Month: February 2023

Siliconized silsesquioxane-based nonstick molds for ultrahigh-resolution lithography was written by Lee, Bong Kuk;Park, Kun-Sik;Kim, Dong-Pyo;Ryu, Jin-Hwa;Park, Jaehoon;Jeong, Ye-Sul;Baek, Kyu-Ha;Do, Lee-Mi. And the article was included in Journal of Materials Chemistry in 2012.Quality Control of Diethyleneglycoldiacrylate This article mentions the following:

A material approach to fabricating high-performance nonstick molds for manufacturing ultrahigh-resolution features (<8 nm) is presented. Low-viscosity liquid blends (4-121 cP) consisting of siliconized silsesquioxane acrylate (Si-SSQA) with low surface energy and difunctional acrylics were used as nonstick replica-molds materials. The cured Si-SSQA-acrylic networks showed a high UV transparency (>92% at 365 nm), high modulus and wide-range modulus tunability (0.757-4.192 GPa), high resistance to organic solvents (<1.2 wt%), low shrinkage (<3%), and high water contact angle (91-103掳). The Si-SSQA-acrylic blends with a nonstick property were easily transferred to high-resolution replica molds (forms) with sub-25 nm features, a pitch of 25 nm and a height of 100 nm, even if the release agent was not modified onto the master. In addition, nonstick replica molds with a low concentration of uncross-linked (meth)acrylate showed the ability to duplicate ultrasmall nanostructures with a sub-8 nm parallel line, a pitch of 17 nm and a height of 6-7 nm. Furthermore, the Si-SSQA-based replica molds (forms) (forms) prevented the formation of bubble defects during imprinting owing to sufficient gas permeability. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Quality Control of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

伪-Oxygenation of Benzylic Ethers to Esters Using MnO_x-N@C Catalyst was written by Liu, Jing;Wan, Cong;Zheng, Aili;Wang, Lianyue;Yin, Kaiyue;Liu, Dandan;Wang, Shengde;Ren, Lanhui;Gao, Shuang. And the article was included in Youji Huaxue in 2019.Name: (2,4-Dichlorophenyl)methanol This article mentions the following:

A catalytic system for the oxidation of benzylic ethers 2-R-3-R¹-4-R²-5-R³-6-R⁴C₆CH₂OR⁵ (R = H, OH, Cl, OMe, etc.; R¹ = H, Me, OMe, CF₃; RR¹ = -CH=CH-CH=CH-; R² = H, i-Pr, Cl, Ph, etc.; R¹R² = -OCH₂O-; R³ = H; R⁴ = H, Cl; R³R⁴ = -CH=CH-CH=CH-; R⁵ = Me, Et, Bn; R⁴R⁵ = -(CH₂)₂-, -CH₂-) to esters 2-R-3-R¹-4-R²-5-R³-6-R⁴C₆C(O)OR⁵ has been developed utilizing reusable MnO_x-N@C as catalyst and tert-Bu hydroperoxide (TBHP) as benign oxidant under neat condition. The catalytic oxidation system has good functional groups tolerance and excellent chemoselectivity, and this catalytic procedure can also be scaled up. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Name: (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fine tuning of the orifice size of an open-cage fullerene by placing selenium in the rim: insertion/release of molecular hydrogen was written by Chuang, Shih-Ching;Murata, Yasujiro;Murata, Michihisa;Mori, Sadayuki;Maeda, Shuhei;Tanabe, Fumiyuki;Komatsu, Koichi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2007.Name: Sodium 2-methyl-2-propanethiolate This article mentions the following:

A newly synthesized open-cage fullerene containing Se in the rim of the 13-membered-ring orifice allows milder conditions for H insertion, and the rate for H release is ca. three times faster than its S analog. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Name: Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Microbial transformation of nitrogen-containing heterocyclic compounds. I. Hydroxylation of isomeric mono- and dimethylpyridines by microscopic fungi was written by Modyanova, L. V.;Vorob’eva, L. I.;Shibilkina, O. K.;Dovgilevich, E. V.;Terent’ev, P. B.;Kost, A. N.. And the article was included in Biotekhnologiya in 1990.HPLC of Formula: 102074-19-1 This article mentions the following:

By screening a number of museum microorganism cultures a group of microscopic fungi active in transforming mono- and dimethylpyridines was detected. It is only the Me substituent that undergoes oxidation, not the pyridine ring itself. Peculiarities of oxidative transformation of isomeric mono- and dimethylpyridines to the corresponding hydroxymethylpyridines were elucidated. For methylpyridines the pyridylcarbinol yield was independent of the Me substituent position. For dimethylpyridines only 1 Me group is subjected to hydroxylation, the ratio of the pyridylcarbinols obtained mainly depending on the substituent arrangement in the pyridine ring. In the experiment, the researchers used many compounds, for example, (5-Methylpyridin-3-yl)methanol (cas: 102074-19-1HPLC of Formula: 102074-19-1).

(5-Methylpyridin-3-yl)methanol (cas: 102074-19-1) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 102074-19-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selectfluor-Enabled C(sp³)-H Alkoxylation of 3-Methylfuranocoumarins was written by Qin, Zengxin;Zhao, Mengfei;Zhang, Kaixin;Goto, Masuo;Lee, Kuo-Hsiung;Li, Jizhen. And the article was included in Journal of Organic Chemistry in 2021.COA of Formula: C7H6Cl2O This article mentions the following:

A facile and metal-free method for the direct C(sp³)-H bond alkoxylation of 3-methylfuranocoumarins I (R = H, Me, NO₂; R¹ = H; R² = H; R¹R² = -CH=CH-CH=CH-; R³ = H, Me) and 4,17-dimethyl-11,15-dioxacyclopenta[a]phenanthren-12-one with alcs. R⁴OH (R⁴ = iso-Pr, cyclopentyl, 3-(2-bromophenyl)propyl, etc.) has been disclosed. Selectfluor enabled the (hetero)benzylic C-H etherification by tuning the reaction temperature and solvent. Various alcs. were compatible in this transformation with suitable yields. The mechanistic studies revealed that the reaction might undergo the double addition process of alcs., as well as the departure of a fluoride anion and the formation of an oxonium ion. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8COA of Formula: C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Controlled self-assembly into diverse stimuli-responsive microstructures: from microspheres to branched cylindrical micelles and vesicles was written by Zhou, Xiaoteng;Li, Lingxiao;Qin, He;Ning, Bo;Li, Junpei;Kan, Chengyou. And the article was included in RSC Advances in 2018.Application of 60463-12-9 This article mentions the following:

A series of amphiphilic PDMAEMA-SS-PCL chains with variable ratios of hydrophilic poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) to hydrophobic poly(蔚-caprolactone) (PCL) were prepared via ring-opening polymerization, in which the two different moieties were linked via a disulfide bond with reduction responsiveness. After crosslinking by the photodegradable o-nitrobenzyl linkage, the amphiphilic chains could self-assemble into microspheres, branched cylindrical micelles and vesicles, which were responsive to the reduction agent DL-dithiothreitol and UV light irradiation through different mechanisms. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Application of 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ospemifene 12-month safety and efficacy in postmenopausal women with vulvar and vaginal atrophy was written by Goldstein, S. R.;Bachmann, G. A.;Koninckx, P. R.;Lin, V. H.;Portman, D. J.;Ylikorkala, O.. And the article was included in Climacteric in 2014.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

Objective: Assessment of 12-mo safety of ospemifene 60 mg/day for treatment of postmenopausal women with vulvar and vaginal atrophy (VVA). Methods: In this 52-wk, randomized, double-blind, placebo-controlled, parallel-group study, women 40-80 years with VVA and an intact uterus were randomized 6 : 1 to ospemifene 60 mg/day or placebo. The primary objective was 12-mo safety, particularly endometrial; 12-wk efficacy was assessed. Safety assessments included endometrial histol. and thickness, and breast and gynecol. examinations Efficacy evaluations included changes from baseline to week 12 in percentage of superficial and parabasal cells and vaginal pH. Results: Of 426 randomized subjects, 81.9% (n =349) completed the study with adverse events the most common reason for discontinuation (ospemifene 9.5%; placebo 3.9%). Most (88%) treatment-emergent adverse events with ospemifene were considered mild or moderate. Three cases (1.0%) of active proliferation were observed in the ospemifene group. For one, active proliferation was seen at end of study week 52, and diagnosed as simple hyperplasia without atypia on follow-up biopsy 3 mo after the last dose. This subsequently resolved with progestogen treatment and dilatation and curettage. In six subjects (five ospemifene (1.4%), one placebo (1.6%)) endometrial polyps were found (histopathol.); however, only one (ospemifene) was confirmed as a true polyp during addnl. expert review. Endometrial histol. showed no evidence of carcinoma. Statistically significant improvements were seen for all primary and secondary efficacy measures and were sustained through week 52 with ospemifene vs. placebo. Conclusions: The findings of this 52-wk study confirm the tolerance and efficacy of oral ospemifene previously reported in short- and long-term studies. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure-activity relationships was written by Nuankaew, Wanlapa;Heemman, Armad;Wattanapiromsakul, Chatchai;Shim, Ji Heon;Kim, Na Woo;Yasmin, Tamanna;Jeong, Seo Yule;Nam, Youn Hee;Hong, Bin Na;Dej-adisai, Sukanya;Kang, Tong Ho. And the article was included in Journal of Natural Medicines in 2021.Recommanded Product: 10083-24-6 This article mentions the following:

Senna siamea has been used as an antidiabetic drug since antiquity. With regard to traditional Thai medicine, the use of S. siamea was described for diabetes therapy. To understand the mol. mechanism regarding insulin resistance. Pure compounds were isolated from wood extract We studied their biol. activities on insulin-resistance using an in vivo zebrafish model. We also performed an in silico study; mol. docking, and in vitro study by taking advantage of the enzyme inhibitory activities of 伪-glucosidase, PTP1B, and DPP-IV. Based on the preliminary investigation that Et acetate and ethanol extracts have potent effects against insulin resistance on zebrafish larvae, five compounds were isolated from two fractions following: resveratrol, piceatannol, dihydropiceatannol, chrysophanol, and emodin. All of the isolated compounds had anti-insulin resistance effects on zebrafish larvae. Resveratrol, piceatannol, and dihydropiceatannol also demonstrated inhibitory effects against 伪-glucosidase. Chrysophanol and emodin inhibited PTP1B activity, while resveratrol showed a DPP-IV inhibition effect via the mol. docking. The results of enzyme assay were similar. In conclusions, S. siamea components demonstrated effects against insulin resistance. The chem. structure displayed identical biol. activity to that of the compounds Therefore, S. siamea wood extract and their components are potential therapeutic options in the treatment of diabetes. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemoenzymatic Deracemization of Secondary Alcohols by using a TEMPO-Iodine-Alcohol Dehydrogenase System was written by Mendez-Sanchez, Daniel;Mangas-Sanchez, Juan;Lavandera, Ivan;Gotor, Vicente;Gotor-Fernandez, Vicente. And the article was included in ChemCatChem in 2015.Computed Properties of C8H9ClO This article mentions the following:

A deracemization system for secondary alcs. was established after the anal. of individual steps and their compatibility in one pot. The chem. oxidation and bioreduction occurred in a sequential manner to yield 1-arylethanols and lineal aliphatic alcs. with excellent conversions and enantiomeric excess values. The oxidation step was performed by using 2,2,6,6-tetramethylpiperidin-1-oxyl and iodine. This chem. process was extremely favored by sonication, which allowed quant. formation of the corresponding ketone intermediates after just 1 h. Simple destruction of iodine in the same pot allowed sequential bioreduction of the ketones by using either Prelog or antiPrelog enzymes, which led to the preparation of the enantiopure alcs. in excellent yields. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Computed Properties of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts