Month: December 2022

Maeder, Patrick published the artcileSynthesis and Biological Evaluation of Endocannabinoid Uptake Inhibitors Derived from WOBE437, Recommanded Product: 4-Propylphenol, the publication is ChemMedChem (2021), 16(1), 145-154, database is CAplus and MEDLINE.

WOBE437 ((2E,4E)-N-(3,4-dimethoxyphenethyl)dodeca-2,4-dienamide, I) is a natural product-derived, highly potent inhibitor of endocannabinoid reuptake. In this study, we synthesized almost 80 analogs of I with different types of modifications in the dodecadienoyl domain as well as the dimethoxyphenylethyl head group, and we investigated their effects on anandamide uptake into U937 cells. Intriguingly, none of these analogs was a more potent inhibitor of anandamide uptake than WOBE437. At the same time, a number of WOBE437 variants exhibited potencies in the sub-100 nM range, with high selectivity over inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase; two compounds were virtually equipotent with I. Interestingly, profound activity differences were observed between analogs in which either of the two methoxy substituents in the head group had been replaced by the same bulkier alkoxy group. Some of the compounds described here could be interesting departure points for the development of potent endocannabinoid uptake inhibitors with more drug-like properties.

ChemMedChem published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nicholson, William I. published the artcileDirect Amidation of Esters by Ball Milling, Quality Control of 6346-09-4, the publication is Angewandte Chemie, International Edition (2021), 60(40), 21868-21874, database is CAplus and MEDLINE.

The direct mechanochem. amidation of esters RC(O)OR¹ (R = Cy, Ph, pyridin-2-yl, etc.; R¹ = Me, Et) by ball milling is described. The operationally simple procedure requires an ester, amines R²NHR³ (R² = H, Me, Et; R³ = i-Pr, Ph, 2,4,6-trimethylphenyl, etc.; R²R³ = -(CH₂)₂O(CH₂)₂-, -(CH₂)₅-, -(CH₂)₆-, etc.) and 1,2,3,4-tetrahydroquinoline, and substoichiometric KOtBu, and was used to prepare a large and diverse library of 78 amide structures RC(O)N(R²)R³ and (3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochem. protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochems. as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.

Angewandte Chemie, International Edition published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Crane, F. L. published the artcileStimulation of photosynthesis by carbonyl compounds and chelators, Application In Synthesis of 1139-46-4, the publication is Biochemical and Biophysical Research Communications (1977), 74(4), 1362-8, database is CAplus and MEDLINE.

A number of carbonyl compounds including HCO3-, ethylene carbonate, dimethyl carbonate, propylene carbonate, bis(pentamethylene)urea, and glycidol, and several chelators were tested for their effect on photosynthetic reactions in isolated spinach chloroplasts. Carbonyl compounds inhibited the DCMU-insensitive silicomolybdate reduction by photosystem II but stimulated the O evolution associated with ferricyanide reduction in the presence of DBMIB and the H2O �methylviologen reaction. Many chelators behaved in the same manner except 1,10-phenanthroline which showed the opposite effect. The carbonyl compounds did not uncouple because they stimulated the proton gradients associated with noncyclic photophosphorylation, whereas some chelators, such as bathocuproine or bathophenanthroline inhibited the proton gradients 100%. Electron transport in the presence of ADP and inorganic phosphate showed a stimulation of rates beyond that obtained in presence of an uncoupler. The data are discussed in terms of inhibition of cyclic electron flow around photosystem II which leads to increased electron transport rates toward photosystem I.

Biochemical and Biophysical Research Communications published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Application In Synthesis of 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rennie, Glen R. published the artcileDiscovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator, Category: alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127886, database is CAplus and MEDLINE.

Soluble guanylate cyclase (sGC) is a clin. validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction pathway. This letter describes the SAR efforts that led to the discovery of CYR715, a novel carboxylic acid-containing sGC stimulator, with an improved metabolic profile relative to our previously described stimulator, IWP-051. CYR715 addressed potential idiosyncratic drug toxicity (IDT) liabilities associated with the formation of reactive, migrating acyl glucuronides (AG) found in related carboxylic acid-containing analogs and demonstrated high oral bioavailability in rat and dose-dependent hemodynamic pharmacol. in normotensive Sprague-Dawley rats.

Bioorganic & Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Macedo, M. C. S. S. published the artcileIron corrosion inhibition by imidazoles in 3.5% NaCl medium: experimental and theoretical results, Application In Synthesis of 23351-09-9, the publication is Journal of the Electrochemical Society (2012), 159(4), C160-C169, database is CAplus.

This paper presents exptl. and theor. results concerning the corrosion inhibitor effect of imidazole and five of its derivatives on iron surface. Gravimetric methods and polarization curves were the exptl. techniques used in this study. The polarization curves showed that the inhibitors have an anodic role on the electrochem. process. Weight-loss measurements indicated that the adsorption process obeys Langmuir’s isotherm. The theor. study was done using ab initio calculations for the organic mols. and complexes formed between imidazoles and a Fe atom, a Fe²⁺ ion, and a Fe³⁺ ion. Correlations between structural properties of the compounds and their exptl. inhibitor efficiencies were analyzed. A satisfactory correlation between quantum-mech. parameters and inhibition efficiency was found.

Journal of the Electrochemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Honing, Maarten published the artcileAdduct ion formation by aromatic amines in thermospray mass spectrometry, Product Details of C7H9NO, the publication is Journal of Mass Spectrometry (1996), 31(5), 527-536, database is CAplus.

The formation of solvent adduct ions in thermospray and ionspray mass spectrometry was studied for twelve aromatic amines: aniline, N-methylaniline, N,N-dimethylaniline, 3-aminophenol, 3-(methylamino)phenol, 3-(dimethylamino)phenol, 2-aminopyridine, 2-(methylamino)pyridine, 2-(dimethylamino)pyridine, 2-amino-5,6-dimethyl-4-hydroxypyrimidine, 2-(methylamino)-5,6-dimethyl-4-hydroxypyrimidine, and 2-(dimethylamino)-5,6-dimethyl-4-hydroxypyrimidine. For all compounds, adduct ions, [M + H + A_n]⁺, with A being methanol or acetonitrile, were observed in the thermospray mass spectra; water adduct ions were observed for a few compounds No adduct ions with ammonia were formed when ammonium acetate was added to the liquid chromatog. carrier stream. These observations cannot be explained on the basis of gas-phase ion-mol. reactions of the neutral analyte and protonated solvent or solvent additive mols. Comparative experiments, changing the pH of the carrier stream in both thermospray and ionspray ionization, showed that the solvent adduct ions present in the thermospray mass spectra are not likely to be formed by ion evaporation processes. Incomplete evaporation of droplets or cluster ions is proposed to be responsible for the observations. With this hypothesis, both the absence of ammonium adduct ions and the dependence of the adduct ion abundances on N-methylation can be related to the adduct-analyte bond strengths.

Journal of Mass Spectrometry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Product Details of C7H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Melucci, Manuela published the artcileSolvent-Free, Microwave-Assisted Synthesis of Thiophene Oligomers via Suzuki Coupling, Quality Control of 239075-02-6, the publication is Journal of Organic Chemistry (2002), 67(25), 8877-8884, database is CAplus and MEDLINE.

The purpose of this study was to obtain a rapid, efficient, and environmentally friendly methodol. for the synthesis of highly pure thiophene oligomers. The solvent-free, microwave-assisted coupling of thienyl boronic acids and esters with thienyl bromides, using aluminum oxide as the solid support, allowed us to rapidly check the reaction trends on changing times, temperature, catalyst, and base and easily optimize the exptl. conditions to obtain the targeted product in fair amounts This procedure offers a novel, general, and very rapid route to the preparation of soluble thiophene oligomers. Thus, for example, quaterthiophene was obtained in 6 min by reaction of 2-bromo-2,2′-bithiophene with bis(pinacolato)diboron (isolated yield 65%), whereas quinquethiophene was obtained in 11 min by reaction of dibromoterthiophene with thienylboronic acid (isolated yield 74%). The synthesis of new chiral 2,2′-bithiophenes is reported. The detailed anal. of the byproducts of some reactions allowed us to elucidate a few aspects of reaction mechanisms. While the use of microwaves proved to be very convenient for the coupling between conventional thienyl moieties, the same was not true for the coupling of thienyl rings to thienyl-S,S-dioxide moieties. Indeed, in this case, the targeted product was obtained in low yields because of the competitive, accelerated, Diels-Alder reaction that affords a variety of condensation products.

Journal of Organic Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Valle, M. published the artcileAccess of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is European Journal of Clinical Pharmacology (2005), 61(2), 103-111, database is CAplus and MEDLINE.

Triflusal has been shown to exert neuroprotective effects by downregulating mols. considered responsible for the development of Alzheimer’s disease (AD). The aim of this study was to develop a population pharmacokinetic model to characterize plasma and cerebrospinal fluid (CSF) pharmacokinetics of the main active metabolite of triflusal-HTB (2-hydroxy-4-trifluoro-methylbenzoic acid)-in healthy volunteers. Data from two studies were combined. Study A: subjects received single oral doses of triflusal 900 mg. Triflusal and HTB plasma concentrations were extensively measured. Study B: triflusal 600 mg once daily was administered orally for 14 days. HTB plasma and CSF concentrations were determined in healthy volunteers. Population pharmacokinetic modeling was performed using NONMEM. A one-compartmental model with rapid first-order absorption for triflusal and first-order formation of HTB best described plasma concentrations Triflusal elimination rate constant was 50 times faster than that estimated for the metabolite. CSF concentrations of HTB ranged between 0.011 μg/mL and 0.341 μg/mL. A CSF-plasma partition coefficient of 0.002 and a k_e0 value of 0.059 h^-1 were estimated by means of population modeling. In the present study in healthy volunteers, HTB penetrated into the CSF in a range of concentrations exptl. proven to have protective effects in AD. These concentrations suggest that triflusal could be used in the treatment of central nervous system diseases in doses similar to those used in cardiovascular diseases. Access to the CSF compartment was characterized by a slow equilibrium rate constant and a low CSF-plasma partition coefficient

European Journal of Clinical Pharmacology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C10H14BNO4S, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Xin published the artcilePolyols with several kinds of Chinese herbal medicine extracts of the anticorrosion composite applied in cosmetics, Formula: C11H24O3, the publication is Guangzhou Huagong (2013), 41(24), 70-72, database is CAplus.

A kind of the anti-corrosion composite containing polyols and several kinds of extracts of Chinese herbal medicine in combination were studied. By use of this kind of compound with combination, a novel cosmetics using antiseptic combination was provided, and the results showed that the combination and the vast majority of cosmetics raw material compatibility were very good, with broad-spectrum antimicrobial activity, which can effectively inhibit gram neg. bacteria, gram-pos. bacteria, yeast and mold, and its bacteriostatic ability was not influenced by surface active agent in cosmetics.

Guangzhou Huagong published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C15H14O3, Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kumar, Rakesh published the artcileDevelopment and validation of RP-HPLC method for the simultaneous estimation of salbutamol sulphate and ambroxol hydrochloride in oral liquid dosage form, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Asian Journal of Pharmaceutical Research and Development (2021), 9(1), 84-94, database is CAplus.

Pharmaceutical anal. is imported branch of science deals with to check the identity, strength, quality and purity of chem. and herbal compounds Qual. anal. of drugs and pharmaceutical compounds Quant. anal. is of much importance and done by various methods. One of the most accurate and precise methods is spectrophotometry which comprises the measurement of intensity of electromagnetic radiation emitted or absorbed by the compound Another most popular method of for quant. anal. is high performance liquid chromatog. (HPLC). In the present article a RP-HPLC method was developed for the simultaneous determination of salbutamol sulfate and ambroxol hydrochloride in oral liquid doses form and validation of the developed method. Developed methods include selection of mobile phase, chromatog. method, and wavelength whereas validation involves the system suitability, accuracy, precision, linearity, reproducibility, robustness, specificity and solution stability of the developed method. The result showed that the developed method is the best suited to the simultaneous determination of salbutamol sulfate and ambroxol hydrochloride and validated as per the standards

Asian Journal of Pharmaceutical Research and Development published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts