieved using 8-[(5-bromo-1,3-benzodioxol-4-yl)methoxy]-3a,4-dihydro-7-(methoxy)naphtho[2,3-c]furan-1(3H)-one as a key intermediate. The title compounds thus formed included (9aR)-9a,10-dihydro-6-methoxy-4H-1,3-benzodioxolo[4,5-c]isobenzofuro[4,5,6-ef][1]benzoxepin-12(9H)-one [(+)-linoxepin] and 10,12b-dihydro-6-methoxy-4H-1,3-benzodioxolo[4,5-c]isobenzofuro[4,5,6-ef][1]benzoxepin-12(9H)-one [racemic isolinoxepin].

European Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Safety of (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavanagh, Joseph E. published the artcileOzonation byproducts: identification of bromohydrins from the ozonation of natural waters with enhanced bromide levels, Product Details of C5H11BrO, the publication is Environmental Science and Technology (1992), 26(8), 1658-62, database is CAplus.

Ozonization of 2 surface waters with enhanced levels of Br^– results in the formation of a group of previously unidentified, labile compounds identified as bromohydrins. The compounds are isolated by liquid-liquid extraction and identified by a combination of GC coupled with IR spectroscopy (GC/FT-IR) and GC coupled with mass spectrometry (GC/MS) using electron impact and chem. ionization sources, with 2% NH₃ in CH₄ as the reagent gas. The principal bromohydrin byproduct is 3-bromo-2-methyl-2-butanol, which was confirmed by independent synthesis and comparison of spectral data. At least 6 other bromohydrins are formed during the ozonization/bromination process. These compounds are also formed by reaction of the natural water with aqueous Br, irresp. of prior ozonization, but the nature of their precursors is unknown.

Environmental Science and Technology published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Product Details of C5H11BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheviet, Thomas published the artcileβ-Hydroxy- and β-Aminophosphonate Acyclonucleosides as Potent Inhibitors of Plasmodium falciparum Growth, Synthetic Route of 57044-25-4, the publication is Journal of Medicinal Chemistry (2020), 63(15), 8069-8087, database is CAplus and MEDLINE.

Malaria is an infectious disease caused by a parasite of the genus Plasmodium, and the emergence of parasites resistant to all current antimalarial drugs highlights the urgency of having new classes of mols. We developed an effective method for the synthesis of a series of β-modified acyclonucleoside phosphonate (ANP) derivatives, using com. available and inexpensive materials (i.e., aspartic acid and purine heterocycles). Their biol. evaluation in cell culture experiments and SAR revealed that the compounds’ effectiveness depends on the presence of a hydroxyl group, the chain length (four carbons), and the nature of the nucleobase (guanine). The most active derivative I inhibits the growth of Plasmodium falciparum in vitro in the nanomolar range (IC₅₀ = 74 nM) with high selectivity index (SI > 1350). This compound also showed remarkable in vivo activity in P. berghei-infected mice (ED₅₀ ~0.5 mg/kg) when administered by the i.p. route and is, although less efficient, still active via the oral route. It is the first ANP derivative with such potent antimalarial activity and therefore has considerable potential for development as a new antimalarial drug.

Journal of Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Synthetic Route of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Herzig, Maryanne C. S. published the artcileSynthesis and characterization of N-hydroxysuccinimide ester chemical affinity derivatives of asialoorosomucoid that covalently crosslink to galactosyl receptors on isolated rat hepatocytes, Related Products of alcohols-buliding-blocks, the publication is Biochemistry (1989), 28(2), 600-10, database is CAplus and MEDLINE.

Asialoorosomucoid (ASOR) was derivatized with 5 homobifunctional N-hydroxysuccinimide (NHS) ester crosslinkers. NHS/ASOR derivatives were synthesized, purified, and applied within 10 min to isolated rat hepatocytes at 4°. Specific binding of these ^125I-labeled derivatives was ∼90% in the presence of either EGTA or excess ASOR. Specific crosslinking, assessed by the resistance of specifically bound NHS/¹²⁵I-ASOR to release by EGTA, was 50-75% of the specifically bound ligand. The extent of specific crosslinking correlated with the average number of NHS groups per ASOR and was controlled by varying the molar ratio of crosslinker to ASOR during the synthesis. Crosslinking proceeded rapidly at 4° as a 1st-order process (k = 0.25 min^-1, t_1/2 = 2.8 min). After being crosslinked with any of the NHS/¹²⁵I-ASOR derivatives, cells were washed with EGTA, solubilized in Triton X 100, and analyzed by SDS-PAGE and autoradiog. Major bands were observed at M_r ≃ 83, 94, and 105 kilodaltons corresponding to the expected size of 1:1 adducts between NHS/ASOR (M_r ≃ 41.3 kilodaltons) and the 3 subunits of the receptor, M_r ≃ 43, 50, and 60 kilodaltons. The 3 subunits, rat hepatic lectin (RHL) 1, 2, and 3, were labeled in the ratio of about 1.0:1.2:1.0, resp. After crosslinking, a polyclonal goat antibody to the receptor immunoprecipitated up to 100% of the specifically crosslinked NHS/¹²⁵I-ASOR. Preimmune IgG immunoprecipitated <1% of the radiolabeled ligand. Cell surface receptors were crosslinked to NHS-ASOR, extracted with Triton X 100, immunoprecipitated with anti-orosomucoid-Sepharose, and subjected to Western blot anal. By use of antisera specific for RHL 1 or RHL 2/3 (from K. Drickamer), crosslinked complexes of M_r ∼85 kilodaltons or ∼90-115 kilodaltons, resp., were detected as were uncrosslinked native subunits. The ratio of free to crosslinked subunits was ∼10:1 for RHL 1 and ∼0.5:1 for RHL 2/3. Apparently, all 3 receptor subunits can crosslink to ligand. A model is proposed in which the native receptor is a heterohexamer composed of 4 subunits of RHL 1 and 2 subunits of RHL 2 and/or RHL 3.

Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mishra, Ratan K. published the artcileEnergy-effective grinding of inorganic solids using organic additives, Application In Synthesis of 122-20-3, the publication is Chimia (2017), 71(7-8), 451-460, database is CAplus and MEDLINE.

We present our research findings related to new formulations of the organic additives (grinding aids) needed for the efficient grinding of inorganic solids. Even though the size reduction phenomena of the inorganic solid particles in a ball mill is purely a phys. process, the addition of grinding aids in milling media introduces a complex physicochem. process. In addition to further gain in productivity, the organic additive helps to reduce the energy needed for grinding, which in the case of cement clinker has major environmental implications worldwide. This is primarily due to the tremendous amounts of cement produced and almost 30% of the associated elec. energy is consumed for grinding. In this paper, we examine the question of how to optimize these grinding aids linking mol. insight into their working mechanisms, and also how to design chem. additives of improved performance for industrial comminution.

Chimia published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application In Synthesis of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Tao published the artcilePhotoinduced Nickel-Catalyzed Deaminative Cross-Electrophile Coupling for C(sp²)-C(sp³) and C(sp³)-C(sp³) Bond Formation, Synthetic Route of 96-20-8, the publication is ACS Catalysis (2021), 11(11), 6519-6525, database is CAplus.

The N-alkylpyridinium salts, e.g., pyridinium, 1-cycloheptyl-2,4,6-triphenyl-, tetrafluoroborate can be efficiently merged with aryl or alkyl halides RX (R = 4-NCC₆H₄, 2-cyanopyridin-4-yl, 1-oxo-2,3-dihydro-1H-inden-5-yl, etc.; X = Br, I) in an intermol. fashion, affording products, e.g., 2-(4-cycloheptylbutyl)isoindoline-1,3-dione in up to 92% yield at ambient temperature These reactions harness the ability of N-alkylpyridinium salts to form electron donor-acceptor complexes with Hantzsch esters, enabling photoinduced single-electron transfer and fragmentation to afford alkyl radicals that are subsequently trapped by a Ni-based catalytic species to promote C(sp₂)-C(sp₃) and C(sp₃)-C(sp₃) bond formation. The operationally simple protocol is applicable to site-selective cross-coupling and tolerates diverse functional groups, including those that are sensitive toward metal reductants.

ACS Catalysis published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C6H13I, Synthetic Route of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Daqian published the artcileTris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases, Product Details of C8H8O3, the publication is Chemico-Biological Interactions (2022), 110027, database is CAplus and MEDLINE.

Tris (2-chloroethyl) phosphate (TCEP) is the most commonly detective organophosphate flame retardant in surroundings. TCEP is also evidenced as endocrine disrupting chems. and has potential adverse effects on metabolic diseases. In this study, we hypothesized that metabolic diseases are adverse outcomes of TCEP exposure. Adult ICR mice was daily treated with TCEP (20 mg/kg and 60 mg/kg, higher than expected level in people) by gavage administration for 9 wk. The results demonstrate that TCEP promoted body weight gain, hypertriglyceridemia, and hepatic steatosis, consistent with upregulation of hepatic lipogenesis-related gene expression. Moreover, TCEP altered the levels of several hepatic metabolites, especially bile acids and downregulated bile acid synthesis pathways. Intriguingly, we found a marked downregulation of the bile acid nuclear reporter, FXR, in TCEP-exposed livers. Mechanistically, TCEP directly interacted with FXR at Lys335 and Lys336. Further studies in this work elucidate the mechanisms of long-term TCEP exposure on hepatic steatosis and obesity in mice via FXR-mediated lipid accumulation. Our results provide insight into the possibility of intermediate TCEP exposure in causing metabolic diseases.

Chemico-Biological Interactions published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C19H15NO3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Qian published the artcileThree-dimensional (3D) thermal controlled polymer for simplified dispersive liquid-liquid microextraction in phthalic acid easters detection of straw, Category: alcohols-buliding-blocks, the publication is Microchemical Journal (2022), 107668, database is CAplus.

In this paper, a three-dimensional (3D) polyfunctional group and thermal controlled polymer p(POSS-co-DMAEMA) was prepared based on the chem. structure of the phthalic acid easters (PAEs) and applied as an extractant for dispersive liquid-liquid microextraction (DLLME) in combination with HPLC-UV. The polymer with good biocompatibility can be dispersed and aggregated by shaking and heating based on the thermal controlled properties without the assistance of instruments, which shortened the DLLME process as low as 5 min. The feasibility of the developed method was verified using 5 PAEs as targets in simulated water samples, which showed good precision (RSD%, 1.3-10.0, n = 3) and low detection limit (0.19-0.52 ng mL-1) under the optimal extraction conditions. This proposed method was successfully applied in analyzing four straws and good spiked recoveries over the range of 91.60-128.00% were obtained. Furthermore, mol. docking was employed to explore the mol. interactions and calculate binding energies between the polymer and organic pollutants, ensuring the synthesized polymer has a strong extraction ability for PAEs. The satisfied extraction efficiency can be attributed to the fact that the p(POSS-co-DMAEMA) is water-soluble at room temperature but hydrophobic at high temperature, and the high extraction ability can be achieved by the strong intermol. forces between the polymer and PAEs. The exptl. results suggest that the proposed method holds good promise for the trace anal. of PAEs.

Microchemical Journal published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts