Author: tianli

Zhu, Han; Cao, Chujin; Wu, Zhongcai; Zhang, Heping; Sun, Zhihong; Wang, Meng; Xu, Huzi; Zhao, Zhi; Wang, Yuxi; Pei, Guangchang; Yang, Qian; Zhu, Fengming; Yang, Juan; Deng, Xuan; Hong, Yu; Li, Yinzheng; Sun, Jie; Zhu, Fan; Shi, Mengxia; Qian, Kun; Ye, Ting; Zuo, Xuezhi; Zhao, Fenfei; Guo, Jing; Xu, Gang; Yao, Ying; Zeng, Rui published the artcile< The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease>, Quality Control of 87-73-0, the main research area is Lactobacillus casei acute chronic kidney disease progression; Lactobacillus casei Zhang; acute kidney injury; chronic kidney disease; gut microbiota; nicotinamide; short-chain fatty acids.

The relationship between gut microbial dysbiosis and acute or chronic kidney disease (CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus casei Zhang (L. casei Zhang) corrected bilateral renal ischemia-reperfusion (I/R)-induced gut microbial dysbiosis, alleviated kidney injury, and delayed its progression to CKD in mice. L. casei Zhang elevated the levels of short-chain fatty acids (SCFAs) and nicotinamide in the serum and kidney, resulting in reduced renal inflammation and damage to renal tubular epithelial cells. We also performed a 1-yr phase 1 placebo-controlled study of oral L. casei Zhang use (Chinese clin. trial registry, ChiCTR-INR-17013952), which was well tolerated and slowed the decline of kidney function in individuals with stage 3-5 CKD. These results show that oral administration of L. casei Zhang, by altering SCFAs and nicotinamide metabolism, is a potential therapy to mitigate kidney injury and slow the progression of renal decline.

Cell Metabolism published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Quality Control of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hong, Yawen; Ying, Tiejin published the artcile< Isolation, molecular characterization and antioxidant activity of a water-soluble polysaccharide extracted from the fruiting body of Termitornyces albuminosus (Berk.) Heim>, Category: alcohols-buliding-blocks, the main research area is Termitomyces fruiting body water soluble polysaccharide antioxidant activty; Antioxidant activity; Polysaccharide; Structure analysis; Termitornyces albuminosus.

A water-soluble polysaccharide WSP1 was extracted from the fruiting body of Termitornyces albuminosus. Its mol. weight, monosaccharide composition and mol. structure were determined by GPC, GC-MS, UV spectroscopy, FT-IR spectroscopy, methylation anal., NMR (1D and 2D) and AFM. Moreover, the antioxidant activity of WSP1 was evaluated in vitro by the tests of reducing power, scavenging ability on DPPH radical and hydroxyl radical, and chelating ability on ferrous ion. The results indicated that the mol. weight of WSP1 was 9 kDa, and it was mainly composed of fucose and galactose in a molar ratio of 1:3.09. Based on monosaccharide composition, methylation anal. and NMR, the possible repeating unit of WSP1 was presented as follows:→2-α-L-Fucp-1→ (6-α-D-Galp-1)3→. The antioxidant assay revealed that, in the concentration range tested in this experiment, WSP1 had strong scavenging ability on DPPH radical, suggesting that WSP1 could be potentially used as a powerful radical scavenger.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hedberg, Christinne; Jessen, Kamilla S.; Hansson, Rikke F.; Heuckendorff, Mads; Jensen, Henrik H. published the artcile< Palladium-Catalyzed C-S Bond Formation as a Tool for Latent-Active Glycosylation>, Electric Literature of 4064-06-6, the main research area is thioglycoside stereoselective glycosylation oligosaccharide preparation; palladium copper triflate catalyst stereoselective glycosylation cross coupling oligosaccharide.

A high-yielding palladium-catalyzed C-S cross-coupling is presented for utilization in carbohydrate chem. as a key transformation for attachment of a second chelating sulfur atom that allows the exploitation of a latent-active glycosylation strategy with Cu(OTf)2 as the promoter. The novel approach employs o-Br-benzyl thioglycosides as latent glycosyl donors and o-SMe-benzyl thioglycosides as the active counterparts.

Organic Letters published new progress about Coupling reaction. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Electric Literature of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Yingying; Zhang, Lang; Liu, Qian; Wang, Yan; Chen, Qian; Kong, Baohua published the artcile< The potential correlation between bacterial diversity and the characteristic volatile flavour of traditional dry sausages from Northeast China>, Synthetic Route of 104-76-7, the main research area is sausage alc ketone terpene flavor Lactobacillus Weissella Northeast China; Bacterial community; HS-SPME-GC-MS; High-throughput sequencing; Traditional dry sausages; Volatile compounds.

The objective of this study was to explore the correlation between bacterial communities and volatile compounds in traditional dry sausages from different regions in Northeast China. The bacterial community structure of dry sausages from five different regions as determined by high-throughput sequencing technol. demonstrated that Firmicutes and Proteobacteria were the predominant phyla; Lactobacillus, Staphylococcus, Leuconostoc, Lactococcus and Weissella were the predominant genera; and Staphylococcus xylosus, Lactobacillus sakei, Weissella hellenica, Leuconostoc citreum, Lactococcus raffinolactis and Lactobacillus plantarum were the predominant species. Meanwhile, a total of 120 volatile compounds were detected in sausages from five different regions and mainly included alcs., acids, aldehydes, ketones, esters and terpenes. Furthermore, the potential correlations between the core bacteria and major volatile compounds (64) were explored based on Spearman’s correlation anal. Pos. correlations were found between W. hellenica, Lb. sakei, Lactococcus lactis, Lactobacillus alimentarius, Lb. plantarum and carboxylic acids and alcs. Lc. lactis, Lb. alimentarius and Lb. plantarum were associated with the production of most esters, aldehydes and ketones. This study provides a deep insight into the relationship between the bacterial community and the volatile flavor profile of dry sausages, which may be helpful for the production of fermented dry sausages.

Food Microbiology published new progress about Acidobacteria. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Synthetic Route of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Zi-Bo; Fang, Hong-Bo; Feng, Quan-Kai; Li, Tao; Li, Jie published the artcile< Prognostic factors of recurrent intrahepatic cholangiocarcinoma after hepatectomy: A retrospective study>, Electric Literature of 1492-18-8, the main research area is intrahepatic cholangiocarcinoma hepatectomy cancer recurrence prognosis chemotherapy; Hepatectomy; Intrahepatic cholangiocarcinoma; Multimodality therapy; Prognosis; Recurrence.

Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor. Hepatectomy is an effective treatment for early ICC, but postoperative recurrence greatly affects patient survival. Studies on recurrent ICC after hepatectomy are lacking. AIM To investigate the clin. characteristics of patients with recurrent ICC after hepatectomy, analyze prognostic factors and explore diagnosis and treatment strategies. A retrospective anal. was performed on all ICC patients undergoing hepatectomy from Jan. 2013 to August 2021. Patients with postoperative recurrence were selected according to the inclusion and exclusion criteria. Cumulative overall survival was plotted by the Kaplan-Meier method, and differences were assessed by univariate survival anal. using the log-rank test. Multivariate anal. of cumulative survival was performed using the Cox proportional risk model. During the 8-yr study period, 103 patients underwent ICC-related hepatectomy, and 54 exhibited postoperative recurrence. The median disease-free survival (DFS) was 6 mo, the median overall survival (OS) was 9 mo, and the cumulative OS rates at 1, 2 and 3 years after the operation were 40.7%, 14.8% and 7.4%, resp. The median OS after recurrence was 4 mo, and the cumulative OS rates at 1, 2 and 3 years after recurrence were 16.1%, 6.7% and 3.4%, resp. Multivariate anal. showed that alc. consumption [hazard ratio (HR) = 4.64, 95% confidence interval (CI): 1.53-14.04, P = 0.007] and DFS < 6 mo (HR = 3.47, 95%CI: 1.59-7.60, P = 0.002) were independent risk factors for the cumulative survival of patients with recurrence, while treatment after recurrence (HR = 0.21, 95%CI: 0.08-0.55, P = 0.001) was an independent protective factor. The median OS time of patients receiving multimodality therapy after recurrence of ICC was 7 mo, which was significantly higher than that of patients receiving only local therapy (3 mo), patients receiving systematic therapy (4 mo) and patients receiving the best supportive therapy (1 mo). Patients with recurrent ICC who received multimodality therapy had a significantly better long-term survival after recurrence than those who did not (P = 0.026). The prognosis of patients with recurrence after ICC-related hepatectomy is poor. Alc. consumption and DFS < 6 mo are independent risk factors in terms of the cumulative survival of patients with recurrence, while treatment after recurrence is an independent protective factor. Multimodality therapy can effectively improve the prognosis of patients. World Journal of Gastroenterology published new progress about Cancer antigen 19-9 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Electric Literature of 1492-18-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Feng-Zhi; Shao, Yuan-Guang; Zhang, Zibin; Shen, Yan-Feng; Huang, Xue-Chun; Zhang, Pei-Ling; Li, Shijun published the artcile< Synthesis of Catenanes from a BMP32C10-Based Cryptand Tuned by the Linkage Length of Paraquat Salts>, Synthetic Route of 627-27-0, the main research area is catenane preparation; BMP32C10 based cryptand paraquat guest olefin metathesis.

A series of catenanes was synthesized through olefin metathesis from a BMP32C10-based cryptand and paraquat guests attached with two terminal alkenes. Distribution of catenane products could be significantly affected by linkage length on paraquat guests. In presence of BMP32C10-based cryptand, paraquat salt with a long linkage facilitates intramol. olefin metathesis to release a [2]catenane as sole catenation product, while use of a paraquat salt with a shorter linkage led to simultaneous generation of [2]-, [3]-, and [4]-catenanes.

Synthesis published new progress about Catenanes Role: SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Kawaljit; Kaur, Gurminder; Shanika, Petrus Siningu; Dziwornu, Godwin Akpeko; Okombo, John; Chibale, Kelly published the artcile< Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity>, SDS of cas: 29335-36-2, the main research area is fusidic acid fusidane triterpenoid synthesis SAR tuberculostatic tuberculosis; Anti-mycobacterial activity; Bioisosteres; Cytotoxicity; Fusidic acid.

Fusidic acid (FA) is a potent congener of the fusidane triterpenoid class of antibiotics. Structure-activity relationship (SAR) studies suggest the chem. structure of FA is optimal for its antibacterial activity. SAR studies from our group within the context of a drug repositioning approach in tuberculosis (TB) suggest that, as with its antibacterial activity, the C-21 carboxylic acid group is indispensable for its anti-mycobacterial activity. Further studies have led to the identification of 16-deacetoxy-16β-ethoxyfusidic acid (58), an analog which exhibited comparable activity to FA with an in vitro MIC99 value of 0.8μM. Preliminary SAR studies around the FA scaffold suggested that the hydrophobic side chain at C-20, like the C-11 OH group, was required for activity. The C-3 OH group, however, can be functionalized to obtain more potent compounds

Bioorganic & Medicinal Chemistry published new progress about Structure-activity relationship. 29335-36-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C3H8N2O, SDS of cas: 29335-36-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

P., Sreejyothi; Sarkar, Pallavi; Dutta, Supriti; Das, Arpan; Pati, Swapan K.; Mandal, Swadhin K. published the artcile< Regioselective ring-opening of epoxides towards Markovnikov alcohols: a metal-free catalytic approach using abnormal N-heterocyclic carbene>, Application In Synthesis of 403-41-8, the main research area is alkyl epoxide borabicyclononane heterocyclic carbene regioselective Markovnikov ring opening; alkanol preparation.

The first metal-free regioselective Markovnikov ring-opening of epoxides (selectivity up to 99%) using an abnormal N-heterocyclic carbene (aNHC) to yield secondary alcs was reported. DFT calculations and X-ray crystallog. suggested that the Markovnikov selectivity originated from the high nucleophilicity and steric factors associated with the aNHC.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aliphatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ottenbacher, Roman V.; Bryliakova, Anna A.; Shashkov, Mikhail V.; Talsi, Evgenii P.; Bryliakov, Konstantin P. published the artcile< To Rebound or...Rebound? Evidence for the ""Alternative Rebound"" Mechanism in C-H Oxidations by the Systems Nonheme Mn Complex/H2O2/Carboxylic Acid>, Reference of 76-84-6, the main research area is oxidation mechanism nonheme manganese complex hydrogen peroxide carboxylic acid.

In this work, it has been shown that aliphatic C-H oxidations by bioinspired catalyst systems Mn aminopyridine complex/H2O2/carboxylic acid in acetonitrile afford predominantly a mixture of the corresponding alc. and the ester. The alc./ester ratio is higher for catalysts bearing electron-donating groups at the aminopyridine core. Isotopic labeling studies witness that the oxygen atom of the alc. originates from the H2O2 mol., while the ester oxygen comes exclusively from the acid. Oxidation of ethylbenzene in the presence of acetic acid affords enantiomerically enriched 1-phenylethanol and 1-Ph acetate, with close enantioselectivities and the same sign of absolute chirality. Exptl. data and d. functional theory calculations provide evidence in favor of the rate-limiting benzylic H atom abstraction by the high-spin (S = 1) [LMnV(O)OAc]2+ active species followed by competitive OH/OC(O)R rebound. This mechanism has been unprecedented for C-H oxidations catalyzed by bioinspired Mn complexes. The trends governing the alc./ester ratios have been rationalized in terms of steric properties of the catalyst, acid, and substrate.

ACS Catalysis published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ng, Teng Wei; Liao, Gang; Lau, Kai Kiat; Pan, Hui-Jie; Zhao, Yu published the artcile< Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity>, Electric Literature of 403-41-8, the main research area is secondary alc preparation Guerbet catalyst enantioselectivity; Guerbet reaction; alkylation; borrowing hydrogen; enantioselectivity; higher-order alcohols.

The authors report herein an unprecedented highly efficient Guerbet-type reaction at room temperature (catalytic TON up to >6000). This β-alkylation of secondary Me carbinols with primary alcs. has significant advantage of delivering higher-order secondary alcs. in an economical, redox-neutral fashion. In addition, the first enantioselective Guerbet reaction also was achieved using a com. available chiral ruthenium complex to deliver secondary alcs. with moderate yield and up to 92% ee. In both reactions, the use of a traceless ketone promoter proved to be beneficial for the catalytic efficiency.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (Me carbinols). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts