Author: tianli

Hong, Fengying published the artcileN-terminal strategy (N1-N4) toward high performance liquid crystal materials, Application In Synthesis of 23351-09-9, the publication is Tetrahedron (2016), 72(10), 1285-1292, database is CAplus.

Liquid crystal materials have a variety of applications in many fields such as display techniques as well as photonics and optics. However, only few design principles have been disclosed on liquid crystal materials with different N-heterocycles as the terminal groups, which hinder the development of the heterocyclic liquid crystals. Here, a strategy of mol. design for N-heterocyclic liquid crystal materials is reported. On the basis of this strategy, a series of convenient N-heterocycles such as pyrrole, pyrazole, imidazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,3,4-tetrazole were applied to synthesize the novel liquid crystals. Most of them have proved to exhibit good mesomorphic behaviors which make them excellent components in the mixture of the LCDs materials. The simple attachment of N-heterocyclic units to the liquid crystal mols. through a mild reaction condition will provide a good prospect for the design of N-heterocyclic liquid crystals.

Tetrahedron published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xiao-Yu published the artcileDual Nickel/Ruthenium Strategy for Photoinduced Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Cycloketone Oxime Esters, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Journal of Organic Chemistry (2021), 86(13), 8829-8842, database is CAplus and MEDLINE.

Herein, a dual nickel/ruthenium strategy is developed for photoinduced decarboxylative cross-coupling between α,β-unsaturated carboxylic acids and cycloketone oxime esters. The reaction mechanism is distinct from previous photoinduced decarboxylation of α,β-unsaturated carboxylic acids. This reaction might proceed through a nickelacyclopropane intermediate. The C(sp²)-C(sp³) bond constructed by the aforementioned reaction provides an efficient approach to obtaining various cyanoalkyl alkenes, which are synthetically valuable organic skeletons in organic and medicinal chem., under mild reaction conditions. The protocol tolerates many critical functional groups and provides a route for the modification of complex organic mols.

Journal of Organic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Juan published the artcileRegulation of pyruvate carboxylase in 3T3-L1 cells, COA of Formula: C18H20N2O12, the publication is Biochemical Journal (1995), 306(1), 205-10, database is CAplus and MEDLINE.

When 3T3-L1 fibroblasts differentiate to adipocytes, the specific activity of pyruvate carboxylase (PC) increases about 25-fold in parallel with its intracellular protein concentration The increase in PC protein concentration is accompanied by a 9-10-fold increase in the relative abundance of 4.2 kb PC mRNA measured by Northern-blot anal. using a cDNA probe encoding a segment of the PC gene of 3T3-L1 adipocytes. The effects of cAMP alone and together with insulin on levels of cellular protein, PC activity, PC protein and on the relative abundance of PC mRNA were examined in mature 3T3-L1 adipocytes. Adipocytes exposed to cAMP for 24 h exhibited a 25% decrease in cellular protein and marked decreases in enzyme activity (88%) and PC mRNA abundance (98%) compared with untreated adipocyte controls. After 48 h of exposure to cAMP, PC activity and PC mRNA diminished to levels approaching their detection limits. When exposed to medium containing cAMP plus insulin, adipocyte enzyme activity and PC mRNA declined more slowly during the first 24 h exposure (about 20% decrease) but after 48 h fell to values comparable with those of adipocytes exposed to cAMP alone. Despite these decreases in enzyme activity, the PC protein content of adipocytes treated with cAMP alone or cAMP plus insulin are nearly identical with that of control adipocytes. The inactivation of PC in cAMP-treated adipocytes does not involve loss of the prosthetic groups from the holoenzyme. Crosslinking experiments suggest that the spatial arrangement of protomers in inactive PC may differ from that in the active tetrameric enzyme. Data presented suggest that, in addition to inducing inactivation, cAMP may also regulate adipocyte PC by decreasing transcription of the PC gene and/or enhancing the rate of degradation of PC mRNA.

Biochemical Journal published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C6H9N3O2S, COA of Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Guang-Bin published the artcilePrediction of Kinetic Isotope Effects for Various Hydride Transfer Reactions Using a New Kinetic Model, Category: alcohols-buliding-blocks, the publication is Journal of Physical Chemistry A (2016), 120(11), 1779-1799, database is CAplus and MEDLINE.

In this work, kinetic isotope effect (KIE_self) values of 68 hydride self-exchange reactions, XH(D) + X⁺ → X⁺ + XH(D), in acetonitrile at 298 K were determined using a new exptl. method. KIE values of 4556 hydride cross transfer reactions, XH(D) + Y⁺ → X⁺ + YH(D), in acetonitrile were estimated from the 68 determined KIE_self values of hydride self-exchange reactions using a new KIE relation formula derived from Zhu’s kinetic equation and the reliability of the estimations was verified using different exptl. methods. A new KIE kinetic model to explain and predict KIE values was developed according to Zhu’s kinetic model using two different Morse free energy curves instead of one Morse free energy curve in the traditional KIE theories to describe the free energy changes of X-H bond and X-D bond dissociation in chem. reactions. The most significant contribution of this paper to KIE theory is to build a new KIE kinetic model, which can be used to not only uniformly explain the various (normal, enormous and inverse) KIE values but also safely predict KIE values of various chem. reactions.

Journal of Physical Chemistry A published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H10N2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xiaoliang published the artcileDetermination of sucrose and sorbitol in ambroxol hydrochloride oral solution by HPLC-RID, Category: alcohols-buliding-blocks, the publication is Jinri Yaoxue (2021), 31(10), 756-760, database is CAplus.

OBJECTIVE To establish a method for determination of sucrose and sorbitol in ambroxol hydrochloride oral solution and investigated the addition among samples from 21 manufacturers all over the whole country. METHODS The HPLC determination was performed on a HYPERSIL amino column (250 mm×4.6 mm, 5 μm). The mobile phase was consisted of acetonitrile and water (80:20, V/V) at the flow rate of 1.0 mL·min^-1. The column temperature was 35°C and the refractive index detector was used. RESULTS Sucrose and sorbitol could be well separated from ambroxol hydrochloride, and they had good linear relationship (n=6) at the range of 1-10 mg·mL^-1 with sucrose (r=0.9996) and sorbitol (r=0.9999), resp. The limits of quantitation of sucrose and sorbitol were 8.03 and 8.04 μg resp. and the average recoveries (n=9) were 101.0% and 100.9% with the RSD 1.03% and 0.97% resp. The samples from 22 enterprises in the whole country were determined and the determinated results for few individual manufacturers were inconsistent with the production prescription. CONCLUSION The established method is simple, accurate and good repeatability which can lay the foundation for the determination of the addition and quality evaluation of flavor agents in oral solution

Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bremner, John B. published the artcileAnnulation of Eight- to Ten-Membered Oxaza Rings to the Benzo[b]thiophene System by Intramolecular Nucleophilic Displacement, COA of Formula: C8H19NO2, the publication is Australian Journal of Chemistry (2014), 67(8 & 9), 1217-1221, database is CAplus.

Concise synthetic routes to 2H-benzo[b]thieno[3,2-b][1,5]oxazocin-6(3H)-one, and the new benzo[b]thieno[3,2-b][1,5]oxazonin-7(2H)-one and 2H-benzo[b]thieno[3,2-b][1,5]oxazecin-8(3H)-one systems, have been developed based on intramol. nucleophilic displacement in the key ring forming step.

Australian Journal of Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Tao published the artcilePromoted Production of Phenolic Monomers from Lignin-First Depolymerization of Lignocellulose over Ru Supported on Biochar by N,P-co-Doping, Category: alcohols-buliding-blocks, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(7), 2343-2354, database is CAplus.

Co-doping of heteroatoms into the support of metal-supported catalysts is a prevalent method to improve the catalytic performance by adjusting metal-support interactions. This paper investigated the catalytic performances of Ru supported on biomass-derived char (Ru@Char), N-doped char (Ru@N-Char), and N,P-co-doped char (Ru@NP-Char) in the emerging lignin-first depolymerization for both poplar (hardwood) and pine (softwood) samples, with an emphasis on the production of phenolic monomers. Various characterizations of the prepared catalysts showed that the codoping of N,P not only facilitated the formation of micropores in the char, but also introduced weak and moderate acid sites. Furthermore, the sizes of Ru nanoparticles on the codoped char became smaller and the proportion of metallic Ru species was increased, resulting from electron transfer from Ru to the codoped char. The yields of the phenolic monomers from poplar and pine over Ru@NP-Char were as high as 57.98 and 17.53 weight %-Klason lignin, resp., which were improved by factors of 1.4-2.5 in comparison to Ru@Char and Ru@N-Char. Full delignification during the depolymerization of both poplar and pine was also achieved over Ru@NP-Char.

ACS Sustainable Chemistry & Engineering published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Ya-rui published the artcileEffects of ambroxol hydrochloride combined with pulmicorin on changes of airway inflammation and allergic reaction EOS, ECP and IL-4 indexes in patients with bronchial asthma, Formula: C13H19Br2ClN2O, the publication is Xiandai Zhenduan Yu Zhiliao (2021), 32(5), 707-708, database is CAplus.

Objective: To investigate the effect of ambroxol hydrochloride combined with pulmicorin on airway inflammation and the changes of EOS, ECP and IL-4 indexes in patients with bronchial asthma. Methods: A total of 60 patients with bronchial asthma who were admitted to our hospital from Feb. 2019 to Dec. 2019 were selected and divided into a control group and an exptl. group with 30 cases in each group according to the method of tossing a coin. The control group was given routine treatment, and the exptl. group was given ambroxol hydrochloride combined with pulmicoride on this basis. The levels of eosinophils (EOS), eosinophil cationic protein (ECP), interleukin-4 (IL-4) and adverse reactions were observed in the two groups. Results: Before treatment, there was no significant difference in the levels of IL-4, ECP and EOS between the two groups (P>0.05). After treatment, the levels of IL-4, ECP and EOS in the two groups were lower than those before treatment, and the exptl. group was significantly lower than the control group (P<0.05). The incidence of adverse reactions in the exptl. group was significantly lower than that in the control group (P<0.05). Conclusion: Ambroxol hydrochloride combined with pulmicoride has pos. effect on airway inflammation and allergic reaction EOS, ECP and IL-4 levels in patients with bronchial asthma, with high safety, which is worthy of clin. application.

Xiandai Zhenduan Yu Zhiliao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C38H74Cl2N2O4, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Miao, Hua published the artcile1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is British Journal of Pharmacology (2022), 179(1), 103-124, database is CAplus and MEDLINE.

In chronic kidney disease (CKD), patients inevitably reach end-stage renal disease and require renal transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the mol. pathways targeted by metabolites remain enigmatic. Here, we describe roles of 1-hydroxypyrene in mediating renal fibrosis. We analyzed 5406 urine and serum samples from patients with Stage 1-5 CKD using metabolomics, and 1-hydroxypyrene was identified and validated using longitudinal and drug intervention cohorts as well as 5/6 nephrectomized and adenine-induced rats. We identified correlations between the urine and serum levels of 1-hydroxypyrene and the estimated GFR in patients with CKD onset and progression. Moreover, increased 1-hydroxypyrene levels in serum and kidney tissues correlated with decreased renal function in two rat models. Up-regulated mRNA expression of aryl hydrocarbon receptor and its target genes, including CYP1A1, CYP1A2 and CYP1B1, were observed in patients and rats with progressive CKD. Further we showed up-regulated mRNA expression of aryl hydrocarbon receptor and its three target genes, plus up-regulated nuclear aryl hydrocarbon receptor protein levels in mice and HK-2 cells treated with 1-hydroxypyrene, which caused accumulation of extracellular matrix components. Treatment with aryl hydrocarbon receptor short hairpin RNA or flavonoids inhibited mRNA expression of aryl hydrocarbon receptor and its target genes in 1-hydroxypyrene-induced HK-2 cells and mice. Metabolite 1-hydroxypyrene was demonstrated to mediate renal fibrosis through activation of the aryl hydrocarbon receptor signalling pathway. Targeting aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression.

British Journal of Pharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Qiuting published the artcileGroup 4 Metallocene Complexes Supported by a Redox-Active O,C-Chelating Ligand, Recommanded Product: 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Organometallics (2022), 41(12), 1488-1500, database is CAplus.

Group 4 metallocene complexes Cp₂M[OC] (Cp = η⁵-C₅H₅; M = Ti (1) or Zr (2); [OC] = κ²-O,C-OC₆H₂-2-CPh₂-4,6-^tBu₂) supported with a redox-active bidentate O,C-ligand were successfully synthesized through salt metathesis. X-ray crystallog. results showed that both complexes maintained similar bent metallocene coordination geometry. A close inspection of the structural parameters revealed a remarkably long Ti-C bond in 1, indicating concomitant intramol. charge transfer upon metathesis and coordination. The electronic structure of 1 was studied by EPR measurements, revealing the presence of a Ti(III) center and one [OC]^•- radical anion. In contrast, the diamagnetic complex 2 was found to comprise a Zr(IV) center and an alkyl/aryloxo dianion. Divergent catalytic reactivity was observed for the two Group 4 derivatives in the reaction between alkenes and HBpin. Specifically, dehydrogenative boration products (i.e., vinyl boronate esters) were obtained exclusively in the presence of the Zr complex (18 examples, up to 90% yield), while the Ti compound selectively promoted the formation of alkyl boronate esters via hydroboration (19 examples, up to 99% yield).

Organometallics published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C48H47FeP, Recommanded Product: 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts