Author: tianli

Herron, Josi M.; Tomita, Hideaki; White, Collin C.; Kavanagh, Terrance J.; Xu, Libin published the artcile< Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3-D in Vitro Model of Neurodevelopment>, SDS of cas: 434-16-2, the main research area is benzalkonium chloride neural stem cell neurosphere apoptosis proliferation stress.

We previously found that the widely used disinfectants, benzalkonium chlorides (BACs), alter cholesterol and lipid homeostasis in neuronal cell lines and in neonatal mouse brains. Here, we investigate the effects of BACs on neurospheres, an in vitro three-dimensional model of neurodevelopment. Neurospheres cultured from mouse embryonic neural progenitor cells (NPCs) were exposed to increasing concentrations (from 1 to 100 nM) of a short-chain BAC (BAC C12), a long-chain BAC (BAC C16), and AY9944 (a known DHCR7 inhibitor). We found that the sizes of neurospheres were decreased by both BACs but not by AY9944. Furthermore, we observed potent inhibition of cholesterol biosynthesis at the step of DHCR7 by BAC C12 but not by BAC C16, suggesting that cholesterol biosynthesis inhibition is not responsible for the observed reduction in neurosphere growth. By using immunostaining and cell cycle anal., we found that both BACs induced apoptosis and decreased proliferation of NPCs. To explore the mechanisms underlying their effect on neurosphere growth, we carried out RNA sequencing on neurospheres exposed to each BAC at 50 nM for 24 h, which revealed the activation of the integrated stress response by both BACs. Overall, these results suggest that BACs affect neurodevelopment by inducing the integrated stress response in a manner independent of their effects on cholesterol biosynthesis.

Chemical Research in Toxicology published new progress about Apoptosis. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, SDS of cas: 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arab, Leila; Seegmueller, Stefan; Kreuzwieser, Juergen; Eiblmeier, Monika; Rennenberg, Heinz published the artcile< Atmospheric pCO2 impacts leaf structural and physiological traits in Quercus petraea seedlings>, Recommanded Product: D-Glucosaccharic acid, the main research area is Quercus seedling leaf structural physiol trait oxidative stress ROS; Amino acid; Carbohydrate; Carbon dioxide; Cellulose; Glutathione reductase; Lignin.

Sessile oak (Quercus petraea Liebl.) was grown for ca. half a year from seeds at ambient control (525 ppm), 750, 900, and 1000 ppm atm. pCO2 under controlled conditions. Increasing pCO2 enhanced biomass production, modified the cell wall composition of the leaves in favor of cellulose at the expense of lignin, and enhanced the foliar non-structural carbohydrate level, in particular the sucrose content; as well as total N content of leaves by increased levels of all major N fractions, i.e., soluble proteins, total amino acids, and structural N. The enhanced total amino acid level was largely due to 2-ketoglutarate and oxalo acetate-derived compounds Increasing pCO2 alleviated oxidative stress in the leaves as indicated by reduced H2O2 contents. High in vitro glutathione reductase activity at reduced H2O2 contents suggests enhanced ROS scavenging, but increased lipid peroxidation may also have contributed, as indicated by a neg. correlation between malone dialdehyde and H2O2 contents. Almost all these effects were at least partially reversed, when pCO2 exceeded 750 or 900 ppm. Apparently, the interaction of atm. pCO2 with leaf structural and physiol. traits of Q. petraea seedlings is characterized by a dynamic response depending on the pCO2 level.

Planta published new progress about Aromatic amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Recommanded Product: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Monteith, John J.; Scotchburn, Katerina; Mills, L. Reginald; Rousseaux, Sophie A. L. published the artcile< Ni-Catalyzed Synthesis of Thiocarboxylic Acid Derivatives>, Application of C4H8O, the main research area is thionoester thioamide dithioester preparation; alkyl xanthate ester thiocarbonyl imidazolide organozinc reagent cross coupling.

A Ni-catalyzed cross-coupling of readily accessible O-alkyl xanthate esters or thiocarbonyl imidazolides and organozinc reagents for the synthesis of thiocarboxylic acid derivatives has been developed. This method benefits from a fast reaction time, mild reaction conditions and ease of starting material synthesis. The use of transition metal catalysis to access a diverse range of thiocarbonyl containing compounds provides a useful complementary approach when compared to previously established methodologies.

Organic Letters published new progress about Aromatic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (thiono-). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pourhanifeh, Mohammad H.; Shafabakhsh, Rana; Reiter, Russel J.; Asemi, Zatollah published the artcile< The Effect of Resveratrol on Neurodegenerative Disorders: Possible Protective Actions Against Autophagy, Apoptosis, Inflammation and Oxidative Stress>, HPLC of Formula: 501-36-0, the main research area is review resveratrol neurodegenerative disorder autophagy apoptosis inflammation oxidative stress; Parkinson’s disease; Resveratrol; apoptosis; autophagy; inflammation; oxidative stress..

A review. The prevalence of neurodegenerative disorders characterized by the loss of neuronal function is rapidly increasing. The pathogenesis of the majority of these diseases is not entirely clear, but current evidence has shown the possibility that autophagy, apoptosis, inflammation and oxidative stress are involved. The present review summarizes the therapeutic effects of resveratrol on neurodegenerative disorders, based on the especially mol. biol. of these diseases. The PubMed, Cochrane, Web of Science and Scopus databases were searched for studies published in English until March 30th, 2019 that contained data for the role of inflammation, oxidative stress, angiogenesis and apoptosis in the neurodegenerative disorders. There are also studies documenting the role of mol. processes in the progression of central nervous system diseases. Based on current evidence, resveratrol has potential properties that may reduce cell damage due to inflammation. This polyphenol affects cellular processes, including autophagy and the apoptosis cascade under stressful conditions. Current evidence supports the beneficial effects of resveratrol on the therapy of neurodegenerative disorders.

Current Pharmaceutical Design published new progress about Alzheimer disease. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Minhas, Muhammad Usman; Abdullah, Orva; Sohail, Muhammad; Khalid, Ikrima; Ahmad, Sarfaraz; Khan, Kifayat Ullah; Badshah, Syed Faisal published the artcile< Synthesis of novel combinatorial drug delivery system (nCDDS) for co-delivery of 5-fluorouracil and leucovorin calcium for colon targeting and controlled drug release>, Formula: C20H21CaN7O7, the main research area is drug delivery systems 5 fluorouracil leucovorin calcium; 5-fluorouracil; Combinatorial gel; colon targeting; controlled release; leucovorin calcium.

Purpose of the current study was to improve the oral effectiveness of 5-fluorouracil (5-FU) by developing novel controlled, combinatorial drug delivery system (nCDDS) for co-delivery of 5-FU and leucovorin calcium (LC) for colon targeting. SignificanceOn the basis of results obtained, novel controlled, combinatorial drug delivery system could be an effective strategy for the colon targeting of 5-FU and LC. Free radical polymerization method was tuned and used to fabricate this nCDDS. The nCDDS is synthesized in two steps, first synthesis of 5-FU/LC calcium loaded nanogels and second, pre-synthesized 5-FU and LC loaded nanogels were dispersed in pectin based polymerized matrix hard gel. The nanogels and nCDDS gels were characterized for network structure, thermal stability, and surface morphol. Swelling and in vitro release studies were carried out at different pH 1.2 and 7.4 both for naive nanogels and combined matrix gels. In vivo study of combinatorial gel was performed on rabbits by using HPLC method to estimate plasma drug concentration and pharmacokinetics parameters. Structure and thermal anal. confirmed the formation of stable polymeric network. SEM of nanogels and combinatorial gels showed that the spongy and rough edges particles and uniformly distributed in the combinatorial gel. The prepared nCDDS showed excellent water loving capacity and pH responsiveness. Combinatorial gel showed excellent characteristic for colonic delivery of drugs, which were confirmed by various in vitro and in vivo characterizations. Acute oral toxicity study of combinatorial gel confirmed the biocompatible and nontoxic characteristics of developed formulation. Conclusively, it can be found that nCDDS showed excellent properties regarding drug targeting in a controllable manner as compared to naive PEGylated nanogels.

Drug Development and Industrial Pharmacy published new progress about Blood. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simental-Mendia, Luis E.; Guerrero-Romero, Fernando published the artcile< Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial>, Synthetic Route of 501-36-0, the main research area is dyslipidemia lipid lowering agent resveratrol; Dyslipidemia; Lipid profile; Lipids; Randomized controlled trial; Resveratrol.

Objectives: The aim of this study was to explore the effect of resveratrol supplementation on lipid profile in individuals with dyslipidemia. Methods: Apparently healthy men and non-pregnant women 20 to 65 y of age with new diagnosis of dyslipidemia were enrolled in a randomized double-blind, placebo-controlled trial and randomly allocated to receive either resveratrol 100mg/d or placebo (sucrose 0.5 g/d) for 2 mo. Smoking, alc. intake, diabetes, acute or chronic renal or hepatic diseases, malignancy, cardiovascular disease, serum triacylglycerol levels ≥400mg/dL, low-d. lipoprotein cholesterol levels ≥190mg/dL, and consumption of lipid-lowering drugs or supplements containing resveratrol were exclusion criteria. Results: Seventy-one individuals with new diagnosis of dyslipidemia were enrolled and randomly allocated to the resveratrol (n = 35) or placebo groups (n = 36). At baseline, there were no significant differences between the study groups. After intervention period, individuals in the resveratrol group showed a significant decrease in total cholesterol (201.4 ± 34.4 vs. 220.6 ± 37.4, P = 0.04) and triacylglycerol (133.4 ± 55.3 vs. 166.7 ± 68.5, P = 0.04) concentrations compared with the placebo group, without significant statistical differences for high-d. lipoprotein cholesterol and low-d. lipoprotein cholesterol levels. Conclusion: The results suggest that resveratrol supplementation significantly reduces total cholesterol and triacylglycerol concentrations in individuals with dyslipidemia.

Nutrition (New York, NY, United States) published new progress about Dyslipidemia. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiong, Jiu-Qiang; Zhao, Chen-Yu; Qin, Jing-Yu; Cui, Pengfei; Zhong, Qiu-Lian; Ru, Shaoguo published the artcile< Metabolic perturbations of Lolium perenne L. by enrofloxacin: Bioaccumulation and multistage defense system>, Synthetic Route of 492-62-6, the main research area is glycolysis tricarboxylic acid metabolic perturbation bioaccumulation Lolium perenne; Defense systems; Ecotoxicological risks; Energy metabolism; Pasture grass; Pharmaceutical contaminants; Reclaimed water.

Plants are readily exposed to the antibiotics residues in reclaimed water indicating an urgent need to comprehensively analyze their ecotoxicol. effects and fate of these emerging contaminants. Here, we unraveled the dissemination of enrofloxacin (ENR) in a pasture grass, Lolium perenne L., and identified multistage defense systems as its adaptation mechanism. Uptaken concentrations of ENR ranged from 1.28 to 246.60μg g-1 with bioconcentration factors (BCF) upto 15.13, and translocation factors (TF) upto 0.332. The antioxidant enzymic activities such as superoxide dismutase, peroxidase, and catalase were increased by upto 115%. Further transcriptomics demonstrated that differentially expressed genes (DEGs) involved in glycolysis, tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and glutathione metabolism were significantly up-regulated by 1.56-5.93, 3-7 and 1.04-6.42 times, resp.; while, the DEGs in nitrogen and sulfur metabolism pathways were significantly up-regulated by 1.06-5.64 and 2.64-3.54 folds. These processes can supply energy, signaling mols., and antioxidants for detoxification of ENR in ryegrass. Such results provide understanding into fasting grass adaptability to antibiotics by enhancing the key protective pathways under organic pollutant stresses in environments.

Journal of Hazardous Materials published new progress about Antibiotics. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhanja, Piyali; Das, Sabuj K.; Bhunia, Kousik; Pradhan, Debabrata; Hayashi, Taku; Hijikata, Yuh; Irle, Stephan; Bhaumik, Asim published the artcile< A New Porous Polymer for Highly Efficient Capacitive Energy Storage>, Application In Synthesis of 4396-13-8, the main research area is porous polymer supercapacitor electrode capacitance triazine isophthalaldehyde.

The new porous polymer TPDA-1 has been synthesized via solvothermal Schiff base condensation reaction between two organic monomers, i.e., 2,4,6-trihydroxyisophthalaldehyde and 1,3,5-tris(4-aminophenyl)triazine. The TPDA-1 material showed a very high specific capacitance of 469.4 F g-1, at 2 mV s-1 scan rate, together with a high sp. surface area of 545 m2 g-1. It also exhibited excellent cyclic stability with 95% retention of its initial specific capacitance after 1000 cycles at 5 A g-1, suggesting its potential as a high performance supercapacitor. Extended π-conjugation and ion conduction inside the micropores throughout the whole polymeric matrix and high BET surface area could be responsible for this high supercapacitor performance in energy storage device. TPDA-1 has been characterized thoroughly by various electrochem. techniques such as cyclic voltammetry, galvanic charge-discharge, and electrochem. impedance spectroscopy. Our exptl. results suggested a high potential of this porous polymer in energy storage devices for future generation.

ACS Sustainable Chemistry & Engineering published new progress about Aminoplasts Role: PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), PREP (Preparation), USES (Uses). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Application In Synthesis of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tavakoli, Ghazal; Prechtl, Martin H. G. published the artcile< The reductive deaminative conversion of nitriles to alcohols using para-formaldehyde in aqueous solution>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is benzylic alkyl primary alc chemoselective preparation; ruthenium catalyst chemoselective reduction nitrile paraformaldehyde water; mechanism reductive deamination nitrile paraformaldehyde water ruthenium catalyst.

In the presence of [Ru(p-cymene)Cl2]2, paraformaldehyde in H2O/toluene acted as a reductant for the chemoselective reductive deamination of alkyl and aryl nitriles to yield alkyl or benzylic primary alcs. The mechanism of the reaction is studied using the characterization of reaction intermediates by mass spectrometry; dimeric ruthenium complexes are necessary to generate reduced ruthenium complexes from paraformaldehyde, while nitrile coordination generates monomeric complexes of ruthenium which reduce the nitriles to alcs.

Catalysis Science & Technology published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Genaro-Mattos, Thiago C.; Klingelsmith, Korinne B.; Allen, Luke B.; Anderson, Allison; Tallman, Keri A.; Porter, Ned A.; Korade, Zeljka; Mirnics, Karoly published the artcile< Sterol Biosynthesis Inhibition in Pregnant Women Taking Prescription Medications>, Category: alcohols-buliding-blocks, the main research area is cholesterol DHCR7 7DHC pregnancy combinations neurodevelopment synergistic effect.

Sterol biosynthesis is a critical homeostatic mechanism of the body. Sterol biosynthesis begins during early embryonic life and continues throughout life. Many commonly used medications, prescribed >200 million times in the United States annually, have a sterol biosynthesis inhibition side effect. Using our high-throughput LC-MS/MS method, we assessed the levels of post-lanosterol sterol intermediates (lanosterol, desmosterol, and 7-dehydrocholesterol (7-DHC)) and cholesterol in 1312 deidentified serum samples from pregnant women. 302 samples showing elevated 7-DHC were analyzed for the presence of 14 medications known to inhibit the 7-dehydrocholesterol reductase enzyme (DHCR7) and increase 7-DHC. Of the 302 samples showing 7-DHC elevation, 43 had detectable levels of prescription medications with a DHCR7-inhibiting side effect. Taking more than one 7-DHC-elevating medication in specific combinations (polypharmacy) might exacerbate the effect on 7-DHC levels in pregnant women, suggesting a potentially additive or synergistic effect. As 7-DHC and 7-DHC-derived oxysterols are toxic, and as DHCR7-inhibiting medications are considered teratogens, our findings raise potential concerns regarding the use of prescription medication with a DHCR7-inhibiting side effect during pregnancy. The use of prescription medications during pregnancy is sometimes unavoidable, but choosing a medication without a DHCR7-inhibiting side effect might lead to a healthier pregnancy and prevent putatively adverse outcomes for the developing offspring.

ACS Pharmacology & Translational Science published new progress about Aging, animal. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts