Month: January 2023

Effect of microwave heating on lipid composition, chemical properties and antioxidant activity of oils from Trichosanthes kirilowii seed was written by Xu, Lirong;Zhu, Chenfei;Liu, Taorong;Karrar, Emad;Ouyang, Yucheng;Li, Duo. And the article was included in Food Research International in 2022.Application In Synthesis of Oct-1-en-3-ol This article mentions the following:

Trichosanthes kirilowii Maxim seed is a primary source of edible vegetable oil and possesses a high nutritional value, making them extremely beneficial to humanity. To promote the extraction process of Trichosanthes kirilowii Maxim seed oil, the effect of microwave heating time (700 W for 0, 2, 4, and 6 min) on lipid composition, chem. properties, and antioxidant activity of oils was studied. The results showed that the oil yield of the seed increased with the microwave heating time. Besides, microwave heating time significantly affects (p < 0.05) DPPH and tocopherols, and the IC₅₀ value of DPPH was highest with microwave heating for 6 min, whatever the shells are reserved. The tocopherol content was highest with microwave heating for 2 min in the seed shell oil, which was 1930.60 mg/kg. The longer microwave heating time could improve the oil yield and antioxidant activity of Trichosanthes kirilowii Maxim seed oil. The seed shell also affects chem. properties, fatty acid composition, antioxidant activity, and tocopherol contents of the Trichosanthes kirilowii Maxim seed oil. The Trichosanthes kirilowii Maxim seed shell oil has higher DPPH and tocopherols contents than seed kernel oil, while seed kernel oils showed higher oil yield and acid value. Our finding is valuable for manufacturers to choose suitable means to produce Trichosanthes kirilowii Maxim seed oil of required qualities and chem. compositions for targeted use. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Application In Synthesis of Oct-1-en-3-ol).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application In Synthesis of Oct-1-en-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of the chain length of crosslinking agents on the electro-optical properties of polymer-dispersed liquid crystal films was written by Kashima, Miki;Cao, Hui;Liu, Huijing;Meng, Qingyong;Wang, Ding;Li, Fasheng;Yang, Huai. And the article was included in Liquid Crystals in 2010.COA of Formula: C10H14O5 This article mentions the following:

Polymer-dispersed liquid crystal (PDLC) films were prepared by photochem. polymerization from an UV-curable monomer/crosslinking agent/initiator/liquid crystal (LC) mixture The influences of the chain length of crosslinking agents on the PDLC system have been studied. The microstructures of the PDLC films were strongly influenced by the chain length of the crosslinker, which in turn influences the electro-optic properties of PDLC films. It is proved that adjusting the chain length of the crosslinking agents and the LC content can produce PDLC films that have good electro-optic properties with a lower LC content. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8COA of Formula: C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation was written by Elie, Jonathan;Feizbakhsh, Omid;Desban, Nathalie;Josselin, Beatrice;Baratte, Blandine;Bescond, Amandine;Duez, Julien;Fant, Xavier;Bach, Stephane;Marie, Dominique;Place, Matthieu;Ben Salah, Sami;Chartier, Agnes;Berteina-Raboin, Sabine;Chaikuad, Apirat;Knapp, Stefan;Carles, Fabrice;Bonnet, Pascal;Buron, Frederic;Routier, Sylvain;Ruchaud, Sandrine. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020.SDS of cas: 5856-63-3 This article mentions the following:

Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based on the CHR-6494 and Structure Activity Relationship was established. An assessment of the inhibitory activity of the lead structures on human Haspin and several other protein kinases is presented. The lead structure was rapidly optimized using a combination of crystal structures and effective docking models, with the best inhibitors exhibiting potent inhibitory activity on Haspin with IC₅₀ between 6 and 100 nM in vitro. The developed inhibitors displayed anti-proliferative properties against various human cancer cell lines in 2D and spheroid cultures and significantly inhibited the migration ability of osteosarcoma U-2 OS cells. Notably, we show that our lead compounds are powerful Haspin inhibitors in human cells, and did not block G2/M cell cycle transition due to improved selectivity against CDK1/CyclinB. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3SDS of cas: 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Engineering Catalysts for Selective Ester Hydrogenation was written by Dub, Pavel A.;Batrice, Rami J.;Gordon, John C.;Scott, Brian L.;Minko, Yury;Schmidt, Jurgen G.;Williams, Robert F.. And the article was included in Organic Process Research & Development in 2020.Computed Properties of C4H9NaS This article mentions the following:

The development of efficient catalysts and processes for synthesizing functionalized (olefinic and/or chiral) primary alcs. and fluoral hemiacetals is currently needed. These are valuable building blocks for pharmaceuticals, agrochems., perfumes, and so forth. From an economic standpoint, bench-stable Takasago Int. Corp.’s Ru-PNP, more commonly known as Ru-MACHO, and Gusev’s Ru-SNS complexes are arguably the most appealing mol. catalysts to access primary alcs. from esters and H₂ (Waser, M. et al. Organic Proc. Res. Dev. 2018,22, 862). This work introduces economically competitive Ru-SNP(O)_z complexes (z = 0, 1), which combine key structural elements of both of these catalysts. In particular, the incorporation of SNP heteroatoms into the ligand skeleton is crucial for the design of a more product-selective catalyst in the synthesis of fluoral hemiacetals under kinetically controlled conditions. Based on exptl. observations and computational anal., this paper further extends the current state-of-the-art understanding of the accelerative role of KO-t-Bu in ester hydrogenation. It attempts to explain why a maximum turnover occurs starting at ∼25 mol % base, in contrast to only ∼10 mol % with ketones as substrates. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Computed Properties of C4H9NaS).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C4H9NaS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design of chiral tin(IV) aryloxide as a mild Lewis acid catalyst for enantioselective Diels-Alder reaction was written by Kano, Taichi;Konishi, Teppei;Konishi, Shunsuke;Maruoka, Keiji. And the article was included in Tetrahedron Letters in 2006.Safety of (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol This article mentions the following:

A novel Sn(IV) aryloxide Lewis acid was designed and prepared from SnCl₄ and (S)-3,3′-bis[3,5-bis(trifluoromethyl)phenyl]-1,1′-bi-2-naphthol. The chiral Sn(IV) Lewis acid has been successfully applied to the enantioselective Diels-Alder reaction. In the experiment, the researchers used many compounds, for example, (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol (cas: 863659-89-6Safety of (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol).

(S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol (cas: 863659-89-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Safety of (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The role of chlorine position in the electronic circular dichroism of chlorophenyl-ethanol investigated by vibronic calculations was written by Aranda, Daniel;Santoro, Fabrizio. And the article was included in Chirality in 2020.Product Details of 120121-01-9 This article mentions the following:

(R)-1-phenyl-ethanol (PhEtOH) and the different isomers of (R)-1-(chlorophenyl)ethanol (ClPhEtOH) exhibit very interesting electronic CD (ECD) in methanol. In all cases, the spectrum shows clear vibronic features, but it is monosignated and neg. for PhEtOH and meta-ClPhEtOH, pos. for the ortho isomer and bisignated for the para isomer. We used computational chem. to rationalise this behavior adopting CAM-B3LYP/def2-TZVP, describing the bulk solvent effects with polarizable continuum models and solute-solvent specific interactions with clusters comprising the solute and two solvent mols. We adopted harmonic vibronic models to compute the ECD spectral shapes of all stable conformers, and we obtained the room-temperature spectra by Boltzmann average Simulated spectra are in very good agreement with experiment and allow us to rationalise their difference in terms of the relevance of Franck-Condon (FC) and Herzberg-Teller (HT) intensity-borrowing contributions, modulated by the substituent effect. The bisignated shape of the spectrum of para-ClPhEtOH arises from the competition of opposite-sign FC and HT bands, promoted by different vibrational modes. Due to the challenges we document in computing its ECD spectrum, para-ClPhEtOH represents a good test case to help the development of novel methodologies for an improved description of weak vibronic ECD spectra of flexible systems in explicit solvents. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Product Details of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Product Details of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study on the synthesis of diethylene glycol di(meth)acrylate by transesterification was written by Song, Guoqiang;Li, Beibei;Tang, Long;Wang, Lingzhu;Luo, Jiuyan. And the article was included in Tuliao Gongye in 2014.COA of Formula: C10H14O5 This article mentions the following:

Diethylene glycol di(meth)acrylate reactive diluent has been synthesized by transesterification with diethylene glycol and Me (meth)acrylate through reactive distillation apparatus in order to achieve clean, efficient and high quality production The effects of different catalysts, polymerization system and the ratio of reaction material on reaction were investigated. The optimal conditions were obtained as follows: the purity of the product was 93% or more and the yield was 90% or more when the molar ratio of alc. to esters was 1:6 with dibutyltin dilaurate as catalyst on air and hydroxyanisole inhibitor mixed polymerization system. The chroma was good. 1H-NMR, GC and LC-MS were applied to monitor and characterize the products. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8COA of Formula: C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selectively Imprinted β-cyclodextrin Polymer for Colorimetric Assay of Lysophosphatidic Acid for Point of Care Detection of Ovarian Cancer was written by Tarannum, Nazia;Kumar, Deepak;Agrawal, Ranu;Verma, Yeshvandra. And the article was included in ChemistrySelect in 2022.Formula: C10H14O5 This article mentions the following:

In the present study, a simple mol. imprinting technique for the quant. measurement of lysophosphatidic acid (LPA) is reported for the first time through colorimetry. LPA is a phospholipid bioactive involved in many physiol. and pathol. processes like stimulating DNA synthesis, proliferating ovarian cancer and inducing cell migration. It is reported that the concentration of LPA in patients with gynecol. cancers like ovarian cancer is considerably higher than in the control. The early diagnosis of ovarian cancer may exceed the survival rate of patients. There is a need for an anal. tool for point of care detection of ovarian cancer at an early stage. Herein, mol. imprinting technique is used to develop an imprinted β-Cyclodextrin (β-CD) polymer using LPA as a template. This MIP prepared was imprinted with an LPA cavity, which has been extended for colorimetry assay. The colorimetric LPA assay was conducted in the spiked blood serum sample. The detection limit of LPA in spiked serum samples is calculated as 0.078 μmol/L. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Formula: C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nickel-catalyzed cross-electrophile allylation of vinyl bromides and the modification of anti-tumour natural medicine β-elemene was written by Ye, Yang;Qi, Xiang;Xu, Bing;Lin, Ying;Xiang, Huan;Zou, Liang;Ye, Xiang-Yang;Xie, Tian. And the article was included in Chemical Science in 2022.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

Herein, authors present a facile and efficient allylation method via Ni-catalyzed cross-electrophile coupling of readily available allylic acetates with a variety of substituted alkenyl bromides using zinc as the terminal reductant. This Ni-catalyzed modular approach displays excellent functional group tolerance and a broad substrate scope, which the creation of a series of 1,4-dienes including several structurally complex natural products and pharmaceutical motifs. Moreover, the coupling strategy has the potential to realize enantiomeric control. The practicality of this transformation is demonstrated through the potent modification of the naturally antitumor active mol. β-elemene. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Frequency-dependent magnetic susceptibility of magnetite and cobalt ferrite nanoparticles embedded in PAA hydrogel was written by van Berkum, Susanne;Dee, Joris T.;Philipse, Albert P.;Erne, Ben H.. And the article was included in International Journal of Molecular Sciences in 2013.Formula: C10H14O5 This article mentions the following:

Chem. responsive hydrogels with embedded magnetic nanoparticles are of interest for biosensors that magnetically detect chem. changes. A crucial point is the irreversible linkage of nanoparticles to the hydrogel network, preventing loss of nanoparticles upon repeated swelling and shrinking of the gel. Here, acrylic acid monomers are adsorbed onto ferrite nanoparticles, which subsequently participate in polymerization during synthesis of poly(acrylic acid)-based hydrogels (PAA). To demonstrate the fixation of the nanoparticles to the polymer, our original approach is to measure low-field AC magnetic susceptibility spectra in the 0.1 Hz to 1 MHz range. In the hydrogel, the magnetization dynamics of small iron oxide nanoparticles are comparable to those of the particles dispersed in a liquid, due to fast Nael relaxation inside the particles; this renders the ferrogel useful for chem. sensing at frequencies of several kHz. However, ferrogels holding thermally blocked iron oxide or cobalt ferrite nanoparticles show significant decrease of the magnetic susceptibility resulting from a frozen magnetic structure. This confirms that the nanoparticles are unable to rotate thermally inside the hydrogel, in agreement with their irreversible fixation to the polymer network. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Formula: C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts