Author: tianli

Jiao, Yang published the artcileA cofactor-substrate-based supramolecular fluorescent probe for the ultrafast detection of nitroreductase under hypoxic Conditions, Quality Control of 622-40-2, the publication is Angewandte Chemie, International Edition (2020), 59(15), 6021-6027, database is CAplus and MEDLINE.

Identifying the location and expression levels of enzymes under hypoxic conditions in cancer cells is vital in early-stage cancer diagnosis and monitoring. By encapsulating a fluorescent substrate, L-NO₂, within the NADH mimic-containing metal-organic capsule Zn-MPB, we developed a cofactor-substrate-based supramol. luminescent probe for ultrafast detection of hypoxia-related enzymes in solution in vitro and in vivo. The host-guest structure fuses the coenzyme and substrate into one supramol. probe to avoid control by NADH, switching the catalytic process of nitroreductase from a double-substrate mechanism to a single-substrate one. This probe promotes enzyme efficiency by altering the substrate catalytic process and enhances the electron transfer efficiency through an intra-mol. pathway with increased activity. The enzyme content and fluorescence intensity showed a linear relationship and equilibrium was obtained in seconds, showing potential for early tumor diagnosis, biomimetic catalysis, and prodrug activation.

Angewandte Chemie, International Edition published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Kai published the artcileFreeze-thaw cycles characterize varietal aroma of Vidal blanc grape during late harvest by shaping self-assembled microeukaryotic communities, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Food Chemistry (2022), 132553, database is CAplus and MEDLINE.

To study the effects of microeukaryotic communities on development of varietal aroma of Vidal blanc grape during late harvest, metagenomics, gas chromatog.-mass spectrometry, climate factors and SEM were jointly used to discover how freeze-thaw stress influences grape skin and shapes the microeukaryotic consortia. Most free terpenes, monoterpenes and C13-norisoprenoids developed during late harvest. Freeze-thaw cycles caused damage of the wax layer and microfissures on the cuticle of grape berries. This increased nutrients availability and supported the dominance of oxidative and fermentative ascomycetous populations. Microbial assemblages possessed certain ecosystem functions, which correlated to the development of characteristic volatile organic compounds, such as free terpenes and phenylalanine derivatives Significantly upregulated genes of CAZy were identified as FENNEDOB12352, OJNJMGIN252777, EGHMEMAM161340, EGHMEMAM158447, KKFIDJDF144524, BEDCFLNK31943, LHALBBHN88115, BEDCFLNK41042. Zymoseptoria tritici, Kluyveromyces lactis, Yarrowia lipolytica, and Pichia kudriavzevii were selected as key factors in yeast assemblage.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Le-ting published the artcileClinical efficacy and mechanism of penehyclidine hydrochloride in reducing adverse reactions of carboprost tromethamine, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(22), 4139-4141, database is CAplus.

Objective: To observe the clin. efficacy and mechanism of penehyclidine hydrochloride in reducing adverse reactions of carboprost tromethamine. Methods: 60 cases of parturients who received carboprost tromethamine injection during cesarean uterine contraction were divided into group A, group B, and group C. Three minutes before intrauterine infusion of carprost tromethamine, group C received i.v. infusion of normal saline, group A received i.v. infusion of penehyclidine hydrochloride 0.5 mg, and group B received i.v. infusion of penehyclidine hydrochloride 1 mg. Result: The incidence of adverse reactions in group A and group B was lower than that in group C, and there was no difference in the incidence of adverse reactions between group A and group B. The levels of motilin and angiotensin in group A and group B were significantly lower than those in group C. Conclusion: Penehyclidine hydrochloride can reduce the clin. adverse reactions of carprost tromethamine. The gastrointestinal adverse reactions may be inhibited by reducing motilin while the cardiovascular adverse reactions may be inhibited by reducing angiotensin II.

Xiandai Zhenduan Yu Zhiliao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Safety of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Xuan published the artcileHydro-deoxygenation at atmospheric pressure converts the phenolic-rich pyrolysis liquid fraction into aromatics, Synthetic Route of 645-56-7, the publication is Journal of Environmental Management (2022), 114429, database is CAplus and MEDLINE.

Ambient pressure hydro-deoxygenation (HDO) of the phenolic-rich pyrolysis liquid fraction is a complex task due to the presence multiple phenolic compounds and light oxygenates. The phenolic-rich fraction differs from the overall pyrolysis liquid, known to be prone to re-polymerization and coking in the reactor or of the catalyst. In the present research, hydro-deoxygenation of oxygen-containing compounds in the phenolic fraction over Mo-based catalysts was carried out for the first time. It was found that Mo-based catalysts can successfully upgrade the phenolics into aromatics, the conversion rate was nearly 100%. The small amount of light oxygenates in the phenolic-rich fraction had no obvious effect on the hydro-deoxygenation reaction, the phenolic conversion was more than 95%. After assessing the performance for a representative phenolic model compound, the reaction was also successfully carried out on the phenolic fraction of the real pyrolysis liquid It can be concluded that the catalysts can also be used for the HDO of the real pyrolysis liquid fraction at atm. pressure.

Journal of Environmental Management published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Synthetic Route of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xing, Yan published the artcileClinical features and treatment of pediatric patients with drug-induced anaphylaxis: a study based on pharmacovigilance data, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is European Journal of Pediatrics (2018), 177(1), 145-154, database is CAplus and MEDLINE.

Pediatric drug-induced anaphylaxis cases collected by the Beijing Pharmacovigilance Database from 2004 to 2014 were analyzed. A total of 91 cases were identified. Drug-induced anaphylaxis was primarily caused by antibiotics (53%). Children of 0-5 years were more likely to develop cyanosis symptoms than children of 13-17 years (OR = 5.14, 95%CI [1.74, 15.20], P = 0.002). Children of 13-17 years were more likely to develop hypotension than children of 6-12 years (OR = 11.79, 95%CI [2.28, 60.87], P = 0.002), and to manifest both neurol. symptoms (OR = 3.56, 95%CI [1.26, 10.08], P = 0.015) and severe anaphylaxis than children of 0-5 years (OR = 15.46, 95%CI [1.85, 129.33], P = 0.002). Supratherapeutic doses of epinephrine were more likely with i.v. (IV) bolus (92%) in contrast to either i.m. (IM) (36%, OR = 19.25, 95% CI [1.77, 209.55], P = 0.009) or s.c. (SC) injections (36%, OR = 19.80, 95% CI [1.94, 201.63], P = 0.005). Only 62 (68%) patients received epinephrine treatment as the first-line therapy. This study demonstrates that antibiotics were the most common cause of pediatric drug-induced anaphylaxis. Children may present with different anaphylactic signs/symptoms based on age groups. Epinephrine is under-utilized and provider education on the proper management of drug-induced anaphylaxis is warranted. The most common cause of anaphylaxis in children is allergies to foods, while the second most common cause of pediatric anaphylaxis is drugs. IM epinephrine is the recommended initial treatment of anaphylaxis. Drug-induced anaphylaxis in pediatric patients has age-related clin. features. IV bolus epinephrine was overused and associated with supratherapeutic dosing.

European Journal of Pediatrics published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C7H7IN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiao, Qian published the artcileDirecting-Group-Assisted Markovnikov-Selective Hydrothiolation of Styrenes with Thiols by Photoredox/Cobalt Catalysis, Safety of 2-Phenylethanethiol, the publication is Organic Letters (2021), 23(9), 3604-3609, database is CAplus and MEDLINE.

In contrast with the well-developed radical thiol-ene reaction to access anti-Markovnikov-type products, the research on the catalytic Markovnikov-selective hydrothiolation of alkenes is very restricted. Because of the catalyst poisoning of metal catalysts by organosulfur compounds, limited examples of transition-metal-catalyzed thiol-ene reactions have been reported. However, in this work, a directing-group-assisted hydrothiolation of styrenes with thiols by photoredox/cobalt catalysis is found to proceed smoothly to afford Markovnikov-type sulfides with excellent regioselectivity.

Organic Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Safety of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pu, Yanchi published the artcileDual-targeting liposomes with active recognition of GLUT₅ and α_vβ₃ for triple-negative breast cancer, HPLC of Formula: 20880-92-6, the publication is European Journal of Medicinal Chemistry (2019), 111720, database is CAplus and MEDLINE.

At present, chemo- and radiotherapies remain to be the mainstream methods for treating triple-neg. breast cancer (TNBC), which is known for poor prognosis and high rate of mortality. Two types of novel dual-targeting TNBC liposomes (Fru-RGD-Lip and Fru+RGD-Lip) that actively recognize both fructose transporter GLUT₅ and integrin α_vβ₃ were designed and prepared in this work. Firstly, a Y-shaped Fru-RGD-chol ligand, where a fructose and peptide Arg-Gly-Asp (RGD) were covalently attached to cholesterol, was designed and synthesized. Then, the Fru-RGD-Lip was constructed by inserting Fru-RGD-chol into liposomes, while Fru+RGD-Lip was obtained by inserting both Fru-chol and RGD-chol (with the molar ratio of 1:1) into liposomes. The particle size, zeta potential, encapsulation efficiency and serum stability of the paclitaxel-loaded liposomes were characterized. The results indicated that the paclitaxel-loaded Fru-RGD-Lip had the strongest growth inhibition against GLUT₅ and α_vβ₃ overexpressed MDA-MB-231 and 4T1 cells. The cellular uptake of Fru-RGD-Lip on MDA-MB-231 cells and 4T1 cells was 3.19- and 3.23-fold more than that of the uncoated liposomes (Lip). The uptake of Fru+RGD-Lip was slightly lower, giving a 2.81- and 2.90-fold increase than that of Lip in two cell lines, resp. The mechanism study demonstrated that the cellular uptake of both dual-targeting liposomes was likely to be recognized and mediated by GLUT₅ and α_vβ₃ firstly, then endocytosed through comprehensive pathways in an energy-dependent manner. Moreover, Fru-RGD-Lip displayed the maximum accumulation, which was 2.62-fold higher than that of Lip for instance, at the tumor sites compared to other liposomes using in vivo imaging. Collectively, the liposomes co-modified by fructose and RGD have enormous potential in the development of targeted TNBC treatment, especially the covalently modified Fru-RGD-Lip, making it a promising multifunctional liposome.

European Journal of Medicinal Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Shuhong published the artcileStudy on changes of volatile components in instant scallop before and after sterilization, Category: alcohols-buliding-blocks, the publication is Shipin Gongye Keji (2012), 33(4), 117-121, database is CAplus.

The influence of sterilization on flavor components in instant scallop was investigated. Gas chromatog.-mass spectrometry (GC-MS) combined with technique of headspace solid phase micro-extraction (HS-SPME) was used to analyze flavor components in instant scallop before and after sterilization. The results showed that 117 flavor components in scallop before sterilization and 119 ones in scallop after sterilization, resp. In the instant scallop before sterilization, the content of alcs., aldehydes, esters, ketones, acids, aromatic series, furans, phenols, hydrocarbon and others content was 3.21%, 4.78%, 2.06%, 0.47%, 0.25%, 8.38%, 0.03%, 0.72%, 32.58% and 47.52%, the number was 7, 9, 9, 4, 2, 22, 1, 1, 33 and 29, resp. In the instant scallop after sterilization, the content of alcs., aldehydes, esters, ketones, acids, aromatic series, furans, phenols, hydrocarbon and others content was 2.85%, 4.48%, 11.54%, 0.90%, 0.49%, 7.81%, 0.86%, 0.55%, 28.20% and 42.32%, the number was 9, 11, 11, 6, 5, 15, 5, 3, 32 and 22, resp., 67 ingredients species were the same in before and after sterilization scallop. The contents of aroma components of instant scallops after sterilization esters and furans were significantly more than that before sterilization. Thus sterilization process on the aroma components of instant scallop had a role in the retention and aroma, making instant scallop seafood was more dense fragrance, aroma coordination.

Shipin Gongye Keji published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yao, Dongxue published the artcileHigh-flux PSF/PES-COOH hollow fiber loose nanofiltration membrane for high-efficiency dye-salt separation, Computed Properties of 80-09-1, the publication is Journal of Environmental Chemical Engineering (2022), 10(4), 108180, database is CAplus.

Loose nanofiltration membranes show great potential to realize the effective separation of dyes and salts but still show low capacity for treating textile wastewater due to low membrane flux. In this work, a high-flux hollow fiber nanofiltration membrane (HFNFM) for the separation of dyes and salts was fabricated through a simple one-step non-solvent induced phase separation (NIPS) method. A carboxylated polyethersulfone (PES-COOH) was synthesized by the polycondensation based on Williamson reaction using diallyl bisphenol sulfur as a commoner followed by the thio-ene reaction with thioglycolic acid. Then PES-COOH was blended with polysulfone (PSF) for hollow fiber spinning based on the NIPS method. The effects of the ratio of PSF to PES-COOH on the membrane structure and performance were studied with scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray photoelectron spectrometer (XPS), water contact angle and zeta potential measurements. Upon optimization, the PSF/PES-COOH HFNFM displayed a water flux of 159.6 L m^-2 h^-1 bar^-1, and a rejection of 99.2% for Congo red at a dye concentration of 100 mg/L and operating pressure of 0.1 MPa. With the effective dye-salt fractionation which was comparative to literature reports, the membrane showed unprecedentedly high flux, which can be attributed to the double layer finger-like structure and hydrophilic PES-COOH as additives. The membrane also presented excellent stability and antifouling property during the treatment of simulated textile wastewater.

Journal of Environmental Chemical Engineering published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C7H6Cl2O, Computed Properties of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Zhiwen published the artcileHighly selective oxidation of organosilanes with a reusable nanoporous silver catalyst, COA of Formula: C6H16OSi, the publication is Catalysis Communications (2014), 53-56, database is CAplus.

Room temperature highly selective oxidation of organosilanes to organosilanols and organosilyl ethers is achieved in liquid-phase with dealloyed nanoporous silver catalysts. In both cases, aromatic and aliphatic silanes can be effectively converted into the corresponding silanols and silyl ethers by using water and alcs. as oxidant, resp. Moreover, hydrogen gas is the only byproduct and the catalyst can be recycled for several times without evident loss of activity and selectivity.

Catalysis Communications published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, COA of Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts