Author: tianli

Synthetic Route of 23377-40-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 23377-40-4 as follows.

9-(5-Phosphono-pent-2-en-l-yl)-adenine mono-(3-hexadecyloxy-l- propyl) phosphonoester (16)A solution of compound 13 (0.12Og, 0.424 mmol), 3-hexadecyloxy- propan-1-ol (HDPOH) (0.191g, 0.64 mmol) and DMAP (0.078g, 0.64 mmol) in DMF (10 mL) was treated with DCC (0.262g, 1.26 mmol) at room temperature. The reaction mixture was warmed up to 8O0C and stirred for overnight. After concentration, the residue was purified with a gradient mixture of chloroform, methanol, ammonia water and water (80:20:1 :1 to 100:40:3:3) by silica gel column chromatography to give 0.065g of product 16 (0.115 mmol, 27% yield); 1H NMR (MeOH-^) 58.21 (s, IH), 8.19 (s, IH) 5.84-5.74 (m, IH), 5.65-5.57 (m, IH), 4.92 (d, J = 7.0 Hz, 2H), 3.94 (q, J = 6.2 Hz, 2H), 3.52 (t, J = 6.2 Hz, 2H), 3.37 (t, J = 6.6 Hz, 2H), 2.58-2.44 (m, 2H), 1.90-1.78 (m, 2H), 1.74-1.62 (m, 2H), 1.54-1.43 (m, 2H), 1.36-1.14 (m, 12H), 0.89 (t, J = 7.0 Hz, 3H); 31P NMR (MeOH-^) 525.89; MS (ESI) m/z 566 (M+H)+, 564 (M-HV.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23377-40-4, its application will become more common.

Reference:
Patent; THE REGENTS OF THE UNIVERISITY OF CALIFORNIA; WO2006/137953; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 4704-94-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol, molecular formula is C4H10O3, molecular weight is 106.12, as common compound, the synthetic route is as follows.

4b. 2-((Nitrooxy)methyl)propane-1,3-diol This compound was isolated from the mixture obtained in Example 4a. 1H NMR (300 MHz, CDCl3) delta 4.61 (d, J=6.5 Hz, 2H), 3.91-3.78 (m, 4H), 2.66 (br, 2H), 2.19-2.14 (m, 1H). 13C NMR (75 MHz, CDCl3) delta 71.1, 61.8, 40.5.

Statistics shows that 4704-94-3 is playing an increasingly important role. we look forward to future research findings about 2-(Hydroxymethyl)propane-1,3-diol.

Reference:
Patent; NitroMed, Inc.; US2004/24014; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 8This example illustrates the preparation of certain compounds of the present invention. The amines used were commercial samples supplied by Fisher Scientific or Sigma Aldrich. Amines were reacted with one of the following: (-)-Ethyl(S)-2-hydroxypropionate (Ethyl-5-lactate, Ex Sigma Aldrich, 98%) (-)-Ethyl(S)-2-hydroxypropionate (Ethyl-L-lactate, Ex Fluka, >99%) 3,6-dimethyl-1,4-dioxane-2,5-dione (Lactide, Ex Aldrich, 99%) Initially reactions were performed in a microwave reactor under the conditions listed in Table 5. Due to the restricted volumes possible and in light of the rapid reactions seen, further reactions were carried out under ambient conditions and over an increased timescale. Reactions were monitored using FT-IR spectroscopy via the reduction in the ester band from ethyl-lactate at ~1750 cm-1 and the corresponding increase in the amide bands at ~1630 cm-1 and ~1550 cm-1. Selected samples were purified via preparatory HPLC and the compounds were identified via GC-MS and NMR. A cleaner, novel synthetic route was later utilised where the amines were reacted with lactide (3,6-dimethyl-1,4-dioxane-2,5-dione). TABLE 5 Reacted Amine Moles With Moles Reaction Conditions Yield Ethylamine 0.126 Ethyl-S- 0.126 Microwave Reactor, 200 C., 20 >75% lactate Bar, 3 minutes Ethanolamine 0.164 Ethyl-S- 0.164 Microwave Reactor, 200 C., 15 >95% lactate Bar, 30 minutes Isopropylamine 0.116 Ethyl-S- 0.116 Microwave Reactor, 200 C., 18 >75% lactate Bar, 30 minutes Diethanolamine 0.104 Ethyl-S- 0.104 Microwave Reactor, 200 C., 15 >75% lactate Bar, 30 minutes Morpholine 0.114 Ethyl-S- 0.114 Microwave Reactor, 200 C., 9 Bar, >75% lactate 30 minutes Benzylamine 0.091 Ethyl-S- 0.091 Microwave Reactor, 200 C., 13 >75% lactate Bar, 30 minutes Diethylamine 0.096 Ethyl-S- 0.096 Microwave Reactor, 200 C., >50% lactate 15 Bar, 30 minutes N-methyl-tert- 0.037 Ethyl-S- 0.037 Microwave Reactor, 200 C., >25% butylamine lactate 12 Bar, 30 minutes N-ethylisopropylamine 0.037 Ethyl-S- 0.037 Microwave Reactor, 175 C., 8 >25% lactate Bar, 30 minutes sec-Butylamine 0.098 Ethyl-S- 0.098 Microwave Reactor, 200 C., >75% lactate 14 Bar, 30 minutes 1-ethylpropylamine 0.085 Ethyl-S- 0.085 Microwave Reactor, 200 C., >75% lactate 12 Bar, 30 minutes N- 0.096 Ethyl-S- 0.096 Microwave Reactor, 150 C., 3 >25% isopropylmethylamine lactate Bar, 30 minutes tert-Butylamine 0.095 Ethyl-S- 0.095 Microwave Reactor, 200 C., >95% lactate 17 Bar, 30 minutes Pyrrolidine 0.119 Ethyl-S- 0.119 Microwave Reactor, 200 C., >75% lactate 14 Bar, 30 minutes 1,3-dimethylbutylamine 0.030 Ethyl-S- 0.030 Microwave Reactor, 200 C., >50% lactate 10 Bar, 30 minutes 2-(ethylamino)ethanol 0.204 Ethyl-L- 0.183 4 days at Ambient >75% lactate Temperature & Pressure 2-amino-1-butanol 0.208 Ethyl-L- 0.188 4 days at Ambient >75% lactate Temperature & Pressure allylamine 0.267 Ethyl-L- 0.240 4 days at Ambient >75% lactate Temperature & Pressure Isobutylamine 0.199 Ethyl-L- 0.179 4 days at Ambient >75% lactate Temperature & Pressure 1-ethylpropylamine 0.171 Ethyl-L- 0.154 4 days at Ambient >25% lactate Temperature & Pressure tert-amylamine 0.170 Ethyl-L- 0.153 3 days at Ambient <25% lactate Temperature & Pressure Dipropylamine 0.146 Ethyl-L- 0.131 2 days at Ambient Negligible lactate Temperature & Pressure Hexylamine 0.151 Ethyl-L- 0.136 3 days at Ambient >75% lactate Temperature & Pressure DL-2-amino-1-pentanol 0.044 Ethyl-L- 0.039 3 days at Ambient >75% lactate Temperature & Pressure N-hexylmethylamine 0.130 Ethyl-L- 0.117 2 days at Ambient >50% lactate Temperature & Pressure N-methylpropylamine 0.047 Ethyl-L- 0.042 4 days at Ambient >50% lactate Temperature & Pressure Dipropylamine 0.047 Lactide 0.025 2 hours at 50 C. <10% Benzylamine 0.053 Lactide 0.028 1 hour at 40 C. >95% 2-benzylaminoethanol 0.069 Lactide 0.035 5 hours at 55 C. >25% N-methylbenzylamine 0.074 Lactide 0.038 12 days at Ambient >50% Temperature & Pressure N-methylbutylamine 0.078 Lactide 0.040 12 days at Ambient >50% Temperature & Pressure 3-diethylamino-propylamine 0.065 Lactide 0.033 12 days at Ambient >75% Temperature & Pressure 2-Ethyl-1-Hexylamine 0.166 Lactide 0.108 4 days at Ambient >95% Temperature & Pressure 3-N-Butoxy Propylamine 0.056 Lactide 0.034 4 days at Ambient >25% Temperature & Pressure 3-Pentylamine 0.059 Lactide 0.040 4 days at Ambient >95% Temperature & Pressure N-(3-Aminopropyl)Morpholine 0.067 Lactide 0.035 4 days at Ambient >95% Temperature & Pressure N-Methylaniline 0.081 Lactide 0.042 4 days at Ambient >25% Temperature & Pressure

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA LIMITED; US2009/227453; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2854-16-2, 1-Amino-2-methylpropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2854-16-2, blongs to alcohols-buliding-blocks compound. SDS of cas: 2854-16-2

General procedure: By the same conditions as the example 2 of an experiment, the compound 7 was synthesized except having replaced with isobutyl amine and having used 2-hydroxy-2-methylpropyl amine. Yield was 67percent. The compound 7 was obtained like the example 7-1 of an experiment except having changed reaction conditions, such as a catalyst, a solvent, reaction temperature, and time, like the following table 2 description. Yield is shown in Table 2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2854-16-2, its application will become more common.

Reference:
Patent; TSUMURA & CO; IGARASHI, YASUSHI; (20 pag.)JP5742190; (2015); B2;,
Alcohol – Wikipedia,
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Related Products of 2854-16-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: The proper 1,4-pentanedione 48 (2.28 mmol) and the suitableamine (2.28 mmol) were dissolved in ethanol (2 ml) in a sealedglass tube equipped with a stirring bar in the presence of p-toluenesulfonicacid (30 mg, 0.17 mmol). The tube was heated in thecavity of the microwave reactor for 30 min (150W, internal temperature160 ¡ãC, and internal pressure 150 psi). At the end, thereaction mixture was cooled down and concentrated. The crudematerial was purified by chromatography on aluminum oxide(activity II-III, according to Brockmann) with cyclohexane to givethe expected pyrroles 49a-n? as solids in satisfactory yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2854-16-2, 1-Amino-2-methylpropan-2-ol, and friends who are interested can also refer to it.

Reference:
Article; Poce, Giovanna; Cocozza, Martina; Alfonso, Salvatore; Consalvi, Sara; Venditti, Giulia; Fernandez-Menendez, Raquel; Bates, Robert H.; Barros Aguirre, David; Ballell, Lluis; De Logu, Alessandro; Vistoli, Giulio; Biava, Mariangela; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 539 – 550;,
Alcohol – Wikipedia,
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Related Products of 35106-82-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35106-82-2, name is (2-Vinylphenyl)methanol, molecular formula is C9H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of 4-bromobutoxymethylstyrene An amount of 20 g (0.5 mol) of sodium hydroxide and 20 ml of water were placed into a four-necked flask of 300 ml in capacity and then stirred to prepare a homogeneous solution. The temperature of this solution was reverted to room temperature, and then thereto a solution as prepared by dissolving 13.42 g (0.1 mol) of vinylbenzyl alcohol (mixture of m-isomer and p-isomer), 32.39 g (0.15 mol) of 1,4-dibromobutane, and 3.22 g (0.01 mol) of tetrabutylammonium bromide into 100 ml of toluene was added. While being vigorously stirred, the resultant mixed solution was allowed to react at 40¡ã C. for 6 hours. Thereafter, the solution was separated and then sufficiently washed with water. The resultant organic layer was dried by adding thereto magnesium sulfate, and then toluene was distilled off under reduced pressure. The resultant solution was distilled in the presence of DPPH (diphenylpicryl-2-hydrazyl) under vacuum (boiling point: 125~128¡ã C./16 Pa) to obtain a colorless transparent liquid of 4-bromobutoxymethylstyrene. The yield amount was 15.0 g, and the yield ratio was 56 mol percent.

According to the analysis of related databases, 35106-82-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nippon Shokubai Co., Ltd.; US6414182; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 1875-88-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1875-88-3 as follows.

Example 15 4-Chlorophenylacetaldehyde (38) Dess-Martin periodinane (1.02 g, 2.4 mmol) was diluted in anhydrous CH2Cl2 (25 mL) under argon, and when solution was affected, 4-chlorophenethyl alcohol (33, 0.313 g, 2 mmol) was added dropwise. The mixture was stirred for 2 h and 15 min at room temperature, and was then quenched by addition of 20 mL sat. aq. Na2S2O3. After stirring at room temperature for 15 min, the layers were separated, and the aqueous layer was extracted with CH2Cl2 (2¡Á50 mL). The organic layer was washed with H2O and sat. aq. NaCl (50 mL each) and was dried over anhydrous sodium sulfate and concentrated. The resulting semisolid residue was triturated with 10% EtOAc in hexanes, and the solid was filtered and discarded. The filtrate was concentrated, and the oily residue was purified by flash column chromatography (SiO2), eluting with a gradient of hexanes to 15% EtOAc in hexanes to afford the title compound as a clear yellow volatile oil (0.211 g, 88%). 1H-NMR (500 MHz; CDCl3): delta 9.75 (t, J=2.1 Hz, 1H), 7.34 (d, J=8.3 Hz, 2H), 7.15 (d, J=8.2 Hz, 2H), 3.69 (d, J=2.0 Hz, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1875-88-3, its application will become more common.

Reference:
Patent; Silverman, Richard B.; Cinelli, Maris A.; US2015/210644; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 68120-35-4, (3-Bromo-4-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (3-Bromo-4-methylphenyl)methanol, blongs to alcohols-buliding-blocks compound. name: (3-Bromo-4-methylphenyl)methanol

n-BuLi [(18.6 g, 2.5 eq (2.5M soln) was added to a stirred solution of (3-bromo-4- methylphenyl) methanol (5.5 g, 27.4 mmol) in THE (50 mL) at -78 00 and was stirred at same temperature for 30 mm. Then, 002 gas was purged (generated from dry ice)for about 10 mm. The reaction mixture thus obtained was quenched with ammonium chloride and acidified with 1 N HCI, extracted with ethyl acetate, the organic layer was washed with water, brine solution. Then the reaction mixture was dried over anhydrous Na2SO4 and concentrated under reduced pressure and washed with nhexane to obtain the title compound (4.0 g, 87.85%) as an off white solid. LOMS165.0 (M-H) 1H NMR: (ODd3, 300MHz) 6 12.67 (5, 1H), 7.79 (5, 1H), 7.36-7.38 (d,1 H), 7.23-7.25 (d, 1 H), 5.23 (5, 1 H), 4.49 (5, 2H), 2.50 (5, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,68120-35-4, (3-Bromo-4-methylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MADANAHALLI RANGANATH RAO, Jagannath; GURRAM RANGA, Madhavan; PACHIYAPPAN, Shanmugam; WO2014/202580; (2014); A1;,
Alcohol – Wikipedia,
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Reference of 623-50-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 623-50-7, name is Ethyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below.

General procedure: General Procedure A. Alkylation of N9: To a solution of purine 3 (1.0 eq) in THF (0.1 M) at room temperature, was added the appropriate alcohol (1.1 eq) followed by triphenylphosphine (PPh3; 1.1 eq) under an N2 atmosphere. To the stirring solution, diisopropylazodicarboxylate (DIAD, 1.0 eq) was added dropwise (over 30 s). According to TLC visualization the reaction was complete after 15 min and the solvent was removed in vacuo. The resulting residue was adsorbed onto silica gel from CH2Cl2, and purified by flash column chomatography (2:1 EtOAc:Hex).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-50-7, Ethyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Article; Shahani, Vijay M.; Ball, Daniel P.; Ramos, Allan V.; Li, Zhihua; Spagnuolo, Paul A.; Haftchenary, Sina; Schimmer, Aaron D.; Trudel, Suzanne; Gunning, Patrick T.; Bioorganic and Medicinal Chemistry; vol. 21; 17; (2013); p. 5618 – 5628;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. A new synthetic method of this compound is introduced below., Safety of Ethyl 6-hydroxyhexanoate

1.4 Synthesis of ethyl 6-[(2-cyanoethyl)( V, V-diisopropylamino)phosphino] oxyhexanoate. Ethyl 6-hydroxyhexanoate (2.44 mL, 15.0 mmol) and diisopropylethylamine (10.4 mL, 60.0 mmol) were dissolved in CH2C12 (60 mL). 2-Cyanoethyl-N,N- diisopropylchlorophosphoramidite (3.51 mL, 15.8 mmol) was added dropwise, and the reaction was stirred for 2 h. The reaction was washed with ice-cold saturated aqueous NaHC03, dried over Na2S04, filtered and concentrated under reduced pressure. The crude material was purified by flash chromatography (Si02, 9: 1 hexane/EtOAc with 0.1%> Et3N) to yield the product (4.20 g, 1 1.7 mmol, 78%) as a colorless liquid. i? 0.80 (2: 1 hexane/EtOAc). Spectral data matched those reported previously (Raddatz et al. , 2002, Nucleic Acids Res. 30, 4793).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5299-60-5, Ethyl 6-hydroxyhexanoate.

Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; LAMBRIS, John D.; RICKLIN, Daniel; WO2015/142701; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts