Author: tianli

Kaneko, Naoki published the artcileIdentification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, Formula: C14H28O5S, the publication is Proceedings of the Japan Academy, Series B: Physical and Biological Sciences (2014), 90(3), 104-117, database is CAplus and MEDLINE.

Proteolytic processing of the amyloid precursor protein (APP) by β-secretase and γ-secretase leads to the generation and deposition of amyloid β (Aβ) in Alzheimer’s disease (AD). N-terminally or C-terminally truncated Aβ variants have been found in human cerebrospinal fluid and cultured cell media using immunoprecipitation and mass spectrometry. Unfortunately, the profile of plasma Aβ variants has not been revealed due to the difficulty of isolating Aβ from plasma. We present here for the first time studies of Aβ and related peptides in human plasma. Twenty-two Aβ-related peptides including novel peptides truncated before the β-secretase site were detected in human plasma and 20 of the peptides were identified by tandem mass spectrometry. Using an internal standard, we developed a quant. assay for the Aβ-related peptides and demonstrated plasma dilution linearity and the precision required for their quantitation. The present method should enhance the understanding of APP processing and clearance in AD progression.

Proceedings of the Japan Academy, Series B: Physical and Biological Sciences published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Formula: C14H28O5S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Matsumori, Nobuaki published the artcileAmphotericin B Covalent Dimers Forming Sterol-Dependent Ion-Permeable Membrane Channels, Name: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Journal of the American Chemical Society (2002), 124(16), 4180-4181, database is CAplus and MEDLINE.

Polyenemacrolides such as amphotericin B (AmB) are thought to assemble together and form an ion channel across plasma membranes. Their antimicrobial activity has been attributed to this assemblage, whose stability and activity are dependent on sterol constituents of lipid bilayer membranes. The structure of this channel-like assemblage formed in biomembranes has been the target of extensive investigations for a long time. As the first step toward this goal, we prepared several AmB dimers with various linkers and tested their channel-forming activity. Among these, AmB dimers that bore an aminoalkyl-dicarboxylate tether covalently linked between amino groups of AmB showed potent hemolytic activity. Furthermore, K⁺ influx actions monitored by measuring the pH of the liposome lumen by ³¹P NMR revealed that the dimers formed a mol. assemblage similar to that of AmB in phospholipid membrane. Judging from changes in ³¹P NMR spectra, the dimers appeared to induce “all-or-none”-type ion flux across the liposome membrane in the presence of ergosterol, which suggests that the ion channel formed by ergosterol/dimer is similar to that of AmB. On the basis of this data, we are now trying to elucidate the structure of the ion-channel complex by making the labeled conjugates of AmB for NMR measurements.

Journal of the American Chemical Society published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Name: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey V. published the artcileSynthesis of novel macrocyclic and heterocyclic taurine derivatives based on the reaction of sodium 2-[(4,4-diethoxybutyl)amino]ethanesulfonate with phenols, Application of 4,4-Diethoxybutan-1-amine, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2020), 56(7), 888-891, database is CAplus.

An approach to the synthesis of novel macrocyclic and heterocyclic taurine derivatives I and II (R = H, Me, OH) based on the reaction of sodium 2-[(4,4-diethoxybutyl)amino]ethanesulfonate with phenols 2-R-3-OHC₆H₃OH in the presence of trifluoroacetic acid has been developed.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C14H12N2S, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Baker, Sarah I. published the artcileEnhanced Reactivity for Aromatic Bromination via Halogen Bonding with Lactic Acid Derivatives, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Organic Chemistry (2022), 87(13), 8492-8502, database is CAplus and MEDLINE.

Herein, a new method for regioselective aromatic bromination using lactic acid derivatives as halogen bond acceptors with N-bromosuccinimide (NBS) is reported. Several structural analogs of lactic acid affected the efficiency of aromatic brominations, presumably via Lewis acid/base halogen-bonding interactions. Rate comparisons of aromatic brominations demonstrated the reactivity enhancement available via catalytic additives capable of halogen bonding. Computational results demonstrated that Lewis basic additives interact with NBS to increase the electropos. character of bromine prior to electrophilic transfer. An optimized procedure using catalytic mandelic acid under aqueous conditions at room temperature has been developed to promote aromatic bromination on a variety of arene substrates with complete regioselectivity.

Journal of Organic Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghoshal, Anirban published the artcile[3 + 2]-Dipolar Cycloaddition of Aldehyde-Tethered Alkynamides and Trimethylsilyl Amino Esters: A Gateway to Uniquely Functionalized Polycyclic N-Heterocycles via Post-Ugi Functionalization, COA of Formula: C8H19NO2, the publication is Journal of Organic Chemistry (2020), 85(23), 14890-14904, database is CAplus and MEDLINE.

An efficient method for the generation of uniquely functionalized pyrrolo-pyrrolizinones, pyrido-pyrrolizinones, and azepino-pyrrolizinones via [3 + 2]-dipolar cycloaddition is described. The method involves the synthesis of tethered alkynamides using Ugi condensation and oxidation that were subsequently subjected to a dipolar cycloaddition reaction with trimethylsilyl amino esters. Further transformations to demonstrate the utility of these scaffolds were also investigated.

Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Yaowen published the artcileEnergy level and molecular structure engineering of conjugated donor-acceptor copolymers for photovoltaic applications, Related Products of alcohols-buliding-blocks, the publication is Macromolecules (Washington, DC, United States) (2009), 42(13), 4491-4499, database is CAplus.

A series of novel soluble conjugated copolymers consisting of coplanar donor (bithiophenevinyl)-acceptor (2-pyran-4-ylidenemalononitrile) (TVM)-based unit coupled to different electron-donating ability moieties were synthesized by Suzuki coupling polymerization The structures of the copolymers were characterized, and their phys. properties were studied. High mol. weight (M_n up to 43.8 kg/mol) and thermostable copolymers were obtained. The combination of TVM unit building block with gradually increased electron-donating ability moieties results in enhanced π-π stacking in solid state and intramol. charge transfer (ICT) transition bands, which lead to an extension of their absorption spectral range. Cyclic voltammetry measurement displayed that the HOMO and LUMO energy levels of the copolymers can be fine-tuned. The resulting copolymers possessed relatively low HOMO energy levels promising good air stability and high open-circuit voltage (V_oc) for photovoltaic application. Bulk heterojunction photovoltaic devices were fabricated by using the copolymers as donors and (6,6)-Ph C₆₁-butyric acid Me ester (PCBM) as acceptor. The V_oc reached 0.90 V, and the power conversion efficiencies (PCE) of the devices were measured between 0.04% and 0.99% under simulated AM 1.5 solar irradiation of 100 mW/cm². The significant improvement of PCE indicates a novel concept for developing TVM-based donor-acceptor (D-A) conjugated copolymers with high photovoltaic performance by adjusting electron-donating ability and coplanarity.

Macromolecules (Washington, DC, United States) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Huan published the artcileConcise total synthesis of opioids, Product Details of C9H11NO4, the publication is Organic Chemistry Frontiers (2022), 9(9), 2322-2327, database is CAplus.

Morphine and its related alkaloids are among the most representative natural medicines that have benefited human beings for over two centuries. Industrial manufacturing of these therapeutically valuable and structurally fascinating mols. relies on farming of opium poppies, causing severe soil erosion and regulation issues. Despite the advances in the development of numerous biosynthesis and chem. synthesis methods, a truly efficient approach to opioids which is competitive in terms of cost with the current manufacturing protocol remains highly desirable. Here we present a concise total synthesis of opioids exemplified by (-)-codeine, (-)-oxycodone, (-)-naloxone, and (-)-naltrexone with by far the highest overall yields (16-34%) from readily available starting materials. Remarkably, central to the success of the present synthesis is the development of a Pd-catalyzed dearomatization arene coupling reaction using an inexpensive, air stable, and robust phosphonium ligand. This bio-inspired step constructs the tetracyclic morphinan core in a manner with excellent regioselectivity, efficiency, and scalability.

Organic Chemistry Frontiers published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Product Details of C9H11NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Lei published the artcileOnline application-oriented optimal scheduling for 2-keto-l-gulonic acid production, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Canadian Journal of Chemical Engineering (2015), 93(7), 1160-1167, database is CAplus.

An optimal scheduling approach for the 2-keto-L-gulonic acid (2-KGA) fermentation process is proposed to improve allocation of L-sorbose resources with the aim of profit maximization in a multi-bioreactor workshop. The empirical operation in 2-KGA cultivation under study is to assign the same quantity of L-sorbose to each batch without taking batch-to-batch variations into account, while the optimal scheduling approach presented in this paper will determine L-sorbose feeding according to the evaluation of the profit-making ability of the individual batch. Each 2-KGA batch is classified online according to the prediction of the profit function, so that each batch is assigned into different profit-making categories. Pseudo-online scheduling is implemented with the data of industrial 2-KGA cultivations. A total profit increase of 6-7 % is found to be achievable for the workshop in comparison with the empirical operation.

Canadian Journal of Chemical Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dominguez-Fernandez, Maite published the artcileQuantitative Assessment of Dietary (Poly)phenol Intake: A High-Throughput Targeted Metabolomics Method for Blood and Urine Samples, Product Details of C8H8O3, the publication is Journal of Agricultural and Food Chemistry (2021), 69(1), 537-554, database is CAplus and MEDLINE.

Many studies have associated the consumption of (poly)phenol-rich diets with health benefits. However, accurate high-throughput quant. methods for estimating exposure covering a broad spectrum of (poly)phenols are lacking. We have developed and validated a high-throughput method for the simultaneous quantification of 119 (poly)phenol metabolites in plasma and urine using ultra high-performance liquid chromatog. coupled with triple quadrupole mass spectrometry, with a very fast sample treatment and a single run time of 16 min. This method is highly sensitive, precise, accurate, and shows good linearity for all compounds (R² > 0.992). This novel method will allow a quant. assessment of habitual (poly)phenol intake in large epidemiol. studies as well as clin. studies investigating the health benefits of dietary (poly)phenols.

Journal of Agricultural and Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xukai published the artcileOlefination via Cu-Mediated Dehydroacylation of Unstrained Ketones, COA of Formula: C12H20O6, the publication is Journal of the American Chemical Society (2021), 143(48), 20042-20048, database is CAplus and MEDLINE.

The dehydroacylation of ketones to olefins was realized under mild conditions, which exhibited a unique reaction pathway involving aromatization-driven C-C cleavage to remove the acyl moiety, followed by Cu-mediated oxidative elimination to form an alkene between the α and β carbons. The newly adopted N’-methylpicolinohydrazonamide (MPHA) reagent was key to enable efficient cleavage of ketone C-C bonds at room temperature Diverse alkyl- and aryl-substituted olefins, dienes and special alkenes were generated with broad functional group tolerance. Strategic applications of this method were also demonstrated.

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C11H12O4, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts