Month: December 2022

Soukup, Ondrej published the artcileThe wide-spectrum antimicrobial effect of novel N-alkyl monoquaternary ammonium salts and their mixtures; the QSAR study against bacteria, Name: 2-Morpholinoethanol, the publication is European Journal of Medicinal Chemistry (2020), 112584, database is CAplus and MEDLINE.

In this study we have prepared 43 novel N-alkyl monoquaternary ammonium salts including 7 N,N-dialkyl monoquaternary ammonium salts differing bearing alkyl chain either of 12, 14 or 16 carbons. Together with 15 already published QASs we have studied the antimicrobial efficacy of all water-soluble compounds together with standard benzalkonium salts against Gram-pos. (G+) and Gram-neg. (G-) bacteria, anaerobic spore-forming Cl. difficile, yeasts, filamentous fungi and enveloped Varicella zoster virus (VZV). To address the mechanism of action, lipophilicity seems to be a key parameter which determines antimicrobial efficacy, however, exceptions are likely to occur and therefore QSAR anal. on the efficacy against G+ and G- bacteria was applied. We showed that antibacterial activity is higher when the mol. is larger, more lipophilic, less polar, and contains fewer oxygen atoms, fewer Me groups bound to heteroatoms or fewer hydrogen atoms bound to polarized carbon atoms. In addition, from an application point of view, we have formulated mixtures, on the basis of obtained efficiency of individual compounds, in order to receive wide-spectrum agent. All formulated mixtures completely eradicated tested G+ and G- strains, including the multidrug-resistant P. aeruginosa as well as in case of yeasts. Finally, 3 out of 4 formulated mixtures were safer than reference com. agent based on benzalkonium salts only in the skin irritation test using reconstructed human epidermidis.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H7N3, Name: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Melukhova, A. G. published the artcileKinetics of choline esterase activity in Ascaris suum, Safety of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1971), 40(6), 672-4, database is CAplus.

Bephenium (I) [7181-73-9], naphthamon [3818-50-6], and preparation 397 were 8, 6, and 22 times more inhibitive toward the cholinesterase [9001-08-5] of the ascarid A. suum than toward the cholinesterase of rat brain. This may account for the selective activity of these antihelminthic preparations against the worm in mammalian bodies.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Safety of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Debbarma, Bimal published the artcileFormulation and in-vitro evaluation of taste masked fast dissolving tablets of Ambroxol hydrochloride, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2021), 10(2), 1528-1550, database is CAplus.

The purpose of the present work was to mask the taste of Ambroxol hydrochloride and to formulate its patient-friendly dosage form. Complexation technique using KYRON -T-114 an ion-exchange resin was used to mask the bitter taste and the drug loading onto the ion-exchange resin was optimized for ratio of drug to resin, effect of pH and effect on soaking time. The resinate was evaluated for taste masking and characterized by FT-IR and DSC. Then the taste-masked drug was formulated into a fast dissolving tablet (FDT). The developed tablets were evaluated for hardness, friability, drug content, weight variation, content uniformity, friability, water absorption ratio, in-vitro disintegration time and in-vitro drug release studies. IR and DSC spectra revealed that there were no possible interactions between the drug and polymer. Maximum loading was obtained at drug- resin ratio 1:2, pH 7, and soaking time 30 min. A successful taste masking of resinate was confirmed by time intensity method. The values of pre-compression parameters evaluated and were within prescribed limits and indicated good free flowing properties. The data obtained of post-compression parameters found superior over conventional formulation. The F3 batch with disintegration time 30.4±0.64 s and dissolution 98.4±2.69 was selected as optimized formulation, This was compared with conventional marketed formulation and was found superior. The obtained results revealed that Ambroxol hydrochloride has been successfully taste masked and formulated into an FDT as a suitable alternative to the conventional tablets.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ben Khemis, Ismahene published the artcileAdsorption of 2-phenylethanethiol on two broadly tuned human olfactory receptors OR1A1 and OR2W1: Interpretation of the effect of copper ions via statistical physics monolayer adsorption model, Safety of 2-Phenylethanethiol, the publication is Journal of Molecular Liquids (2021), 116926, database is CAplus.

This paper aims to investigate the effect of metal especially copper ions on the adsorption of a key food odorant (2-phenylethanethiol) on two human olfactory receptors OR1A1 and OR2W1 that was interpreted via a statistical physics monolayer model. To this purpose, four exptl. dose-olfactory response curves were used without and with the presence of Cu2+ for each human receptor. In order to reach a theor. interpretation of the exptl. data and understand the effect of the used metal on adsorption process introduced on the olfaction mechanism, a statistical physics monolayer adsorption model with identical and independent sites was applied. The used model showed that the presence of copper ions decreased the efficacy (olfactory response at saturation) of 2-phenylethanethiol key food odorant activating OR1A1, suggesting a neg. allosteric action. However, the presence of Cu2+ reduced the potency (concentration at half saturation) of the studied thiol key food odorant in activating OR2W1, suggesting an orthosteric competitive action. Furthermore, the molar adsorption energies retrieved from data anal. varied from 5.568 to 9.886 kJ/mol in studied systems, whose values showed that the process based on a phys. adsorption. Lastly, the dose-olfactory response curves of 2-phenylethanethiol on two broadly tuned human olfactory receptors OR1A1 and OR2W1 provided access to the olfactory receptor site size distribution (RSD) and also the adsorption energy distribution (AED).

Journal of Molecular Liquids published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Safety of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rashidi, Masih published the artcileThe selective cleavage of lignin aliphatic C-O linkages by solvent-assisted fast pyrolysis (SAFP), HPLC of Formula: 70110-65-5, the publication is Journal of Inclusion Phenomena and Macrocyclic Chemistry (2019), 94(3-4), 297-307, database is CAplus.

We report the effect of an organic solvent on the selective cleavage of individual lignin model compounds and lignin C-O linkages during the fast thermal pyrolysis of lignin. During this process, it was possible to lower the aliphatic hydroxyl contents of lignin, along with increasing the amount of single and double bonded aliphatics. It was found that the addition of solvent during fast pyrolysis of lignin lowered the mol. weight distribution of the obtained bio-oil (�49-52% decrease) and at the same time inhibited the formation of a high amount of char. A detailed study of the cleavage of complex model compounds using Ethanol-Assisted Fast Pyrolysis (EAFP) revealed that the aliphatic hydroxyl groups and etheric linkages are very reactive during this process. By the use of deuterated lignin model compounds and solvent, it was then possible to elucidate the mechanism for cleavage of lignin in the EAFP process that involves the formation of a transition state between solvent and oxygen bonds of lignin. This transition state involves the cleavage of etheric bonds by the in situ transfer of hydrogen from ethanol to this linkage.

Journal of Inclusion Phenomena and Macrocyclic Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, HPLC of Formula: 70110-65-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lopez de Laorden, Carlos published the artcileNanostructured Indium Tin Oxide Slides for Small-Molecule Profiling and Imaging Mass Spectrometry of Metabolites by Surface-Assisted Laser Desorption Ionization MS, HPLC of Formula: 85618-21-9, the publication is Analytical Chemistry (Washington, DC, United States) (2015), 87(1), 431-440, database is CAplus and MEDLINE.

Due to their elec. conductivity and optical transparency, slides coated with a thin layer of indium tin oxide (ITO) are the standard substrate for protein imaging mass spectrometry on tissue samples by MALDI-TOF MS. The authors have now studied the radiofrequency magnetron sputtering deposition parameters to prepare ITO thin films on glass substrates with the required nanometric surface structure for their use in the matrix-free imaging of metabolites and small-mol. drugs, without affecting the transparency required for classical histol. The custom-made surfaces were characterized by at. force microscopy, SEM, ellipsometry, UV, and laser desorption ionization MS (LDI-MS) and employed for the LDI-MS-based anal. of glycans and druglike mols., the quantification of lactose in milk by isotopic dilution, and metabolite imaging on mouse brain tissue samples.

Analytical Chemistry (Washington, DC, United States) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, HPLC of Formula: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Huan-Ming published the artcileThree-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides, Recommanded Product: 3-Morpholinophenol, the publication is Journal of the American Chemical Society (2020), 142(22), 10173-10183, database is CAplus and MEDLINE.

Developing efficient and selective strategies to approach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and industry. Catalytic cascade reactions represent a powerful means of rapidly leveraging mol. complexity from simple feedstocks. Unfortunately, carrying-out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing to unavoidable β-hydride elimination. Herein, we show that a modular, practical and general palladium catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substitution sequence mediated by visible light. Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achieved by employing different com. available nitrogen-, oxygen-, sulfur- or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5 E/Z, >20:1 rr). Sequential C(sp3)-C(sp3) and C-X (N, O, S) bonds have been constructed efficiently with a broad scope and high functional group tolerance. The flexibility and versatility of the strategy has been illustrated in a gram-scale reaction and streamlined syntheses of complex ether, sulfone and tertiary amine products, some of which would be difficult to access via currently established methods.

Journal of the American Chemical Society published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Huan-Ming published the artcileThree-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides, COA of Formula: C10H9NO, the publication is Journal of the American Chemical Society (2020), 142(22), 10173-10183, database is CAplus and MEDLINE.

Developing efficient and selective strategies to approach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and industry. Catalytic cascade reactions represent a powerful means of rapidly leveraging mol. complexity from simple feedstocks. Unfortunately, carrying-out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing to unavoidable β-hydride elimination. Herein, we show that a modular, practical and general palladium catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substitution sequence mediated by visible light. Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achieved by employing different com. available nitrogen-, oxygen-, sulfur- or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5 E/Z, >20:1 rr). Sequential C(sp3)-C(sp3) and C-X (N, O, S) bonds have been constructed efficiently with a broad scope and high functional group tolerance. The flexibility and versatility of the strategy has been illustrated in a gram-scale reaction and streamlined syntheses of complex ether, sulfone and tertiary amine products, some of which would be difficult to access via currently established methods.

Journal of the American Chemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Huan-Ming published the artcileRadical Carbonyl Umpolung Arylation via Dual Catalysis, SDS of cas: 111-29-5, the publication is Journal of the American Chemical Society (2022), 144(4), 1899-1909, database is CAplus and MEDLINE.

A series of aryl benzoates I [R = iPr, tBu, cyclohexyl, etc.; R¹ = 4-NCC₆H₄, 2-NCC₆H₄, 2-pyridyl, etc.] via dual nickel and photoredox catalyzed radical carbonyl umpolung arylation of aldehydes and aryl bromides was reported. This redox-neutral approach provided a complementary method to construct Grignard-type products from (hetero)aryl bromides and aliphatic aldehydes, without the need for prefunctionalization. Sequential activation, hydrogen atom transfer and halogen atom transfer process could directly converted aldehydes to the corresponding ketyl radicals, which further react with aryl-nickel intermediates in an overall polarity-reversal process. This radical strategy tolerated-among others-acidic functional groups, heteroaryl motifs and sterically hindered substrates and was applied in the late-stage modification of drugs and natural products.

Journal of the American Chemical Society published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brun, Elodie published the artcileDiastereo- and enantioselective synthesis of 1,3,5,7-tetraol structural units using a Prins cyclisation-reductive cleavage sequence, Synthetic Route of 57044-25-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(51), 6718-6721, database is CAplus and MEDLINE.

Stereocontrolled and efficient access to all the diastereomers of 1,3,5,7-tetraol structural units I was developed using a Prins cyclization-reductive cleavage sequence applied to tetrahydropyran aldehydes II. Furthermore, these tetraols can be selectively functionalized.

Chemical Communications (Cambridge, United Kingdom) published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Synthetic Route of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts