Month: February 2023

Ruthenium(II) Complexes of Monodonor Ligands: Efficient Reagents for Asymmetric Ketone Hydrogenation was written by Xu, Yingjian;Clarkson, Guy C.;Docherty, Gordon;North, Carl L.;Woodward, Gary;Wills, Martin. And the article was included in Journal of Organic Chemistry in 2005.Related Products of 120121-01-9 This article mentions the following:

A series of BINOL-derived ligands have been prepared and incorporated into ruthenium(II) complexes containing a diamine ligand. The complexes have proven to be excellent catalysts for the asym. hydrogenation of ketones, giving reduction products with enantiomeric excesses of up to 99%. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Related Products of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Varenicline: An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation was written by Coe, Jotham W.;Brooks, Paige R.;Vetelino, Michael G.;Wirtz, Michael C.;Arnold, Eric P.;Huang, Jianhua;Sands, Steven B.;Davis, Thomas I.;Lebel, Lorraine A.;Fox, Carol B.;Shrikhande, Alka;Heym, James H.;Schaeffer, Eric;Rollema, Hans;Lu, Yi;Mansbach, Robert S.;Chambers, Leslie K.;Rovetti, Charles C.;Schulz, David W.;Tingley, F. David III;O’Neill, Brian T.. And the article was included in Journal of Medicinal Chemistry in 2005.Application of 230615-52-8 This article mentions the following:

Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dependence-producing effects of nicotine. We have pursued α4β2 nicotinic receptor partial agonists to inhibit dopaminergic activation produced by smoking while simultaneously providing relief from the craving and withdrawal syndrome that accompanies cessation attempts. Varenicline displays high α4β2 nAChR affinity and the desired in vivo dopaminergic profile. In the experiment, the researchers used many compounds, for example, 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8Application of 230615-52-8).

2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 230615-52-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chokeberry Pomace as a Component Shaping the Content of Bioactive Compounds and Nutritional, Health-Promoting (Anti-Diabetic and Antioxidant) and Sensory Properties of Shortcrust Pastries Sweetened with Sucrose and Erythritol was written by Raczkowska, Ewa;Nowicka, Paulina;Wojdylo, Aneta;Styczynska, Marzena;Lazar, Zbigniew. And the article was included in Antioxidants in 2022.Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

In this study, an attempt was made to develop shortcrust pastries containing different amounts of chokeberry pomace (0%, 10%, 30%, 50%), modulating their degree of sweetness via the application of sucrose or erythritol. The obtained products were assessed for their nutritional value (energy value, protein, fats, dietary fiber, sugars, minerals). Bioactive compounds, as well as antioxidant and anti-diabetic properties in an in vitro model and sensory attributes, were also analyzed. Increasing the proportion of chokeberry pomace in shortcrust pastries improved their nutritional value, especially their energy value (reduction of nearly 30% for shortcrust pastries with 50% pomace sweetened with erythritol), nutritional fiber content (10-fold higher in shortcrust pastries with the highest proportion of pomace) and potassium, calcium, magnesium, and iron content. Chokeberry pomace was also a carrier of 14 bioactive compounds The most beneficial antioxidant and anti-diabetic effect was shown for shortcrust pastries containing 50% chokeberry pomace. In addition, it was shown that the use of erythritol as a sweetener has a beneficial effect on the perception of sensory attributes. Finally, it was shown that the developed products could be excellent alternatives to traditional shortcrust pastries and, at the same time, be a good way to utilize waste from the fruit industry. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinaseγ was written by Lanni, Thomas B.;Greene, Keri L.;Kolz, Christine N.;Para, Kimberly S.;Visnick, Melean;Mobley, James L.;Dudley, David T.;Baginski, Theodore J.;Liimatta, Marya B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

The Type 1 PI3-Kinases comprise a family of enzymes, which primarily phosphorylate PIP2 to give the second messenger PIP3, a key player in many intracellular signaling processes. Of the four type 1 PI3Ks, the γ-isoform, which is expressed almost exclusively in leukocytosis of particular interest with respect to its role in inflammatory diseases such as rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD). Investigation of a series of 4,6-disubstituted-4H-benzo[1,4]oxazin-3-ones, e.g., I, has led to the identification of single-digit nanomolar inhibitors of PI3Kγ, several of which had good cell based activity and were shown to be active in vivo in an aspectic peritonitis model of inflammatory cell migration. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Presence of polarization bonds in some copper(II) complexes was written by Hall, D.;McKinnon, A. J.;Waters, J. M.;Waters, T. N.. And the article was included in Nature (London, United Kingdom) in 1964.SDS of cas: 1122-71-0 This article mentions the following:

The structures of bis(N-methyl-2-hydroxy-1-naphthaldiminato)copper(II) (I) and a second crystal modification of bis(salicylaldehydrato)copper(II) (II) were determined by space group requirements and 3-dimensional Fourier syntheses. The space group of I is P2₁/n with Z = 2, a 3.86, b 19.55, c 12.57, and β = 91.1°. II belongs to space group P2₁/c with Z = 2, a 11.75, b 4.00, c 12.42, and β = 90.3°. I and II are essentially sq. planar but the mols. pack so that there is an axial approach of 2.94 and 3.15 A., resp., to the hydroxy O of neighboring mols. and thus a deviation from overall mol. planarity. Within one mol. the 2 ligands are individually planar but mean planes through them are separated by 1.16 A. and 0.36 A. The distortions indicate that definite weak interactions exist; polarization bonding is suggested. The polarization bonds can involve different regions of the ligand, being to the O of the chelated ring in II and to a C of the benzene ring in the previously reported modification of II. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0SDS of cas: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Halobenzyl alcohols as structurally simple organogelators was written by Prathap, Annamalai;Ravi, Arthi;Pathan, Javed R.;Sureshan, Kana M.. And the article was included in CrystEngComm in 2019.Recommanded Product: 1777-82-8 This article mentions the following:

We report 11 simple halobenzyl alcs., each comprising of only 16 atoms, as organogelators for aliphatic hydrocarbon solvents. Comparison of PXRD profiles of wet gels and xerogels with the simulated profiles from the single crystal XRD data confirmed that the mol. packing in gels and crystals are identical. Therefore single crystal X-ray structures were analyzed to understand the mol. level interactions involved in the self-assembly in gel state. Each of these compounds undergoes a faster linear assembly along the crystallog. direction associated with the OH···O hydrogen bond and a supplementary non-covalent interaction (NCI). In directions perpendicular to the direction of OH···O Hydrogen bonding, mols. associate through various relatively weaker NCIs. Notably, halogen bonds, X···X, C-H···X interactions play major role in the lateral growth. In the case of gels, the linear growth is faster than lateral growth leading to the formation of long fibers, which entangles to a 3D fibrous network. This study reveals that halogen atoms in halobenzyl alcs. impart mol. features that contribute to their self-assembly in solution and hence in gelation. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ex vivo, in vitro, and in silico approaches to unveil the mechanisms underlying vasorelaxation effect of Mentha Longifolia (L.) in porcine coronary artery was written by Alamgeer;Asif, Hira;Chohan, Tahir Ali;Irfan, Hafiz Muhammad;Asim, Mulazim Hussain;Bukhari, Syed Nasir Abbas;Younis, Waqas;Althobaiti, Yusuf S.;Ullah, Aman;Khan, Abdul Qayyum;Hakami, Alqassem Y.. And the article was included in Biomedicine & Pharmacotherapy in 2022.Quality Control of 5-Isopropyl-2-methylphenol This article mentions the following:

Mentha (M.) longifolia (L.) is traditionally used for various ailments. The current study was intended to explore the underlying vasorelaxation mechanisms of M. longifolia. Aqueous-methanol extract from the aerial parts of M. longifolia was prepared and subjected to activity-guided fractionation. The vasorelaxant activity was performed using porcine coronary arteries with intact and denuded endothelium. In-vitro PDE inhibitory activity of the active fraction was carried out using the radio-enzymic assay. The active fraction was also subjected to GCMS. Docking and mol. dynamic simulation studies were also performedWe had observed that aqueous-methanolic extract induced relaxation in the coronary artery in a dose-dependent manner when the endothelium was intact and denuded. n-butanol fraction (MLB) has produced a maximum effect, and it was selected for mechanistic studies. MLB has significantly enhanced the relaxation produced by cAMP and cGMP, elevating atrial natriuretic peptide, sodium nitroprusside, isoproterenol, and forskolin. The pre-treatment with MLB inhibited the contractile response produced by KCl, U46619, and CaCl2 in without endothelium rings. MLB has non-selectively inhibited the PDE isoforms. GCMS anal. of MLB has revealed the presence of menthol, thymol, and carvacrol in the active fraction. Docking and mol. dynamic simulation studies have indicated that thymol can be a competitive inhibitor for PDE1. It is postulated that an n-butanol fraction of Mentha longifolia produced endothelium-independent relaxation due to increased levels of cAMP and cGMP caused by the inhibition of various PDEs. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Quality Control of 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of a thermoresponsive crosslinked MEO₂MA polymer coating on microclusters of iron oxide nanoparticles was written by Lapresta-Fernandez, Alejandro;Salinas-Castillo, Alfonso;Capitan-Vallvey, Luis Fermin. And the article was included in Scientific Reports in 2021.Application of 109-17-1 This article mentions the following:

Encapsulation of magnetic nanoparticles (MNPs) of iron (II, III) oxide (Fe₃O₄) with a thermopolymeric shell of a crosslinked poly(2-(2-methoxyethoxy)ethyl methacrylate) P(MEO₂MA) is successfully developed. Magnetic aggregates of large size, around 150-200 nm are obtained during the functionalization of the iron oxide NPs with vinyl groups by using 3-butenoic acid in the presence of a water soluble azo-initiator and a surfactant, at 70°C. These polymerizable groups provide a covalent attachment of the P(MEO₂MA) shell on the surface of the MNPs while a crosslinked network is achieved by including tetraethylene glycol dimethacrylate in the precipitation polymerization synthesis. Temperature control is used to modulate the swelling-to-collapse transition volume until a maximum of around 21:1 ratio between the expanded: shrunk states (from 364 to 144 nm in diameter) between 9 and 49°C. The hybrid Fe₃O₄@P(MEO₂MA) microgel exhibits a lower critical solution temperature of 21.9°C below the corresponding value for P(MEO₂MA) (bulk, 26°C). The MEO₂MA coating performance in the hybrid microgel is characterized by dynamic light scattering and transmission electron microscopy. The content of preformed MNPs [up to 30.2 (wt%) vs. microgel] was established by thermogravimetric anal. while magnetic properties by vibrating sample magnetometry. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application of 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application of 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of ospemifene on moderate or severe symptoms of vulvar and vaginal atrophy was written by Bruyniks, N.;Nappi, R. E.;Castelo-Branco, C.;de Villiers, T. J.;Simon, J.. And the article was included in Climacteric in 2016.Application In Synthesis of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

To determine whether assessment of all moderate-to-severe symptoms at baseline gives a more accurate evaluation of the treatment effect of ospemifene in vulvovaginal atrophy (VVA) than the most bothersome symptom (MBS) approach. Data were pooled from two pivotal phase-III clin. trials evaluating the efficacy and safety of oral ospemifene 60 mg/day for the treatment of symptoms of VVA (n = 1463 subjects). Symptoms of vaginal dryness, dyspareunia, and vaginal and/or vulvar irritation/itching reported as moderate or severe at baseline were evaluated. Clin. relevant differences between ospemifene and placebo were analyzed using a four-point severity scoring system and presented as improvement, substantial improvement, or relief. Subjects in these studies reported statistically significant improvement, substantial improvement, and relief for vaginal dryness (p < 0.00001), dyspareunia (p < 0.001) and statistically significant improvement and relief for vaginal and/or vulvar irritation/itching (p < 0.01) from baseline to week 12 with ospemifene compared with placebo. A similar trend was observed for women who reported substantial improvement of vaginal and/or vulvar irritation/itching. For drug registration purposes, the use of the MBS model is appealing because of its simplicity and ease of scientific validation. However, the MBS model may underestimate the total magnitude of the clin. benefit of ospemifene treatment for symptomatic women suffering from VVA. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Application In Synthesis of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Second-Generation Palladium Catalyst System for Transannular C-H Functionalization of Azabicycloalkanes was written by Cabrera, Pablo J.;Lee, Melissa;Sanford, Melanie S.. And the article was included in Journal of the American Chemical Society in 2018.Product Details of 230615-52-8 This article mentions the following:

This article describes the development of a second-generation catalyst system for the transannular C-H functionalization of alicyclic amines. Pyridine- and quinoline-carboxylate ligands are shown to be highly effective for increasing the reaction rate, yield, and scope of Pd-catalyzed transannular C-H arylation reactions of azabicyclo[3.1.0]hexane, azabicyclo[3.1.1]heptane, azabicyclo[3.2.1]octane, and piperidine derivatives Mechanistic studies reveal that the pyridine/quinoline-carboxylates play a role in impeding both reversible and irreversible catalyst decomposition pathways. These ligands enable the first reported examples of the transannular C-H arylation of the ubiquitous tropane, 7-azanorbornane, and homotropane cores. Finally, the pyridine/quinoline-carboxylates are shown to promote both transannular C-H arylation and transannular C-H dehydrogenation on a homotropane substrate. In the experiment, the researchers used many compounds, for example, 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8Product Details of 230615-52-8).

2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 230615-52-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts