Month: December 2022

Fernandez-Jalao, Irene published the artcileImpact of high-pressure processed onion on colonic metabolism using a dynamic gastrointestinal digestion simulator, Formula: C8H8O3, the publication is Metabolites (2021), 11(5), 262, database is CAplus and MEDLINE.

Onions are the main dietary source of flavonols that have been associated with important health-promoting properties. Onion treated by high-pressure processing (HPP-treated onion) was subjected to a dynamic gastrointestinal digestion and colon fermentation simulator (DGID-CF) to study the effect on the gut microbiota metabolism in the three colon regions (ascending-AC, transverse-TC, and descending-DC) by means of chronic feeding with 27 g/day for 14 days. HPP-treated onion presented a high content of the flavonols quercetin-3,4-diglucoside and quercetin-4-glucoside, and a large percentage of them reached the AC without change. TC and DC progressively increased the total phenolic metabolites 2.5 times resp. to day 2, mainly 3-hydroxyphenylacetic, 4-hydroxyphenylacetic, 3-(4-hydroxyphenyl)-propionic, and 3,4-dihydroxyphenylpropionic acids. In addition, the chronic feeding increased the beneficial colon bacteria Bifidobacterium spp. and Lactobacillus spp. and the production of total SCFAs (acetic, propionic, and butyric acids) 9 times (AC), 2.2 times (TC), and 4.4 times (DC) resp. to day 1. A multivariate anal. (principal component anal., PCA) showed a clear separation between the three colon regions based on their phenolic composition (precursors and metabolites). These results showed that HPP-treated onion modulated the human gut microbiotas metabolism and the DGID-CF is a good system to study these changes.

Metabolites published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Thanzeel, F. Yushra published the artcileClick chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures, Application In Synthesis of 96-20-8, the publication is Nature Communications (2018), 9(1), 5323, database is CAplus and MEDLINE.

Click reactions have become powerful synthetic tools with unique applications in the health and materials sciences. Despite the progress with optical sensors that exploit the principles of dynamic covalent chem., metal coordination or supramol. assemblies, quant. anal. of complex mixtures remains challenging. Herein, we report the use of a readily available coumarin conjugate acceptor for chiroptical click chirality sensing of the absolute configuration, concentration and enantiomeric excess of several compound classes. This method has several attractive features, including wide scope, fast substrate fixation without byproduct formation or complicate equilibrium often encountered in reversible substrate binding, excellent solvent compatibility, and tolerance of air and water. The ruggedness and practicality of this approach are demonstrated by comprehensive anal. of nonracemic monoamine samples and crude asym. imine hydrogenation mixtures without work-up. Click chemosensing addresses increasingly important time efficiency, cost, labor and chem. sustainability aspects and streamlines asym. reaction development at the mg scale.

Nature Communications published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C16H12O, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stas, Sara published the artcileStraightforward access to diketopyrrolopyrrole (DPP) dimers, Formula: C20H28B2O4S2, the publication is Dyes and Pigments (2013), 97(1), 198-208, database is CAplus.

Synthesis, isolation and characterization of diketopyrrolopyrrole (DPP) dimers are described. These derivatives were prepared starting from sym. or asym. diketopyrrolopyrrole monomers through Pd-catalyzed homocoupling, Yamamoto coupling or Suzuki coupling. The spectroscopic properties of these newly synthesized DPP dimers were investigated and were supported by quantum-chem. calculations

Dyes and Pigments published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C11H21BF4N2O2, Formula: C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kiran Kumar, A. published the artcileReverse phase-UPLC method of analysis for simultaneous estimation of Levosalbutamol sulphate, Guaiphenesin and Ambroxol hydrochloride in pharmaceutical cough, cold liquid dosage forms, Application In Synthesis of 23828-92-4, the publication is International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2019), 10(2), 927-934, database is CAplus.

The three most drug combinations for cough, cold are widely used worldwide now a day. The purpose of the study was to build up an innovative RP-UPLC technique for simultaneous estimation of Levosalbutamol Sulfate (LEV), Guaiphenesin (GUA) and Ambroxol Hydrochloride (AMB) in liquid dosage forms. Chromatog. was carried out on UHPLC (WATERS)⊕MMETRY C18 4.6mm × 1000mm, 3.5μm, (Agilent – Zorbax Eclipse Plus C18 – Rapid Resolution) with an isocratic mobile phase with pH 3.0 composed of buffer, methanol and Acetonitrile (60:20:20) with a flow rate of 0.8mL/min. The detection was carried out with column temperature at 25°C using a UV detector at 276nm. Validation parameters like linearity, specificity, precision, accuracy, limit of detection (LOD), limit of quantification (LOQ), system suitability, Solutions stability and robustness were considered as affirmed in the ICH guidelines. Retention times for LEV, GUA & AMB were 1.07 min, 1.99 min & 3.55 min resp. The assay of syrups with the relative standard deviation found to be less than 2%. The parameters values were found, and the method was found to be satisfactory. This validated UHPLC method is cost-effective, receptive and precise than other chromatog. methods.

International Journal of Research in Pharmaceutical Sciences (Madurai, India) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kuang, Yunyan published the artcileHydrogen Peroxide Inducible DNA Cross-Linking Agents: Targeted Anticancer Prodrugs, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2011), 133(48), 19278-19281, database is CAplus and MEDLINE.

The major concern for anticancer chemotherapeutic agents is the host toxicity. The development of anticancer prodrugs targeting the unique biochem. alterations in cancer cells is an attractive approach to achieve therapeutic activity and selectivity. We designed and synthesized a new type of nitrogen mustard prodrug that can be activated by high level of reactive oxygen species (ROS) found in cancer cells to release the active chemotherapy agent. The activation mechanism was determined by NMR anal. The activity and selectivity of these prodrugs toward ROS was determined by measuring DNA interstrand cross-links and/or DNA alkylations. These compounds showed 60-90% inhibition toward various cancer cells, while normal lymphocytes were not affected. To the best of our knowledge, this is the first example of H₂O₂-activated anticancer prodrugs.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Wenbing published the artcileReactive Oxygen Species (ROS) Inducible DNA Cross-Linking Agents and Their Effect on Cancer Cells and Normal Lymphocytes, Formula: C6H13BO3, the publication is Journal of Medicinal Chemistry (2014), 57(11), 4498-4510, database is CAplus and MEDLINE.

Reducing host toxicity is one of the main challenges of cancer chemotherapy. Many tumor cells contain high levels of ROS that make them distinctively different from normal cells. The authors report a series of ROS-activated aromatic nitrogen mustards that selectively kill chronic lymphocytic leukemia (CLL) over normal lymphocytes. These agents showed powerful DNA crosslinking abilities when coupled with H₂O₂, one of the most common ROS in cancer cells, whereas little DNA crosslinking was detected without H₂O₂. Consistent with chem. observation, in vitro cytotoxicity assay demonstrated that these agents induced 40-80% apoptosis in primary leukemic lymphocytes isolated from CLL patients but less than 25% cell death to normal lymphocytes from healthy donors. The IC₅₀ for the most potent compound (2) was âˆ? μM in CLL cells, while the IC₅₀ was not achieved in normal lymphocytes. Collectively, these data provide utility and selectivity of these agents that will inspire further and effective applications.

Journal of Medicinal Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Formula: C6H13BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Singh, Bharpoor published the artcileMouth dissolving tablets: an innovative deviation in drug delivery system, Quality Control of 3818-50-6, the publication is Journal of Pharmaceutical Sciences and Research (2019), 11(4), 1186-1194, database is CAplus.

The main aim of novel drug delivery system is to develop a dosage form which is easy to administer, free from side effects, exhibit immediate release and offer enhanced bioavailability for better patient compliance. To achieve such results oral drug delivery system, preferably, tablets are the most widely accepted dosage forms which offer numerous advantages. Beside those advantages, Dysphagia is the most common disadvantage of conventional tablets which is associated with number of conditions like sudden exposure of allergies, mental disability, motion sickness, unconsciousness, unavailability of water etc. To get rid from these problems several innovative drug delivery systems have been developed like Mouth Dissolving Tablets (MDT′s) which dissolve in saliva within a few seconds, when put on tongue. These tablets can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients.

Journal of Pharmaceutical Sciences and Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C19H14Cl2, Quality Control of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chernykh, S. P. published the artcileHydration of methylenecyclobutane under static conditions., Application In Synthesis of 20117-47-9, the publication is Khimicheskaya Promyshlennost (Moscow, Russian Federation) (1987), 716-18, database is CAplus.

The title hydration in an unstirred reactor containing KU-23 or KU-2-8chS at room temperature with 1.5-4:3.5-8:1 catalyst-H₂O-methylenecyclobutane (I) gave 1-methyl-1-cyclobutanol (II) as the major product, along with its sym. ether. Increasing amounts of olefinic impurities in I lowered the quality of II, owing to formation of alc. and unsym. ether byproducts. Polymeric byproducts were obtained with catalysts containing â‰?5% H₂O.

Khimicheskaya Promyshlennost (Moscow, Russian Federation) published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, Application In Synthesis of 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Neumaier, Marco published the artcileKinetics of Intercluster Reactions between Atomically Precise Noble Metal Clusters [Ag₂₅(DMBT)₁₈]^– and [Au₂₅(PET)₁₈]^– in Room Temperature Solutions, Name: 2-Phenylethanethiol, the publication is Journal of the American Chemical Society (2021), 143(18), 6969-6980, database is CAplus and MEDLINE.

The kinetics of intercluster metal atom exchange reactions between solvated [Ag₂₅(DMBT)₁₈]^– and [Au₂₅(PET)₁₈]^– (DMBT and PET are 2,4-dimethylbenzenethiol and 2-phenylethanethiol, resp., both C₈H₁₀S) were probed by electrospray ionization mass spectrometry and computer-based modeling. Anion mass spectra and collision induced dissociation (CID) measurements show that both cluster monomers and dimers are involved in the reactions. We have modeled the corresponding kinetics assuming a reaction mechanism in which metal atom exchange occurs through transient dimers. Our kinetic model contains three types of generic reactions: dimerization of monomers, metal atom exchange in the transient dimers, and dissociation of the dimers to monomers. There are correspondingly 377 discrete species connected by in total 1302 reactions (i.e., dimerization, dissociation and atom exchange reactions) leading to the entire series of monomeric and dimeric products [Ag_mAu_25-m]^– (m = 1-24) and [Ag_mAu_50-m]^2- (m = 0-50), resp. The rate constants of the corresponding reactions were fitted to the exptl. data, and good agreement was obtained with exchange rate constants which scale with the probability of finding a silver or gold atom in the resp. monomeric subunit of the dimer, i.e., reflecting an entropic driving force for alloying. Allowing the dimerization rate constant to scale with increasing gold composition of the resp. reactants improves the agreement further. The rate constants obtained are phys. plausible, thus strongly supporting dimer-mediated metal atom exchange in this intercluster reaction system.

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Panchale, Wrushali A. published the artcileFirst-order derivative spectrophotometric estimation of gemifloxacin mesylate and ambroxol HCl in tablet dosage form, Category: alcohols-buliding-blocks, the publication is GSC Biological and Pharmaceutical Sciences (2021), 14(2), 29-36, database is CAplus.

Aim of present work was to develop and validate a simple, precise and accurate uv-vis spectrophotometric method for the simultaneous estimation of gemifloxacin mesylate (GEMI) and ambroxol HCl (AMB) in their combined tablet dosage form. The method is based on first-order derivative spectroscopy. For determination of sampling wavelengths, each of GEMI and AMB were scanned in the wavelength range of 200-400 nm in the spectrum mode and sampling wavelengths were selected at 360 nm (zero crossing of GEMI) where AMB showed considerable absorbance and at 221.6 nm (zero crossing of AMB) where GEMI showed considerable absorbance. The linearity was obtained in the concentration range of 32-192μg/mL for GEMI and 7.5-45μg/mL for AMB. The correlation coefficients were found to be 0.9987 and 0.9992 for GEMI and AMB, resp. The method was validated as per ICH guidelines. Mean recoveries were found satisfactory. All the data of validation study was found to be satisfactorily. The proposed method can be applied for simultaneous estimation of both the drugs.

GSC Biological and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts