Author: tianli

Related Products of 624-95-3, Adding some certain compound to certain chemical reactions, such as: 624-95-3, name is 3,3-Dimethylbutan-1-ol,molecular formula is C6H14O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-95-3.

12.2 g of 3, 3-Dimethyl-l-butanol of 98% purity (117.3 mmol) and 0.049 g 4- Acetamido-TEMPO (0. 223MMOL) are charged in a jacketed glass reaction flask as in Example I. Sodium borate (0.294 g, 0.76 mmol), NAHC03 (1. 472 g, 17. 5MMOL) and NACL (2 g) are dissolved in water (25 cc) and the aqueous solution is added to the stirred organic fraction at 1000RPM in the reaction flask. The stirred suspension is cooled to 0C and the emulsion is re-adjusted to pH 8.6 using 40% solution OF NAOH. When the temperature of the reactants reached 0C, 69.8 g (123.1 mmol) of 13.1% aqueous NAOCI solution are pumped in via a gas-tight syringe over 55 minutes. The reaction mixture is stirred for an additional 15 min at 0C and the organic layer is sampled for GC assay. The yield of 3, 3-dimethylbutyraldehyde is 88.3% at 2 MIN of post bleach-addition time and 92. 1 % at 15 min reaction time.

According to the analysis of related databases, 624-95-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE NUTRASWEET COMPANY; WO2004/67484; (2004); A2;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56-81-5, name is Propane-1,2,3-triol, molecular formula is C3H8O3, molecular weight is 92.0938, as common compound, the synthetic route is as follows.Computed Properties of C3H8O3

Will be 920g of glycerin,990gParaformaldehyde and20 g of the supported solid super acid catalyst prepared in Example 2 was addedIn the reaction device, the reaction is heated to 80 C, and the water having a lower boiling point and the trioxane formed in the reaction process enters the fractionation device.According to the principle that the boiling point of paraformaldehyde is lower than water, the triacetal is fractionated back to the reaction unit through a fractionation device.The reaction was carried out as a raw material, and the reaction was completed for 5 hours to obtain glycerol formal, and the product was analyzed by HPLC-MS.At 96.3%, the ratio of the six-membered ring product to the product of the five-membered ring in the product was 70:25.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56-81-5, Propane-1,2,3-triol, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang Haotang Industrial Co., Ltd.; Liu Demin; (5 pag.)CN109535122; (2019); A;,
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Related Products of 2615-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of Compound 29a To a solution of hexaethylene glycol (25.0 g, 88.5 mmol) in DCM (100 mL) were added triethylamine (61.7 mL, 443 mmol) and ^-toluenesulfonyl chloride (50.6 g, 266 mmol) at 0 C under N2. After 5 hours at 0 C, the reaction mixture was poured into 1 N aq. HC1 (200 mL) and extracted with DCM (2 x 200 mL). The combined organic layers were washed with saturated aq. NaHCO3 (100 mL) and brine (100 mL), and dried over anhydrous Na2SO4. After filtration and concentration, the residue was purified by column chromatography, which produced the compound 29a (45.0 g, 87 %) as brown oil. 1H- MR (400 MHz, CDC13) delta 7.79 (d, J= 7.6 Hz, 4H), 7.34 (d, J= 7.6 Hz, 4H), 4.16-4.14 (m, 4H), 3.69-3.67 (m, 4H), 3.64-3.56 (m, 16H), 2.44 (s, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; LEGOCHEM BIOSCIENCES, INC.; KIM, Yong, Zu; OH, Yeong, Soo; CHAE, Jeiwook; SONG, Ho, Young; CHUNG, Chul-woong; PARK, Yun, Hee; CHOI, Hyo, Jung; PARK, Kyung, Eun; KIM, Hyoungrae; KIM, Jinyeong; MIN, Ji, Young; KIM, Sung, Min; LEE, Byung, Soo; WOO, Dong, Hyun; JUN, Ji, Eun; LEE, Su, In; (272 pag.)WO2017/89890; (2017); A1;,
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Synthetic Route of 22436-06-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 22436-06-2 as follows.

Under a nitrogen atmosphere, a 1 L three-necked glass vial was charged with 54 g of (±)-2-methyl-3-phenyl-1-propanol, 64 g of phthalic anhydride, 1.38 g of pyridine, and 540 g of tetrahydrofuran.The reaction was stirred at 0 C – 20 C for 30 hours, and concentrated to give a crude product (122 g).After crystallization with ethyl acetate as a solvent,103 g of (±)-2-methyl-3-phenyl-1-propanol-phthalic acid monoester were obtained, and the purity of the liquid chromatography was ?98%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,22436-06-2, its application will become more common.

Reference:
Patent; Jiangsu Guangyu Chemical Co., Ltd.; Diao Bozhen; Zhang Limeng; Kang Jie; (12 pag.)CN109503319; (2019); A;,
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Related Products of 83647-43-2, Adding some certain compound to certain chemical reactions, such as: 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83647-43-2.

Step B: 5-Bromo-4-methyl-2-benzofuran-l(3H)-one To a flask charged with (3-bromo-2-methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M trifluoroacetic acid solution of thallium trifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 min to ensure complete removal of TFA. To the residue was then added palladium(II) chloride (529 mg, 2.98 mmol), lithium chloride (2.53 g, 59.7 mmol), magnesium oxide (2.41 g, 59.7 mmol), and methanol (150 mL). The reaction was flushed with CO twice, and kept under CO at room temperature. Analysis by LC showed a big product spot within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The black solution was filtered through a diatomaceous earth pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to afford 5-bromo-4-methyl-2-benzofuran-l(3H)-one. 1H-NMR (500 MHz, CDC13) delta ppm 7.71 (d, J= 8.0 Hz, 1H), 7.58 (d, J 2H), 2.37 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 83647-43-2, (3-Bromo-2-methylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
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Electric Literature of 23147-58-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23147-58-2, name is Glycerol aldehyde dimer. A new synthetic method of this compound is introduced below.

Compound I-ee was prepared using the method of Example 7. To a solution of compound I-ee (0.1 mmol) in methanol (1 mL) was added the aldehyde or ketone (0.2 mmol) and acetic acid (0.4 mmol), followed by sodium cyanoborohydride (0.2 mmol). The solution was stirred at 20 to 25 C (for reactive aldehydes) or 50 to 60 C (for less reactive aldehydes and ketones) until all of Compound I-ee was consumed. The reaction mixture was concentrated on a rotary evaporator, re-dissolved in a mixture of water-acetonitrile, filtered through a one-gram plug of C-18 silica gel, and purified by reversed-phase HPLC, eluted using a gradient of acetonitrile in water containing 0.1% acetic acid. The product was obtained as a white solid after lyophilization of desired fractions. EPO [00182] Compound I-nn (5S,6R)-5-[N-(2-hydroxyethyl)methylamino]polyangi-l ,6- diol) was synthesized using glycolaldehyde dimer at room temperature. ESI-TOF-MS m/z 518.3839, calcd for C31H52NO5 ([M + H]+) 518.3840.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23147-58-2, Glycerol aldehyde dimer, and friends who are interested can also refer to it.

Reference:
Patent; KOSAN BIOSCIENCES INCORPORATED; WO2006/66147; (2006); A2;,
Alcohol – Wikipedia,
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Synthetic Route of 1992-09-2, Adding some certain compound to certain chemical reactions, such as: 1992-09-2, name is 2-(4-Amino-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C10H9F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1992-09-2.

2.73 g of 2-(3′-methyl-4′-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanolCompound of formula VAnd 4.89 g of cesium carbonate was added to the dried reaction flask,Add in 20 ml of DMF and stir at room temperature for 30 minutes.1.70 g of methyl iodide was slowly added to the reaction flask with a syringe,Stirring was continued at room temperature and TLC was detected until the conversion of the starting material was complete.After the reaction was completed, it was extracted with a saturated aqueous solution of ammonium chloride and ethyl acetate.The organic phase was dried over anhydrous sodium sulfate and dried under reduced pressure.The crude oily intermediate VIa was obtained for subsequent reaction.

According to the analysis of related databases, 1992-09-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; East China University of Science and Technology; Cao Song; Zhao Xianghu; He Jingjing; Li Jialu; Liu Yisen; Li Chunmei; Xu Sixue; Huang Qingchun; (19 pag.)CN110272361; (2019); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, the common compound, a new synthetic route is introduced below. Quality Control of 1-Chloro-2-methyl-2-propanol

EXAMPLE 1 Preparation of 2-(2-hydroxy-2-methylpropoxy)phenol from 1-chloro-2-methyl-2-propanol Catechol (11.0 g, 0.10 mole), sodium carbonate (10.6 g, 0.10 mole) and 100 g methanol were combined in a 250 ml 3-necked round bottom flask equipped with an air stirrer, heating mantle, condenser and thermometer, and heated to reflux (approximately 65° C.). 1-Chloro-2-methyl-2-propanol (10.9 g, 0.10 mole) was added by syringe. The mixture was refluxed for 3 hours, then left standing overnight. Water (40 ml) was added and the mixture was refluxed for 2 hours. After cooling, the water was extracted three times with 100 ml of dichloromethane. The combined dichloromethane layers were washed twice with 100 ml of water, then concentrated to afford 4.40 g (24percent) of waxy yellow solid. Recrystallization from ethyl acetate (10 g) and hexane (50 g) gave a white solid. 1 Hnmr analysis was consistent with the structural formula of 2-(2-hydroxy-2-methylpropoxy)phenol. Analysis: Cald., C 65.91percent, H, 7.74percent; found, C 65.85, 66.05, H 7.66, 7.66.

The synthetic route of 558-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Union Carbide Corporation; US4639536; (1987); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1072-52-2

Example 15 (Table 1, entry 8 and Scheme 11): Preparation of methyl 3-[(2-bromoethyl)- 2-[(methylsulfonyloxy)ethyl]amino]-2,6-dinitrobenzoate (27b); A solution of methyl 3- chloro-2,6-dinitrobenzoate (25) (1.15 g, 5.0 mmol) in dry DMF (10 mL) was treated with aziridineethanol (1.3 g, 15.0 mmol) and LiBr (4.35 g, 50 mmol)and stirred at room temperature for 6 h. The mixture was diluted with brine (40 mL) and extracted with EtOAc (2×60 mL). The combined organic fractions were washed with brine dried and concentrated under reduced pressure. Chromatography of the residue on silica gel, eluting with EtOAc/petroleum ether gave methyl 3-[(2-chloroethyl)(2-hydroxyethyl)amino]-2,6-dinitrobenzoate (26b) (0.40 g, 36% based on consumed starting material) as a yellow oil: 1H NMR [(CD3)2SO] delta 8.24 (d, / = 9.4 Hz, 1 H), 7.62 (dj = 9.4 Hz, 1 H), 4.79 (vbr s, 1 H), 3.78 (s, 3 H), 3.77 (t, / = 6.2 Hz, 2 H), 3.65 (t, / = 6.1 Hz, 2 H), 3.53 (t, / = 5.4 Hz, 2 H), 3.36 (t, / = 5.3 Hz, 2 H); 13C NMR delta163.2, 147.6, 136.4, 134.5, 128.1, 126.3, 121.9, 58.1, 53.8, 53.6, 52.5, 29.7. 38b: HRMS (FAB) calcd for C12H1579BrN3O7 [M+H]+ m/z 392.0093; found 392.0093.

With the rapid development of chemical substances, we look forward to future research findings about 1072-52-2.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Synthetic Route of 18776-12-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18776-12-0, name is 3-Chloro-1-phenylpropan-1-ol, molecular formula is C9H11ClO, molecular weight is 170.64, as common compound, the synthetic route is as follows.

To a solution of the 3-chloro-1-phenyl-propan-1-ol (1.5 g, 8.79 mmol) in DCM at 0 C. (50 mL) was added TEA (1.6 mL, 11.4 mmol) followed by MsCl (0.75 mL, 9.7 mmol). The reaction mixture was stirred 1.5 hours at 0 C., quenched with ice, and partitioned between a saturated solution of NaHCO3 and DCM. The organic layer was separated, washed with brine, dried over MgSO4, filtered, and concentrated at 0 C. The methanesulfonic acid 3-chloro-1-phenyl-propyl ester (95% crude yield, 2.08 g) thus prepared was used in the next step without purification.

The chemical industry reduces the impact on the environment during synthesis 18776-12-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Roche Palo Alto LLC; US2007/123535; (2007); A1;,
Alcohol – Wikipedia,
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