Author: tianli

Wang, Jie published the artcilePreparation of N-aryl-salicylamide derivatives as antitumor agents, HPLC of Formula: 328-90-5, the publication is Youji Huaxue (2013), 33(5), 1026-1034, database is CAplus.

According to the scaffold hopping, a series of N-aryl-salicylamide derivatives, which have fragments of tyrosine kinase inhibitors lapatinib and neratinib were designed and synthesized. Their structures were identified by IR, ¹H NMR, ¹³C NMR and MS techniques. The target compounds were tested for cytotoxic activity against four cancer cell lines, including A549, MCF-7, SGC-7901, Bel-7402, by Me thiazolyl tetrazolium (MTT) in vitro. All the compounds demonstrated certain antitumor abilities, and some of them were better than gefitinib.

Youji Huaxue published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C16H20N2, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pedrick, E. A. published the artcileReductive silylation of a uranyl dibenzoylmethanate complex: an example of controlled uranyl oxo ligand cleavage, Application of Triethylsilanol, the publication is Chemical Science (2014), 5(8), 3204-3213, database is CAplus.

Reaction of UO₂(dbm)₂(THF) (dbm = OC(Ph)CHC(Ph)O) with 1 equiv of R₃SiH (R = Ph, Et), in the presence of B(C₆F₅)₃, gave U(OB{C₆F₅}₃)(OSiR₃)(dbm)₂(THF) (R = Ph, 1; Et, 2), which were isolated as red-orange crystalline solids in good yields. The addition of 1 equiv of H(dbm) to 2 results in protonation of the -OSiEt₃ ligand and formation of U(OB{C₆F₅}₃)(dbm)₃ (4) in 33% yield, along with formation of HOSiEt₃. Furthermore, addition of HOSiEt₃ and 1 equiv of THF to 4, results in the formation 2, revealing that this process is reversible. The two-step conversion of UO₂(dbm)₂(THF) to 4 represents a rare example of controlled uranyl oxo ligand cleavage at ambient temperature and pressure. Comparison of diffraction and d. functional theory data for 4 suggests the inverse trans influence (ITI), with a very shallow potential energy well for distortion along the trans U-O bond.

Chemical Science published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Lili published the artcileCopper-catalysed N-arylation of pyrrole with aryl iodides under ligand-free conditions, COA of Formula: C10H9NO, the publication is Journal of Chemical Research (2014), 38(3), 180-182, database is CAplus.

A simple, inexpensive and ligand-free copper-catalyzed N-arylation of nitrogen containing heterocycles such as pyrrole, imidazole, indole, and benzimidazole with aryl iodides has been developed, giving N-arylated products in moderate to excellent yields. The catalyst loading is relative low (5 mol%) and the catalyst system was stable in air.

Journal of Chemical Research published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Gaoxiaozheng published the artcileConcise synthesis of xanthones by the tandem etherification-Acylation of diaryliodonium salts with salicylates, Computed Properties of 596-38-3, the publication is Chinese Chemical Letters (2018), 29(6), 985-988, database is CAplus.

An efficient synthetic method for multi-substituted xanthones, e.g., I was developed. The reaction of diaryliodonium salts (RC₆H₄)₂I⁺OTf^– (R = H, 3-Me, 4-F, etc.) and salicylates R¹C(O)₂CH₃ (R¹ = 4-Br-2-HOC₆H₃, 3-hydroxythiophen-2-yl, 3-hydroxynaphth-2-yl, etc.) was employed for the preparation of the xanthones. This method proceeded through an intermol. etherification-acylation to give target heterocycles in good yields (up to 91%). Multi-substituted xanthones I were gained by shifting the substituent of salicylates or diaryliodonium salts.

Chinese Chemical Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Computed Properties of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pilkington-Miksa, Michael A. published the artcileTargeting lipopolyplexes using bifunctional peptides incorporating hydrophobic spacer amino acids: Synthesis, transfection, and biophysical studies, Related Products of alcohols-buliding-blocks, the publication is Bioconjugate Chemistry (2007), 18(6), 1800-1810, database is CAplus and MEDLINE.

We have developed efficient synthetic routes to two hydrophobic amino acids, suitably protected for solid-phase peptide synthesis, and have successfully synthesized peptides containing these or other hydrophobic amino acids as spacers between a Lys₁₆ moiety and an integrin-targeting motif. These peptides have in turn been used to formulate a range of lipopolyplex vectors with Lipofectin and plasmid DNA. The transfection efficiencies of these vectors and their aggregation behavior in buffers and in serum have been studied. We have shown that vectors containing peptides incorporating long linkers that are entirely hydrophobic are less efficient transfection agents. However, linkers of equivalent length that are in part hydrophobic show improved transfection properties, which is probably due to the improved accessibility of the integrin-binding motif.

Bioconjugate Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elslager, Edward F. published the artcileSynthetic schistosomicides. XVI. 5-(Mono- and dialkylamino)-2-nitrosophenols, 2-amino-5-(dialkylamino)phenols, and related compounds, Formula: C10H13NO2, the publication is Journal of Medicinal Chemistry (1970), 13(3), 370-6, database is CAplus and MEDLINE.

Various 5-(mono- and dialkylamino)-2-nitrosophenols were prepared by nitrosation of the corresponding m-(mono- and dialkylamino)phenols, obtained by heating resorcinol with an excess of the appropriate amine at 200°, or by alkylation of m-aminophenol with an alkyl halide. 5-(Dimethylamino)-2-nitrosophenol, 5-(diethylamino)-2-nitrosophenol (I), 2-nitroso-5-(1-pyrrolidinyl)phenol, and 2-amino-5-(diethylamino)phenol, a potential metabolite of I, displayed strong schistosomicidal activity and effected a 70-100% reduction of adult Schistosoma mansoni in mice at daily doses of 177-568 mg/kg for 14 days. Structure-activity relationship are summarized, and information concerning potential metabolites and the possible mode of action of the nitrosophenols is discussed.

Journal of Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dinkloh, A. published the artcileContact sensitization in patients with suspected cosmetic intolerance: results of the IVDK 2006-2011, Quality Control of 70445-33-9, the publication is Journal of the European Academy of Dermatology and Venereology (2015), 29(6), 1071-1081, database is CAplus and MEDLINE.

Background : Ingredients of leave-on cosmetics and body care products may sensitize. However, not every case of cosmetic intolerance is due to contact sensitization. Objective : To describe the frequency of contact sensitization due to cosmetics in a large clinic population, and a possible particular allergen pattern. Methods : Retrospective anal. of data from the Information Network of Departments of Dermatol., 2006-2011. Results : Of 69 487 patients tested, ‘cosmetics, creams, sunscreens’ was the only suspected allergen source category in 10 124 patients (14.6%). A final diagnosis ‘allergic contact dermatitis’ was stated in 2658 of these patients (26.3%).Compared to a control group, there were significantly more reactions to fragrance mixes I and II, balsam of Peru, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and lanolin alcs. No special pattern of fragrance sensitization could be identified. Among the preservatives, MI was by far the leading allergen, while sensitization to other widely used compounds like parabens or phenoxyethanol was rare. Conclusions : True allergic reactions to cosmetic ingredients are rarer than generally assumed. Limitation of exposure to MI in leave-on cosmetics and body care products is urgently needed.

Journal of the European Academy of Dermatology and Venereology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Safitri, Baiq Firyal Salsabila published the artcileMorphology Modulation in Self-Assembly of Chiral 2-Hydroxy-2-Phenylacetic Acids in Polymeric Diluents, Formula: C8H8O3, the publication is Crystals (2022), 12(6), 807, database is CAplus.

This study focused on the chirality effects that control the lamellar bending sense in self-assembled crystals of chiral 2-hydroxy-2-phenylacetic acids. 2-Hydroxy-2-phenylacetic acid or mandelic acid (MA) was crystallized in the presence of poly(4-vinyl phenol) (PVPh), and its crystalline structures and morphologies were assessed using polarized optical microscopy and SEM . MA of two opposite chiral forms (S- and R-) was crystallized with PVPh as the morphol. modulator; with adjustment of the PVPh content, the morphol. of MA crystals transforms from ring-banded spherulites to highly dendritic spherulites. For MA/PVPh (50/50 weight/weight) blend and neat MA at same T_c, the dendritic spherulites are packed with single crystals where the lamellae bend at a specific direction varying with T_c and chirality. Contrary to conventional thought, the bending senses of the MA lamellae in the dendritic spherulites are not solely governed by the MA mol. chirality (S or R), but also by T_c. Only at high Tc (>65°C) is the lamellar bending direction in dendritic spherulites of (S)-MA or (R)-MA blended with PVPh dictated by the chirality, i.e., displaying counterclockwise and clockwise bending direction for (S)-MA/PVPh and (R)-MA/PVPh, resp. Nevertheless, at low T_c (45°C), the bending sense of dendritic spherulites displays an opposite direction from those at the higher T_c, which is to say that the chirality alone does not control the lamellar bending direction.

Crystals published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Johnston, L. J. published the artcileCharacterization of the triplet excited state of the phenylxanthenium carbocation, Formula: C19H14O2, the publication is Canadian Journal of Chemistry (1992), 70(1), 280-2, database is CAplus.

The triplet excited state of the 9-phenylxanthenium cation is observed directly by both luminescence and transient absorption techniques. The triplet-triplet absorption shows λ_max ≤ 300 nm and decays over a period of several microseconds in the absence of easily oxidized donors. The triplet cation reacts with 9-phenylxanthydrol and biphenyl via electron transfer to give the corresponding radical and radical cation and also reacts rapidly with both oxygen and 1,3-cyclohexadiene.

Canadian Journal of Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Formula: C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ganda, Sylvia published the artcileCorona-Loading Strategies for Crystalline Particles Made by Living Crystallization-Driven Self-Assembly, COA of Formula: C12H20O6, the publication is Macromolecules (Washington, DC, United States) (2021), 54(14), 6662-6669, database is CAplus.

Self-assembled block copolymer (BCP) nanoparticles offer exciting opportunities for drug delivery applications. A key feature of using BCP nanoparticles for drug delivery is their ability to accommodate therapeutic cargoes within their particle core. This has become widely established for BCP nanoparticles with an amorphous core. The same, however, cannot be achieved with BCP nanoparticles with a crystalline core. This is because the encapsulation of therapeutic cargoes in a crystalline particle core disrupts crystallinity and ultimately leads to particle disassembly. Herein, we present several strategies to incorporate therapeutics and other functional cargoes onto the surface of crystalline particles, as this helps to ensure that the crystallinity of the particle core is maintained and the particle morphol. is hence unaffected. As a platform to showcase our strategies, in this study, we used biodegradable and bioactive 2D glycoplatelets prepared by living crystallization-driven self-assembly (CDSA). Specifically, we show that we can incorporate either an anticancer drug, doxorubicin (DOX), or a fluorescent dye, Cyanine5 (Cy5), onto the surface of glycoplatelets by seeded growth of prefunctionalized polymers or via postmodification using polymers with reactive handles. We believe that the strategies presented herein are versatile and should thus be applicable to other CDSA systems. Overall, our findings present new opportunities for crystalline particles to be used in drug delivery application.

Macromolecules (Washington, DC, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts