Author: tianli

Wang, Jun published the artcileProphylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress, Related Products of alcohols-buliding-blocks, the publication is Translational Psychiatry (2020), 10(1), 183, database is CAplus and MEDLINE.

Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in exptl. models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans.

Translational Psychiatry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C9H8BNO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Shicun published the artcileDevelopment of a minimal chemically defined medium for Ketogulonicigenium vulgare WSH001 based on its genome-scale metabolic model, COA of Formula: C6H10O7, the publication is Journal of Biotechnology (2014), 15-22, database is CAplus and MEDLINE.

Com. production of 2-keto-L-gulonic acid (2-KLG), the immediate precursor of L-ascorbic acid, is by Ketogulonicigenium vulgare in co-culture with Bacillus megaterium. We used flux balance anal. (FBA) to study a genome-scale metabolic model (GSMM) of K. vulgare, iWZ663, and found that K. vulgare is deficient in nutrient biosynthetic pathways. Individually omitting L-glycine, L-cysteine, L-methionine, L-tryptophan, adenine, thymine, thiamine and pantothenate from complete chem. defined medium (CDM), caused biomass formation of K. vulgare to decrease to 1%, 21%, 16%, 1%, 26%, 57%, 73% and 24%, resp. Based on these results and FBA, a minimal chem. defined medium (MCDM) was developed that supported monoculture of K. vulgare (0.28 OD₆₀₀) and 2-KLG production (3.59 g/L), which were similar to those in complete CDM or corn steep liquor powder (CSLP) medium. This study demonstrated the potential of using GSMM and FBA to characterize nutrient requirements, optimize CDM, and study interactions in co-culture.

Journal of Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, COA of Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dou, Zhaolin published the artcilePhotocatalytic Upgrading of Lignin Oil to Diesel Precursors and Hydrogen, SDS of cas: 645-56-7, the publication is Angewandte Chemie, International Edition (2021), 60(30), 16399-16403, database is CAplus and MEDLINE.

Producing renewable biofuels from biomass is a promising way to meet future energy demand. Here, we demonstrated a lignin to diesel route via dimerization of the lignin oil followed by hydrodeoxygenation. The lignin oil undergoes C-C bond dehydrogenative coupling over Au/CdS photocatalyst under visible light irradiation, co-generating diesel precursors and hydrogen. The Au nanoparticles loaded on CdS can effectively restrain the recombination of photogenerated electrons and holes, thus improving the efficiency of the dimerization reaction. About 2.4 mmol g_catal^-1 h^-1 dimers and 1.6 mmol g_catal^-1 h^-1 H₂ were generated over Au/CdS, which is about 12 and 6.5 times over CdS, resp. The diesel precursors are finally converted into C16-C18 cycloalkanes or aromatics via hydrodeoxygenation reaction using Pd/C or porous CoMoS catalyst, resp. The conversion of pine sawdust to diesel was performed to demonstrate the feasibility of the lignin-to-diesel route.

Angewandte Chemie, International Edition published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, SDS of cas: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Bowen published the artcileHalf-sandwich ruthenium (II) complexes with bidentate NN ligands: active catalysts for synthesis of quinolines and pyrroles by acceptorless dehydrogenative cyclization, Quality Control of 96-20-8, the publication is Youji Huaxue (2020), 40(1), 53-60, database is CAplus.

Four (η6-p-cymene)Ru(II) complexes with bidentate NN ligands, (η6-p-cymene)Ru(C₅H₄N-C₅H₃N-OH), (η6-p-cymene)Ru(C₅H₄N-CH₂-C₅H₄N), (η6-p-cymene)Ru(C₅H₄N-CH₂-C₅H₃N-OH) and (η6-p-cymene)Ru(C₅H₄N-CH₂-C₅H₃N-OCH₃) were prepared These complexes were all characterized by 1H NMR, 13C NMR and elemental anal., and (η6-p-cymene)Ru(C₅H₄N-CH₂-C₅H₄N) was further determined by single crystal crystallog. Complexes were treated as catalysts for cyclizations of amino alcs. with ketones, and (η6-p-cymene)Ru(C₅H₄N-CH₂-C₅H₃N-OH) exhibited the highest activity. The cyclization reactions proceeded in toluene with 0.5 mol% catalyst loading, and a series of quinolines and pyrroles were synthesized.

Youji Huaxue published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Dandan published the artcileAminoalcohol-induced activation of organophosphorus hydrolase (OPH) towards diisopropylfluorophosphate (DFP), Name: Triisopropanolamine, the publication is PLoS One (2017), 12(1), e0169937/1-e0169937/23, database is CAplus and MEDLINE.

Aminoalcs. have been addressed as activating buffers for alk. phosphatase. However, there is no record on the buffer activation regarding organophosphorus hydrolase (OPH). Here we reported the activating effects of aminoalcs. on OPH-catalyzed hydrolysis of diisopropylfluorophosphate (DFP), an analog mol. of G-type warfare agents. The kinetic parametors kcat, Vmax and kcat/Km in the OPH reaction were remarkably increased in the buffers (pH 8.0, 25 °C) containing aminoalcs. with C2 between nitrogen (N) and oxygen (O) in their structures, including triethanolamine (TEA), diethanolamine, monoethanolamine, 1-amino-2-propanol, 2-amino-2-methyl-1-propanol, and triisopropanolamine. In contrast, much lower or no rate-enhancing effects were observed in the adding of amines, alcs., amine/alc. mixtures, or 3-amino-1-propanol (C3 between N and O). The 300 mM TEA further increased DFP-degrading activities of OPH mutants F132Y and L140Y, the previously reported OPH mutants with desirable activities towards DFP. However, the treatment of ethylenediaminetetraacetate (EDTA) markedly abolished the TEA-induced activation of OPH. The product fluoride effectively inhibited OPH-catalyzed hydrolysis of DFP by a linear mixed inhibition (inhibition constant Ki ∼ 3.21 mM), which was partially released by TEA adding at initial or later reaction stage. The obtained results indicate the activation of OPH by aminoalc. buffers could be attributed to the reduction of fluoride inhibition, which would be beneficial to the hydrolase-based detoxification of organophosphofluoridate.

PLoS One published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Name: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Shu-xia published the artcileNew progress on two-step mixed cultures fermentation for 2-KGA production of vitamin C precursor, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Weishengwuxue Zazhi (2015), 35(3), 1-8, database is CAplus.

A review. Two-step mixed cultures fermentation initiatively established with independent intellectual property rights is a microbial transformation method used in vitamin C industrial production in China. 2-Keto-L-gulonic acid (2-KGA), the precursor of vitamin C, is transformed from L-sorbose through the mixed culture fermentation that has the advantages of simple operation, less pollution and lower energy consumption. In this paper, the latest new progresses of mixed cultures fermentation producing 2-KGA are reviewed from the aspects of key enzymes of Ketogulonicigenium vulgare, extracellular substances of co-helper, Omics and exogenous additives. Meanwhile, the prospective research fields are also mentioned in order to provide some references for the researchers.

Weishengwuxue Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Da-Wei published the artcileEfficient solvent-free synthesis of bis(indolyl)methanes on SiO₂ solid support under microwave irradiation, HPLC of Formula: 438565-33-4, the publication is Chemical Papers (2015), 69(3), 470-478, database is CAplus.

An efficient synthesis of bis(indolyl)methanes I (R¹ = C₆H₅, 3-pyridinyl, 4-CH₃C₆H₄, etc.) was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85-98%). Solid support SiO₂ was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring II (R² = H, t-Bu, 4-Cl, etc.) were synthesized via this method in excellent yields (> 94%) using 3-substituted isoxazole-5-carbaldehydes and indole.

Chemical Papers published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C9H11NO4, HPLC of Formula: 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Da-wei published the artcileUltrasonic-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles via various terminal acetylenes and azide and their quorum sensing inhibition, Product Details of C10H8ClNO2, the publication is Ultrasonics Sonochemistry (2017), 343-353, database is CAplus and MEDLINE.

An efficient synthesis of 1,4-disubstituted 1,2,3-triazole derivatives I (R = C₆H₅, 2-ClC₆H₄, 3-O₂NC₆H₄, etc.) and II was studied. 1,4-Disubstituted 1,2,3-triazoles containing isoxazole and thymidine structures were synthesized in 84-96% yields starting from various terminal isoxazole ether alkynes and β-thymidine azide derivatives via a 1,3-dipolar cycloaddition using copper acetate, sodium ascorbate as the catalyst under ultrasonic assisted condition. Furthermore, the quorum sensing inhibitory activities of synthesized compounds were evaluated with Chromobacterium violaceum (C. Violaceum CV026) based on their inhibition of violacein production, with compound C₁₀-HSL as a pos. control. The compounds II (R = C₆H₅, 4-ClC₆H₄,and 4-C(CH₃)₃C₆H₄) exhibited considerable levels of inhibitory activity against violacein production, and IC₅₀ values were 217 +/- 19, 223 +/- 20 and 42.8 +/- 4.5 μM, resp., which highlighted the potential of these compounds as lead structures for further research towards the development of novel QS inhibitors.

Ultrasonics Sonochemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C12H17NS2, Product Details of C10H8ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Chuansheng published the artcileOne-pot synthesis of (3-phenylisoxazol-5-yl)methanol derivatives under ultrasound, Quality Control of 438565-33-4, the publication is Letters in Organic Chemistry (2011), 8(4), 278-281, database is CAplus.

An ultrasonic-assisted, one-pot, efficient, convenient procedure for the synthesis of (3-phenylisoxazol-5-yl)methanol derivatives was developed. (3-Phenylisoxazol-5-yl)methanol derivatives with biol. and pharmaceutical property were synthesized in moderate to excellent yields. The synthetic methods possess the advantages of high yield, facile operation process and shorter reaction time, and so on.

Letters in Organic Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C24H29N5O3, Quality Control of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Zuoyi published the artcileStructural characterisation and antioxidant activity of melanoidins from high-temperature fermented apple, HPLC of Formula: 96-20-8, the publication is International Journal of Food Science and Technology (2021), 56(5), 2471-2480, database is CAplus.

Summary : High-temperature fermented apple is a new fermented product with characteristic black appearance, which is prepared through natural fermentation of whole fresh apple at controlled high temperature (60-90°C) and humidity (relative humidity of 50-90%). In this work, melanoidins from high-temperature fermented apple were obtained by ultrafiltration and subsequent diafiltration. The structural characterization of melanoidins was investigated in the present study. Results showed that the mol. weight of the obtained melanoidins was about 179 kDa and the melanoidins were comprised primarily of furans by pyrolysis-gas chromatog.-mass spectrometry. Antioxidant activities of the high-temperature fermented apple and its melanoidins were evaluated by ABTS, DPPH, hydroxyl radicals, ferric reducing antioxidant power and Fe2+-chelating assays. Both high-temperature fermented apple and its melanoidins showed extremely high antioxidant activities in scavenging hydroxyl radicals. High correlation between the antioxidant activity assayed methods and the physicochem. characteristics of melanoidins was obtained. The contribution of melanoidins to the total antioxidant capacity of high-temperature fermented apple was determined

International Journal of Food Science and Technology published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C8H8O3, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts