Author: tianli

Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Sjoberg, Berndt; Stjernstrom, Nils E.; Westin, Gertrud published the artcile< Potential hypolipidemic agents. VI. Syntheses of some new halo-substituted pyridine compounds. Effects on noradrenaline-stimulated free fatty acid mobilization>, Formula: C6H6ClNO, the main research area is pyridine halo hydroxy hypolipidemic; hypolipidemic halopyridine.

The pyridines I (R = CHO, CH2OH, CH2CN, CH2CO2H, CH2OCH2Ph, CH2O2CNHPh CH2O2CCMe2OC6H4Cl-p, etc.; R1 = 5-F, 6-F, 5-Cl, 6-Cl, 5-Br) were prepared Thus I (R = CH2OH, R1 = 5-F) was treated with SOCl2 and the product treated with KCN to give I (R = CH2CN, R1 = 5-F), which was hydrolyzed to give I (R = CH2CO2H, R1 = 5-F). 5-Fluoronicotinic acid and 5-fluoro-3-pyridylmethanol were oxidized with H2O2 to give the pyridine oxides (II, R = CO2H, R = CH2OH, resp.). The N-methylnicotinic acid (III) was also prepared The pharmacol. effects of the compounds on noradrenaline-induced free fatty acid mobilization in dogs was determined and related to nicotinic acid.

Acta Pharmaceutica Suecica published new progress about Lipids Role: RCT (Reactant), RACT (Reactant or Reagent). 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Formula: C6H6ClNO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iona, Roberto; Bassetti, Mauro published the artcile< Dimerization of Aromatic Terminal Alkynes Featuring Hydrophilic Functional Groups under Ruthenium and Acid Promoted Catalysis. Competitive Alkyne Hydration upon Substituent Effect>, Formula: C9H8O, the main research area is dimeric diarylenyne stereoselective preparation; aryl terminal alkyne hydrophilic functional group dimerization ruthenium catalyst.

The self-coupling (hydroalkynylation) process of aromatic terminal alkynes RC6H4CCH to give dimeric 1,4-diaryl-1-en-3-yne products (trans-RC6H4CCCH=CHC6H4R) is catalyzed by the complex [{RuCl(μ-Cl)(η6-p-cymene)}2] with sodium acetate co-catalyst dissolved in neat acetic acid, the reaction proceeding with high trans-stereoselectivity under mild conditions (r.t.) even for substrates with protic or polar substituent groups (e. g. R = 3-OH, 4-CH2OH, 4-NHAc, -CHO, 4-tetra-O-acetyl-β-D-glucopyranoside). In presence of strongly electron donating arene substituents, NMe2 and NH2, the triple bond is activated toward exclusive triple bond hydration by reaction with acetic acid at room temperature also in absence of the ruthenium catalyst.

ChemistrySelect published new progress about Alkenynes Role: SPN (Synthetic Preparation), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tsui, Brian T. H.; Sung, Molly M. H.; Kinas, Jenny; Hahn, F. Ekkehardt; Morris, Robert H. published the artcile< A Ruthenium Protic N-Heterocyclic Carbene Complex as a Precatalyst for the Efficient Transfer Hydrogenation of Aryl Ketones>, Reference of 403-41-8, the main research area is bipyridinylimidazolylidene ruthenium pincer complex preparation catalyst reduction aryl ketone; crystal structure bipyridinylimidazolylidene ruthenium pincer complex; mol structure bipyridinylimidazolylidene ruthenium pincer complex.

A neutral azole precursor to a protic N-heterocyclic carbene (pNHC) ligand, 6-((4,5-diphenyl-1H-imidazol-1-yl)methyl)-2,2′-bipyridine (3), was prepared from 6-(bromomethyl)-2,2′-bipyridine (2) and 4,5-diphenylimidazole. [RuCl(pNHC-bpy)(PPh3)2](PF6) (4) bearing a protic, bipyridine-tethered NHC ligand was prepared by refluxing 3 with RuCl2(PPh3)3 and KPF6 in MeOH and was characterized by NMR spectroscopy, mass spectrometry, elemental anal., and a single-crystal x-ray diffraction study. The hydrido complex [RuH(pNHC-bpy)(PPh3)2](PF6) (5) was prepared by reaction of 4 with NaBH4 in EtOH and characterized by NMR and FTIR spectroscopy. Complex 5 was used as the catalyst (0.1 mol % loading) in the transfer hydrogenation of a range of alkyl/aryl ketones in basic iso-PrOH at 60°. Bulky alkyl groups or ortho-substituted aryl groups at the ketones slowed down or inhibited the catalytic transformation. The addition of an excess of PPh3 also slowed the catalysis, providing an indication for a mechanism involving phosphine dissociation, while the addition of an excess of elemental Hg had only a small effect on the conversion. The importance of K cations in the mechanism is consistent with the observation of reduced catalytic conversion when [2,2,2]-cryptand was present or when 1,8-diazabicyclo[5.4.0]undec-7-ene was used as the base. A plausible homogeneous catalysis mechanism involving the innersphere addition of hydride to the substrate in the transition state TS1 is supported by d. functional theory calculations where the K ion has replaced the H atom of the N-H group in a protic NHC.

Organometallics published new progress about Alkylidenes Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PROC (Process), PREP (Preparation) (Ru pincer complexes). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molaei, Somayeh; Tamoradi, Taiebeh; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash published the artcile< Synthesis and characterization of MCM-41@AMPD@Zn as a novel and recoverable mesostructured catalyst for oxidation of sulfur containing compounds and synthesis of 5-substituted tetrazoles>, Recommanded Product: 2-(Phenylthio)ethanol, the main research area is mesoporous silica zinc bound preparation recyclable oxidation cycloaddition catalyst; sulfoxide disulfide preparation; tetrazole preparation; oxidation sulfide thiol peroxide zinc bound mesoporous silica catalyst; cycloaddition azide nitrile zinc bound mesoporous silica catalyst.

Zinc bound to mesoporous silica MCM-41 functionalized with (3-chloropropyl)trimethoxysilane and 2-amino-2-methyl-1,3-propanediol was prepared as a recyclable catalyst for solvent-free oxidation of sulfides and thiols with H2O2 to form sulfides and disulfides, resp., and for the cycloaddition of NaN3 to nitriles in PEG-400 to yield tetrazoles. The catalyst was used eight times for oxidation and cycloaddition reactions with < 10% decrease in yield over the eight reaction cycles. Microporous and Mesoporous Materials published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Recommanded Product: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Irene S.; Loree, Jonathan M. published the artcile< FOLFOXIRI plus Bevacizumab Versus FOLFOX plus Panitumumab for Metastatic Left-Sided RAS / BRAF Wild-Type Colorectal Cancer: Which ′′Side′′ Are You On?>, Product Details of C20H21CaN7O7, the main research area is review FOLFOXIRI bevacizumab FOLFOX panitumumab RAS BRAF colorectal cancer.

A review. This commentary focuses on the results of the study by Pietrantonio et al., which evaluated the clin. conundrum of triplet vs. doublet chemotherapy in combination with targeted therapy for metastatic left-sided RAS/BRAF wild-type colorectal cancer and appears in this issue. Both FOLFOXIRI [fluorouracil, leucovorin, oxaliplatin, and irinotecan] plus bevacizumab and FOLFOX [fluorouracil, leucovorin, and oxaliplatin] plus panitumumab have shown impressive activity in this population; however, the two have not been directly compared. The article by Pietrantonio et al. presents a propensity score-adjusted anal. using information from five previous randomized trials and provides best available evidence comparing these regimens. This commentary will discuss their results and how their findings fit in current treatment paradigms.

Oncologist published new progress about Antitumor agents. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Product Details of C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mollaei, Mahdi; Ghoreishi, Sayed Mehdi; Khoobi, Asma published the artcile< Multivariate optimization and validation of a new procedure for simultaneous determination of folic acid and folinic acid based on enhancement effect of n-dodecylpyridinium chloride>, Reference of 1492-18-8, the main research area is folinic acid dodecylpyridinium chloride optimization enhancement effect.

The present study is a first report about of an electrochem. sensor for simultaneous determination of folic acid (FA) and calcium folinate (CF). Also, the work is a first successful application of n-dodecylpyridinium chloride (DPC) as a modifier in simultaneous measurement of folates. This study is based on the adsorption of cationic surfactants at the surface of a carbon paste electrode (CPE) to improve the electrochem. response of the tow analytes. The enhancement effect of DPC is compared with CTAB by differential pulse voltammetry (DPV) technique and DPC shows the better results as a modifier. Other novelty of the work is application of multivariate optimization for optimization of effective parameters in the voltammetric peak current of the analytes. Under the optimized conditions, a peak separation of CF and FA is higher than 270 mV. CPE in the presence of DPC shows wide linear responses for CF and FA in the concentration ranges of 0.1-100.0μM and 0.05-10.0μM with detection limits of 24.0 nM and 7.5 nM (3s), resp. CPE in the presence of DPC exhibits good repeatability and stability for the two analytes. At the last, CPE in the presence of DPC was successfully applied to the simultaneous detection of FA and CF in urine real samples.

Microchemical Journal published new progress about Adsorption. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Reference of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Xu; Song, Ning; Saidahmatov, Abdusaid; Wang, Peipei; Wang, Yong; Hu, Xiaobei; Kan, Weijuan; Zhu, Wei; Gao, Lixin; Zeng, Mingjie; Wang, Yujie; Li, Chunpu; Li, Jia; Liu, Hong; Zhou, Yubo; Wang, Jiang published the artcile< Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia>, Recommanded Product: 3-Aminocyclohexanol, the main research area is acute myeloid leukemia CDK9 inhibitors antiproliferative activity bioavailability SAR.

CDK9 is an essential drug target correlated to the development of acute myeloid leukemia (AML). Starting from the hit compound 10, which was discovered through a screening of our inhouse compound library, the structural modifications were carried out based on the bioisosterism and scaffold hopping strategies. Consequently, compound 37 (I) displayed the optimal CDK9 inhibitory activity with an IC50 value of 5.41 nM, which was nearly 1500-fold higher than compound 10. In addition, compound 37 exhibited significant antiproliferative activity in broad cancer cell lines. Further investigation of in vivo properties demonstrated that compound 37 could be orally administrated with an acceptable bioavailability (F = 33.7%). In MV-4-11 s.c. xenograft mouse model, compound 37 (7.5 mg/kg) could significantly suppress the tumor progression with a T/C value of 27.80%. Compound 37 represents a promising lead compound for the development of a novel class of CDK9 inhibitors for the treatment of acute myeloid leukemia.

Journal of Medicinal Chemistry published new progress about Acute myeloid leukemia. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Recommanded Product: 3-Aminocyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Das, Sabuj Kanti; Bhanja, Piyali; Kundu, Sudipta K.; Mondal, Saptarsi; Bhaumik, Asim published the artcile< Role of Surface Phenolic-OH Groups in N-Rich Porous Organic Polymers for Enhancing the CO2 Uptake and CO2/N2 Selectivity: Experimental and Computational Studies>, Electric Literature of 4396-13-8, the main research area is surface phenolic porous carbon dioxide polyamine aminoplast; CO2 uptake; N-rich porous surface; phenolic-OH groups; porous organic polymers; selective CO2/N2 adsorption.

Design and successful synthesis of phenolic-OH and amine-functionalized porous organic polymers as adsorbent for postcombustion CO2 uptake from flue gas mixtures along with high CO2/N2 selectivity is a very demanding research area in the context of developing a suitable adsorbent to mitigate greenhouse gases. Herein, we report three triazine-based porous organic polymers TrzPOP-1, -2, and -3 through the polycondensation of two triazine rings containing tetraamine and three dialdehydes. These porous organic polymers possess high Brunauer-Emmett-Teller (BET) surface areas of 995, 868, and 772 m2 g-1, resp. Out of the three materials, TrzPOP-2 and TrzPOP-3 contain addnl. phenolic-OH groups along with triazine moiety and secondary amine linkages. At 273 K, TrzPOP-1, -2, and -3 displayed CO2 uptake capacities of 6.19, 7.51, and 8.54 mmol g-1, resp., up to 1 bar pressure, which are considerably high among all porous polymers reported till date. Despite the lower BET surface area, TrzPOP-2 and TrzPOP-3 containing phenolic-OH groups showed higher CO2 uptakes. To understand the CO2 adsorption mechanism, we have further performed the quantum chem. studies to analyze noncovalent interactions between CO2 mols. and different polar functionalities present in these porous polymers. TrzPOP-1, -2, and -3 have the capability of selective CO2 uptake over that of N2 at 273 K with the selectivity of 61:1, 117:1, and 142:1 by using the initial slope comparing method, along with 108.4, 140.6, and 167.4 by using ideal adsorbed solution theory (IAST) method, resp. On the other hand, at 298 K, the calculated CO2/N2 selectivities in the initial slope comparing method for TrzPOP-1, -2, and -3 are 27:1, 72:1, and 96:1, whereas those using IAST method are 42.1, 75.7, and 94.5, resp. Cost effective and scalable synthesis of these porous polymeric materials reported herein for selective CO2 capture has a very promising future for environmental clean-up.

ACS Applied Materials & Interfaces published new progress about Activation energy. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Electric Literature of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cabeza, Javier A.; Fernandez-Colinas, Jose M.; Garcia-Alvarez, Joaquin; Garcia-Alvarez, Pablo; Laglera-Gandara, Carlos J.; Ramos-Martin, Marina published the artcile< Dipyrromethane-Based PGeP Pincer Germyl Rhodium Complexes>, SDS of cas: 403-41-8, the main research area is crystal structure mol dipyrromethane pincer germyl rhodium complex preparation; dipyrromethane pincer germyl rhodium complex hydroboration catalyst styrene catecholborane; PGeP pincers; germylenes; hydroboration; pincer complexes; rhodium.

A family of germyl rhodium complexes derived from the PGeP germylene 2,2′-bis(di-isopropylphosphinylmethyl)-5,5′-dimethyldipyrromethane-1,1′-diylgermanium(II), Ge(pyrmPiPr2)2CMe2 (1), has been prepared Germylene 1 reacted readily with [RhCl(PPh3)3] and [RhCl(cod)(PPh3)] (cod=1,5-cyclooctadiene) to give, in both cases, the PGeP-pincer chloridogermyl rhodium(I) derivative [Rh{κ3P,Ge,P-GeCl(pyrmPiPr2)2CMe2}(PPh3)] (2). Similarly, the reaction of 1 with [RhCl(cod)(MeCN)] afforded [Rh{κ3P,Ge,P-GeCl(pyrmPiPr2)2CMe2}(MeCN)] (3). The methoxidogermyl and methylgermyl rhodium(I) complexes [Rh{κ3P,Ge,P-GeR(pyrmPiPr2)2CMe2}(PPh3)] (R=OMe, 4; Me, 5) were prepared by treating complex 2 with LiOMe and LiMe, resp. Complex 5 readily reacted with CO to give the carbonyl rhodium(I) derivative [Rh{κ3P,Ge,P-GeR(pyrmPiPr2)2CMe2}(CO)] (6), with HCl, HSnPh3 and Ph2S2 rendering the pentacoordinate methylgermyl rhodium(III) complexes [RhHX{κ3P,Ge,P-GeMe(pyrmPiPr2)2CMe2}] (X=Cl, 7; SnPh3, 8) and [Rh(SPh)2{κ3P,Ge,P-GeMe(pyrmPiPr2)2CMe2}] (9), resp., and with H2 to give the hexacoordinate derivative [RhH2{κ3P,Ge,P-GeMe(pyrmPiPr2)2CMe2}(PPh3)] (10). Complexes 3 and 5 are catalyst precursors for the hydroboration of styrene, 4-vinyltoluene and 4-vinylfluorobenzene with catecholborane under mild conditions.

Chemistry – A European Journal published new progress about Crystal structure. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, SDS of cas: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tyula, Yunes Abbasi; Zabardasti, Abedien; Goudarziafshar, Hamid; Kucerakova, Monika; Dusek, Michal published the artcile< A new supramolecular zinc(II) complex containing 4-biphenylcarbaldehyde isonicotinoylhydrazone ligand: Nanostructure synthesis, catalytic activities and Hirshfeld surface analysis>, Product Details of C8H10OS, the main research area is Hirshfeld surface analysis intermol interaction zinc biphenyl carboxaldehyde complex; sulfide selective oxidation sulfoxide preparation zinc biphenyl carboxaldehyde catalyst; crystal structure zinc dibromo biphenyl carboxaldehyde complex preparation.

A new potentially tridentate hydrazone ligand, 4-biphenylcarbaldehyde isonicotinoylhydrazone (4-bpinh), was prepared by the condensation of biphenyl-4-carboxaldehyde with isonicotinic acid hydrazide. Then, its nano-sized and single crystal of zinc complex were synthesized using sonochem. and heat gradient methods, resp. The structure of complex, [Zn(4-bpinh)2Br2] (1), was determined by single-crystal x-ray diffraction, FTIR, and elemental anal., and the nano-structure of complex was characterized by FTIR, XRD, and SEM. The single crystal x-ray structure of complex showed that the metal center has a distorted tetrahedral geometry and the hydrazone ligand acts as monodentate trough the pyridyl N atom. Moreover, the anal. of crystal structures indicates the existence of intermol. interactions such as N/C-H···Br/O, N/C-H···π, and π···π stacking in the stabilization of complex structure which finally gave the three-dimensional supramol. structure. Also, the impact of this interactions was more studied using Hirshfeld surface anal. and corresponding 2D fingerprint plots. Furthermore, the catalytic activity of 1 was studied in the selective oxidation of various sulfides to corresponding sulfoxides using hydrogen peroxide as the oxidative agent.

Applied Organometallic Chemistry published new progress about Crystal structure. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Product Details of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts