Author: tianli

Huang, Yuan published the artcileRapid and reagent-free bioassay using autobioluminescent yeasts to detect agonistic and antagonistic activities of bisphenols against rat androgen receptor and progesterone receptor, Synthetic Route of 80-09-1, the publication is Journal of Steroid Biochemistry and Molecular Biology (2022), 106151, database is CAplus and MEDLINE.

Bisphenol A (BPA) and its analogs have been classified as endocrine disruptors via binding to nuclear receptors. Two novel bioassays, BLYrARS and BLYrPRS, were developed for rapid detection of agonistic and antagonistic activities of BPA and five of its analogs binding rat androgen receptor (rAR) and rat progesterone receptor (rPR). The reporter bioassay was based on two autonomously bioluminescent strains of the yeast Saccharomyces cerevisiae, recombined with a bacterial luciferase reporter gene cassette (lux) that can produce autofluorescence, regulated by the corresponding hormone response element acting as the responsive promoter. The bioluminescent signal is autonomous and continuous without cell lysis or addition of exogenous reagents. The AR agonist R1881 could be detected at 4 h with a half-maximal effective concentration (EC50) of ∼9.4 nM. The PR agonist progesterone could be determined at 4 h with an EC50 of ∼2.74 nM. None of the sixteen bisphenols presented agonistic activities against rAR and rPR. However, thirteen BPs were rAR antagonists and eleven BPs acted as rPR antagonists with different potency. The BLYrARS and BLYrPRS bioassay characterized by automated signal acquisition without addnl. manipulations or cost can be applied for simple and rapid detection of agonistic and antagonistic activities of BPs and other compounds acting as agonists or antagonists of rAR and rPR. Based on data derived by use of this bioassay endocrine-disrupting activities of some BPA analogs are more potent than BPA.

Journal of Steroid Biochemistry and Molecular Biology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Synthetic Route of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Minbo published the artcileEffect of centrifugal pre-treatment on flavor change of cloudy orange juice: Interaction between pectin and aroma release, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Food Chemistry (2022), 131705, database is CAplus and MEDLINE.

Cloud loss of orange juice could be effectively inhibited by centrifugal treatment, but it can induce flavor changes, which become a new challenge for the industry. This work aims to investigate the effect of centrifugation on flavor changes in orange juice and explore its possible mechanism. Taste- and aroma-related attributes were analyzed, and pectin was characterized. Indicated that pH (4.00), total soluble solid (9.67°Brix), titratable acidity (0.42%), sucrose (44%), fructose (29%), and glucose (27%) were less affected by centrifugation (P > 0.05). However, aroma compounds significantly changed (P < 0.05), where terpenes and alcs. tended to be distributed in pulp and serum after centrifugation, resp. Pearson correlation anal. showed that aroma compound distribution induced by centrifugation was highly related to chelator-solubilized pectin fraction and sodium carbonate-solubilized pectin fraction (|R| > 0.9). In general, centrifugation clearly changed aroma of orange juice, which was mainly affected by pectin characteristics.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Lingxiao published the artcileUnraveling the Role of Metal in M/NiAl₂O₄ (M = Pt, Pd, Ru) Catalyst for the Self-Reforming-Driven Hydrogenolysis of Lignin, Quality Control of 645-56-7, the publication is Industrial & Engineering Chemistry Research (2021), 60(31), 11699-11706, database is CAplus.

Previously, we found that, by self-reforming-driven hydrogenolysis of lignin or lignin oils, 4-alkylphenols can be produced directly under hydrogen-free conditions over Pt//NiAl₂O₄ catalyst (ACS Catal. 2020, 10, 15197-15206). That work mainly focused on the exploration of a new strategy and the reaction pathways of the hydrogen contained in lignin during its valorization. In this work, we use M/NiAl₂O₄ (M = Pt, Pd, Ru) catalysts to investigate the rate-determined step, structure-activity relationships, the adsorbed species, and the essence of different metals and finally screen a good catalyst with excellent performance. A temporal profile of reaction using a model compound and kinetic measurements disclosed that demethoxylation is the rate-determined step, in which Ru/NiAl₂O₄ has superior ability probably due to the faster removal of products that enables the rapid recovery of active sites for demethoxylation when compared to Pt/NiAl₂O₄. In contrast, side reactions and a low rate of demethoxylation were observed over Pd/NiAl₂O₄. In the self-reforming-driven hydrogenolysis of birch lignin and lignin oil, Ru/NiAl₂O₄ exhibited again its excellence in gaining 4-alkylphenols with yields of 40.7 and 92.8 mol % (5.7 and 44.5 weight %), from lignin and lignin oil, resp. This comprehensive study would help to design catalysts with higher activity for the self-reforming process of biomass resources.

Industrial & Engineering Chemistry Research published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Quality Control of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Baoguo published the artcileEffect of triisopropanolamine on compressive strength and hydration of cement-fly ash paste, Recommanded Product: Triisopropanolamine, the publication is Construction and Building Materials (2018), 89-99, database is CAplus.

This paper aims to investigate the effect of triisopropanolamine (TIPA) on compressive strength and hydration of cement-fly ash paste. The samples with various dosages of TIPA were prepared with 30% fly ash (FA) and 70% cement (water/binder ratio by weight = 0.38), and cured under the standard condition. The compressive strength, pore structure, hydration process, and hydration products were investigated. The results show that TIPA can obviously increase the compressive strength of cement-FA system at the age of 7 d and 60 d, and the reasons are involved in pore structure and hydration of cement-FA system. Pore structure was characterized with mercury intrusion porosimetry, and the results show that TIPA can reduce total porosity but increase the amount of pore with size more than 50 nm, implying the air-entraining effect with neg. effect on compressive strength. The result suggests that TIPA and defoaming agent should be used together to minimize the neg. effect in real concrete. Furthermore, anal. of hydration products shows that TIPA can accelerate the hydration of both cement and FA, and this can also be illustrated from solid-state NMR. It is noticed that TIPA can hasten the conversion of AFt to AFm, which can be indicated from hydration heat. Addnl., the acceleration of pozzolanic reaction of FA is because TIPA can accelerate the dissolution of aluminate, silicate, and ferric into liquid paste which was demonstrated from morphol. characterization and the change of ions in pore solution Such results would be expected to provide experience for the use of alkanolamine in promoting the performance of cement-based materials.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Jiacheng published the artcileIntegrative analysis of fecal metabolome and gut microbiota in high-fat diet-induced hyperlipidemic rats treated with Rosa Roxburghii Tratt juice, Related Products of alcohols-buliding-blocks, the publication is Journal of Functional Foods (2022), 104978, database is CAplus.

The fruit of Rosa Roxburghii Tratt (RRT) is edible and has been considered as a medicinal fruit with a lipid-lowering effect, but the mechanism is still unclear. In this study, we integrated the results of 16S rRNA gene sequence and fecal metabolome to explore the potential mechanisms of RRTJ treatment in hyperlipidemia. The result suggests the useful effects of RRT juice (RRTJ) in hyperlipidemic rats. The 12 wk of RRT juice (RRTJ) treatment decreased serum lipids, fat accumulation, body weight and liver weight RRTJ treatment reversed the HFD-induced gut dysbiosis by lowering Dorea, Coprobacillus abundance and enriching Bifidobacterium, Roseburia abundance. Also, we conducted a targeted metabolic profile anal. of 160 metabolites in feces and 19 feces metabolites have significant changes. Correlation analyzes suggest that the reductions in serum lipids by RRTJ are associated with the gut microbial community (Dorea, Coprobacillus and Roseburia, Bifidobacterium) and their associated metabolites (palmitoleic acid, succinic acid, propionic acid, Glyceric acid). In conclusion, the 12 wk of treatment with RRT juice (RRTJ) can regulate dyslipidemia by improving intestinal microbiota disorders and related metabolites disorders.

Journal of Functional Foods published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Jiacheng published the artcileIntegrative analysis of fecal metabolome and gut microbiota in high-fat diet-induced hyperlipidemic rats treated with Rosa Roxburghii Tratt juice, Application of 3-Hydroxyphenylacetic acid, the publication is Journal of Functional Foods (2022), 104978, database is CAplus.

The fruit of Rosa Roxburghii Tratt (RRT) is edible and has been considered as a medicinal fruit with a lipid-lowering effect, but the mechanism is still unclear. In this study, we integrated the results of 16S rRNA gene sequence and fecal metabolome to explore the potential mechanisms of RRTJ treatment in hyperlipidemia. The result suggests the useful effects of RRT juice (RRTJ) in hyperlipidemic rats. The 12 wk of RRT juice (RRTJ) treatment decreased serum lipids, fat accumulation, body weight and liver weight RRTJ treatment reversed the HFD-induced gut dysbiosis by lowering Dorea, Coprobacillus abundance and enriching Bifidobacterium, Roseburia abundance. Also, we conducted a targeted metabolic profile anal. of 160 metabolites in feces and 19 feces metabolites have significant changes. Correlation analyzes suggest that the reductions in serum lipids by RRTJ are associated with the gut microbial community (Dorea, Coprobacillus and Roseburia, Bifidobacterium) and their associated metabolites (palmitoleic acid, succinic acid, propionic acid, Glyceric acid). In conclusion, the 12 wk of treatment with RRT juice (RRTJ) can regulate dyslipidemia by improving intestinal microbiota disorders and related metabolites disorders.

Journal of Functional Foods published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Application of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Yang published the artcileCatalytic Asymmetric 1,4-Reduction of α-Branched 2-Vinyl-azaarenes by a Chiral SPINOL-Derived Borophosphate, Synthetic Route of 25240-59-9, the publication is ACS Catalysis (2020), 10(19), 10914-10919, database is CAplus.

The catalytic asym. 1,4-reduction of α-branched 2-vinylazaarenes by a SPINOL-derived borophosphate has been realized. A SPINOL-derived phosphoric acid is used to form a bifunctional phosphoryl boronate catalyst in situ in the presence of pinacolborane. This asym. 1,4-reduction reaction provides a convenient procedure to access chiral alkylated quinolines I (R¹ = 4-Cl, 4-CF₃, 3-OMe, etc.; R² = H, 6-CO₂Me, 6-NO₂, 7-F, etc.) and benzothiazoles II (R³ = 6-Me, 5-Cl, 6-CO₂Me, etc.) in high yields (up to 94%) and with good stereoselectivities (up to 98%).

ACS Catalysis published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Synthetic Route of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yan published the artcileEffect of chemically modified recycled carbon fiber composite on the mechanical properties of cementitious mortar, Computed Properties of 122-20-3, the publication is Composites, Part B: Engineering (2019), 106853, database is CAplus.

Proper chem. treatment of recycled carbon fiber composites (RCFC) has been demonstrated to potentially add value to them, by improving the performance of cementitious materials incorporating them. This laboratory investigation mainly explored the use of saturated (simulated concrete) pore solution (SPS) to treat RCFC that contains cured epoxy resin, before its use in cementitious mortar. A total of seven mortar mixtures were fabricated, incorporating untreated RCFC, RCFC treated by SPS for different time periods followed by triisopropanolamine (TIPA), or RCFC treated by montmorillonite nanoclay emulsion (mNCE, at the nanoclay dosage of 0.75% by weight of cementitious binder). The water-to-binder (w/b) ratio of all mortar mixtures was 0.50 and the RCFC was admixed at 1% by volume The compressive strength and splitting tensile strength of RCFC reinforced mortar were evaluated. The chem. characterization (by FTIR), thermogravimetric anal., and microscopic investigation (by SEM) helped explain the observed engineering performance data. The residue epoxy resin on the surface of the RCFC was removed by the immersion in SPS, but a long-time treatment may result in damage of the fiber surface. The chem. treatment of RCFC showed both mech. and chem. benefits to its adhesion with the cementitious mortar. Admixing mNCE achieved outstanding strengths of the mortar similar to those of mortars treated by SPS for 0.5 h and then TIPA.

Composites, Part B: Engineering published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C18H35NO, Computed Properties of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Ruipu published the artcileBio-inspired lanthanum-ortho-quinone catalysis for aerobic alcohol oxidation: semi-quinone anionic radical as redox ligand, Related Products of alcohols-buliding-blocks, the publication is Nature Communications (2022), 13(1), 428, database is CAplus and MEDLINE.

Oxidation reactions are fundamental transformations in organic synthesis and chem. industry. With oxygen or air as terminal oxidant, aerobic oxidation catalysis provides the most sustainable and economic oxidation processes. Most aerobic oxidation catalysis employs redox metal as its active center. While nature provides non-redox metal strategy as in pyrroloquinoline quinone (PQQ)-dependent methanol dehydrogenases (MDH), such an effective chem. version is unknown. Inspired by the recently discovered rare earth metal-dependent enzyme Ln-MDH (methanol dehydrogenases), this study shows that an open-shell semi-quinone anionic radical species in complexing with lanthanum could serve as a very efficient aerobic oxidation catalyst under ambient conditions. In this catalyst, the lanthanum(III) ion serves only as a Lewis acid promoter and the redox process occurs exclusively on the semiquinone ligand. The catalysis is initiated by 1e^–-reduction of lanthanum-activated ortho-quinone to a semiquinone-lanthanum complex La(SQ^-.)₂, which undergoes a coupled O-H/C-H (PCHT: proton coupled hydride transfer) dehydrogenation for aerobic oxidation of alcs. such as benzyl alc., 1,4-butane-diol, 1-(2-furyl)ethanol, etc. with up to 330 h^-1 TOF.

Nature Communications published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C23H43NP2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Kai published the artcileSynthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices, Quality Control of 673456-16-1, the publication is ACS Sensors (2021), 6(4), 1543-1551, database is CAplus and MEDLINE.

Reliable and accurate glucose detection in biol. samples is of great importance in clin. diagnosis and medical research. Chem. probes are advantageous in simple operation and flexible design, especially for the development of fluorescent probes. Anthracene-based diboronic acid (P-DBA) has shown potential in glucose probing because of its high sensitivity. However, poor solubility limits its applications in aqueous media. In this work, we systemically modify P-DBA by introducing fluoro (F-), chloro (Cl-), methoxyl (MeO-), or cyano (CN-) substituents. Among these probes, the cyano-substituted probe (CN-DBA) displays the highest glucose-binding constant (6489.5 M^-1, 33% MeOH). More importantly, it shows good water solubility in the aqueous solution (0.5% MeOH), with ultrasensitive recognition with glucose (LOD = 1.51 μM) and robust sensing from pH 6.0 to 9.0. Based on these features, the CN-DBA is finally applied to detect glucose in cell lysates and plasma, with satisfactory recovery and precision. These results demonstrate that CN-DBA could serve as an accurate, sensitive fluorescent probe for glucose assays in biol. samples.

ACS Sensors published new progress about 673456-16-1. 673456-16-1 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester,, name is 2-(2-(Bromomethyl)-4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C6H4ClNO2, Quality Control of 673456-16-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts