Author: tianli

Application of 1072-52-2, Adding some certain compound to certain chemical reactions, such as: 1072-52-2, name is 2-(Aziridin-1-yl)ethanol,molecular formula is C4H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-52-2.

Into a dry 500 mL distillation flask there was placed 91 mL (1.14 mole) of aziridineethanol to which there was added 495 mg of NaH (60% dispersion in mineral oil). The mixture was stirred for 30 min and the flask was vented. Dimethyl adipate (48 mL, 0.29 mole) was added to the mixture and the flask was connected to a distillation column. The resulting mixture was then heated and methanol was removed at reduced pressure during a period of one hour. Excess aziridineethanol was then removed by heating the mixture to 70 C at a pressure of 0.15 mm Hg. The desired product was then distilled off from the mixture at 130 C at a pressure of 0.15 mm Hg to obtain 49 g (0.18 mole, 60% yield) of di[2-(1-aziridinyl)ethyl]adipate as a colorless oil having the following analysis: 1H NMR (400 MHz, DMSOd6) delta=1.10-1.11(m, 4H, CH2). 1.51-1.55(m, 8H, CH2), 2.28-2.35(m, 8H, CH2), 4.09(t, J=4.0 Hz, 4H, CH2) ppm. 3C NMR (100 MHz, DMSOd6) delta=24.6; 27.0; 33.8; 59.7; 64.2; 173.3 ppm IR: 3064.42; 2952.38; 1731.46; 1454.54; 1264.33; 1174.82 cm-1

According to the analysis of related databases, 1072-52-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gianolio, Diego A.; Calias, Pericles; Miller, Robert J.; US2005/222081; (2005); A1;,
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Related Products of 61487-25-0, Adding some certain compound to certain chemical reactions, such as: 61487-25-0, name is (2-Amino-3-chlorophenyl)methanol,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61487-25-0.

EXAMPLE 82 Preparation of 2-chloro-6-methoxymethylaniline A solution of 4.00 g (25.4 mmol) of 2-amino-3-chlorobenzyl alcohol in 30 ml of dry THF was cooled to -78 C., treated with 16.7 ml (26.7 mmol) of 1.60M n-butyllithium in hexane, warmed to 0-5 C., treated with 3.61 g (25.4 mmol) of methyl iodide and heated at reflux for 5.5 hours. The solvent was removed by evaporation at reduced pressure. The residue was partitioned between 175 ml of ether and water, and the organic phase was separated and dried (MgSO4). The solvent was removed by evaporation at reduced pressure, and the residue was purified by HPLC eluding with ETOAc (5:95, v/v) to afford 1.1 g of the desired product as a pale brown oil. IR and 1 H NMR spectra were in agreement with the assigned structure. Analysis: Calculated for C8 H10 ClNO: C, 56.00; H, 5.87; N, 8.16; Found: C, 56.25; H, 5.98; N, 8.28.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61487-25-0, (2-Amino-3-chlorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Dow Chemical Company; US4755212; (1988); A;,
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Adding a certain compound to certain chemical reactions, such as: 53463-68-6, 10-Bromodecanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 53463-68-6, blongs to alcohols-buliding-blocks compound. COA of Formula: C10H21BrO

DHP (6 mL, 65.82 mmol) and PPTS (127 mg, 0.50 mmol) were added to a solution of bromo-alcohol (12 g, 50.63 mmol) in 100 mL of CH2Cl2 and the mixture was stirred for 16 h. The reaction mixture was quenched with 2 M Na2CO3 solution and extracted with CH2Cl2. The organic layer was dried over Na2SO4, concentrated under reduced pressure. Purification by flash column (6percent EtOAc/hexanes) yielded 16 (14.9 g, 92percent) as a colorless oil. Rf=0.65 (10percent EtOAc/hexanes); 1H NMR (500 MHz, CDCl3): delta 4.54 (dd, J=3.9, 2.9 Hz, 1H), 3.83 (ddd, J=11.7, 8.7, 2.9 Hz, 1H), 3.69 (dt, J=9.7, 6.8 Hz, 1H), 3.47 (m, 1H), 3.36 (m, 3H), 1.81 (m, 3H), 1.67 (m, 1H), 1.53 (m, 6H), 1.39 (m, 2H), 1.28 (m, 10H); 13C NMR (75 MHz, CDCl3): delta 98.7, 67.5, 62.2, 33.9, 32.7, 30.6, 29.6, 29.3, 29.2, 28.6, 28.0, 26.1, 25.4, 19.5; IR (neat): numax 2924, 2855, 1454, 1354, 1126, 1072, 1028 cm?1; HRMS (ESI): calcd for C15H29O2NaBr [M+Na]+ 343.1248; found 343.1251.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,53463-68-6, its application will become more common.

Reference:
Article; Kadam, Vilas D.; Sudhakar, Gangarajula; Tetrahedron; vol. 71; 7; (2015); p. 1058 – 1067;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 110-73-6

The synthesis of INI-12 : [Show Image] 8 g (26 mmol) 2-(3-chloropropoxy)-9H-thioxanthen-9-one was dissolved in 80 mL acetonitrile. The mixture was heated to reflux and 13.2 mL (130 mmol) 2-(ethylamino)-ethanol was added. The reaction was allowed to continue for 24 hours at reflux. 0.7 g sodium iodide was added and the reaction was allowed to continue for another 24 hours at reflux. The precipitated salts were removed by filtration and the solvent was removed under reduced pressure. The residue was dissolved in 150 mL t.butyl methyl ether and extracted 4 times with 100 mL 0.1 N hydrochloric acid. The aqueous fractions were pooled and the pH was adjusted to 12, using a 5 N NaOH solution. The mixture was extracted with 200 mL t.butyl methyl ether. The organic fraction was dried over MgSO4 and evaporated under reduced pressure. 7.6 g (82 %) of the intermediate was isolated.

The synthetic route of 110-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGFA Graphics NV; EP2130817; (2009); A1;,
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Related Products of 2566-44-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Cyclopropylethanol, (21.35 g, 248 mmol, Lancaster), imidazole (25.32 g, 372.4 mmol, Aldrich), and [TRIPHENYLPHOSPHINE] (84.64 g, 323 mmol, Aldrich) were dissolved into methylene chloride (300 mL). The resulting mixture was cooled to [0C] in an ice bath. Afterward, iodine (75.37 g, 298 mmol, Aldrich) was added portion- wise such that the temperature remained at less than [30C.] After this addition was complete, the mixture was allowed to warm to ambient temperature and mix under N2 overnight. The mixture was then diluted with deionized water (250 mL). Subsequently, the layers were separated. The methylene chloride layer was washed with 200 mL each of 10% HCl (aq) (200 mL), saturated [NAHC03 (AQ)] (200 mL), and 10g Na2S203 in deionized water (200 mL). The methylene chloride layer was dried over [MGS04,] filtered, and concentrated in vacuo with a rotovap having a bath temperature of less than [25C] to form solids. Hexanes (150 mL) were added to the solids, and the mixture was slurried for approximately [LHR.] The solids were-then filtered and washed with hexanes (150 mL). The filtrate was passed through a pad of silica (pre-washed with hexanes), with the silica being washed with hexanes to elute the product through the silica. Five bulk fractions of 350 mL each were taken. Product was detected in the first 3 fractions, and had little [TRIPHENYLPHOSPHINE] contamination. Those fractions were combined and concentrated in vacuo with a [ROTOTRAP] having a bath temperature of less than [25C] to form 30.08 g of an oil (62% [YIELD). 1H] NMR was consistent with the desired cyclopropyl ethyl iodide intermediate product.

According to the analysis of related databases, 2566-44-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2004/811; (2003); A1;,
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Related Products of 7589-27-7, Adding some certain compound to certain chemical reactions, such as: 7589-27-7, name is 2-(4-Fluorophenyl)ethanol,molecular formula is C8H9FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7589-27-7.

Step 1: Preparation of 1-(2-bromoethy -4-fluorobenzenePhosphorus tribromide (19.3 g, 71.3 mmol) was added slowly into a solution of 2-(4- fluorophenyl)ethanol (5.0 g, 35.7 mmol) in hexane at 0 ‘C. After 12 hours under stirring, the reaction mixture was diluted with a 10% aqueous solution of NaHC03 and ethyl acetate. The organic layer was washed with water and brine, dried (Na2S04) and concentrated under vacuum to give the title compound (5.7 g, 78 %). TLC: ethylacetate/ Hexane (3/7): R, : 0.85. 1H NMR (CDCI3, 400 MHz): delta 7.20-7.16 (m, 2H), 7.03-6.99 (m, 2H), 3.56 (t, J=7.40 Hz, 2H), 3.15 (t, J=7.44 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7589-27-7, 2-(4-Fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARES TRADING S.A.; JORAND-LEBRUN, Catherine; SWINNEN, Dominique; GERBER, Patrick; KULKARNI, Santosh; WO2012/130915; (2012); A1;,
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Electric Literature of 4277-34-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4277-34-3 as follows.

(E)-2-Cyanoethyl cyclooct-4-enyl diisopropylphosphoramidite (2). To a solution of (E)-Cyclooct-4-enol (70 mg, 0.56 mmol) in 2 ml of absolute CH2Cl2 under argon diisopropylethylamine (0.33 ml, 1.90 mmol) was added. The mixture was cooled to 0C and 2-cyanoethyl-N,N-diisopropylchlorophosphoramidite (141 mul, 0.63 mmol, 1.05 eq) was added. After stirring for one hour at RT, the reaction mixture was directly loaded on a silica column. Purification by flash chromatography (hexane/ethyl acetate 95:5) yielded the product as colourless oil (100 mg, 0.31 mmol, 55%). 1H-NMR (500 MHz, CDCl3, 25C, TMS): delta = 1.16-1.19 (m, 12H), 1.55-1.63 (m, 2H), 1.86-2.37 (m, 8H), 2.63 (t, J = 6.55 Hz, 2H), 3.51-3.61 (m, 3H), 3.72-3.85 (m, 2H), 5.38-5.44 (m, 1 H), 5.54-5.61 (m, 1H). 13C {1H, 31P} NMR (75 MHz, CDCl3, 25C, TMS): delta=20.3, 24.4, 24.6, 31.1, 31.3, 32.7, 32.8, 34.4, 40.0, 40.3, 42.9, 43.0, 43.2, 58.1, 58.3, 79.6, 80.0, 117.6, 132.6, 135.1, 135.2. 31P-NMR (121 MHz, CDCl3,25C, H3PO4): delta=145.5, 146.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4277-34-3, its application will become more common.

Reference:
Patent; Deutsches Krebsforschungszentrum; Ruprecht-Karls-Universitaet Heidelberg; Schoch, Juliane; Jaeschke Andres; Samanta, Ayan; Wiessler, Manfred; EP2565199; (2013); A1;,
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Application of 39590-81-3 , The common heterocyclic compound, 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 22 Synthesis of [l-({[t-butyl (diphenyl) silyl] oxy} methyl) cyclopropylmetbanol Lithium aluminum hydride (LAH) 15.3g was dissolved in 39g of tetrahydrofuran, and 11.7g of the carboxylic acid prepared in Preparation 21 was slowly added dropwise at OIT. The reaction solution was refluxed for 17 hours. The reaction was stopped by adding 10% HCl at room temperature and the mixture was extracted with ethyl acetate. The extract was distilled under reduced pressure and the residue was purified by silica gel column to give 8.2g of diol compound. ‘H NMR (CD3) 6 0.56 (s, 4H), 2.22 (s, 2H), 3.63 (s, 4H) The compound thus obtained (400mg) was dissolved in 12mNo. of THF, 184mg of NaH and 1. 16g of t-butyldiphenylsilylchloride (TBDPSCI) were added, and the resulting mixture was refluxed for 6 hours. The reaction was stopped by adding I OmUSD of water and the mixture was extracted with ethyl acetate, The extract was distilled under reduced pressure and the residue was purified by silica gel column to give l. lg of the title compound. 1H NMR(CDCl3) No. 0.33 (t, 2H), 0. 48 (t, 2E9, 1.23 (s, 9H), 3.59 (d, 4H), 7.42 (m, 6H), 7.68

The synthetic route of 39590-81-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANADYS PHARMACEUTICALS, INC.; WO2005/79812; (2005); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol. A new synthetic method of this compound is introduced below., name: (3-Bromo-2-methylphenyl)methanol

Step B: 5-Bromo-4-methyl-2-benzofuran-U3H)-one: To a flask charged with (3-bromo-2- methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M TFA solution of ThalliumTrifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 min to ensure complete removal of TFA. To the residue was then added palladium(II) chloride (529 mg, 2.98 mmol), lithium chloride (2.53 g, 59.7 mmol), magnesium oxide (2.41 g, 59.7 mmol), and MeOH (150 mL). The reaction was flushed with CO twice, and kept under CO at RT. Analysis by LC showed a formation of product within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The solution was filtered through a celite pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to provide the title compound

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 83647-43-2, (3-Bromo-2-methylphenyl)methanol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; TANG, Haifeng; PIO, Barbara; TEUMELSAN, Nardos; PASTERNAK, Alexander; DEJESUS, Reynalda; WO2013/62892; (2013); A1;,
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Application of 1072-52-2, Adding some certain compound to certain chemical reactions, such as: 1072-52-2, name is 2-(Aziridin-1-yl)ethanol,molecular formula is C4H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-52-2.

EXAMPLE 9 4-(2-hydroxyethyl)-3-thiamorpholinone (Compound 14) To a solution, stirred at ambient temperature, of 120 g of ethyl thioglycolate (1 mole) in 300 cm3 of absolute ethanol, placed under an inert atmosphere, there is slowly added a solution of 87 g (1 mole) of N-(2-hydroxyethyl)aziridine diluted in 100 cm3 of ethanol. The reaction is exothermic and the temperature of the reaction mixture is maintained at a temperature lower than 50 C. One half hour after the end of the introduction, the solution is brought to reflux for 6 hours. The ethanol is then removed and the resulting liquid is distilled under reduced pressure. BP/0.1-0.3 mm=167-170 C. The 4-(2-hydroxyethyl)-3-thiamorpholinone is a light yellow, viscous and hygroscopic liquid whose elemental analysis under the hydrated form is as follows:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1072-52-2, 2-(Aziridin-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; L’Oreal; US4539320; (1985); A;,
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