Author: tianli

Lu, Li-ping published the artcileHemabate combined with sodium potassium magnesium calcium and glucose injection in high-risk cesarean section, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Shequ Yixue Zazhi (2012), 10(24), 33-34, database is CAplus.

Objective: To discuss the application of Hemabate combined with Na-K-Mg-Ca-glucose injection to high-risk cesarean section. Methods: 80 women with indication of high-risk cesarean section were divided into a Hemabate combined with Na-K-Mg-Ca-glucose injection group (group A) and a Hemabate combined with Ringer’s lactate injection group (group B). The blood pressure, HR, PaO₂, hemorrhage, Hemabate dose, and side effect ratio were monitored. Results: Hemabate dose of Group A was 250 μg 32 cases, 500 μg 6 cases, and 750 μg 2 cases, and that of Group B was 250 μg 22 cases, 500 μg 12 cases, and 750 μg 6 cases with statistical significance (P < 0.05). Group B had high hemorrhage than Group A 2 h postoperatively and 24 h postoperatively with statistical significance (all P < 0.05). Group A had postoperative hemorrhage > 500 mL 8 cases (20%), uterine filling and surgery 3 cases (7.5%) and nausea and vomiting 17 cases (42.5%). Group B had postoperative hemorrhage 500 mL 17 cases (42.5%), uterine filling and surgery 6 cases (15), and nausea and vomiting 32 cases (80%) with statistical significance (all P < 0.05). Conclusion: The Hemabate combined with perioperative i.v. infusion of Na-K-Mg-Ca-glucose injection for high-risk cesarean section could reduce hemorrhage, Hemabate dose, and nausea and vomiting.

Shequ Yixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cen, Xufeng published the artcileTargeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease, Related Products of alcohols-buliding-blocks, the publication is Autophagy (2021), 17(3), 818-819, database is CAplus and MEDLINE.

Mitochondrial dysfunction is associated with the occurrence of a variety of neurodegenerative diseases, especially Alzheimer disease (AD). As a mitochondrial quality control process, mitophagy is greatly inhibited in AD; increasing evidence shows that the induction of mitophagy is an effective therapeutic intervention strategy. However, the lack of more safe, effective, and clear mechanisms for mitophagy inducers has limited the clin. application. In recent studies, we have identified a small mol. compound, UMI-77, that can safely and effectively induce mitophagy. UMI-77 is an established BH3-mimetic for MCL1 and was developed to induce apoptosis in cancer cells. We found that UMI-77 can bind MCL1 and enhance its function as a mitophagy receptor protein, thus enhancing its interaction with LC3A to induce mitophagy. UMI-77 effectively improves the cognitive decline seen in an AD mouse model. Our findings shed light on the novel mechanisms of mitophagy, reveal that MCL1 is a mitophagy receptor that can be targeted to induce mitophagy, and identify MCL1 as a drug target for therapeutic intervention in AD.

Autophagy published new progress about 518303-20-3. 518303-20-3 belongs to alcohols-buliding-blocks, auxiliary class Apoptosis,Bcl-2, name is 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, and the molecular formula is C18H14BrNO5S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Jia-Hui published the artcileSynthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms, Quality Control of 2240-88-2, the publication is European Journal of Medicinal Chemistry (2021), 113691, database is CAplus and MEDLINE.

The Staphylococcus aureus can switch to a transient genotype-invariant dormancy, known as a persister, to survive treatment with high doses of antibiotics. This transient persister is an important reason underlying its resistance. There is an urgent need to find new antibacterial agents capable of eradicating methicillin-resistant S. aureus (MRSA) persisters. In this study, 37 new derivatives of cajaninstilbene acid (CSA) were designed and synthesized, and their biol. activity against MRSA persisters was evaluated. Most of the newly synthesized derivatives exhibit more potent antimicrobial properties against S. aureus and MRSA than CSA itself, and 23 of the 37 derivatives show a tendency to eradicate MRSA persisters. A representative compound, I, was demonstrated to target bacterial cell membranes. It eradicated the adherent biofilm of MRSA in a concentration dependent manner, and showed a synergistic antibacterial effect with piperacilin. In a model mouse abscess caused by MRSA persisters, I effectively reduced the bacterial load in vivo. These results indicate that I is a potential candidate for treatment of MRSA persister infections.

European Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C11H15NOS, Quality Control of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Heng published the artcileSynthesis and evaluation of fluorine-substituted phenyl acetate derivatives as ultra-short recovery sedative/hypnotic agents, Product Details of C3H5F3O, the publication is PLoS One (2014), 9(5), e96518/1-e96518/14, 14 pp., database is CAplus and MEDLINE.

Soft drugs are mols. that are purposefully designed to be rapidly metabolized (metabolically labile). In anesthesia, the soft drug is useful because it enables precise titration to effect and rapid recovery, which might allow swift and clear-headed recovery of consciousness and early home readiness. Propofol may cause delayed awakening after prolonged infusion. Propanidid and AZD3043 have a different metabolic pathway compared to propofol, resulting in a short-acting clin. profile. Fluorine imparts a variety of properties to certain medicines, including an enhanced absorption rate and improved drug transport across the blood-brain barrier. The authors hypothesized that the introduction of fluorine to the frame structure of propanidid and AZD3043 would further accelerate the swift and clear-headed recovery of consciousness. To test this hypothesis, we developed a series of fluorine-containing Ph acetate derivatives Fluorine-containing Ph acetate derivatives were synthesized, and their hypnotic potencies and durations of LORR following bolus or infusion administration were determined in mice, rats and rabbits. The metabolic half-lives in the blood of various species were determined chromatog. In vitro radioligand binding and γ-aminobutyric acid A (GABAA) receptor electrophysiol. studies were performed. Among the 12 synthesized fluorine-containing Ph acetate derivatives, compound 5j induced comparable duration of LORR with AZD3043, but more rapid recovery than AZD3043, propanidid and propofol. The time of compound 5j to return to walk and behavioral recovery are approx. reduced by more than 50% compared to AZD3043 in mice and rats and rabbits. The HD50 of compound 5j decreased with increasing animal size. The rapid recovery might make compound 5j suitable for precise titration and allow swift and clear-headed recovery of consciousness and early home readiness.

PLoS One published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C15H21BO2, Product Details of C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Xingliang published the artcileIntroducing A New Class of Sulfonyl Fluoride Hubs via Radical Chloro-Fluorosulfonylation of Alkynes, Name: 2-Phenylethanethiol, the publication is Angewandte Chemie, International Edition (2021), 60(40), 22035-22042, database is CAplus and MEDLINE.

A new and powerful class of sulfonyl fluoride hubs, β-chloro alkenylsulfonyl fluorides (BCASF) (E)/(Z)-RC(R¹)=CHS(O)₂F (R = n-Pr, Ph, naphthalen-2-yl, cyclohexyl, thiophen-3-yl, etc.; R¹ = Cl, Ph, pyrrolidin-1-yl, thiophen-3-yl, etc.), which can be constructed via radical chloro-fluorosulfonyl difunctionalization of alkynes RCCR¹ under photoredox conditions was introduced. BCASF mols. exhibit versatile reactivities and well undergo a series of transformations at the chloride site while keeping the sulfonyl fluoride group intact, including reduction, Suzuki coupling, Sonogashira coupling, as well as nucleophilic substitution with various nitrogen, oxygen, and sulfur nucleophiles. By using BCASF as a synthetic hub, a wide range of sulfonyl fluorides becomes readily accessible, such as cis alkenylsulfonyl fluorides, dienylsulfonyl fluorides, and ynenylsulfonyl fluorides, which are challenging or even not possible to synthesize before with the known methods. Moreover, further application of BCASF to the late-stage modification of peptides and drugs is also demonstrated.

Angewandte Chemie, International Edition published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Dehua published the artcileMicroporous Aluminophosphate ULM-6: Synthesis, NMR Assignment, and Its Transformation to AlPO₄-14 Molecular Sieve, Category: alcohols-buliding-blocks, the publication is Journal of Physical Chemistry C (2016), 120(22), 11854-11863, database is CAplus.

A pure fluorinated aluminophosphate [Al₈P₈O₃₂F₄·(C₃H₁₂N₂)₂(H₂O)₂] (ULM-6) was synthesized via an aminothermal strategy, in which triisopropanolamine (TIPA) was used as the solvent together with the addition of propyleneurea and HF. The ¹³C NMR spectrum demonstrates that 1,3-diaminopropane, the in situ decomposer of propyleneurea, is the real structure-directing agent (SDA) for ULM-6 crystals. The local Al, P, and F environments of the dehydrated ULM-6 were studied by 1-dimensional and 2-dimensional solid-state NMR spectroscopy. The spatial proximities are extracted from ¹⁹F{²⁷Al}, ¹⁹F{³¹P}, ²⁷Al{¹⁹F}, and ³¹P{¹⁹F} rotational-echo double resonance (REDOR) NMR experiments as well as ¹⁹F → ³¹P heteronuclear correlation (HETCOR) NMR and {³¹P}²⁷Al HMQC NMR experiments, allowing a full assignment of all the ¹⁹F, ²⁷Al, and ³¹P resonances to the corresponding crystallog. sites. Also, the structure of ULM-6 is closely related to that of AlPO₄-14. A combination of high-temperature powder XRD, thermal anal., and ¹⁹F NMR reveals that the removal of F atoms at higher temperature is crucial to the phase transformation of ULM-6 to AlPO₄-14. The calcined product shows high CO₂/CH₄ and CO₂/N₂ selectivity with ratios of 15.5 and 29.1 (101 kPa, 25°), resp.

Journal of Physical Chemistry C published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C38H24F4O4P2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wan, Ruiying published the artcileConstruction of ion conducting channels by embedding hydrophilic oligomers in piperidine functionalized poly(2,6-dimethyl-1,4-phenylene oxide) membranes, SDS of cas: 6346-09-4, the publication is European Polymer Journal (2021), 110150, database is CAplus.

A suitable microphase separation morphol. has been demonstrated to be an efficient strategy to achieve high ionic conductivity with reasonable durability to anion exchange membranes (AEMs). Herein, hydrophilic oligomers of polyethylene glycols (PEGs) with different mol. weights were blended, sep., with poly(2,6-dimethyl-1,4-phenylene oxide) modified by 4,4-diethoxybutan-1-amine and 1-methylpiperidine (20PDM). The presence of hydrophilic PEGs facilitates the formation of the interconnected nano-channels in the AEMs for ion conduction according to the anal. results by both transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The membrane containing 2 wt% PEGs with a mol. weight of 2 kDa reaches a hydroxide conductivity of 97.2 mS cm^-1 at 80°C, which is 25 mS cm^-1 higher than that the pristine 20PDM membrane possessing the same ion exchange capacity. A peak power d. of 328 mW cm^-2 is attained at 60°C by the proposed membrane based single fuel cell fueling with humidified H₂ and O₂ with 0.1 MPa of back pressure. The chem. structure, water uptake and swelling as well as resistance to hot alkali solutions of the prepared membranes were investigated.

European Polymer Journal published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H14Cl2S2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luo, Shanshan published the artcileDesign and synthesis of novel SCM-198 analogs as cardioprotective agents: Structure-activity relationship studies and biological evaluations, Recommanded Product: 2-Morpholinoethanol, the publication is European Journal of Medicinal Chemistry (2020), 112469, database is CAplus and MEDLINE.

SCM-198 (Leonurine) has attracted great attention due to its cardioprotective effects in myocardial infarction (MI). However, no systematic modifications and structure-activity relationship (SAR) studies could be traced so far. In this study, 35 analogs of SCM-198 were designed, synthesized and their cardioprotective effects were evaluated. The cell viability assay on cardiomyocyte cell line H9c2 challenged with H₂O₂ showed that several analogs exhibited more potent cytoprotective effects than SCM-198 at 1μM and 10μM concentrations LDH release level in cells treated with 1μM 14o was comparable with cells treated with 10μM SCM-198. Results of Bcl-2 expression and caspase-3 activation accordingly indicated higher protective activity of 14o than SCM-198. Moreover, in a mouse model of MI, the mice pretreated with 14o had much lower infarct size compared with that of SCM-198. The mechanism study suggested that 14o improved cardiac morphol. and reduced apoptosis of cardiomyocytes in the border zone of infarction, as proved by H&E and TUNEL staining.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pan, Dandan published the artcilePd-Catalyzed Intermolecular Transthiolation of Ar-OTf Using Methyl 3-(Methylthio) Propanoate as a Thiol Surrogate, Application In Synthesis of 4410-99-5, the publication is European Journal of Organic Chemistry (2021), 2021(33), 4616-4619, database is CAplus.

A method for the odorless synthesis of unsym. sulfides ArSR¹ [Ar = naphth-1-yl, 3-NCC₆H₄, 4-F₃CSC₆H₄, etc.; R¹ = Me, Bn, CH₂CH₂Ph, etc.] via Csp²-O and Csp³-S bond activation was presented. Using Me 3-(methylthio) propanoate as a MeSH surrogate, a series of substituted aryl Me sulfides have been obtained in moderate to good yields. This catalytic protocol could also tolerated Me 3-(methylthio)propionate derivatives to afford the corresponding aryl sulfides.

European Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application In Synthesis of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qu, Chun-Ping published the artcileA new heterocycles compound combined with focused ultrasound inhibits breast cancer cell proliferation and invasion, Quality Control of 57044-25-4, the publication is Latin American Journal of Pharmacy (2021), 40(11), 2817-2820, database is CAplus.

The new (S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (1), designed using (R)-3-chloropropane-1,2-diol and nitrobenzene as start material, was successfully obtained via multiple synthesis routes and finally characterized by IR, ¹H NMR, and single crystal X-ray crystallog. Its application values on the breast cancer treatment were evaluated and the related mechanism was explored as well. The CCK-8 assay was firstly conducted and the inhibitory effect of the new compound on the breast cancer cells was measured. Then, the reduction effect of the new compound on the breast cancer migration and invasion activity was measured with trans-well assay.

Latin American Journal of Pharmacy published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Quality Control of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts