Author: tianli

Wang, Hai-ou; Liu, Si-hong; Zhou, Xue-jie; Yang, Xiao-yue; Gao, Qi; Tanokura, Masaru; Xue, You-lin published the artcile< Treatment with hydrogen peroxide improves the physicochemical properties of dietary fibres from Chinese yam peel>, Computed Properties of 492-62-6, the main research area is hydrogen peroxide Chinese yam peel dietary fiber physicochem property.

Summary : Yam is a common ‘medicine food homol.’ vegetable in Asia, and its peel is often considered a food residue during processing or cooking. In this work, the effects of hydrogen peroxide modification on the dietary fibers (DFs) from Chinese yam peel (CYP) were investigated. The structural characteristics of soluble dietary fiber (SDF), insoluble dietary fiber (IDF), modified soluble dietary fiber (MSDF) and modified insoluble dietary fiber (MIDF) were analyzed using Fourier-transform IR spectroscopy, X-ray diffraction, differential scanning calorimetry, granularity anal., SEM and GC-MS (monosaccharide composition). As results, after modification with hydrogen peroxide, the sizes of the DFs were reduced and MIDF exposed more cellulose. Experiments on the physicochem. and functional properties of DFs showed that MSDF and MIDF obtained a better water holding capacity, oil absorption capacity, swelling capacity and absorption abilities with altered structures, which is of great importance in food processing and development.

International Journal of Food Science and Technology published new progress about Crystallinity. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Guodong; Zhong, Miao; Zhao, Jintao; Gao, Hao; Gan, Lu; Zhang, Hong; Zhang, Shengxiang; Fang, Jianguo published the artcile< Fluorescent Probes for Imaging Protein Disulfides in Live Organisms>, Product Details of C19H16O, the main research area is fluorescent probe imaging protein disulfide in vivo; environment-sensitive probes; fluorescent probes; in vivo imaging; mouse stroke model; protein disulfides; two-photon.

Cellular redox homeostasis is predominantly controlled by the ratio of thiols and disulfides, and reversible thiol-disulfide exchange reactions are fundamental of the biol. redox regulation. However, due to the dynamic exchanges of thiols and disulfides, the detection, especially the in situ detection, of protein disulfides (PDS) is challenging. We employ the strategy, i.e., the increase of emission upon an environment-sensitive dye binding to proteins, to design PDS probes and discover a two-photon probe PDSTP590 (S6) (I) that selectively recognizes PDS in live organisms. With the aid of the probe, we further disclose the elevation of PDS in brains of the mouse stroke model.

ACS Sensors published new progress about Bovine serum albumin Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Choong, Ingrid C.; Serafimova, Iana; Fan, Junfa; Stockett, David; Chan, Erica; Cheeti, Sravanthi; Lu, Yafan; Fahr, Bruce; Pham, Phuongly; Arkin, Michelle R.; Walker, Duncan H.; Hoch, Ute published the artcile< A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties>, Synthetic Route of 6850-39-1, the main research area is diaminocyclohexyl analog SNS 032 preparation permeability bioavailability CDK inhibition.

The identification of a selective CDK2, 7, and 9 inhibitor (compound 4) with improved permeability is described. Compound 4 exhibits comparable CDK selectivity profile to SNS-032, but shows improved permeability and higher bioavailability in mice.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 6850-39-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H13NO, Synthetic Route of 6850-39-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Mengyun; Chen, Jiajun; Liu, Xiaozhen; Xie, Mingyong; Nie, Shaoping; Chen, Yi; Xie, Jianhua; Yu, Qiang published the artcile< Structural characteristics and functional properties of soluble dietary fiber from defatted rice bran obtained through Trichoderma viride fermentation>, Product Details of C6H12O6, the main research area is Trichoderma fermentation soluble dietary fiber defatted rice bran.

Trichoderma viride was utilized to ferment the defatted rice bran (DRB), and soluble dietary fiber was prepared before and after fermentation, named as B-SDF and F-SDF, resp. Optimum fermentation conditions for yield of F-SDF were determined using response surface methodol. (RSM). The yield of F-SDF was significantly increased from 10.5 (weight/weight, %) to 33.4 (weight/weight, %) under the optimal conditions (inoculum size = 10%, pH = 5.8 and time = 41 h). Fourier transform IR spectroscopy (FTIR) demonstrated that both B-SDF and F-SDF had typical characteristics of the IR spectrum of polysaccharides, and X-ray diffraction (XRD) revealed they were mainly substances of amorphous structure. In addition, F-SDF showed looser structure by SEM (SEM) anal., increased mol. weight by high-performance gel permeation chromatog. (HPGPC) anal., and more complex monosaccharide composition by high-performance anion exchange chromatog. (HPAEC) anal. Furthermore, functional properties anal. showed that F-SDF exhibited higher water-holding capacity (WHC), oil-holding capacity (OHC), water solubility (WS) and cholesterol absorption capacity (CAC) than B-SDF. In summary, the present study suggested that SDF from defatted rice bran obtained through Trichoderma viride fermentation has a higher potential to be used as a functional ingredient in foods.

Food Hydrocolloids published new progress about Dietary fiber. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hirbawi, Nadia; Lin, Patricia C.; Jarvo, Elizabeth R. published the artcile< Halogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents>, Electric Literature of 627-27-0, the main research area is alkyl halide preparation; alc alkyl Grignard reagent halogenation.

Herein, an example of Grignard reagents acting as halide nucleophiles to form alkyl iodides RI [R = 1-(4-methoxyphenyl)-5-phenylpentan-3-yl, 4-phenylbutan-2-yl, 4-(2H-1,3-benzodioxol-5-yl)butan-2-yl, etc.] and alkyl bromides R1Br [R1 = 3-[4-(3-methoxyphenyl)phenyl]propyl, 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl, 3-(4-bromophenyl)propyl, etc.] was reported. This work establishes that Grignard reagents can convert alkyl mesylates ROMs/R1OMs into alkyl halides RI/R1Br, as well as be employed in a one-pot halogenation reaction starting from alcs. ROH/R1OH, which proceed through mesylate intermediates. The halogenation reaction is confirmed to occur by an SN2 pathway with the inversion of configuration and is demonstrated to be efficient on a gram scale.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Caputo, Lucia; Piccialli, Ilaria; Ciccone, Roselia; de Caprariis, Paolo; Massa, Antonio; De Feo, Vincenzo; Pannaccione, Anna published the artcile< Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity>, Quality Control of 78-70-6, the main research area is Lavender Coriander essential oil linalool neuroprotective agent neurotoxicity; Alzheimer’s disease; amyloid-β oligomers; coriander essential oil; lavender essential oil; linalool; neuroprotection.

Alzheimer’s disease (AD) is a neurodegenerative disorder leading to cognitive deficits and cognitive decline. Since no cure or preventing therapy is currently available to counteract AD, natural-derived compounds are investigated to find new potential neuroprotective agents for its treatment. In the present study, we tested the neuroprotective effect of lavender and coriander essential oils (EOs) and their main active constituent linalool, against the neurotoxicity elicited by Aβ1-42 oligomers, a key mol. factor in the neurodegeneration of AD. Importantly, our findings on neuronally differentiated PC12 cells exposed to Aβ1-42 oligomers are in accordance with previous in vivo studies reporting the neuroprotective potential of lavender and coriander EOs and linalool. We found that lavender and coriander EOs at the concentration of 10μg/mL as well as linalool at the same concentration were able to improve viability and to reduce nuclear morphol. abnormalities in cells treated with Aβ1-42 oligomers for 24 h. Lavender and coriander EOs and linalool also showed to counteract the increase of intracellular reactive oxygen species production and the activation of the pro-apoptotic enzyme caspase-3 induced by Aβ1-42 oligomers. Our findings provide further evidence that these EOs and their main constituent linalool could be natural agents of therapeutic interest against Aβ1-42-induced neurotoxicity.

Phytotherapy Research published new progress about Alzheimer disease. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Quality Control of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wo, Jennifer Y.; Clark, Jeffrey W.; Eyler, Christine E.; Mino-Kenudson, Mari; Klempner, Samuel J.; Allen, Jill N.; Keane, Florence K.; Parikh, Aparna R.; Roeland, Eric; Drapek, Lorraine C.; Ryan, David P.; Corcoran, Ryan B.; Van Seventer, Emily; Fetter, Isobel J.; Shahzade, Heather A.; Khandekar, Melin J.; Lanuti, Michael; Morse, Christopher R.; Heist, Rebecca S.; Ulysse, Christine A.; Christopher, Benjamin; Baglini, Christian; Yeap, Beow Y.; Mullen, John T.; Hong, Theodore S. published the artcile< Results and molecular correlates from a pilot study of neoadjuvant induction FOLFIRINOX followed by chemoradiation and surgery for gastroesophageal adenocarcinomas>, Computed Properties of 1492-18-8, the main research area is FOLFIRINOX chemoradition gastroesophageal adenocarcinomas.

We performed a NCI-sponsored, prospective study of neoadjuvant FOLFIRINOX followed by chemoradiation with carboplatin/paclitaxel followed by surgery in patients with locally advanced gastric or gastroesophageal cancer. Patients and Methods: The primary objective was to determine completion rate of neoadjuvant FOLFIRINOX x 8 followed by chemoradiation. Secondary endpoints were toxicity and pathol. complete response (pCR) rate. Exploratory anal. was performed of circulating tumor DNA (ctDNA) to treatment response. From Oct. 2017 to June 2018, 25 patients were enrolled. All patients started FOLFIRINOX, 92% completed all eight planned cycles, and 88% completed chemoradiation. Twenty (80%) patients underwent surgical resection, and 7 had a pCR (35% in resected cohort, 28% intention to treat). Tumor-specific mutations were identified in 21 (84%) patients, of whom 4 and 17 patients had undetectable and detectable ctDNA at baseline, resp. Presence of detectable post-chemoradiation ctDNA (P = 0.004) and/or postoperative ctDNA (P = 0.045) were associated with disease recurrence. Here we show neoadjuvant FOLFIRINOX followed by chemoradiation for locally advanced gastroesophageal cancer is feasible and yields a high rate of pCR. ctDNA appears to be a promising predictor of postoperative recurrence.

Clinical Cancer Research published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (AKTl1). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Computed Properties of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Guan-Yi; Liao, Ai-Mei; Huang, Ji-Hong; Zhang, Jian-Guo; Thakur, Kiran; Wei, Zhao-Jun published the artcile< Evaluation of structural, functional, and anti-oxidant potential of differentially extracted polysaccharides from potatoes peels>, Quality Control of 3458-28-4, the main research area is potato peel polysaccharide structural functional property antioxidant potential; Anti-oxidant; Differential extraction; Physicochemical; Polysaccharides; Potato peel.

Potato peel was used for the extraction of three types of polysaccharides (PW, PAL, and PAC) using water, alk., and acid treatments, resp. The structure of the PP polysaccharides was examined by means of Fourier transform IR spectroscopy (FT-IR) anal. and Gas chromatog.-mass spectrometry (GC-MS). The results suggest that the extracted polysaccharides constituted essentially three functional groups: C=O, C-H, and O-H. The polysaccharides were comprised of low proportions of proteins, 17-23% uronic acids, and approx. 70% carbohydrates. PAL, PW, and PAC with mol. weights of 2.25 × 103, 2.18 × 103, and 1.92 × 103 kDa, resp., were composed of rhamnose, xylose, mannose, arabinose, glucose, and galactose. Functional properties (solubility, oil holding capacity, foaming, and emulsion properties) of these polysaccharides were evaluated. Among three, PAL showed the highest fat-binding capacity which was 7.50 g/g with the solubility of 95.06%. The three polysaccharides possessed appreciable in vitro anti-oxidant (scavenging DPPH and ABTS+ radicals, chelating ferrous ions, and reducing power) potential. PAL exhibited the strongest reducing power, scavenging activity on DPPH radicals and chelating capability on ferrous ions. PP polysaccharides can be used as promising natural antioxidants in food, pharmaceutical, and cosmetic preparations

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Isaksson, Marléne; Karlberg, Ann-Therese; Nilsson, Ulrika published the artcile< Allergic contact dermatitis caused by oxidized linalool in a deodorant.>, Electric Literature of 78-70-6, the main research area is allergic contact dermatitis; armpit dermatitis; case report; chemical analysis; fragrances; hydroperoxides of linalool; linalool oxidation products; patch testing.

There is no abstract available for this document.

Contact dermatitis published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts