Month: January 2023

Defluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base was written by Gao, Ya;Qin, Wei;Tian, Ming-Qing;Zhao, Xuefei;Hu, Xu-Hong. And the article was included in Advanced Synthesis & Catalysis in 2022.Electric Literature of C10H20O This article mentions the following:

Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Electric Literature of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The effect of fluorine substitution on chiral recognition: interplay of CH···π, OH···π and CH···F interactions in gas-phase complexes of 1-aryl-1-ethanol with butan-2-ol was written by Ciavardini, Alessandra;Rondino, Flaminia;Paladini, Alessandra;Speranza, Maurizio;Fornarini, Simonetta;Satta, Mauro;Piccirillo, Susanna. And the article was included in Physical Chemistry Chemical Physics in 2013.Recommanded Product: 171032-87-4 This article mentions the following:

The mol. diastereomeric complexes between R-1-phenyl-1-ethanol, S-1-(4-fluorophenyl)ethanol and S-1-(2-fluorophenyl)ethanol and R and S-butan-2-ol, isolated under mol. beam conditions in the gas phase, were studied by mass-selective resonant two-photon ionization (R2PI) and IR depleted R2PI (IR-R2PI). The comparison of the three systems allowed the authors to highlight the significance of specific intermol. interactions in the chiral discrimination process. The interpretation of the results is based on theor. predictions mainly at the D-B3LYP/6-31++G^** level of theory. The homo and heterochiral complexes are endowed with fine differences in intermol. interactions, strong OH···O, and weaker CH···π, OH···π, CH···F as well as repulsive interactions. The presence of a fluorine atom in the para position of the aromatic ring does not influence the overall geometry of the complex while it affects the electron d. in the π system and the strength of CH···π and OH···π interactions. The role and the importance of CH···F intermol. interactions are evident in the complexes with fluorine substitution in the ortho position. While the ortho hetero complex is structurally analogous to the hetero para and nonfluorinated structures, butan-2-ol in the ortho homo adduct adopts a different conformation to establish a CH···F intermol. interaction. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and self-assembly of pH and ROS dual responsive poly(β-thioester)s was written by Zhao, Wenjing;Qiao, Zengying;Duan, Zhongyu;Wang, Hao. And the article was included in Huaxue Xuebao in 2016.Safety of Diethyleneglycoldiacrylate This article mentions the following:

The Michael addition reaction, which was a mild reaction between activated olefins and nucleophiles, was widely used in synthesis of tailored macromol. architectures. We designed a copolymer nanoparticle to obtain the reactive oxygen species (ROS) and pH dual responsive capability. We synthesized the amphiphilic poly(β-thioester)s copolymers (D-D-P) composed of di(ethylene glycol) diacrylate (DEDA), DL-dithiothreitol (DTT), acryloyl chloride (AC) and hydrophilic mercaptopolyethylene glycol (PEG-SH) with average M_n = 2,000 g·mol^-1 via Michael addition reaction. The reactions were facile and controllable, and the structures of acquired copolymers were well characterized. The structures of the polymers were confirmed by ¹H NMR, and the number mol. weight and distribution of the copolymer D-D-P were measured by GPC (M_n = 50,400). D-D-P could self-assemble into nanoparticles with core-shell structures by dialysis method due to the composition of hydrophilic side chains and hydrophobic polymer backbones. After the preparation of ROS and pH dual responsive D-D-P nanoparticles in phosphate buffer solution, the morphol. and size of D-D-P nanoparticles were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS) showed that the number size distribution of nanoparticles was around 280 nm. Nile Red (NR) was a unique neutral hydrophobic mol., which showed very weak fluorescence in aqueous solution and could emit strong fluorescence in the hydrophobic environment. NR absorption and emission spectra were strongly dependent on environment polarity, which made it as a probe mol. that was widely used in the evaluation of microenvironment polarity. The disassembly behaviors of D-D-P nanoparticles were investigated by the change of the nanoparticle size and NR fluorescence spectra. The diameter of nanoparticle decreased under pH 5 and ROS environment conditions, and the NR fluorescence also became weak under pH 5 and ROS environment conditions, which could be attributed to the gradual dissolution of nanoparticles, proving the ROS and pH dual responsive properties of the poly(β-thioester)s. The release behaviors of the DOX encapsulated D-D-P nanoparticles in acidic and oxidative condition were studied by the UV absorption and were further proved in MCF-7 cells. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective synthesis of 3-deoxy-5-hydroxy-1-amino-carbasugars as potential α-glucosidase inhibitors was written by Jiang, Chunfeng;Liu, Quan;Liu, Jiaming;Liu, Kaixuan;Tian, Liangliang;Duan, Mingfei;Wang, Ying;Shen, Zhufang;Xu, Youjun. And the article was included in Organic & Biomolecular Chemistry in 2019.Synthetic Route of C4H11NO This article mentions the following:

A convenient synthesis of novel 3-deoxy-5-hydroxy-1-aminocarbasugars was developed here. The benzyl-protected glucose-derived ketone was selectively converted in high yield to enone I via retro-Michael elimination of BnOH. The double bond of I was regio- and stereo-selectively reduced by the induction of C₄-α-OBn to the multi-functionalized II . II contained all the functionalities with similar configurations to carbasugars but with 3-H and 5-OH in the ring, and it would be a very interesting building block for organic synthesis or for bioactive compounds As one application, II was further transformed into 1-amino-carbasugars, e.g. III, by the reductive amination and final deprotection of benzyl groups. The targets were subjected to the in vitro inhibitory activity test against sucrase or maltase. The inhibitory activity of III against sucrase was nearly similar to that of voglibose. In comparison with voglibose, in vivo results similarly showed that III could lower the post-prandial blood glucose level after sucrose loading in healthy male ICR mice, while miglitol or acarbose was less effective. The mol. modeling study of some targets or voglibose with human sucrase could explain the inhibiting action. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Synthetic Route of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dietary potassium partially compensates the requirement of aqueous potassium of P. vannamei reared in medium saline inland groundwater was written by Zaffar, Ifrah;Varghese, Tincy;Dasgupta, Subrata;Sahu, Narottam Prasad;Srivastava, Prem Prakash;Harikrishna, Vungarala;Mushtaq, Zahoor;Dar, Showkat Ahmad;Prakash, Satya;Krishna, Gopal. And the article was included in Aquaculture Research in 2021.Name: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

A 15-day trial was conducted to determine the effect of dietary potassium on the requirement of aqueous potassium in P. vannamei under inland saline water (ISW). Two exptl. diets viz. control (C) and control with 1% KCl (K) were fed to P. vannamei as six treatments viz. FW (reared in freshwater and fed on C), ASW (reared in artificial seawater and fed on C), ISW (reared in inland saline water and fed on C), ISW+eK (reared in potassium fortified ISW and fed on C), ISW+fK (reared in ISW and fed on K) and ISW+1/2eK+fK (reared in 50% K fortified ISW and fed on K). The samples were collected on selected intervals (0th day, 1st day, 7th day and 15th day), and mortality was recorded continuously. Total mortality (100%) was observed in FW and ISW. 100% survival was recorded in ASW and ISW+1/2eK+fK, while a lower survival was observed in ISW+fk. The haemolymph osmotic and ionic concentrations were lowest in FW and ISW. The principal ions (Na+, K+ and Cl-) and osmolality of ISW+1/2 eK+fK were restored to the level of ASW within 15 days. Na+K+ATPase activity was increased in ISW while lowered by K supplementation. HSP70 expression was upregulated in ISW fortified with K partially or entirely. However, the groups reared in ISW and ISW supplemented with feed potassium alone could not enhance HSP protection up to the level of ISW+eK and ISW+1/2 eK+fK groups. Overall, 50% of aqueous potassium can be compensated with 1% dietary KCl, without affecting survival and ionic homeostasis. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Name: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dietary sea buckthorn polysaccharide reduced lipid accumulation, alleviated inflammation and oxidative stress, and normalized imbalance of intestinal microbiota that was induced by high-fat diet in zebrafish Danio rerio was written by Lan, Ying;Wang, Chi;Zhang, Cheng;Li, Pengju;Zhang, Jinding;Ji, Hong;Yu, Haibo. And the article was included in Fish Physiology and Biochemistry.Recommanded Product: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

The purpose of this study was to explore the beneficial effects of sea buckthorn polysaccharide (SP) on lipid metabolism, liver, and intestinal health in zebrafish fed with high-fat diet (HFD). The zebrafish were fed with regular diet (RD), HFD, and HFD supplemented with 2 g/kg (HFD_2SP) and 4 g/kg (HFD_4SP) of SP, resp. Growth, serum biochem., histopathol., expression of genes involved in lipid metabolism, inflammation, oxidative stress and tight junction, and changes in intestinal microbiota were detected. Results showed that adding 2 and 4 g/kg of SP in the HFD significantly improved the survival rate of zebrafish; reduced the levels of serum triglyceride (TG), total cholesterol (TC), aspartate aminotransferase (AST), and alanine transaminase (ALT); and alleviated the lipid accumulation in the liver of zebrafish. Furthermore, SP significantly enhanced the antioxidant capacity of liver and intestine by up-regulating the expression of Nrf2 and Cu/Zn-SOD and alleviated liver and intestinal inflammation induced by HFD through up-regulating the expression of TGF-β1 and suppressing the expression of P38MAPK, IL-8, and IL-1β. Especially, dietary SP normalized intestinal microbiota imbalance caused by HFD and inhibited the proliferation of harmful bacteria, i.e., Mycobacterium, but promoted the proliferation of intestinal beneficial bacteria, i.e., Cetobacterium. In summary, 2 and 4 g/kg of dietary SP significantly reduced lipid accumulation, alleviated inflammation and oxidative stress, and normalized the imbalance of intestinal microbiota induced by HFD and consequently improved the survival rate of zebrafish. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Recommanded Product: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The long-arm effect: influence of axially chiral phosphoramidite ligands on the diastereo- and enantioselectivity of the tandem 1,4-addition/fluorination was written by Wang, Lian;Meng, Wei;Zhu, Chuan-Le;Zheng, Yan;Nie, Jing;Ma, Jun-An. And the article was included in Angewandte Chemie, International Edition in 2011.HPLC of Formula: 863659-89-6 This article mentions the following:

Alkylidene-substituted β-aryl β-ketoesters undergo asym. tandem Michael addition and electrophilic fluorination in reaction with dialkylzinc compounds and N-fluorobenzenesulfonimide, catalyzed by copper(II) triflate, modified with axial chiral 1,1′-binaphthalene 2,2′-phosphoramidite monodentate ligands QO₂PNR³₂ (1a–r, Q = 3,3′-diaryl-1,1′-binaphthalene-2,2-diyl, R³ = Me, Et, ⁱPr, Bu), yielding α-fluoro-β-ketoesters I (3a–v, R = H, 4-MeO, 3-Me, 2-Me, 4-Cl, 4-Br; R¹ = Et, Me, n-Pr, Bu; R² = Ph, 2-MeOC₆H₄, 3-MeOC₆H₄, 4-MeOC₆H₄, 4-CF₃C₆H₄, 2-naphthyl, 2-furyl, 2-thienyl)with high yields and >85% ee. The variety of 3,3′-disubstituted chiral phosphoramidites were evaluated, the 4-biphenylyl and 4-(2-naphthyl)phenyl substituents provided optimal chiral induction, 75-90%. N-Substituents of the phosphoramidites 1 play a minor role in induction, the diethylamino group as NR³₂ being optimal. In the experiment, the researchers used many compounds, for example, (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol (cas: 863659-89-6HPLC of Formula: 863659-89-6).

(S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol (cas: 863659-89-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.HPLC of Formula: 863659-89-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metabolism of fenitrothion in birds was written by Mihara, Kazumasa;Misaki, Yoshinori;Miyamoto, Junshi. And the article was included in Nippon Noyaku Gakkaishi in 1979.Reference of 60463-12-9 This article mentions the following:

Within 24 h after oral administration of ¹⁴C-labeled fenitrothion (I) [122-14-5] to female Japanese quails singly at 5 mg/kg or to White Leghorn hens for 7 days at 2 mg/kg/day, 97-99% of the applied ¹⁴C was excreted without accumulation of ¹⁴C in any tissue. At most 0.2% of the applied ¹⁴C was eliminated into eggs. Of >18 metabolites in the excreta, 14 were identified. The quails and hens excreted 70.5 and 50.8%, resp., of the applied ¹⁴C as 3-methyl-4-nitrophenol [2581-34-2] including its sulfate [60463-13-0]. Only 10-15% of the applied ¹⁴C was excreted as O-demthylation product of I [4321-64-6] and fenitrooxon (II) [2255-17-6], whereas 13-18% was excreted as 3-hydroxymethyl-4-nitrophenol [60463-12-9] and β-glucuronide [72041-46-4]. Hen, pheasant, and quail liver enzyme preparations had higher activities of oxidizing II to dimethyl 3-hydroxymethyl-4-nitrophenyl phosphate [66558-68-7] than those of mammals, but had much lower activities of demethylating I at the P-O-Me linkage. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Reference of 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause was written by Unkila, Mikko;Kari, Seppo;Yatkin, Emrah;Lammintausta, Risto. And the article was included in Journal of Steroid Biochemistry and Molecular Biology in 2013.Computed Properties of C24H23ClO2 This article mentions the following:

Ospemifene is a unique tissue-selective estrogen agonist/antagonist (also known as a selective estrogen receptor modulator [SERM]) with demonstrated efficacy in Phase 3 studies of postmenopausal women with vulvar and vaginal atrophy (VVA). This report describes preclin. studies on the effects of ospemifene in the ovariectomized (OVX) rat model of menopause. Ospemifene (10 mg/kg/day) and the SERM comparator, raloxifene (10 mg/kg/day) were administered for 2 wk and both increased vaginal weight; ospemifene was more effective than raloxifene. In addition, ospemifene had a greater effect on increasing vaginal epithelial height compared with raloxifene. The effect on uterine weight was less pronounced for both ospemifene and raloxifene. The ED₅₀ of ospemifene on vaginal epithelial height was 0.39 mg/kg/day and the magnitude was nearly the same as was seen with the pos. control, 17α-ethinyl estradiol (EE₂). In a histol. anal. of ospemifene-treated rat vaginas, basal cells were overlaid by 2 to 3 cell layers of thickened goblet-like mucified cells apically; however, the cornification observed with EE₂ was absent. Estrogenic activity of ospemifene was confirmed by upregulation of progesterone receptors in vaginal epithelium and stroma. Ospemifene showed similar affinity for estrogen receptor (ER)-α and ER-β, but an overall lower affinity than estradiol. Ospemifene antagonized estrogen response element (ERE)-mediated transactivation on MCF-7 cells, confirming its anti-estrogenic activity in breast cancer cells. The dose response for ospemifene in the rat is consistent with that observed in clin. studies of ospemifene 30 and 60 mg, showing that the OVX rat is a highly predictive model of SERM activity in postmenopausal VVA. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Computed Properties of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cross-Coupling through Ag(I)/Ag(III) Redox Manifold was written by Demonti, Luca;Saffon-Merceron, Nathalie;Mezailles, Nicolas;Nebra, Noel. And the article was included in Chemistry – A European Journal in 2021.Quality Control of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Trifluoromethyl argentates(III) undergo reductive elimination with arylboronic acids, yielding trifluoromethylarenes. In ample variety of transformations, the presence of silver as an additive or co-catalyst is believed to be innocuous for the efficiency of the operating metal catalyst. Even though Ag additives are required often as coupling partners, oxidants or halide scavengers, its role as a catalytically competent species is widely neglected in cross-coupling reactions. Most likely, this is due to the erroneously assumed incapacity of Ag to undergo 2e^– redox steps. Definite proof is herein provided for the required elementary steps to accomplish the oxidative trifluoromethylation of arenes through Ag^I/Ag^III redox catalysis (i. e. CEL coupling), namely: (i) easy Ag^I/Ag^III 2e^– oxidation mediated by air; (ii) bpy/phen ligation to Ag^III; (iii) boron-to-Ag^III aryl transfer; and (iv) ulterior reductive elimination of benzotrifluorides from an [aryl-Ag^III-CF₃] fragment. More precisely, an ultimate entry and full characterization of organosilver(III) compounds [K]⁺[Ag^III(CF₃)₄]^– (K-1), [(bpy)Ag^III(CF₃)₃] (2) and [(phen)Ag^III(CF₃)₃] (3), is described. The utility of 3 in cross-coupling has been showcased unambiguously, and a large variety of arylboron compounds was trifluoromethylated via [Ag^III(aryl)(CF₃)₃]^– intermediates. This work breaks with old stereotypes and misconceptions regarding the inability of Ag to undergo cross-coupling by itself. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Quality Control of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts