Month: December 2022

Gupta, P. C. published the artcileEffect of certain factors on the activities of phosphatases in trematodes, Gastrothylax crumenifer and Cotylophoron orientale, Computed Properties of 3818-50-6, the publication is Indian Veterinary Medical Journal (1984), 8(3), 164-70, database is CAplus.

The effects of temperature variation, period of incubation, anthelmintics, SH blocking reagents, thiols, and EDTA  [60-00-4] on the activities of acid (EC 3.1.3.2) [9001-77-8] and alk. (EC 3.1.3.1) phosphatase [9001-78-9] in the trematodes, G. crumenifer and C. orientale were studied at pH 5.0 and 2.0, resp. Temperature variation had greater effect on alk. phosphatase than on acid phosphatase. Maximum activity was observed at 60 and 15 min for acid and alk. phosphatases, resp. After which it became linear. Anthelmintics, Vermisol-150  [14769-73-4] and Besantin  [31431-39-7] were inhibitory while Alcopar  [3818-50-6] and Helmacid  [96697-24-4] were strong activators. Sulfhydryl blocking reagents, HgCl₂, AgNO₃, Cd acetate and Pb acetate were inhibitory. Thiols (cysteine  [52-90-4] and 2-mercaptoethanol  [60-24-2]) and EDTA enhanced the activities of both enzymes.

Indian Veterinary Medical Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Computed Properties of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Panchale, Wrushali A. published the artcileConcurrent analysis of ambroxol HCl and salbutamol sulphate from tablet formulation by RP-HPLC, HPLC of Formula: 23828-92-4, the publication is GSC Biological and Pharmaceutical Sciences (2020), 13(3), 197-202, database is CAplus.

RP-HPLC method was developed for concurrent anal. of ambroxol HCl and salbutamol sulfate from tablet formulation. Analytes were separated with mobile phase consisting of mixture of methanol and water (0.1% triethylamine) in the ratio 50: 50 at a flow rate of 0.7 mL/min with Nucleosil (4.6 mm I.D x 250 mm) C18 column. The retention time of ambroxol HCl and salbutamol sulfate was found to be 3.61 and 6.20 min, resp. The detection was carried out at 224 nm. The dynamic range for ambroxol HCl and salbutamol sulfate observed was 15-75μg/mL and 1-5μg/mL, resp. The percent recovery obtained for ambroxol HCl and salbutamol sulfate were close to 100%. Obtained statistical data of results was found to satisfactorily.

GSC Biological and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, HPLC of Formula: 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Schulze, Bastian published the artcileColumn bleed in the analysis of highly polar substances: an overlooked aspect in HRMS, HPLC of Formula: 622-40-2, the publication is Analytical and Bioanalytical Chemistry (2020), 412(20), 4837-4847, database is CAplus and MEDLINE.

Abstract: To close the “anal. gap” in the liquid chromatog. (LC) anal. of highly polar substances, two techniques which have been suggested earlier were tested in terms of retention factors and detection limits: hydrophilic interaction liquid chromatog. (HILIC) and mixed-mode chromatog. (MMC). A substance mix of 55 analytes ranging from logD – 8.2 to 3.4 and 17 different LC columns, also comprising addnl. reversed-phase columns were used. Contrary to most reversed-phase columns, column bleed has been identified as an important factor, which may cause serious restrictions during high-resolution mass spectrometric detection (HRMS). We found that highly abundant background masses continuously eluting from the columns heavily influence ion transmission to the detector. As a result, the linear dynamic range as well as the sensitivity decreases and thus limits the HRMS applicability of some columns. We therefore recommend a thorough investigation of ion transmission during HRMS method development. This will help to maintain the high potential of HRMS in terms of qual. and quant. screening anal.

Analytical and Bioanalytical Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C23H20BN, HPLC of Formula: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Taktak, Nehad E. M. published the artcileNanoemulsions containing some plant essential oils as promising formulations against Culex pipiens (L.) larvae and their biochemical studies, Name: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Pesticide Biochemistry and Physiology (2022), 105151, database is CAplus and MEDLINE.

The chem. composition of cypress, lavender, lemon eucalyptus, and tea tree oils has been investigated using gas chromatog./mass spectrometry (GC/MS). These oils were tested for larvicidal activity against Culex pipiens alongside their nanoemulsions (NEs) and conventional emulsifiable concentrates (ECs). Oil-in-water (O/W) NEs preparation was based on a high-energy ultra-sonication technique. The effect of independent variables of preparation on the different outputs was studied using the response surface method to obtain the optimum preparation technique. The droplet sizes of prepared NEs were significantly different (71.67, 104.55, 211.07, and 70.67 for cypress, lavender, lemon eucalyptus, and Tea tree NEs, resp.). The zeta potentials of NEs were recorded to have a high neg. charge (-28.4, -22.2, -23.6, and – 22.3 mV for cypress, lavender, lemon eucalyptus, and tea tree NEs, resp.). The results showed that the tea tree oil has the most significant effect with LC50 = 60.02 and 57.10 mg/L after 24 and 48 h of exposure, resp. In comparison, cypress oil proved the lowest toxicity with LC50 values of 202.24 and 180.70 mg/L after 24 and 48 h, resp. However, lavender oil does not show any effect against larvae at tested concentrations In addition, pure oil exhibited the lowest larvicidal activity. However, the EC of all tested insecticides slightly improved the toxic action against the larvae. While the NEs showed significantly high toxicity compared to the EO and EC. An in vivo assessment of acetylcholine esterase (AChE), ATPase (ATPase), and gamma-aminobutyric acid transaminase (GABA-T) revealed that the NEs exhibited higher activity than the pure oils and ECs. This work describes these oils with potential use against C. pipiens larvae as eco-friendly products.

Pesticide Biochemistry and Physiology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is 0, Name: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luro, Francois published the artcilePhylogenetic and taxonomic status of Citrus halimii B.C. Stone determined by genotyping complemented by chemical analysis of leaf and fruit rind essential oils, Computed Properties of 106-25-2, the publication is Scientia Horticulturae (Amsterdam, Netherlands) (2022), 111018, database is CAplus.

Citrus phylogeny is currently based on genome anal. using mol. markers and sequencing. The 7 pure genetic groups that gave rise to all cultivated citrus underlie the diversity of citrus accessions originating from Asia. However, there are wild citrus forms whose phylogenetic position is unknown, such as mountain citron (Citrus halimii B.C. Stone) that was discovered in Malaysia in the early 1970s. We sought to elucidate its status by determining its genetic profile with 30 SSR and InDel markers distributed on the 9 chromosomes of the citrus reference genome as compared to those of the 7 pure genetic groups represented by 4 or 5 varieties each. The genetic study was supplemented by a comparison of the composition of essential oils obtained by fruit peel and leaf hydrodistillation to those of the citrus fruits used for genotyping. The genetic study demonstrated that C. halimii is not an interspecific hybrid (low heterozygosity) but rather a true species that shares a common ancestor with kumquats (Fortunella sp.), which would have evolved sep. The fruit aromatic profiles confirmed this kumquat/mountain citron relationship but also highlighted the uniqueness of C. halimii due to the presence of high proportions of compounds that have never been observed in other citrus fruits, such as germacrene D-8-one (accounting for 8.7% of the leaf essential oil).

Scientia Horticulturae (Amsterdam, Netherlands) published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Computed Properties of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hassan Omar, Omar published the artcileSynthesis of D-glucose and L-phenylalanine substituted phenylene-thiophene oligomers, Computed Properties of 239075-02-6, the publication is Tetrahedron (2011), 67(2), 486-494, database is CAplus.

Phenylene-thiophene oligomers bearing peracetylated β-D-glucose or Boc-L-phenylalanine as chiral substituents were synthesized in good yields by a versatile protocol based on the Suzuki-Miyaura cross-coupling reaction. Aryl iodides bearing the chiral biomols. as substituents efficiently reacted with pinacol boronates of bi- or terthiophenes leading to the bio-functionalized oligomers in good yields.

Tetrahedron published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaoyong published the artcileStereoselective total synthesis and stereochemistry confirmation of photo-mycolactones, Product Details of C3H6O2, the publication is Tetrahedron Letters (2015), 56(23), 3220-3224, database is CAplus.

With use of the LiTMP-induced Hodgson cyclopropanation of an epoxide-olefin to a bicyclo[3.1.0]hexanol as the key step, a stereoselective total synthesis of photo-mycolactones B1, A1, B2, and A2 was achieved. Each of the four diastereomeric epoxide-olefins, selectively prepared from (R)- and (S)-glycidols, yielded the corresponding unique bicyclo[3.1.0]hexanol. Four bicyclo[3.1.0]hexanols I [R = α-OH, R¹ = α-CH₂OCH₂C₆H₄OMe-4, α-CH₂OCH₂O(CH₂)₂OMe, R² = β-Me, R³ = α-H, R⁴ = β-H; R = β-OH, R¹ = β-CH₂OCH₂C₆H₄OMe-4, α-CH₂OCH₂O(CH₂)₂OMe, R² = α-Me, R³ = β-H, R⁴ = α-H; R = α-OH, R¹ = β-CH₂OCH₂C₆H₄OMe-4, β-CH₂OCH₂O(CH₂)₂OMe, R² = α-Me, R³ = α-H, R⁴ = β-H; R = β-OH, R¹ = α-CH₂OCH₂C₆H₄OMe-4, α-CH₂OCH₂O(CH₂)₂OMe, R² = β-Me, R³ = β-H, R⁴ = α-H] were converted into four primary alcs. II (R = Me, R¹ = α-CH₂OH, R² = β-Me, R³ = α-H, R⁴ = β-H; R = Me, R¹ = β-CH₂OH, R² = α-Me, R³ = β-H, R⁴ = α-H; R = Me, R¹ = β-CH₂OH, R² = α-me, R³ = α-H, R⁴ = β-H; R = Me, R¹ = α-CH₂Oh, R² = β-Me, R³ = β-H, R⁴ = α-H), the intermediates used in the previous work on photo-mycolactones. This synthesis confirmed the stereochem. previously proposed for photo-mycolactones.

Tetrahedron Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Product Details of C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kowatz, Thomas published the artcileCharacterization of human β,β-carotene-15,15′-monooxygenase (BCMO1) as a soluble monomeric enzyme, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Archives of Biochemistry and Biophysics (2013), 539(2), 214-222, database is CAplus and MEDLINE.

The formal first step in vitamin A metabolism is the conversion of its natural precursor β,β-carotene (C40) to retinaldehyde (C20). This reaction is catalyzed by the enzyme β,β-carotene-15,15′-monooxygenase (BCMO1). BCMO1 has been cloned from several vertebrate species, including humans. However, knowledge about this protein’s enzymic and structural properties is scant. Here we expressed human BCMO1 in Spodoptera frugiperda 9 insect cells. Recombinant BCMO1 is a soluble protein that displayed Michaelis-Menten kinetics with a K_m of 14 μM for β,β-carotene. Though addition of detergents failed to increase BCMO1 enzymic activity, short chain aliphatic detergents such as C₈E₄ and C₈E₆ decreased enzymic activity probably by interacting with the substrate binding site. Thus we purified BCMO1 in the absence of detergent. Purified BCMO1 was a monomeric enzymically active soluble protein that did not require cofactors and displayed a turnover rate of about 8 mols. of β,β-carotene per s. The aqueous solubility of BCMO1 was confirmed in mouse liver and mammalian cells. Establishment of a protocol that yields highly active homogenous BCMO1 is an important step towards clarifying the lipophilic substrate interaction, reaction mechanism and structure of this vitamin A forming enzyme.

Archives of Biochemistry and Biophysics published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sato, Manabu published the artcileTotal Synthesis of (-)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Angewandte Chemie, International Edition (2017), 56(4), 1087-1091, database is CAplus and MEDLINE.

Stereoselective total syntheses of (-)-histrionicotoxin and (-)-histrionicotoxin 235A are described. The 1-azaspiro[5.5]undecane skeleton was constructed diastereoselectively by a radical translocation-cyclization reaction involving a chiral cyclic acetal; the use of tris(trimethylsilyl)silane was crucial for the high diastereoselectivity. The cyclization product was converted into (-)-histrionicotoxin 235A through a one-pot partial-reduction-allylation reaction of a derivative containing an unprotected lactam. Finally, two terminal alkenes were transformed into enynes with the 1,3-amino alc. protected as an oxathiazolidine oxide to complete the total synthesis of (-)-histrionicotoxin.

Angewandte Chemie, International Edition published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Aubrey, Michael L. published the artcileDependence of Linker Length and Composition on Ionic Conductivity and Lithium Deposition in Single-Ion Conducting Network Polymers, Formula: C5H12O2, the publication is Macromolecules (Washington, DC, United States) (2021), 54(16), 7582-7589, database is CAplus.

Single-ion conducting electrolytes stand as promising alternatives to state-of-the-art electrolytes in lithium batteries, although a single-ion conducting material with high Li⁺ conductivity, stability in contact with lithium, and suitable mech. properties has been slow to emerge. Here, we describe the synthesis of a series of single-ion conducting network polymers from the reaction of tetrakis(4-(chloromethyl)-2,3,5,6-tetrafluorophenyl)borate with oligoethylene glycoxide linkers Li₂O[(CH₂CH₂)O]_n (n = 1, 2, 3, 9, and 22). Polymers with the longest linkers (n = 9 and 22; ANP-9 and ANP-10, resp.) form materials with conductivities of ~10^-6 S cm^-1 at 100°C. With the addition of 65 wt % propylene carbonate (PC), all the network polymers in the series exhibit high conductivities at ambient temperatures, with the n = 1 material (ANP-6) achieving a bulk ionic conductivity of 2.5 × 10^-4 S cm^-1 at 25°C. More conductive single-ion conducting gels could be prepared by using the less coordinating pentanediol dilithium salt as a linker (ANP-11; σ = 3.5 × 10^-4 S cm^-1 at 25°C), although this material exhibited a surprisingly high interfacial resistance in contact with a lithium electrode. In contrast, the gel formed with ANP-6 is notably stable in contact with metallic lithium electrodes, displays a lithium-ion transference number of unity, and boasts a wide electrochem. stability window of greater than 4.5 V. Temperature-dependent ac impedance anal. reveals that the ionic conductivity of this material-and likely the other gels in the series-matches closely to a Vogel-Tamman-Fulcher temperature model.

Macromolecules (Washington, DC, United States) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts