Author: tianli

Application of 869725-53-1 ,Some common heterocyclic compound, 869725-53-1, molecular formula is C8H6BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

STEP A: Preparation of (2-bromo-5-trifluoromethyl-benzyloxy)-tert-butyl-dimethyl-silane To a solution of (2-bromo-5-(trifluoromethyl)phenyl)methanol (from Preparation 2, 10 g, 39 mmol) in DMF (20 mL) was added imidazole (5.87 g, 86.3 mmol) followed by t-butyldimethylsilyl chloride (7.11 g, 47.2 mmol) and the reaction was stirred at room temperature for 16 hours. The mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by chromatography over 25+M Biotage silica column (eluted with 0-20% ethyl acetate in heptane) (5CV), 20% (1 CV) to afford a colorless oil (14 g, 97%) of the title compound. 1H NMR (400 MHz, CDCl3) delta ppm 0.15 (s, 6H) 0.98 (s, 9H) 4.75 (s, 2H) 7.36 (m, 1H) 7.60 (d, J=8.3 Hz, 1H) 7.84 (s, 1H)). GCMS: 311 (M-57, t-bu).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 869725-53-1, 2-Bromo-5-(trifluoromethyl)benzyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pfizer Inc; US2007/213371; (2007); A1;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Benzyl 2-hydroxyacetate

General procedure: The suitable acid (1.1 equiv), DCC (1.1 equiv) and a catalytic amount of DMAP (0.1-0.2 equiv.) were added to a solution of the alcohol in anhydrous DCM, and stirred at room temperature for several hours. The solid was removed by filtration, and the filtrate was washed successively with a 1N aqueous acetic acid solution and water, dried over MgSO4, filtered, and concentrated under vacuum.The resulting residue was purified by silica gel chromatography to yield the expected compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Article; El Hilali, Mostafa; Reux, Bastien; Debiton, Eric; Leal, Fernand; Galmier, Marie-Josephe; Vivier, Magali; Chezal, Jean-Michel; Miot-Noirault, Elisabeth; Coudert, Pascal; Weber, Valerie; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5692 – 5708;,
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Adding a certain compound to certain chemical reactions, such as: 4249-72-3, 2-Phenoxy-1-phenylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Phenoxy-1-phenylethanol, blongs to alcohols-buliding-blocks compound. Safety of 2-Phenoxy-1-phenylethanol

General procedure: In a typical reaction, 125 ML phosphate buffer (0.2 mol L-1, pH 7),90 ML distilled water, 265 ML AuNPs-GQDs18 (0.72 g L-1, 0.01 mg gold)were mixed. Then, 0.1 mg substrate in 50 ML ethanol was dried at 50 Cin an open bottle. The bottle was sealed after the AuNPs-GQDs18 solutionand 20 ML fresh H2O2 (30 g L-1) was injected into it. The reactionmixture was heated at 75 C for 4 h in a horizonal oscillator. The conversionand yield were determined by HPLC. The catalyst could be recoveredby dialysis (8000-140,000 Da) and reused for 2 times (seeTable S3).

The synthetic route of 4249-72-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Fangwei; Zhang, Jiali; Guo, Shouwu; Inorganic Chemistry Communications; vol. 104; (2019); p. 105 – 109;,
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Related Products of 13726-17-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13726-17-5, name is (4-Chloro-3-methoxyphenyl)methanol, molecular formula is C8H9ClO2, molecular weight is 172.61, as common compound, the synthetic route is as follows.

[00154] Step 2. A suspension of pyridinium chlorochromate (1.37 g, 6.34 mmol) in dichloromethane (35 mL) was treated with Celite (2.0 g) and stirred at rt. A solution of (4-chloro-3-methoxyphenyl)methanol (730 mg, 4.23 mmol) in dichloromethane (5 mL) was added in one portion, and the resulting mixture was stirred at rt for 3 h. After this time, the mixture was diluted with diethyl ether, and stirred vigorously. The mixture was then filtered through a pad of silica gel and the collected solids were rinsed with additional diethyl ether. The combined filtrates were concentrated under vacuum to provide 4-chloro-3-methoxybenzaldehyde as a pale tan-yellow solid (630 mg, 87%). 1H NMR (400 MHz, CDCl3) delta ppm 3.98 (s, 3 H) 7.41 (dd, J=I.9, 1.8 Hz, 1 H) 7.45 (d, J=2.0 Hz, 1 H) 7.55 (d, J=7.6 Hz, 1 H) 9.95 (s, I H).

The chemical industry reduces the impact on the environment during synthesis 13726-17-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BATT, Douglas, G.; WO2010/9069; (2010); A1;,
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Related Products of 3513-81-3, Adding some certain compound to certain chemical reactions, such as: 3513-81-3, name is 2-Methylenepropane-1,3-diol,molecular formula is C4H8O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3513-81-3.

To a solution of 2-methylene-1, 3-propane diol (5.28g, 0.06 mmol) and di-tert-butyl dicarbonate (35 g, 0.16 mol) in 150 ml of dichloromethane was added 6N NaOH (70 ml) and tetrabutylammoniahydrogensulfate (3.4 g, 10 mmol). The mixture was stirred at room temperature overnight. The organic layer was separated, washed with NaHC03 (200 mi x 3) and brine (200 ml), dried over anhydrous MgS04, concentrated and dried over vacuum to give the title compound. ‘H NMR (CDC13) : 5 5.20 (s, 2H); 4.44 (s, 4H); 1. 18 (s, 18H). 13c NMR (CDC13) : No. 153.3, 138.5, 117.3, 82.3, 66.9, 27.8.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3513-81-3, 2-Methylenepropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WO2005/61526; (2005); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4170-90-5, name is Mesitylmethanol. A new synthetic method of this compound is introduced below., SDS of cas: 4170-90-5

General procedure: To a stirred mixture of Ph2PCl (6.0mmol), NaI (6.0 mmol) and anhydrous CH3CN (5 mL) was added alcohol 2 (1.0 mmol) at room temperature under argon atmosphere. The reaction mixture was stirred at 80 C in oil bath for 12 h. When the reaction temperature was cooled to room temperature, aqueous Na2S2O3 (2.0 mL) was added to the reaction mixture, and stirred for another 10 minutes. The organic layer was extracted with dichloromethane, washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by chromatography on silica gel to obtain the corresponding phosphine sulfoxide.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4170-90-5, Mesitylmethanol.

Reference:
Article; Ma, Yutao; Chen, Feng; Bao, Jifeng; Wei, Hao; Shi, Min; Wang, Feijun; Tetrahedron Letters; vol. 57; 23; (2016); p. 2465 – 2467;,
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Application of 6850-65-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6850-65-3, name is 4-Aminocyclohexan-1-ol(isomers mixture), molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A: Tert-butyl 4-hydroxycyclohexylcarbamate. To a solution of 4-aminocyclohexanol (23 g, 0.2 mol) and Et3N (60 g, 0.6 mol) in THF (230 mL) was added (Boc)20 (87 g, 0.4 mol). The resulting solution was stirred at room temperature overnight. The solvent was removed under reduced pressure and the residue was extracted with EtOAc (3 x 200 mL). The combined organic layers were washed with water (2 x 200 mL) and brine (200 mL), dried over anhydrous Na2S04 and concentrated. The residue was purified by column chromatography on silica gel using DCM/ MeOH (V:V, 20: 1 ) to afford the desired product as a white solid. MS: 216.2 (M+l )+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6850-65-3, 4-Aminocyclohexan-1-ol(isomers mixture).

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding; WO2015/10297; (2015); A1;,
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Application of 2215-78-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, molecular weight is 200.2332, as common compound, the synthetic route is as follows.

General procedure: p-Nitrobenzyl alcohol (0.25 g, 1.63 mmol) was dissolved in anhydrous CH2Cl2 under N2. Triethylamine (0.227 mL, 1.63 mmol) was added and the resulting solution was cooled to 0 C. S2Cl2 (65.3 muL, 0.82 mmol) was added dropwise over 20 min. The solution was stirred at 0 C for 2 h before being allowed to equilibrate to room temperature for 3 h. The reaction was quenched with dH20, washed with 2 × 20 mL aliquots of brine. The aqueous phase was extracted with CH2Cl2 (2 × 10 mL), and the combined organic was dried over MgSO4, filtered, and concentrated under reduced pressure. Column chromatography with a 2.5:1 ratio of hexanes:ethyl acetate afforded:

The chemical industry reduces the impact on the environment during synthesis 2215-78-3, I believe this compound will play a more active role in future production and life.

Reference:
Article; Stoutenburg, Eric G.; Palermo, Anne E.; Priefer, Ronny; Thermochimica Acta; vol. 551; (2013); p. 99 – 103;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol

STR4 2-(Perfluorohexyl)ethanol 18.2 g (0.05 mol), 5% Pd-C (pH 7.2) 1.5 g as a catalyst were charged in a 70 ml autoclave equipped with a hydrogen gas inlet and a stirrer, to which was added dropwise dodecylaldehyde 13.8 g (0.075 mol) under atmospheric pressure over 6 hours and stirring was conducted at 105 C. for 8 hours while hydrogen was flowed continuously at 15 ml/min. After reaction was completed, the catalyst was removed by filtration, and an excess of dodecylaldehyde was removed under reduced pressure to provide the objective dodecyl{2-(perfluorohexyl)ethyl}ether 25.3 g (0.048 mol) as a colorless, transparent liquid. Isolation yield was 95%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol.

Reference:
Patent; Kao Corporation; US6002048; (1999); A;,
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Related Products of 56239-26-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 56239-26-0 as follows.

90 mg (0.59 mmol) of cis 4-amino-cyclohexanol hydrochloride were dissolved in 10 ml dimethyl acetamide and 59.3 mg (1.48 mmol) of sodium hydride (60percent) were added. After stirring 30 minutes at room temperature, a solution of 200 mg (0.49 mmol) of 7- benzylsulfanyl-6-fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (126) in 20 ml of dimethyl acetamide was added and the mixture was stirred at 80 0C for 1 h, then at 130 0C for 3 h. Another 1.2 equivalents of cis 4-amino-cyclohexanol hydrochloride and 2.5 equivalents of sodium hydride were added and the temperature was increased to 160 0C. After 8h the solution is cooled down to room temperature and the solvent is removed under reduced pressure. The residue is dissolved in dichloromethane, washed with water and dried with magnesium sulfate. After evaporation of the solvent and purification by preparative HPLC, the title compound was isolated as trifluoroacetate. R1 = 1.18 min (Method C). Detected mass: 501.6 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56239-26-0, its application will become more common.

Reference:
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; WO2007/12422; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts